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Reposted by Hallou Lab

Miki Ebisuya @ebisuyamiki.bsky.social · 6h

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

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Hallou Lab @halloulab.bsky.social · 1d

Delighted that the Nobel Prize for Physics has been awarded to Professor John Clarke FRS, an alumnus of my old Cambridge College @darwincollegecam.bsky.social ! John was the first president of the Darwin Student Association and is the seventh Nobel Prize laureate in the College's 60-year history !

Darwin College, University of Cambridge @darwincollegecam.bsky.social · 1d

Enormous congratulations to Darwin alumnus Professor John Clarke, who has been jointly awarded the Nobel Prize for Physics.

John joined Darwin in 1965, as one of our first PhD students. He became an Honorary Fellow in 2023.

www.darwin.cam.ac.uk/news/alumnus...

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Hallou Lab @halloulab.bsky.social · 1d

John was a true gentleman scientist. I remember how he took time to speak to me after my first talk as a postdoc @gurdoninstitute.bsky.social & his enthusiasm when he told me one morning he was excited to do his "1st single-cell experiment" while queuing behind me at the ice machine! Vale Sir John!

James Briscoe @jamesbriscoe.bsky.social · 1d

Very sad news, John Gurdon has died.

A developmental biologist's developmental biologist, Nobel prize winner

His work is the foundation of much of today's dev & stem cell bio.

An inspiration to many, including me. Always asking questions & wanting the answers

www.magd.cam.ac.uk/news/profess...

Professor Sir John Gurdon FRS (1933-2025) | Magdalene College

Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.

www.magd.cam.ac.uk

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Hallou Lab @halloulab.bsky.social · 1d

Beautiful study on the role of mechanosensing and ECM in the establisment of multicellularity and tissue growth control 🤩!! Many congratulations @thibautbrunet.bsky.social and to all authors !

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Thibaut Brunet @thibautbrunet.bsky.social · 3d

Latest from ours: www.cell.com/cell-reports...

This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵

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Reposted by Hallou Lab

Guillaume Charras @gcharras.bsky.social · 9d

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

elifesciences.org

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Hallou Lab @halloulab.bsky.social · 3d

Really sadened to hear that Jochen Guck has passed away. I vividly remember attending one of his lecture while I was a grad student @cam.ac.uk... Mechanobiology has lost another giant...

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Hallou Lab @halloulab.bsky.social · 8d

Very exciting study! Given the role of th Golgi in exocytosis, this has possibly key implications on the establishement of mechanochemical feedback loops with secreted ligands such as morphogens or growth factors! Congratulations @felixmendu.bsky.social and to all authors 👏😀!!

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Felix Campelo @felixmendu.bsky.social · 16d

🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...

Mechanical forces stimulate Golgi export

Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...

www.biorxiv.org

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Hallou Lab @halloulab.bsky.social · 8d

A landmark study by @sarawickstrom.bsky.social @katemiro.bsky.social and colleagues elucidating the relative contribution of GF and nuclear mechanics on cell fate decisions🤩 !! Many congratulations on this 'tour de force' 👏🎉 (pun on words intended 😉!) !!

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Reposted by Hallou Lab

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Hallou Lab @halloulab.bsky.social · 9d

Many congratulations @frelab.bsky.social and to all authors 👏😀!!

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Reposted by Hallou Lab

Silvia Fre lab @frelab.bsky.social · 9d

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social

It just came out online, check it out here:
rdcu.be/eIIKD

Contractile fibroblasts form a transient niche for the branching mammary epithelium

Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

rdcu.be

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Reposted by Hallou Lab

Hallou Lab @halloulab.bsky.social · 12d

Absolutely delighted to host Dr Jenna Cash from @edinburgh-uni.bsky.social for our next @kiroxford.bsky.social External Seminar on Monday 29 September at 12 pm !

Please join us if you want to learn more about how the most recent spatial omics technologies can be used to understand skin biology!

Kennedy Institute of Rheumatology @kiroxford.bsky.social · 13d

On Monday 29 September, Dr Jenna Cash from the University of Edinburgh will visit us to talk about "Derailed Cellular Choreography in the Skin Ulcer Niche: Roadblocks to Repair". Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/743...

