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Silvia Fre lab @frelab.bsky.social · 5d

Thanks a lot @halloulab.bsky.social , looking forward to working together soon!

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Silvia Fre lab @frelab.bsky.social · 5d

thank you @campaslab.bsky.social ! The next story together? 😉

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Reposted by Silvia Fre lab

James Briscoe @jamesbriscoe.bsky.social · 5d

Mechanical constraints disrupt gastruloid polarisation without changing gene expression - uncouples morphogenesis & patterning

Gregor & co use tunable hydrogels to show cell motility, not gene expression, drives axis formation in gastruloids

journals.biologists.com/dev/article/...

Fine-tuning mechanical constraints reveals uncoupled patterning and gene expression programs in murine gastruloids

Highlighted Article: A bioinert confinement system enables dissection of how stiffness and timing shape gastruloid development, revealing uncoupling between polarization and transcriptional programs.

journals.biologists.com

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Silvia Fre lab @frelab.bsky.social · 9d

So proud of the exciting story from my PhD student Jakub Sumbal on contractile fibroblasts shaping branching morphogenesis!
Fantastic collaboration with the lab of Zuzana Koledova in Prague!
@sumbalovakoledova.bsky.social

It just came out online, check it out here:
rdcu.be/eIIKD

Contractile fibroblasts form a transient niche for the branching mammary epithelium

Nature Communications - Fibroblasts represent a heterogenous cell population but how their differences reflect their plasticity and origin is not fully understood. Here, the authors map the origin...

rdcu.be

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Silvia Fre lab @frelab.bsky.social · 29d

Geometry first: how positional cues dictate fate in bilayered epithelia thenode.biologists.com/geometry-fir...

Geometry first: how positional cues dictate fate in bilayered epithelia - the Node

Behind the paper story focussed on research on early fate decisions in bilayered epithelia.

thenode.biologists.com

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Reposted by Silvia Fre lab

midnightsun49.bsky.social @midnightsun49.bsky.social · Jul 20

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Silvia Fre lab @frelab.bsky.social · Jul 15

Super happy to share the work by my post-doc Candice Merle on breast cancer obtained @institutcurie.bsky.social thanks to funding from ARC:
www.fondation-arc.org/actualites/2...

Pour mieux comprendre la transformation cancéreuse des cellules mammaires

Une exploration des mécanismes moléculaires qui permettent aux cellules mammaires de modifier leur identité donne des éléments fondamentaux pour comprendre certains phénomènes de la transformation can...

www.fondation-arc.org

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Reposted by Silvia Fre lab

Robin Journot 🔬| 🎾 @robinjournot.bsky.social · Jul 1

🧵Just out !
We reveal how 4 branched epithelia—mammary, lacrimal, salivary & prostate—use a conserved YAP–Notch–p63 circuit to self-organize during development & regeneration.
Here’s the story👇
authors.elsevier.com/c/1lM285Sx5g...
Work done in @frelab.bsky.social at ‪
‪ @institutcurie.bsky.social

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Silvia Fre lab @frelab.bsky.social · Jun 30

Bravo Jean Léon and good luck now, I'll be right next door if you have questions! 😉

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Silvia Fre lab @frelab.bsky.social · Jun 17

1000 congrats to Walid @wtklab.bsky.social !!! Plenty of success!

European Research Council (ERC) @erc.europa.eu · Jun 17

Could this be the future of cancer prevention?

Walid Khaled‬, a new ERC Advanced Grant recipient @cam.ac.uk‬, will work on a preventive vaccine for breast cancer.

Learn more 👉 buff.ly/s6cBCwL

#ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social‬

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Silvia Fre lab @frelab.bsky.social · Mar 12

Beautiful and insightful review! Congrats to @sarawickstrom.bsky.social and @clemvilleneuve.bsky.social

Sara Wickstrom @sarawickstrom.bsky.social · Mar 10

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

Measuring and manipulating mechanical forces during development - Nature Cell Biology

This Review discusses the recent advances in experimental approaches to interrogate the mechanical forces that mediate tissue deformations during development, highlighting the insights afforded at bot...

www.nature.com

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Silvia Fre lab @frelab.bsky.social · Mar 7

#StandUpForScience #StandUpForScience2025

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Silvia Fre lab @frelab.bsky.social · Mar 7

Dev Bio @institutcurie.bsky.social #standupforscience

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Reposted by Silvia Fre lab

c0nc0rdance @c0nc0rdance.bsky.social · Feb 10

This is a room where we turn very modest salaries and budgets (and lots of coffee) into new knowledge, life-saving innovations, and technology that feeds business growth.

It's literally the loom that spins hay into gold but these numpties are suddenly worried about the cost of hay.

A research lab from Northwestern, chosen because it's generic and sort of zoomed out. Three scientists are visible in lab coats, and there are benches and shelving, with glass along one wall showing another high-rise building nearby. Overhead fluorescents provide light.

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Reposted by Silvia Fre lab

Walid Khaled @wtklab.bsky.social · Jan 15

JOB ALERT
We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster.

www.jobs.cam.ac.uk/job/49939/

@scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social

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Reposted by Silvia Fre lab

Financial Times @financialtimes.com · Jan 13

The man in charge of social media platforms used by billions should show some moral courage, writes @jemima.bsky.social www.ft.com/content/682c...

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