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andreasschoenit.bsky.social
Andreas Schoenit
@andreasschoenit.bsky.social
180 followers 250 following 13 posts
PostDoc in the Ladoux-Mège lab at Institute Jacques Monod in Paris. Interested in mechanobiology, epithelial dynamics, cell competition and differentiation
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andreasschoenit.bsky.social
Andreas Schoenit @andreasschoenit.bsky.social · Mar 16
What happens between cells with adhesion differences in crowded tissues? Mechanical cell competition!

Check the final version of our study to learn more about compression-independent cell elimination, interactions at tissue interfaces and the role of force transmission in that

tinyurl.com/4yw97bm3
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Reposted by Andreas Schoenit
sarawickstrom.bsky.social
Sara Wickstrom @sarawickstrom.bsky.social · 9d
How do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Mechano-osmotic signals control chromatin state and fate transitions in pluripotent stem cells - Nature Cell Biology
McCreery, Stubb et al. show that mechano-osmotic changes in the nucleus induce general transcriptional repression and prime chromatin for cell fate transitions by relieving repression of specific differentiation genes.
www.nature.com
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Reposted by Andreas Schoenit
gcharras.bsky.social
Guillaume Charras @gcharras.bsky.social · 10d
Can pressure gradients persist over long timescales in animal cells? We induced intracellular pressure gradients and examined the resulting flows in single cells. We reveal surprisingly long lasting pressure gradients.

More here: elifesciences.org/reviewed-pre...
elifesciences.org
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Reposted by Andreas Schoenit
ehannezo.bsky.social
Edouard Hannezo @ehannezo.bsky.social · 12d
Now out in final published form - with a new title "Mechanical control of cell fate decisions in the skin epidermis" and simulations/quantifications! See below for thread of how unbalanced tensions can bias fate choices in minimal 3D models of tissues! www.nature.com/articles/s41...
ehannezo.bsky.social
Edouard Hannezo @ehannezo.bsky.social · Dec 17
Happy to share the latest work from Preeti Sahu, with Adriana Sanchez-Danes on the biomechanics of cell fate choices during tumor initiation! We implement/test a 3D vertex model with proliferation and fate choices for multilayered tissues! See 🧵 below (1/n) bit.ly/3ZXxJzk
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Reposted by Andreas Schoenit
danielalber.bsky.social
Daniel Alber @danielalber.bsky.social · 20d
A ring of cells deforms into a triangular keyhole in just 15 minutes. Meet the hindgut, a model for boundary-driven morphogenesis!

Out now in @pnas.org at doi.org/10.1073/pnas... with @zhaoshh.bsky.social, Alex Jacinto, Eric Wieschaus, Stas Shvartsman, @lepuslapis.bsky.social (1/8)
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Reposted by Andreas Schoenit
nveits.bsky.social
Nisha Veits @nveits.bsky.social · 16d
How is developmental speed regulated ? 🪰

Happy to share my PhD story from Schweisguth Lab @devstempasteur.bsky.social. Here we show that cellular NAD+ availability and redox constrain developmental speed in the fly eye.

www.biorxiv.org/content/10.1...

A big thanks to everyone involved!
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Reposted by Andreas Schoenit
bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 21d
We’re organizing a conference at @ijmonod.bsky.social in Paris, January 2026, in memory of M.P. Sheetz — pioneer in cell mechanics and mechanobiology, co-discoverer of kinesin, and founder of @mbisg.bsky.social. Join us to explore his legacy.

