Nature Structural & Molecular Biology, Published online: 06 October 2025; doi:10.1038/s41594-025-01686-3Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.

Exile, discovery, and resilience have shaped my journey as a group leader in Mexico. From exploring chromatin architecture to building a lab and community, this is how science became my vocation and my home.

Nature Structural & Molecular Biology, Published online: 25 September 2025; doi:10.1038/s41594-025-01681-8This study reveals how human small ubiquitin-like modifier (SUMO) E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway.

We highlight primary research and commissioned content that delve into the biology of ubiquitylation and degradation mechanisms.

Nature Reviews Molecular Cell Biology, Published online: 09 September 2025; doi:10.1038/s41580-025-00898-1Break-induced replication (BIR), a DNA double-strand break repair mechanism, was first studied in the 1960s in bacteriophages, showing that DNA could recombine by a 'break–copy' mechanism.

Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.

Nagano et al. identify the third mitotic cohesin complex, STAG3–cohesin, which, with its unique biophysical properties, weakens insulation and rewires regulatory interactions of spermatogonial stem ce...

Returning to Central Europe was appealing and challenging. Here, I reflect on my part in rebuilding a research career in Czechia and fostering a collaborative scientific community across the region.

Francesca Mattiroli leads a research group at the Hubrecht Institute in Utrecht in the Netherlands, delving into the dynamics of chromatin during DNA synthesis. Here we ask her about her research etho...

Yael David leads her lab focused on studying the fundamental mechanisms of epigenetic regulation of transcription at Memorial Sloan Kettering Cancer Center, and Charles Rice is the Maurice R. and Cori...

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Here, the authors comprehensively discuss the different mechanisms for origin licensing in yeast and human cells. Importantly, they present intuitive videos illustrating such mechanisms with unprecede...

Xu et al. establish the importance of H2A.Z in mouse oocyte development. H2A.Z is incorporated into chromatin at promoters and putative enhancers, and its presence promotes histone acetylation in full...

We outline a pilot starting at several Nature Portfolio journals aimed at improving and standardizing the reporting of light and fluorescence microscopy experiments.