Journal of Cell Biology
@jcb.org
Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org
🌐 https://rupress.org/jcb
🌐 https://rupress.org/jcb
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Journal of Cell Biology
@jcb.org
· Dec 3
Our annual collection highlights 13 of the year's most impactful papers that have garnered exceptional interest from our readership. Explore cutting-edge findings spanning the diverse spectrum of cell biology 👉 rupress.org/jcb/collecti...
#CellBio2025
@ascbiology.bsky.social
#CellBio2025
@ascbiology.bsky.social
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
#CellCycle #Biochemistry #Chromatin
January 9, 2026 at 6:30 PM
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
#CellCycle #Biochemistry #Chromatin
New study from Chou, McCartney et al. @cmu.edu demonstrates coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
January 9, 2026 at 5:45 PM
New study from Chou, McCartney et al. @cmu.edu demonstrates coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
At long last, a plausible explanation for the tight association between #keratin 15 and the epithelial progenitor epithelial cell state in skin is provided in a new study by Redmond, Coulombe et al. @umich.edu: rupress.org/jcb/article/...
#Cytoskeleton #StemCells
#Cytoskeleton #StemCells
January 9, 2026 at 5:00 PM
At long last, a plausible explanation for the tight association between #keratin 15 and the epithelial progenitor epithelial cell state in skin is provided in a new study by Redmond, Coulombe et al. @umich.edu: rupress.org/jcb/article/...
#Cytoskeleton #StemCells
#Cytoskeleton #StemCells
Reposted by Journal of Cell Biology
Congrats to Duncan lab alum Lucas Marmorale for his recent co-first author paper in @jcb.org showing that ESCRTS and NEDD promote TDP-43 endolysosomal clearance.
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Rsp5/NEDD4 and ESCRT regulate TDP-43 toxicity and turnover via an endolysosomal clearance mechanism | Journal of Cell Biology | Rockefeller University Press
Byrd, Marmorale and colleagues conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in ALS cell models. They found that ESCRT
rupress.org
January 8, 2026 at 7:20 PM
Congrats to Duncan lab alum Lucas Marmorale for his recent co-first author paper in @jcb.org showing that ESCRTS and NEDD promote TDP-43 endolysosomal clearance.
rupress.org/jcb/article/...
rupress.org/jcb/article/...
Reposted by Journal of Cell Biology
Really thrilled to have our work on mitochondrial presequence strength out today @jcb.org. We establish quantitative parameters to better define "strong" and "weak" presequences both in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a BBSB graduate student in my lab.
Yan, @ianofbristol.bsky.social, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
January 8, 2026 at 5:47 PM
Really thrilled to have our work on mitochondrial presequence strength out today @jcb.org. We establish quantitative parameters to better define "strong" and "weak" presequences both in vitro and in vivo. This work was spearheaded by the ever talented Youmian Yan, a BBSB graduate student in my lab.
Yan, @ianofbristol.bsky.social, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
January 8, 2026 at 5:00 PM
Yan, @ianofbristol.bsky.social, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
📣 Our 2025 Cover of the Year goes to this beautiful confocal microscopy image of an adult #Drosophila eye from this May 2025 study (rupress.org/jcb/article/...). Congrats to Vaisaly R. Nath, Padinjat Raghu (@rpadinjat.bsky.social) and colleagues, and thank you to everyone who voted!
January 8, 2026 at 4:15 PM
📣 Our 2025 Cover of the Year goes to this beautiful confocal microscopy image of an adult #Drosophila eye from this May 2025 study (rupress.org/jcb/article/...). Congrats to Vaisaly R. Nath, Padinjat Raghu (@rpadinjat.bsky.social) and colleagues, and thank you to everyone who voted!
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
January 7, 2026 at 7:30 PM
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
January 7, 2026 at 7:00 PM
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
New research from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology #ActinDynamics
#CellBiology #ActinDynamics
January 7, 2026 at 6:30 PM
New research from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology #ActinDynamics
#CellBiology #ActinDynamics
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
#Trafficking
#Trafficking
January 7, 2026 at 5:45 PM
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
#Trafficking
#Trafficking
#Collagen IV intercellular concentrations mediate cell–cell #adhesion in the #Drosophila #adipose tissue. New study from Almasoud, Franz et al. @ucl-cdb.bsky.social finds that the adipose tissue has apical-basal cell #polarity, which regulates this adhesion. rupress.org/jcb/article/...
January 7, 2026 at 5:31 PM
#Collagen IV intercellular concentrations mediate cell–cell #adhesion in the #Drosophila #adipose tissue. New study from Almasoud, Franz et al. @ucl-cdb.bsky.social finds that the adipose tissue has apical-basal cell #polarity, which regulates this adhesion. rupress.org/jcb/article/...
Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
#Organelles
#Organelles
January 7, 2026 at 4:15 PM
Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
#Organelles
#Organelles
Lund et al. @ucph.bsky.social reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
January 7, 2026 at 3:31 PM
Lund et al. @ucph.bsky.social reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
Yaqi Li et al. report a novel Cas9-based spatiotemporal gene-editing approach in #zebrafish. Given the limited germline transmission efficiency of knock-in alleles in zebrafish, this system enables rapid and high-throughput genetic screening in vivo. rupress.org/jcb/article/...
#Development #CRISPR
#Development #CRISPR
January 7, 2026 at 2:45 PM
Yaqi Li et al. report a novel Cas9-based spatiotemporal gene-editing approach in #zebrafish. Given the limited germline transmission efficiency of knock-in alleles in zebrafish, this system enables rapid and high-throughput genetic screening in vivo. rupress.org/jcb/article/...
#Development #CRISPR
#Development #CRISPR
Spotlight: Eunjoon Kim discusses work by Yamasaki et al. (rupress.org/jcb/article/...) on how GARLH4 regulates neuroligin sorting, demonstrating that #synapse identity is a tunable outcome of protein competition. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
January 7, 2026 at 2:15 PM
Spotlight: Eunjoon Kim discusses work by Yamasaki et al. (rupress.org/jcb/article/...) on how GARLH4 regulates neuroligin sorting, demonstrating that #synapse identity is a tunable outcome of protein competition. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
Cong et al. reveal that exportin CRM1 plays a “two birds with one stone” function by suppressing NPAT condensation and exporting NPAT to regulate #histone locus body formation. rupress.org/jcb/article/...
#Organelles #Biochemistry #Biocondensates
#Organelles #Biochemistry #Biocondensates
January 6, 2026 at 9:30 PM
Cong et al. reveal that exportin CRM1 plays a “two birds with one stone” function by suppressing NPAT condensation and exporting NPAT to regulate #histone locus body formation. rupress.org/jcb/article/...
#Organelles #Biochemistry #Biocondensates
#Organelles #Biochemistry #Biocondensates
Review: Siqi Deng, Zhiqiang Yan et al. summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. rupress.org/jcb/article/...
#Physiology #Neuroscience #Mechanobiology #IonChannels
#Physiology #Neuroscience #Mechanobiology #IonChannels
January 6, 2026 at 9:02 PM
Review: Siqi Deng, Zhiqiang Yan et al. summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. rupress.org/jcb/article/...
#Physiology #Neuroscience #Mechanobiology #IonChannels
#Physiology #Neuroscience #Mechanobiology #IonChannels
Review: Michael Worcester, @gerryhammond.bsky.social et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study #lipids. rupress.org/jcb/article/...
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
January 6, 2026 at 8:30 PM
Review: Michael Worcester, @gerryhammond.bsky.social et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study #lipids. rupress.org/jcb/article/...
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...
January 6, 2026 at 7:02 PM
How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...
Prado-Mantilla, @terrylechler.bsky.social et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. rupress.org/jcb/article/...
#Technology #ProteinHomeostasis
#Technology #ProteinHomeostasis
January 6, 2026 at 6:30 PM
Prado-Mantilla, @terrylechler.bsky.social et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. rupress.org/jcb/article/...
#Technology #ProteinHomeostasis
#Technology #ProteinHomeostasis
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
January 6, 2026 at 6:01 PM
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
Reposted by Journal of Cell Biology
#teamtomo gets another quantitative cell biology tool!
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/...
#CryoET
#CryoET
January 6, 2026 at 1:51 AM
#teamtomo gets another quantitative cell biology tool!
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
We extend our Surface Morphometrics pipeline to measure membrane thickness.
Alongside many biological findings, we show that our 3D measurements closely match in vitro vesicle measurements from 2D EM (collab w/Neal Waxham and Fred Heberle).
Xiong, Gao, Wu et al. present new mouse models for visualizing the selective degradation of #peroxisomes (#pexophagy) in living animals. rupress.org/jcb/article/...
January 5, 2026 at 9:00 PM
Xiong, Gao, Wu et al. present new mouse models for visualizing the selective degradation of #peroxisomes (#pexophagy) in living animals. rupress.org/jcb/article/...
Sebinelli, Syska, Razmazma et al. @umontpellier.bsky.social show that the yeast protein Ist2, which localizes to ER–PM contact sites, possesses a #phospholipid scramblase activity in its ER-localized transmembrane domain that is important for several ER-related processes. rupress.org/jcb/article/...
January 5, 2026 at 8:45 PM
Sebinelli, Syska, Razmazma et al. @umontpellier.bsky.social show that the yeast protein Ist2, which localizes to ER–PM contact sites, possesses a #phospholipid scramblase activity in its ER-localized transmembrane domain that is important for several ER-related processes. rupress.org/jcb/article/...