mikeinmemoriam.sciencesconf.org
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Reposted by Andreas Schoenit
bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 21d
Happy to share our new study @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social with C. Duclut and J. Prost. on forces generated by active fluid transport in epithelia and their role in tissue dynamics.
Congrats to Huiqiong Wu, G. Arkowitz and R. Chilupuri!
www.biorxiv.org/content/10.1...
Regulation of epithelial tissue homeostasis by active trans-epithelial transport
Epithelia are intricate tissues whose function is intimately linked to mechanics. While mechanobiology has primarily focused on factors such as cell-generated contractility and mechanical properties o...
www.biorxiv.org
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Reposted by Andreas Schoenit
bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · 28d
Very happy to share our new study from CAM team @ijmonod.bsky.social and @mpi-scienceoflight.bsky.social (MPZPM) on the unanticipated “hidden fluidity” in jammed epithelia. Congrats to Yuan Shen and great collaboration with Walter Kob.
www.biorxiv.org/content/10.1...
The complex microscopic dynamics of cells in high-density epithelial tissues
Epithelial tissues line the surfaces of vital organs and are often densely packed in a disordered, mechanically arrested state, referred to as jammed or glassy state. While collective migration at low...
www.biorxiv.org
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Reposted by Andreas Schoenit
danielkrueger.bsky.social
Daniel Krüger @danielkrueger.bsky.social · Sep 6
Out in @science.org! We found that the intestine doesn’t just push out cells when crowded. Instead, cells are in a mechanical tug-of-war, and weaker ones are extruded. A new view of how our gut keeps its balance and stays healthy.
www.science.org/doi/10.1126/...
Epithelial tension controls intestinal cell extrusion
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In th...
www.science.org
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Reposted by Andreas Schoenit
epimechfc.bsky.social
epithelial mechanics fan club @epimechfc.bsky.social · Aug 31
Are different cell types like oil and water? Over a century ago, researchers found that dissociated sponges and embryonic tissues can self-assemble into functional structures. Join me, @benswedlund.bsky.social to explore the differential adhesion hypothesis & its applications in tissue engineering!
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andreasschoenit.bsky.social
Andreas Schoenit @andreasschoenit.bsky.social · Aug 21
Excited for my thesis defence, join us for a discussion on the role of mechanical forces in building and maintaining epithelial tissues if you happen to be in Paris in September!
ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · Aug 21
📢 PhD Thesis defense

📅 September 11th
📍 Institut Jacques Monod

Andreas Schoenit @andreasschoenit.bsky.social ( @bladoux.bsky.social / @rmmege.bsky.social Lab) will defend his PhD thesis "Mechanical forces in cell competition and epidermal stratification"

More informations ➡️ buff.ly/yhtJMsu
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Reposted by Andreas Schoenit
ijmonod.bsky.social
Institut Jacques Monod @ijmonod.bsky.social · Aug 21
📢 Institut Jacques Monod Seminar

📅 September 11th
📍 Institut Jacques Monod

Invited by @bladoux.bsky.social / @rmmege.bsky.social 's Lab , Stephanie Ellis ( @maxperutzlabs.bsky.social ) give the IJM Seminar "Understanding mosaic tissue dynamics through cell competition. "

➡️ buff.ly/V6LaKMz
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Reposted by Andreas Schoenit
juliaeckert.bsky.social
Julia Eckert @juliaeckert.bsky.social · Aug 15
Now published in @natcomms.nature.com! 🥳

👉 rdcu.be/eATn3

We developed image analysis tools to capture the nematic orientation field of 3D tissue surfaces. Tested on epithelial aggregates, zebrafish hearts, myoblasts on spheres & micro-vessels, we combined soft matter physics with exp. biology.
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Reposted by Andreas Schoenit
adacavalcanti.bsky.social
Ada Cavalcanti @adacavalcanti.bsky.social · Aug 13
🚀 New in Advanced Science: RAB5A drives active fluid wetting in breast cancer spheroids by reprogramming cell mechanics.

doi.org/10.1002/advs...

👏 Kudos to first author Grégoire Lemahieu and our amazing co-authors for this joint effort!

