Journal of Cell Biology
@jcb.org
Journal of Cell Biology publishes peer-reviewed research on all aspects of cellular structure and function. Published by Rockefeller University Press @rupress.org
🌐 https://rupress.org/jcb
🌐 https://rupress.org/jcb
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
#CellCycle #Biochemistry #Chromatin
January 9, 2026 at 6:30 PM
Takao Ono, Tatsuya Hirano et al. show that #condensin II collaborates with #cohesin to establish and maintain #chromosome territories, revealing a cooperative mechanism supporting large-scale #genome organization in #interphase. rupress.org/jcb/article/...
#CellCycle #Biochemistry #Chromatin
#CellCycle #Biochemistry #Chromatin
New study from Chou, McCartney et al. @cmu.edu demonstrates coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
January 9, 2026 at 5:45 PM
New study from Chou, McCartney et al. @cmu.edu demonstrates coregulation of #actin filament assembly/bundling and #microtubule nucleation/organization during #Drosophila #oogenesis, highlighting the coordinated regulation of the #cytoskeleton required during #development. rupress.org/jcb/article/...
At long last, a plausible explanation for the tight association between #keratin 15 and the epithelial progenitor epithelial cell state in skin is provided in a new study by Redmond, Coulombe et al. @umich.edu: rupress.org/jcb/article/...
#Cytoskeleton #StemCells
#Cytoskeleton #StemCells
January 9, 2026 at 5:00 PM
At long last, a plausible explanation for the tight association between #keratin 15 and the epithelial progenitor epithelial cell state in skin is provided in a new study by Redmond, Coulombe et al. @umich.edu: rupress.org/jcb/article/...
#Cytoskeleton #StemCells
#Cytoskeleton #StemCells
Yan, @ianofbristol.bsky.social, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
January 8, 2026 at 5:00 PM
Yan, @ianofbristol.bsky.social, @nieminm.bsky.social et al. define quantitative parameters underlying the strength of mitochondrial-targeting presequences, and demonstrate that yeast require strong presequences to facilitate select metabolic pathways in #mitochondria. rupress.org/jcb/article/...
📣 Our 2025 Cover of the Year goes to this beautiful confocal microscopy image of an adult #Drosophila eye from this May 2025 study (rupress.org/jcb/article/...). Congrats to Vaisaly R. Nath, Padinjat Raghu (@rpadinjat.bsky.social) and colleagues, and thank you to everyone who voted!
January 8, 2026 at 4:15 PM
📣 Our 2025 Cover of the Year goes to this beautiful confocal microscopy image of an adult #Drosophila eye from this May 2025 study (rupress.org/jcb/article/...). Congrats to Vaisaly R. Nath, Padinjat Raghu (@rpadinjat.bsky.social) and colleagues, and thank you to everyone who voted!
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
January 7, 2026 at 7:30 PM
Bohra and Mazumder @tifrhyderabad.bsky.social show that HP1 protein dynamics at #heterochromatin damage sites differentially regulate recruitment of DSB repair factors. Disruption of phosphorylation S11–S14 residues of HP1α impairs homologous recombination. rupress.org/jcb/article/...
#Chromatin
#Chromatin
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
January 7, 2026 at 7:00 PM
Byrd, Marmorale, Buchan et al. @uarizona.bsky.social conducted a yeast genome-wide screen to identify genes affecting TDP-43 clearance in #ALS cell models. They found that #ESCRT complex genes and the #ubiquitin ligase Rsp5/NEDD4 facilitate TDP-43 endolysosomal clearance. rupress.org/jcb/article/...
New research from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology #ActinDynamics
#CellBiology #ActinDynamics
January 7, 2026 at 6:30 PM
New research from Lee, Higgs et al. shows how #INF2, a key #actin regulator, is activated by calcium-calmodulin and free actin monomers. Actin-binding proteins like profilin and thymosin aren't just helpers - they directly tune INF2 activity. rupress.org/jcb/article/...
