Lightnews — Scholar-powered news

Amro Hussien @amrohussien.bsky.social · 9d

Check out this beautiful work by @mccreery.bsky.social, Aki Stubb and @sarawickstrom.bsky.social (et. al.) unearthing a critical mechanochemical feedback mechanism that integrates #mechanics with biochemical signalling to control stem cell fate transitions 🔥🔥

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Reposted by Amro Hussien

Sara Wickstrom @sarawickstrom.bsky.social · 9d

How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇

Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology

McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.

www.nature.com

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Reposted by Amro Hussien

Nature @nature.com · 16d

Gene-editing tools transform cells into record-keepers, capturing hidden timelines of health and disease

go.nature.com/4pBRRlh

Real-time molecular recorders expose the inner lives of cells

Gene-editing tools transform cells into record-keepers, capturing hidden timelines of health and disease.

go.nature.com

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Reposted by Amro Hussien

Denis Wirtz @deniswirtz.bsky.social · 17d

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics.

We applied this workflow to map precancerous lesions of the fallopian tubes.

More here: www.biorxiv.org/content/10.1...

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Reposted by Amro Hussien

Swiss National Science Foundation (SNSF) @snsf.ch · 20d

The Federal Council wants to cut costs in the ERI sector despite widespread objections. Cuts of over 10 percent per year are planned for the SNSF over the next few years. Above all, this plan jeopardises the innovation potential and competitiveness of the Swiss economy. ⤵️ www.snf.ch/en/9a7Fhnojt...

The SNSF urges against cuts

In its statement on "Relief Package 27", the SNSF speaks out against the proposed annual cuts of 10 percent.

www.snf.ch

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Reposted by Amro Hussien

Jan Lammerding - Lab @lammerdinglab.bsky.social · 20d

Detailed transcriptomic analyses indicate that a subset of cardiomyocytes drives disease progression by expression of genes associated with sterile inflammation, likely downstream of nuclear envelope rupture and activation of cytosolic DNA sensors, independent of cGAS/STING.

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Reposted by Amro Hussien

Journal of Cell Biology @jcb.org · 21d

In this Viewpoint, Adam Zweifach explains how to calculate how many cells to analyze per sample to achieve reasonable statistical power in #microscopy experiments. rupress.org/jcb/article/...

📕 In #Reproducibility and Best Practices in Cell Biology: rupress.org/jcb/collecti...

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Reposted by Amro Hussien

Benoit Ladoux @bladoux.bsky.social · 21d

We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.

mikeinmemoriam.sciencesconf.org

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Reposted by Amro Hussien

Shruti Naik @drshrutinaik.bsky.social · 22d

📢 📢📢📢 📢 Mechanosensitive fibroblasts fuel strictures via YAP/TAZ signaling—opening doors to new anti-fibrotic therapies. Grateful to be part of this transformative study with the Longaker lab! 🙏🙏🙏
www.sciencedirect.com/science/arti...
STAY TUNED for more in IBD damage from the #Naiklab

Creeping fat-derived mechanosensitive fibroblasts drive intestinal fibrosis in Crohn’s disease strictures

A significant complication of Crohn’s disease (CD) is intestinal fibrosis, which narrows the bowel lumen to form a stricture. Creeping fat (CF) is the…

www.sciencedirect.com

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Reposted by Amro Hussien

Nature @nature.com · 24d

Nature research paper: Energy deficiency selects crowded live epithelial cells for extrusion

go.nature.com/42tmu2l

Energy deficiency selects crowded live epithelial cells for extrusion - Nature

Crowded epithelial cells with the least energy and membrane potential are selected for extrusion.

go.nature.com

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Reposted by Amro Hussien

Benoit Ladoux @bladoux.bsky.social · Sep 4

Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions | Science Advances www.science.org/doi/10.1126/...

Tuning collagen nonlinear mechanics with interpenetrating networks drives adaptive cellular phenotypes in three dimensions

This work demonstrates that changes in the nonlinear elasticity of collagen in hybrid networks tunes cell-matrix interactions.

www.science.org

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Amro Hussien @amrohussien.bsky.social · Sep 4

Great news - congratulations Can 🎊

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Amro Hussien @amrohussien.bsky.social · Sep 4

Fantastic news. Congratulations Tom 🎊

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Amro Hussien @amrohussien.bsky.social · Aug 30

Super cool. Congratulations Shiori 🎉 and see you soon 🤩

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Reposted by Amro Hussien

Shiori Iida @shiori-iida.bsky.social · Aug 28

Our new preprint is out!
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing

Full story & movies👇

Kazuhiro Maeshima @kazu-maeshima.bsky.social · Aug 28

Is euchromatin really “open”? Our new study @bioRxiv suggests otherwise. Using super-resolution imaging @shiori-iida.bsky.social‬ @masaashimazoe.bsky.social reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing.
www.biorxiv.org/cgi/content/...