#CancerMechanobiology #CellAdhesion #RAB5A #TeamScience
RAB5A Promotes Active Fluid Wetting by Reprogramming Breast Cancer Spheroid Mechanics
RAB5A-mediated unjamming enhances active wetting through distinct biomechanical processes: a) upregulation of specific integrin subunits, enhanced focal adhesions kinetics and activity; b) supracellu...
doi.org
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Reposted by Andreas Schoenit
ritamateus.bsky.social
Rita Mateus @ritamateus.bsky.social · Aug 9
Hot off the press!!! Proudly presenting our lab's new review on how do cells communicate to control organ size :) We focus specially on dynamic connections that operate at different timescales to regulate organ growth and morphogenesis. #devbio #SizeandShape www.sciencedirect.com/science/arti...
Start-Shape-Stop: Cell communication mechanisms controlling organ size
Accurate growth control is critical for the achievement of proportional organs during animal development and repair processes. Either extra or deficie…
www.sciencedirect.com
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Reposted by Andreas Schoenit
giuliapaci.bsky.social
Giulia Paci @giuliapaci.bsky.social · Aug 11
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
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Reposted by Andreas Schoenit
bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · Aug 1
To what extent does crowding modulate diffusion across the cytoplasm?
Thrilled to contribute to this study alongside O. Destrian, M. Chabanon, and B. Goyeau!
www.biorxiv.org/content/10.1...
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion
Intracellular transport of macromolecules is crucial for the proper functioning of most cellular processes. Although intracellular crowding is known to strongly alter macromolecule mobility, how cytop...
www.biorxiv.org
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Reposted by Andreas Schoenit
kgoepfrich.bsky.social
Kerstin Göpfrich @kgoepfrich.bsky.social · Jul 28
Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social
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Reposted by Andreas Schoenit
marija-matejcic.bsky.social
Marija Matejčić @marija-matejcic.bsky.social · Jul 4
On cell extrusion in the #intestine!
After 80 years of observations, we finally took a deeper look thanks to 2D #organoids. We report:

3D #forces, #extrusion still only in the villus even without curvature, #lamellipodia generate 3D force.. and more. Have a look!
www.biorxiv.org/content/10.1...
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Reposted by Andreas Schoenit
bladoux.bsky.social
Benoit Ladoux @bladoux.bsky.social · Jun 18
Congrats to @luanger.bsky.social and @andreasschoenit.bsky.social for receiving the prestigious 'Les Grandes Avancées en Biologie' award 🏅 from the @academiesciences.bsky.social !
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Reposted by Andreas Schoenit
epimechfc.bsky.social
epithelial mechanics fan club @epimechfc.bsky.social · Jun 8
What do we see when looking at cells under the microscope? 👉Some are bigger than others, some are elongated and align with the neighbors & others seem to move. Cool, right? But wouldn't it be cooler to quantify these observations?

I'm @juliaeckert.bsky.social. Let's explore some analysis software!‬
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Reposted by Andreas Schoenit
tomcumming.bsky.social
Tom Cumming @tomcumming.bsky.social · May 21
The effector caspases drive cell death, but their activation can often be survived, so how do cells make this decision? Our new preprint from @levayerr.bsky.social shows that instantaneous caspase activity is important, but past activation has a key role to play!

www.biorxiv.org/content/10.1...
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Reposted by Andreas Schoenit
amichaut.bsky.social
Arthur Michaut 🔬🐣 @amichaut.bsky.social · May 12
🚨📣 New preprint alert!
Excited to share my new postdoc work on direct force and mechanical properties measurements in live embryos!
A great team effort with A. Chamolly (theory), under the supervision of F. Corson and @jeromegros.bsky.social
📄 www.biorxiv.org/content/10.1...
#devbio #mechanics
Direct measurements of active forces and material properties unveil the active mechanics of early embryogenesis
Despite progress in probing tissue mechanics, direct long-term measurements in live embryonic epithelia are lacking. This limits our understanding of amniote embryonic morphogenesis, which takes place...
www.biorxiv.org
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Reposted by Andreas Schoenit
epimechfc.bsky.social
epithelial mechanics fan club @epimechfc.bsky.social · May 11
Collective cell migration is fascinating!
Some tissues behave like fluids (motile), others like solids (jammed).

Check out some papers exploring this topic in this thread.
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Reposted by Andreas Schoenit
epimechfc.bsky.social
epithelial mechanics fan club @epimechfc.bsky.social · May 6
Shen, Y. et al. Flocking and giant fluctuations in epithelial active solids. Proceedings of the National Academy of Sciences (2025). #EpithelialMechanics
buff.ly/IJXBWq9
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