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molgen.mpg.de
Max Planck Institute for Molecular Genetics
@molgen.mpg.de
3.9K followers 100 following 130 posts
The Max Planck Institute for Molecular Genetics in Berlin. We want to understand how the genome works and how it is regulated, especially during embryonic development & disease. Imprint: https://www.molgen.mpg.de/impressum
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 4h
🚨 Please share! We are seeking motivated PhD students who wish to work at the intersection of molecular life sciences and computational sciences.
#IMPRS #IMPRSBAC @freieuniversitaet.bsky.social @maxplanck.de
Check out our projects and apply by Jan 7th, 2026!
www.molgen.mpg.de/IMPRSPhDproj...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 5h
Using a CRISPR screening approach, first author @tschwammle.bsky.social identified new regulators of Xist, and discovered a two-step process that controls and regulates this important gene behind X-inactivation
Read more: www.molgen.mpg.de/2025-10-06-s...
Publication: doi.org/10.1038/s415...
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A switch and a dial
A study by the Schulz lab describes a novel regulatory principle involved in X-chromosome inactivation during development
www.molgen.mpg.de
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 5h
New paper! In female mammals, one X-chromosome is inactive in each cell. In some cats, this causes typical color patterns, depending on which X is active and the color it codes for. The @eddaschulz.bsky.social lab found a new regulatory principle behind X-inactivation. 1/2 Note: AI generated image
Calico cat on a neutral background. Image is AI generated with Adobe Firefly.
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Reposted by Max Planck Institute for Molecular Genetics
eddaschulz.bsky.social
Edda Schulz @eddaschulz.bsky.social · 2d
⚠️ Paper alert: Using a novel CRISPR screening approach, we mapped the entire regulatory network controlling Xist—key for X-chromosome inactivation.
👉 We discover how sex and development signals are decoded at a single gene locus.
www.nature.com/articles/s41...
👇 Bluetorial
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus - Nature Structural & Molecular Biology
Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
www.nature.com
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Reposted by Max Planck Institute for Molecular Genetics
fueyoraquel.bsky.social
Raquel Fueyo @fueyoraquel.bsky.social · 2d
⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 2d
In our “Meet the first author” interview series, we take a look behind the scenes of science. This time we spoke with Francesca Rossi, first author of a recent collaborative paper in Nucleic Acids Research from the Kinkley Lab.

👉 Read the interview here: www.molgen.mpg.de/2025-09-22-m...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 7d
Great to see our Alumni Hossein and Uirá named among the 100 most influential scientists in Berlin by @tagesspiegel.de! They are co-founders of Lucid Genomics, a startup that develops algorithms to analyze the non-coding genome for potential use in precision medicine. Congratulations!
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 12d
2nd Meeting on Early Embryogenesis and Epigenetics
16 - 18 Feb 2026 at MPI for Molecular Genetics, Berlin
with support by the Weizmann Institute for Science.
Early bird registration until 30 Sep - register now👇
www.molgen.mpg.de/embryo2026
Save-the-date information: New approaches to Early embryogenesis & epigenetics February 16 - 18 2026 Max Planck Institute for Molecular Genetics, Berlin, Germany
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 21d
📢 Don't miss! Steven Reilly of Yale School of Medicine will speak at our #DahlemColloquium!

📆 22. SEP, 11:00 AM (CET)
📍 MPIMG, Berlin
🔗 www.molgen.mpg.de/events/42874...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 27d
📢 Don't miss! Pavel Pevzner of University of California, San Diego, USA will speak at our #DahlemColloquium!
📜 A new parameter-free framework for sequence comparison
📆 15. SEP, 11:00 AM (CET)
📍MPIMG, Berlin
🔗 www.molgen.mpg.de/events/42633...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 28d
Congratulations to Claudia Giesecke-Thiel on her ERC Starting Grant! Her project will focus on how the site of infection influences immune responses.
She will be moving from the MPIMG to Charité, where she will launch her own research group in Jan 2026.
Read more: www.molgen.mpg.de/news-2025-er...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · 29d
📢 Don't miss! Aziz Al'Khafaji of Broad Institute of MIT and Harvard will speak at our #DahlemColloquium!

