Lightnews — Scholar-powered news

Barriga Lab

@eliasbarrigalab.bsky.social

920 followers 640 following 78 posts

We study the molecular and biophysical mechanisms underlying tissue morphogenesis @poldresden.bsky.social @tudresden.bsky.social @erc.europa.eu @embo.org https://physics-of-life.tu-dresden.de/team/pol-groups/barriga

physics-of-life.tu-dresden.de

Posts Media Videos Starter Packs

Pinned

Barriga Lab @eliasbarrigalab.bsky.social · Apr 7

REPOSTING this here just to officially leave "the other place"

Our work on the role of endogenous electric fields in guiding collective cell migration during #morphogenesis is out @naturematerials.bsky.social
nature.com/articles/s41...

Stretch-induced endogenous electric fields drive directed collective cell migration in vivo - Nature Materials

Electric fields guide collective cell migration in developing embryos of Xenopus laevis via a voltage-sensitive phosphatase.

nature.com

7 32 140

Reposted by Barriga Lab

Denis Krndija @deniskrndija.bsky.social · 14h

Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11)
🔗 www.biorxiv.org/content/10.1...

Robust pan-junctional reinforcement preserves the gut epithelial barrier under mechanical stress

Epithelia are specialized tissue barriers that safeguard the organism's internal milieu from the hostile external environment, a function critically dependent on intercellular junctions. In the colon,...

www.biorxiv.org

1 8 15

Reposted by Barriga Lab

Konstantinos Miti @mitisbio.bsky.social · 2d

Our calcium paper is out in PLOS Biology!
Check it out! #Calcium #Embryo #Development

PLOS Biology @plosbiology.org · 2d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

9 14

Barriga Lab @eliasbarrigalab.bsky.social · 5d

😜

Barriga Lab @eliasbarrigalab.bsky.social · 6d

Thanks Dr Sędziński!

1 1

Barriga Lab @eliasbarrigalab.bsky.social · 6d

Grateful for the support from @erc.europa.eu @embo.org @dfg.de @tudresden.bsky.social & @poldresden.bsky.social

@Julien Marcetteau for the illustrations and referees for their comments.

and congrats to Custodio for his first paper at the lab!

Barriga Lab @eliasbarrigalab.bsky.social · 6d

We also highlight our recent discovery about electrosensing: Voltage-Sensitive Phosphatase 1 (VSP1) acts as an electrosensor during electrotaxis, guiding migrating cells under endogenous electric fields in vivo.

#VSP1 #Electrotaxis

1 1

Barriga Lab @eliasbarrigalab.bsky.social · 6d

For years, limited data, forceful approaches & over-interpretations made non-neural bioelectricity seem like fiction. Nonetheless, in this review, we discuss several studies showing how bioelectricity integrates with molecular & cellular programs to influence morphogenesis.

Barriga Lab @eliasbarrigalab.bsky.social · 6d

New Review! #devbiol #bioelectricity #CellBiology #tissueregeneration

In our new @annualreviews.bsky.social piece, we explore how bioelectricity is generated, sensed & translated into responses that sculpt tissues, guide growth & enable tissue regeneration.

www.annualreviews.org/content/jour...

Bioelectricity in Morphogenesis

Bioelectricity is likely as old as life itself. From the moment the first proto-cell was enclosed in a lipid bilayer, a membrane potential arose. Thus, one can expect that bioelectrical activities inf...

www.annualreviews.org

1 15 37

Barriga Lab @eliasbarrigalab.bsky.social · 8d

Beautiful, congratulations Sara and team!

1 1

Barriga Lab @eliasbarrigalab.bsky.social · 8d

Congratulations!

1 1

Reposted by Barriga Lab

Guillaume Charras @gcharras.bsky.social · 10d

Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...

elifesciences.org

21 36

Barriga Lab @eliasbarrigalab.bsky.social · 11d

Great to collaborate with you Artemis 💪🏼🙌🏼

Reposted by Barriga Lab

Alfonso Martinez Arias @amartinezarias.bsky.social · 13d

Today is the 100th anniversary of the birth of Robert Edwards, #IVF pioneer and someone who, unknowingly, bridged #DevBio #Gynecology and Endocrinology in a highly successful manner.

2 3 8

Reposted by Barriga Lab

paveltomancak.bsky.social @paveltomancak.bsky.social · Sep 4

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

16 120 340

Barriga Lab @eliasbarrigalab.bsky.social · 14d

Thank you very much Oscar, hope things are going well for you!

Barriga Lab @eliasbarrigalab.bsky.social · 14d

Thank you, hope you like 😃

Barriga Lab @eliasbarrigalab.bsky.social · 15d

Thanks Pavel 🐸

Barriga Lab @eliasbarrigalab.bsky.social · 15d

Thanks Adrien!

Reposted by Barriga Lab

Physics of Life Dresden @poldresden.bsky.social · 15d

🇬🇧Attention colleagues! We are hiring a new Building Manager to join our team at PoL. Please share with your network 👥

Learn more and apply here: tud.link/f4wf13
🗓️Deadline: 14.10.2025

2 2

Reposted by Barriga Lab

Physics of Life Dresden @poldresden.bsky.social · 15d

🚨 #WeAreHiring!

Wir beim Physics of Life suchen eine engagierte Persönlichkeit zur Verstärkung unseres Teams im infrastrukturellen Gebäudemanagement! Wir freuen uns auf Ihre Bewerbung.

🗓️ Frist: 14.10.2025
Alle Details hier: tud.link/f4wf13

#wearehiring #sachsenjobs #joboffer #jobsdeutschland

2 1

Barriga Lab @eliasbarrigalab.bsky.social · 15d

Thanks to Julien Marcetteau for the drawing ✍️ 🐸

1 2

Barriga Lab @eliasbarrigalab.bsky.social · 15d

Finally, our work reveals a hidden mechanical state of regeneration where tissue stiffening instruct cells to transit into regenerative states...

Far from perfect but always looking forward to hearing from you #Regeneration #Mechanobiology #Piezo1 #Yap1 #Xenopus #FrogPower #Morphogenesis

1 3

Barriga Lab @eliasbarrigalab.bsky.social · 15d

... for me the most striking result was that by activating this mechanosensitive cascade in NON-regenerative stages was sufficient to reactivate regenerative programs and induce di novo regeneration of full tails...!

1 3

Barriga Lab @eliasbarrigalab.bsky.social · 15d

... then we found that cells sense this stiffening via #Piezo1, which in turn activates #Yap1. This Piezo1–Yap1 cascade relays tissue mechanics into transcriptional programs that support the transition into regenerative bud states...

1 3

Barriga Lab @eliasbarrigalab.bsky.social · 15d

Using #Xenopus tails + in vivo #AFM, we found that tissue stiffening emerges right after injury. This stiffening is required for wounded epithelial tissues to transit into regenerative bud states...

1 2