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Reposted by Amro Hussien

Science Magazine @science.org · Aug 27

Researchers can now study the dynamics of embryo implantation using a platform amenable to live fluorescence imaging and traction force microscopy.

This work in #ScienceAdvances may offer new ways to view implantation failure. https://scim.ag/4oQ6xwN

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Reposted by Amro Hussien

Human Frontier Science Program @hfspo.bsky.social · Aug 14

🧪 From petri dish to embryo model: @jacob-hanna.bsky.social work shows how naïve pluripotent stem cells can self-organize into advanced developmental stages.
The 2025 #HFSPNakasoneAward lecture reveals the science behind synthetic embryo models.

Full lecture 🎥 👉 zurl.co/Tgf4f
#sts

HFSP Nakasone Award 2025 Lecture – Jacob Hanna on Synthetic Embryo Models

In this official HFSP Nakasone Award lecture, Professor Jacob (Yaqub) Hanna of the Weizmann Institute of Science shares the groundbreaking research that earn...

www.youtube.com

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Reposted by Amro Hussien

Science Magazine @science.org · Aug 1

A 2024 Science study in mice identifies chromatin plasticity as a novel form of plasticity important for information encoding.

Learn more in this #SciencePerspective: scim.ag/3HgM6bt #ScienceMagArchives

Neurons of the amygdala display intrinsic variations in epigenetic state. An increase in histone acetylation leads to an increase in neuronal excitability and synaptic remodeling, which primes neurons to become part of an engram—neurons that “store” a memory—during learning.

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Reposted by Amro Hussien

Senator Bernie Sanders @sanders.senate.gov · Jul 30

End U.S. military aid to Israel.

End U.S. military aid to Israel | Sen. Bernie Sanders

YouTube video by Senator Bernie Sanders

youtu.be

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Reposted by Amro Hussien

The Wyss Institute at Harvard University @wyssinstitute.bsky.social · Jul 30

"This is my way of trying to make the world a better place, try to come up with new cures, new therapies, to help people live healthier and better lives." -David Mooney

In this video, he explains his work and emphasizes the profound responsibility researchers carry.

David Mooney on the Mission to Save Lives Through Cancer Research

David Mooney, Core Faculty member of the Wyss Institute and Robert Pinkas Family Professor of Bioengineering in the Harvard School of Engineering and Applied Sciences, discusses training immune cells ...

wyss.harvard.edu

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Amro Hussien @amrohussien.bsky.social · Jul 25

For every €1 invested in Horizon Europe programme, Europe is expected to get as much as €11 in GDP return

Source: www.innovationnewsnetwork.com/horizon-euro...

Horizon Europe delivers €11 GDP return for every €1 invested

Learn how Horizon Europe is driving innovation and growth across the EU, with up to €11 in GDP returns and sixfold societal benefits by 2045.

www.innovationnewsnetwork.com

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Amro Hussien @amrohussien.bsky.social · Jul 25

For every 1 Swiss franc invested in ETH Zurich, Switzerland gets 5-6 francs back

Source: ethz.ch/staffnet/en/...

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Amro Hussien @amrohussien.bsky.social · Jul 25

Congratulations Leo 🎊 Looking forward to the top science coming from your group

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Reposted by Amro Hussien

Max-Planck-Gesellschaft @maxplanck.de · Jul 8

Closer science ties across the Atlantic: the Max Planck Society has just launched its new #Transatlantic Program to boost collaboration with top U.S. institutions & open up more chances for researchers at every level - from #PhDs & #postdocs to directors!🌍🔬 www.mpg.de/25034916/max...

Max Planck Transatlantic Program

With its new Transatlantic Program, the Max Planck Society aims to strengthen collaboration and partnerships between its Institutes and leading U.S. institutions. At the same time, it seeks to counter...

www.mpg.de

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Reposted by Amro Hussien

ETH Zurich @ethz.ch · Jul 4

Chronic wounds are burdening healthcare systems with billions of dollars in costs every year. Börte Emiroglu ,
@ethmavt.bsky.social, is developing a new product: a selective, sponge-like hydrogel that reduces inflammatory signals and actively promotes healing.
ethz.ch/en/news-and-...

Intelligent wound dressing controls inflammation

Chronic wounds are a major medical challenge, burdening healthcare systems with billions of dollars in costs every year. Pioneer Fellow Börte Emiroglu is developing a new product: a selective, sponge-...

ethz.ch

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