📜 Advances in Transcriptomics, Methods and Applications
📆 12. SEP, 11:00 AM (CET)
📍 MPIMG, Berlin
🔗 www.molgen.mpg.de/events/42555...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Sep 8
In late August we had the pleasure of welcoming BSc students from the EPFL in Switzerland. They learned about our IMPRS-BAC graduate program and enjoyed a tour of the institute and the Vallier lab with Maïa Pesic.
We wish the students all the best in their future careers!
@vallierlab.bsky.social
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Aug 28
📢 Don't miss! Dan Landau of Weill Cornell College of Medicine, and the New York Genome Center will speak at our #DahlemColloquium!
📜 The somatic genome - from basic discovery to clinical application
📆 04. SEP, 11:00 AM (CET)
📍 MPIMG, Berlin
🔗 www.molgen.mpg.de/events/42554...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Aug 26
Congratulations to Aydan Bulut-Karslıoğlu on receiving the GSCN Young Investigator Award 2025! The award recognizes her lab’s research on dormancy.
Read more: www.molgen.mpg.de/news-2025-gs...

@bulutkarslioglu.bsky.social
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Aug 15
A big thank you to Alessa Ringel, Christian Feregrino, Jonathan J. Froehlich and Michaela Reissland for organizing this year’s MPIMG Postdoc Retreat!

Our postdocs enjoyed an inspiring mix of skills development, career insights, and networking both within and beyond the MPIMG community.
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Aug 14
A recent study from the Meissner and Smith labs in Genome Biology reveals that widely used cancer models fail to replicate the DNA methylation patterns found in actual tumors.

Read more in our news: www.molgen.mpg.de/2025-08-12-m...

Picture: Dr. Cecil Fox, Wikimedia Commons
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Reposted by Max Planck Institute for Molecular Genetics
cnag-eu.bsky.social
CNAG @cnag-eu.bsky.social · Jul 30
📢New paper in @natecoevo.nature.com!
🦇Research reveals that bat wings form by reusing existing genetic programs

By @molgen.mpg.de, @mdc-berlin.bsky.social,
@cabd-upo-csic.bsky.social (@dariloops.bsky.social‬, @fany-real.bsky.social) & CNAG (@mamartirenom.bsky.social‬)

www.cnag.eu/news/flying-...
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Aug 1
🧬 New study from the Kinkley Lab! 🧬 In collaboration with the Vingron and Hnisz labs at the MPIMG the team has gained new insights how the epigenetic reader PHF13 regulates it´s affinity to bind to chromatin.
Read more: www.molgen.mpg.de/2025-07-28-o...
Congrats to first author Francesca Rossi!
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Reposted by Max Planck Institute for Molecular Genetics
annaamonaco.bsky.social
Anna A Monaco @annaamonaco.bsky.social · Jul 23
Pretty surreal to see my artwork on the cover of Nature Genetics! Big congrats to @julianeg.bsky.social, @stemundi.bsky.social and the others, and thank you Juliane for letting me help bring your research to life visually.

www.nature.com/ng/volumes/5...
The cover of Nature Genetics July 2025 issue. Digital art of a mouse paw skeletal prep on dark background, digits I to IV disintegrating into viral particles. A caption says “An endogenous retrovirus causes limb malformation”.
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Jul 16
Link to the original publication in Nature Ecology & Evolution: www.nature.com/articles/s41...
Congratulations also to first authors Magdalena Schindler and Christian Feregrino! Picture: Gene expression of bat wings, cell by cell. (c) Jim Hsu
Comparative single-cell analyses reveal evolutionary repurposing of a conserved gene programme in bat wing development - Nature Ecology & Evolution
Single-cell comparison of developing bat and mouse limbs reveals conservation of cell populations and gene expression patterns, and suggests repurposing of genes involved in proximal limb development ...
www.nature.com
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Jul 16
How did the bat get its wings? New research from a collaboration between the labs of Stefan Mundlos (MPIMG), Dario G. Lupiáñez, and Francisca M. Real (@cabd-upo-csic.bsky.social) show how genetic programs were reused during the evolution of mammalian flight. --> www.molgen.mpg.de/news-2025-fl...
Flying with hands – The evolution of bat wings
www.molgen.mpg.de
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Reposted by Max Planck Institute for Molecular Genetics
julianeg.bsky.social
Juliane Glaser @julianeg.bsky.social · Jul 9
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Jul 9
Picture shows retrotransposon viral-like particles in developmental limb malformation made by @annaamonaco.bsky.social.

Link to the original publication: www.nature.com/articles/s41...

Link to News & Views article: www.nature.com/articles/s41...
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
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molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Jul 9
New paper in @natgenet.nature.com by the Mundlos lab! The team has identified the mechanism by which a retrotransposon of viral origin causes limb malformations. Congratulations to first author @julianeg.bsky.social, now group leader @mpi-ie.bsky.social!
--> www.molgen.mpg.de/news-2025-an...
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