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Isabela Corina Fortunato, PhD @icfortunato.bsky.social · 7d

Thank you, Elias! 🙏

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Isabela Corina Fortunato, PhD @icfortunato.bsky.social · 8d

Thank you, Nimesh 😊🙏

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Isabela Corina Fortunato, PhD @icfortunato.bsky.social · 11d

Paper 👉 www.nature.com/articles/s41...

Single-cell migration along and against confined haptotactic gradients - Nature Physics

Haptotaxis was traditionally seen as migration up protein gradients. It is now shown that cells can also oscillate or migrate down the gradient.

www.nature.com

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Reposted by Isabela Corina Fortunato, PhD

David Brückner @davidbrueckner.bsky.social · 11d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

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Isabela Corina Fortunato, PhD @icfortunato.bsky.social · 11d

Happy to share that my PhD has finally taken the shape of a paper! ✨

Huge thanks to all authors, especially @davidbrueckner.bsky.social & @ehannezo.bsky.social for leading the modeling and @raimonsunyer.bsky.social & @xaviertrepat.bsky.social for their invaluable supervision.

🧵👇

David Brückner @davidbrueckner.bsky.social · 11d

How do cells navigate up gradients of adhesive proteins?
🤔

Termed "Haptotaxis", this effect is ubiquitous in cell migration, but it's mechanism was poorly understood

We show that passive friction directs cells & explains complex trajectories on gradients

👉 www.nature.com/articles/s41...

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Reposted by Isabela Corina Fortunato, PhD

Steffen Grosser @steffengrosser.bsky.social · Sep 3

Stoked to announce that I received a poster award! 🔥😍

Many thanks to the #25EngLife organizers for the amazing meeting!

Felix Rico @felixrico.bsky.social · Sep 3

Congratulations to the poster prize winners of the #25EngLife Thank you again for the organisation. It's been a fantastic meeting!

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Reposted by Isabela Corina Fortunato, PhD

Hao Yin @haoyin.bsky.social · Mar 11

The role of MicroRNAs in #MesenchymalStemCell differentiation into vascular #SmoothMuscleCell

miR-1/-133/-206
miR-143/-145
miR-221/-222-5p
miR-24
miR-181
miR-503

#CellDiv 2025
celldiv.biomedcentral.com/articles/10....

The role of MicroRNAs in mesenchymal stem cell differentiation into vascular smooth muscle cells - Cell Division

MicroRNAs (miRNAs) are small, noncoding RNA molecules that play a vital role in regulating gene expression, especially in the differentiation of mesenchymal stem cells (MSCs) into vascular smooth musc...

celldiv.biomedcentral.com

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Reposted by Isabela Corina Fortunato, PhD

Hao Yin @haoyin.bsky.social · Mar 7

Looking for #MaterialStiffness of #BasementMembrane across tissues?
Excellent literature resource here😆👇

The basement membrane as a structured surface – role in vascular health and disease

@claireleclech.bsky.social @jcellsci.bsky.social 2020
journals.biologists.com/jcs/article/...

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Reposted by Isabela Corina Fortunato, PhD

Claire Dessalles @clairedessalles.bsky.social · Jan 21

Might be an interesting review on that topic !
www.cell.com/trends/cell-...

Leveraging computational modeling to explore epithelial and endothelial cell monolayer mechanobiology

Endothelial cells (ENCs) and epithelial cells (EPCs) form monolayers whose barrier function is critical for the maintenance of physiological processes and extremely sensitive to mechanical cues. Compu...

www.cell.com

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Reposted by Isabela Corina Fortunato, PhD

Alice Perucca @aliperri.bsky.social · Feb 10

1/7: New paper alert! Excited to share our co-first author paper on Micro Immune Response On-chip (MIRO) a model that recreates the tumour-stroma interface for immunotherapy testing! @oriolmb.bsky.social and I wrote this thread to break it down for you. 👇🧵
Read more: www.nature.com/articles/s41...

Micro Immune Response On-chip (MIRO) models the tumour-stroma interface for immunotherapy testing - Nature Communications

Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...

www.nature.com

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Reposted by Isabela Corina Fortunato, PhD

Zebrafish Rock! @zebrafishrock.bsky.social · Jan 26

Regrowing a zebrafish heart. Credit to @cao-lab.bsky.social. #ZebrafishZunday 🧪

Cao and colleagues found that the depleted heart tissue regenerates itself in a wave, led by a front of fast-moving, supersized cells and trailed by smaller cells that multiply to produce others.

The image above shows the large cells that contain multiple nuclei per cell (magenta). These cells are under more mechanical tension (aqua streaks) than trailing cells, which divide to produce cells with one nucleus each.

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Reposted by Isabela Corina Fortunato, PhD

epithelial mechanics fan club @epimechfc.bsky.social · Jan 26

Let's look at some cool bilateral cellular flows videos
IMHO: this is a goldmine for #EpithelialMechanics
Movie from Asai et al 2024 shows beautiful counter rotating flows.

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Reposted by Isabela Corina Fortunato, PhD

epithelial mechanics fan club @epimechfc.bsky.social · Jan 18

Is endothelium a type of epithelium?

I am @icfortunato.bsky.social & I would like to discuss this with a short🧵 focused on cell-cell junctions, specifically adherens junctions.

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Reposted by Isabela Corina Fortunato, PhD

Stephan Huveneers @huveneerslab.bsky.social · Jan 14

Curvature-sensing BAR proteins control junction turnover to promote collective migration of endothelial cells in angiogenesis. rdcu.be/d6a04

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Reposted by Isabela Corina Fortunato, PhD

Andreas Schoenit @andreasschoenit.bsky.social · Dec 21

Thrilled to share our new manuscript on how force transmission can regulate mechanical cell competition!

Fun collaboration between the @bladoux.bsky.social / @rmmege.bsky.social and the Doostmohammadi group combining experiments and simulations.
Main points below 👇

www.biorxiv.org/content/10.1...

Force transmission is a master regulator of mechanical cell competition

Cell competition is a tissue surveillance mechanism for eliminating unwanted cells and as such is indispensable in development, infection and tumorigenesis. Although different biochemical mechanisms a...

www.biorxiv.org

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Isabela Corina Fortunato, PhD @icfortunato.bsky.social · Dec 4

😊

Xavier Trepat @xaviertrepat.bsky.social · Dec 3

🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1

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Reposted by Isabela Corina Fortunato, PhD

Xavier Trepat @xaviertrepat.bsky.social · Dec 3

🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1

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