#CellBiology #ActinDynamics
#CellBiology #ActinDynamics
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
#Trafficking
#Trafficking
January 7, 2026 at 5:45 PM
The small #GTPase Rab1 is a master regulator of #Golgi traffic and #autophagy. van Vliet, Munro et al. @mrclmb.bsky.social performed a proteomic screen to identify novel Rab1 effectors, including a #dynein motor adaptor and cargo receptors for autophagy. rupress.org/jcb/article/...
#Trafficking
#Trafficking
#Collagen IV intercellular concentrations mediate cell–cell #adhesion in the #Drosophila #adipose tissue. New study from Almasoud, Franz et al. @ucl-cdb.bsky.social finds that the adipose tissue has apical-basal cell #polarity, which regulates this adhesion. rupress.org/jcb/article/...
January 7, 2026 at 5:31 PM
#Collagen IV intercellular concentrations mediate cell–cell #adhesion in the #Drosophila #adipose tissue. New study from Almasoud, Franz et al. @ucl-cdb.bsky.social finds that the adipose tissue has apical-basal cell #polarity, which regulates this adhesion. rupress.org/jcb/article/...
Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
#Organelles
#Organelles
January 7, 2026 at 4:15 PM
Qiuyuan Yin, Chonglin Yang et al. reveal a plasma membrane-to-lysosome signaling pathway mediated by the non-receptor tyrosine kinase FGR and the serine/threonine kinase AKT2, which regulates TFEB/TFE3 activation for #lysosome biogenesis in #endocytosis. rupress.org/jcb/article/...
#Organelles
#Organelles
Lund et al. @ucph.bsky.social reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
January 7, 2026 at 3:31 PM
Lund et al. @ucph.bsky.social reveal that coupling of neuropeptide-containing dense core vesicles undergoing axonal transport to #kinesin-1 & #dynein is mediated by an adaptor complex composed of Syd/dJIP3/4 and RUFY, controlled by Rab2, Arl8, & the Arl8 activator BORC. rupress.org/jcb/article/...
Yaqi Li et al. report a novel Cas9-based spatiotemporal gene-editing approach in #zebrafish. Given the limited germline transmission efficiency of knock-in alleles in zebrafish, this system enables rapid and high-throughput genetic screening in vivo. rupress.org/jcb/article/...
#Development #CRISPR
#Development #CRISPR
January 7, 2026 at 2:45 PM
Yaqi Li et al. report a novel Cas9-based spatiotemporal gene-editing approach in #zebrafish. Given the limited germline transmission efficiency of knock-in alleles in zebrafish, this system enables rapid and high-throughput genetic screening in vivo. rupress.org/jcb/article/...
#Development #CRISPR
#Development #CRISPR
Spotlight: Eunjoon Kim discusses work by Yamasaki et al. (rupress.org/jcb/article/...) on how GARLH4 regulates neuroligin sorting, demonstrating that #synapse identity is a tunable outcome of protein competition. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
January 7, 2026 at 2:15 PM
Spotlight: Eunjoon Kim discusses work by Yamasaki et al. (rupress.org/jcb/article/...) on how GARLH4 regulates neuroligin sorting, demonstrating that #synapse identity is a tunable outcome of protein competition. rupress.org/jcb/article/...
#Neuroscience
#Neuroscience
Cong et al. reveal that exportin CRM1 plays a “two birds with one stone” function by suppressing NPAT condensation and exporting NPAT to regulate #histone locus body formation. rupress.org/jcb/article/...
#Organelles #Biochemistry #Biocondensates
#Organelles #Biochemistry #Biocondensates
January 6, 2026 at 9:30 PM
Cong et al. reveal that exportin CRM1 plays a “two birds with one stone” function by suppressing NPAT condensation and exporting NPAT to regulate #histone locus body formation. rupress.org/jcb/article/...
#Organelles #Biochemistry #Biocondensates
#Organelles #Biochemistry #Biocondensates
Review: Siqi Deng, Zhiqiang Yan et al. summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. rupress.org/jcb/article/...
