💫NEW: @sarawickstrom.bsky.social @katemiro.bsky.social & co show that mechano-osmotic changes in the #nucleus induce general #transcriptional repression and prime #chromatin for cell fate transitions by relieving repression of specific differentiation genes. #pluripotency
bit.ly/3VMcyNZ

See this? This = implanting mouse embryo. Usually this happens inside its mother and is invisible to us, but we can actually watch implantation ex vivo with the hope of understanding why implantation goes awry in embryos of older women. A 🧵...

Check out this beautiful work by @mccreery.bsky.social, Aki Stubb and @sarawickstrom.bsky.social (et. al.) unearthing a critical mechanochemical feedback mechanism that integrates #mechanics with biochemical signalling to control stem cell fate transitions 🔥🔥

Amazing to have our work finally out!!! 😍🤩😍

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells @natcellbio.nature.com @sarawickstrom.bsky.social @akistubb.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...

Our paper is out in Nature Cell Biology! 🚀 Growth factors, mechanical forces, and osmotic stress work together to guide stem cell differentiation. Delighted to see these discoveries out in the world 🔥

How do LMNA mutations cause dilated cardiomyopathy (DCM) and other #laminopathies? In our latest preprint (doi.org/10.1101/2024...), led by the amazing Noam Zuela-Sopilniak and Julien Morival, we show that cardiomyocyte-specific lamin A/C depletion causes severe DCM, consistent with other studies.

Another paper bluetorial! Today: how does the spatial location of genes influence their function? (1/n) www.nature.com/articles/s41...

How do altered levels of lamins and other nuclear envelope proteins contribute to cancer metastasis, and what role does #mechanobiology play here? Learn more in our recent review by fantastic Sarah Henretta, now out in NPJ - Biological Physics and Mechanics, open access: doi.org/10.1038/s443...

Cool new method to integrate mechanics and transcriptomics, can’t wait to try it out 🤓 Congratulations Adrien @halloulab.bsky.social & team!

Our review "Measuring and manipulating mechanical forces during development" is now published in Nature Cell Biology!

#Mechanobiology #DevelopmentalBiology

UVM is now a Carnegie R1 institution! This achievement reflects decades of dedication to cutting-edge research, innovation, and excellence. With over $260M in funding (FY24) and groundbreaking projects, we're on the course for an even more ambitious future! #UVMresearch