A purple and white poster reads "the Kennedy Institute of Rheumatology External Seminar: derailed cellular choreography in the skin ulcer niche: roadblocks to repair". The speaker is Dr Jenna Cash from the University of Edinburgh. The seminar will take place on 29 Sept 2025 in the Kennedy Lecture Theatre from 12:00-13:00. It is open to all members of the University of Oxford, and is hosted by Adrien Hallou.

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Hallou Lab @halloulab.bsky.social · 11d

Very cool study showing how 3D tissue mechanics models can help us better understand the dynamics of stratified epithelia !! Many congratulations @ehannezo.bsky.social and to all authors 👏😀!!

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Reposted by Hallou Lab

Edouard Hannezo @ehannezo.bsky.social · 12d

Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...

Edouard Hannezo @ehannezo.bsky.social · Dec 17

Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk

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Hallou Lab @halloulab.bsky.social · 12d

Many congratulations Zoe @zoenahas.bsky.social 🎉👏🍾😀!!

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Hallou Lab @halloulab.bsky.social · 12d

Absolutely delighted to host Dr Jenna Cash from @edinburgh-uni.bsky.social for our next @kiroxford.bsky.social External Seminar on Monday 29 September at 12 pm !

Please join us if you want to learn more about how the most recent spatial omics technologies can be used to understand skin biology!

Kennedy Institute of Rheumatology @kiroxford.bsky.social · 13d

On Monday 29 September, Dr Jenna Cash from the University of Edinburgh will visit us to talk about "Derailed Cellular Choreography in the Skin Ulcer Niche: Roadblocks to Repair". Our External Seminars are open to any member of the University of Oxford. Don't miss it! talks.ox.ac.uk/talks/id/743...

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Hallou Lab @halloulab.bsky.social · 14d

Very exciting study !! Congratulations @eliasbarrigalab.bsky.social and to all authors👏😀!!

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Barriga Lab @eliasbarrigalab.bsky.social · 15d

Are you interested on how regenerating tissues transit between stages? Am sharing here our work showing that during #Xenopus tail regeneration, tissue stiffening activates a Piezo1-Yap1 mechanosensitive cascade to allow wounded epithelia to transit into regenerative states!

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Reposted by Hallou Lab

Rashmi Priya @rashmi-priya.bsky.social · 19d

Development does not happen in isolation! Material properties, geometry, stiffness, fluid flows...can all steer how development unfolds. If you’re exploring these kinds of questions, we’d love to see your work @dev-journal.bsky.social
More info below ⬇️

Development @dev-journal.bsky.social · Sep 1

📢Call for papers. Submit your latest research to our upcoming special issue – The Extracellular Environment in Development, Regeneration and Stem Cells

Guest Editors: Alex Hughes and Rashmi Priya

📅 Deadline: 1 March 2026

journals.biologists.com/dev/pages/ex...

#DevBio

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Hallou Lab @halloulab.bsky.social · 19d

Very elegant and efficient methodology to recover spatial patterns from multi-modal spatial datasets 👌!! Many congratulations @paulvilloutreix.bsky.social and to all authors👏😀!!

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Paul Villoutreix @paulvilloutreix.bsky.social · 19d

Very happy to introduce jsPCA, a fast and interpretable computational framework for spatial transcriptomics that simultaneously identifies spatial domains and variable genes across multi-slice and multi-sample data.

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Reposted by Hallou Lab

Levayer Lab @levayerr.bsky.social · 19d

We only had a very minor contribution to this story with Alexis, but definitly worth a reading for those interested by patterning, precision and refinment. Nice combining of quantitative live imaging, modeling and optogenetics to dissect vein patterning dynamics
www.cell.com/developmenta...

Signaling-dependent refinement of cell fate choice during tissue remodeling in Drosophila pupal wings

Herszterg et al. show that during morphogenesis of the Drosophila pupal wing, a wave of Notch signaling activity updates cell fates to ensure robust and precise patterning of wing veins.

www.cell.com

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Hallou Lab @halloulab.bsky.social · 20d

Many congratulations @zenahadjivasiliou.bsky.social and to all authors 👏🎉!!

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