#Physiology #Neuroscience #Mechanobiology #IonChannels
#Physiology #Neuroscience #Mechanobiology #IonChannels
January 6, 2026 at 9:02 PM
Review: Siqi Deng, Zhiqiang Yan et al. summarize the physiological functions and structural basis of OSCA/TMEM63 proteins, positioning them within a mechanosensitive ion channel superfamily. rupress.org/jcb/article/...
#Physiology #Neuroscience #Mechanobiology #IonChannels
#Physiology #Neuroscience #Mechanobiology #IonChannels
Review: Michael Worcester, @gerryhammond.bsky.social et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study #lipids. rupress.org/jcb/article/...
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
January 6, 2026 at 8:30 PM
Review: Michael Worcester, @gerryhammond.bsky.social et al. describe a suite of molecular tools and approaches that can be used to probe and experimentally study #lipids. rupress.org/jcb/article/...
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
#Methods #Reproducibility #Membrane #lipid #Biochemistry #Cancer
How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...
January 6, 2026 at 7:02 PM
How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...
Prado-Mantilla, @terrylechler.bsky.social et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. rupress.org/jcb/article/...
#Technology #ProteinHomeostasis
#Technology #ProteinHomeostasis
January 6, 2026 at 6:30 PM
Prado-Mantilla, @terrylechler.bsky.social et al. develop a mouse line to allow cell type–specific, rapid, and reversible degradation of GFP-tagged proteins. rupress.org/jcb/article/...
#Technology #ProteinHomeostasis
#Technology #ProteinHomeostasis
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
January 6, 2026 at 6:01 PM
Spotlight: Michael J. Clague @liverpooluni.bsky.social highlights recent work by Xiong et al. (rupress.org/jcb/article/...), describing a mouse model to monitor #pexophagy dynamics in vivo. rupress.org/jcb/article/...
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
#Physiology #ProteinHomeostasis #Peroxisomes #Autophagy
Xiong, Gao, Wu et al. present new mouse models for visualizing the selective degradation of #peroxisomes (#pexophagy) in living animals. rupress.org/jcb/article/...
January 5, 2026 at 9:00 PM
Xiong, Gao, Wu et al. present new mouse models for visualizing the selective degradation of #peroxisomes (#pexophagy) in living animals. rupress.org/jcb/article/...
Sebinelli, Syska, Razmazma et al. @umontpellier.bsky.social show that the yeast protein Ist2, which localizes to ER–PM contact sites, possesses a #phospholipid scramblase activity in its ER-localized transmembrane domain that is important for several ER-related processes. rupress.org/jcb/article/...
January 5, 2026 at 8:45 PM
Sebinelli, Syska, Razmazma et al. @umontpellier.bsky.social show that the yeast protein Ist2, which localizes to ER–PM contact sites, possesses a #phospholipid scramblase activity in its ER-localized transmembrane domain that is important for several ER-related processes. rupress.org/jcb/article/...
Jordan Matthew Ngo, Randy Schekman et al. @berkeleymcb.bsky.social identify the selective #autophagy receptor p62 as a quality control factor that selectively sorts cargo into #exosomes. rupress.org/jcb/article/...
#Trafficking #Biochemistry
#Trafficking #Biochemistry
January 5, 2026 at 8:30 PM
Jordan Matthew Ngo, Randy Schekman et al. @berkeleymcb.bsky.social identify the selective #autophagy receptor p62 as a quality control factor that selectively sorts cargo into #exosomes. rupress.org/jcb/article/...
#Trafficking #Biochemistry
#Trafficking #Biochemistry
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/...
#CryoET
#CryoET
January 5, 2026 at 8:15 PM
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/...
#CryoET
#CryoET
Hyun Gwan Park et al. show that #Drosophila Abi, a regulator of #actin cytoskeletal dynamics, controls blood cell homeostasis by activating #Notch signaling through #clathrin-mediated receptor #endocytosis. rupress.org/jcb/article/...
January 5, 2026 at 8:00 PM
Hyun Gwan Park et al. show that #Drosophila Abi, a regulator of #actin cytoskeletal dynamics, controls blood cell homeostasis by activating #Notch signaling through #clathrin-mediated receptor #endocytosis. rupress.org/jcb/article/...