Current antimalarials often fail to target mature stage V gametocytes. To aid antimalarial drug discovery, the authors present a preclinical malaria transmission-blocking drug research platform, using engineered parasites, that facilitates the screening for gametocytocidal compounds in vitro and the evaluation of transmission-blocking drug activity in vivo.

In this study, the authors determine the structure of a Type I-A retron from E. coli FORC82 and reveal the functional interplay between Reverse Transcriptases (RTs) and Structural Maintenance of Chromosomes (SMC) ATPases.’

This study used multiplex serology to monitor multiple diseases simultaneously from a single serosurvey. Seroprevalence estimates were performed for five disease categories in Zambezia Province, Mozambique.

Machine learning (ML) is rapidly influencing the development of many research areas, including biocatalysis, the use of enzymes and living systems to mediate chemical reactions, often of pharmaceutical and industrial importance. To find out how can machine learning be applied to biocatalysis research, we talked to three scientists, Professor Rebecca Buller (Zurich University of Applied Sciences), Dr. Stanislav Mazurenko (Masaryk University) and Associate Professor Yang Yang (University of California, Santa Barbara). We discussed the potentials and challenges associated with ML, how collaborations between computational and biocatalysis experts can be promoted, and how will the field develop in the future.

The Biomolecular Screening Facility has contributed to a successful collaborative study led by Till Voss (Swiss Tropical and Public Health Institute, University of Basel), resulting in the development of a robust, all in one pipeline for the discovery and testing of transmission blocking drugs against Plasmodium falciparum. This multidisciplinary effort combines a high-throughput in vitro assay with a novel in vivo model, enabling systematic evaluation of compounds that target mature stage V gametocytes - the only forms of the parasite that infect mosquitoes.

Dengue virus transmission by Ae. aegypti mosquitoes poses a significant public health threat, necessitating innovative control strategies. Here, the authors demonstrate that, while successive blood fe...

Serological studies are needed to understand the ongoing clade Ib mpox outbreak in the Democratic Republic of the Congo and neighboring countries. Here, the authors conduct a cross-sectional serological study in South Kivu, highlighting the role of professional sex workers and household transmission in mpox epidemiology.

In this study, the authors determine the structure of a Type I-A retron from E. coli FORC82 and reveal the functional interplay between Reverse Transcriptases (RTs) and Structural Maintenance of Chromosomes (SMC) ATPases.’

Niclosamide has been shown to have activity against SARS-CoV-2 in vitro, but poor bioavailability has hindered clinical development. In this clinical trial, the authors show that the niclosamide nanohybrid CP-COV03 alleviates COVID-19 symptoms and reduces viral load, offering a promising therapeutic option.

The Biomolecular Screening Facility has contributed to a successful collaborative study led by Till Voss (Swiss Tropical and Public Health Institute, University of Basel), resulting in the development of a robust, all in one pipeline for the discovery and testing of transmission blocking drugs against Plasmodium falciparum. This multidisciplinary effort combines a high-throughput in vitro assay with a novel in vivo model, enabling systematic evaluation of compounds that target mature stage V gametocytes - the only forms of the parasite that infect mosquitoes.

Dengue virus transmission by Ae. aegypti mosquitoes poses a significant public health threat, necessitating innovative control strategies. Here, the authors demonstrate that, while successive blood feeding increases earlier dengue virus dissemination, the inhibitory effects of Wolbachia remain strong, highlighting Wolbachia’s potential to disrupt dengue transmission under natural feeding conditions.

Nature Communications - Dengue virus transmission by Ae. aegypti mosquitoes poses a significant public health threat, necessitating innovative control strategies. Here, the authors demonstrate...

Serological studies are needed to understand the ongoing clade Ib mpox outbreak in the Democratic Republic of the Congo and neighboring countries. Here, the authors conduct a cross-sectional serological study in South Kivu, highlighting the role of professional sex workers and household transmission in mpox epidemiology.

Serological studies are needed to understand the ongoing clade Ib mpox outbreak in the Democratic Republic of the Congo and neighboring countries. Here, the authors conduct a cross-sectional serologic...

Multidrug-resistant Klebsiella pneumoniae is a critical priority pathogen. Here, the authors explore its evolution in 110 patients during a hospital outbreak, highlighting selected mutation-driven adaptations that alter its key virulence traits.

Here, the authors profile the EBV transcriptome during lytic replication and identify over 1,400 unique EBV transcript isoforms, resolving major isoforms of most lytic open reading frames, alternative and biphasic promoters and an enhancer function for the viral lytic origin of replication.

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In this work, authors utilise a prefractionation natural product extract screening platform, which uncovers coniotins, lipopeptaibiotics with broad antifungal activity and a mechanism of action that targets fungal cell wall β-glucan.