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Kerstin Göpfrich @kgoepfrich.bsky.social · Sep 8

Curious about RNA, aptamers, lipid membranes, molecular dynamics simulations, synthetic cells - and how these topics come together? Join @floppleton.bsky.social's talk in the unano webinar blogs.ed.ac.uk/unanowebinars

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Kerstin Göpfrich @kgoepfrich.bsky.social · Sep 2

RNA droplets that grow and segregate by ribozyme catalysis. Check out our latest preprint www.biorxiv.org/content/10.1101/2025.08.29.673008v1

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Kerstin Göpfrich @kgoepfrich.bsky.social · Aug 1

@tranmai.bsky.social handed in her PhD thesis! Celebrating in style with egg coffee from Hanoi, Mai's place of birth. P.S.: Mai is looking for a PostDoc position! Check out her latest RNA nanostructures for synthetic cells @natnano.nature.com doi.org/10.1038/s415...

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Reposted by Kerstin Göpfrich

Erik Poppleton @floppleton.bsky.social · Jul 28

DNA hydrogels as mechanical sensors in cell-culture systems by @towalther.bsky.social 🧬🧬🧬

If you catch him at a conference bar, ask him the story, it’s an adventure and a half!

Kerstin Göpfrich @kgoepfrich.bsky.social · Jul 28

Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social

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Reposted by Kerstin Göpfrich

Manuel Thery @manuelthery.bsky.social · Jul 29

EMBL Cell Biology and Biophysics department is searching for a new director. A major position to lead this field in Europe and beyond.
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Head of the Cell Biology and Biophysics Unit

The European Molecular Biology Laboratory (EMBL) is Europe’s flagship life sciences organisation, and one of the world’s leading research institutions. An intergovernmental organisation of 29 Member S...

embl.wd103.myworkdayjobs.com

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Reposted by Kerstin Göpfrich

Tobias Walther @towalther.bsky.social · Jul 28

So excited to finally be able to share this manuscript!! Thanks to all collaborators for making this possible! Special thanks to @kgoepfrich.bsky.social and @xaviertrepat.bsky.social for their guidance and supervision in this!

Kerstin Göpfrich @kgoepfrich.bsky.social · Jul 28

Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social

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Kerstin Göpfrich @kgoepfrich.bsky.social · Jul 28

Preprint by @towalther.bsky.social at al! We design DNA hydrogel microparticles with sequence-controlled stiffness from 30 Pa to 6.5 kPa. They are remodelled in fibroblast spheroids www.biorxiv.org/content/10.1... Thanks @ibecbarcelona.eu @xaviertrepat.bsky.social @pcusachs.bsky.social

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Reposted by Kerstin Göpfrich

Laborjournal @laborjournal.bsky.social · Jul 14

Leben aus toter Materie zu erschaffen ist ein zentrales Thema der Synthetischen Biologie. @kgoepfrich.bsky.social‬ et al. liefern dazu RNA-Origami-Strukturen, die sich selbst organisieren und eine cytoskelettartige Architektur aufbauen. Holger Dill berichtet mehr: www.laborjournal.de/rubric/journ...

Screenshot der ersten halben Seite des im Post verlinkten Print-Artikels mit Überschrift "Künstliche Cytoskelette aus RNA-Origami" sowie Vorspann und einigen Textzeilen. Zentral das Foto einer Konfokalmikroskopie von Cytoskelett-ähnlichen RNA-Origami-Nanoröhrchen.

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Reposted by Kerstin Göpfrich

Ulrich Schwarz @ulrichschwarz.bsky.social · Jun 22

📢Conference alert📢

Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.

engineering-life-dresden.de

Engineering Life 2025: ORIGIN AND FUNCTION OF MECHANICAL FORCES IN BIOLOGY

Engineering Life 2025, biological forces, force spectroscopy, measuring forces, developmental forces, molecular motors, forces in morphogenesis, cytoskeleton, DNA mechanics, bionanotechnology

engineering-life-dresden.de

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Kerstin Göpfrich @kgoepfrich.bsky.social · Jun 11

#SCNAC2025 we are looking forward to hear about your thoughts on our RNA design tool #PyFuRNAce pyfurnace.streamlit.app developed by @monari-luca.bsky.social

pyFuRNAce

Alt Text

pyfurnace.streamlit.app

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Kerstin Göpfrich @kgoepfrich.bsky.social · Jun 11

Good, well educated PhD student

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Kerstin Göpfrich @kgoepfrich.bsky.social · Jun 11

I watched too many traction force microscopy talks - maybe that community recognizes the characteristic move!

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Kerstin Göpfrich @kgoepfrich.bsky.social · Jun 3

I am excited to be talking to @neildegrassetyson.com soon! What should I tell him from his German fan community?

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Kerstin Göpfrich @kgoepfrich.bsky.social · May 26

Thank you! Lots of new synbio funded in Germany with Biosystem Design in Munich, Microbes for Climate in Marburg and SynthImmune in Heidelberg, I think that's a win for the field as a whole - following Evolve in the Netherlands!

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Reposted by Kerstin Göpfrich

European Synthetic Cell Initiative @syncelleu.bsky.social · May 26

News on clusters of excellence in Germany. The DFG has announced the continuation of 45 projects already funded and 25 new clusters

Congrats to the SynCellEU community members - Kerstin Gopfrich, Tobias Erb and more - whose applications have been successful and who will receive funding for 7 years

Kerstin Göpfrich @kgoepfrich.bsky.social · May 22

#SynthImmune is getting real! Super excited that our excellence cluster got funded today @dfg.de Thanks to everyone involved @uniheidelberg.bsky.social, especially @dimichelelab1.bsky.social and Oliver Fackler!

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Kerstin Göpfrich @kgoepfrich.bsky.social · May 26

A nice thread on our recent paper in Nature Nanotechnology by the first author and PhD student from the group @tranmai.bsky.social 👇

Mai Tran @tranmai.bsky.social · May 26

🧬 Thrilled to share that our work is featured on the cover of @natnano.nature.com (May issue)!
We genetically encoded RNA origami that self-assembles into cytoskeletal nanotubes inside synthetic cells.
📄 Paper: www.nature.com/articles/s41...
🧵👇

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Kerstin Göpfrich @kgoepfrich.bsky.social · May 22

#SynthImmune is getting real! Super excited that our excellence cluster got funded today @dfg.de Thanks to everyone involved @uniheidelberg.bsky.social, especially @dimichelelab1.bsky.social and Oliver Fackler!

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Reposted by Kerstin Göpfrich

N. Heinzelmann @nheinzelmann.bsky.social · May 20

New technology challenges communication inside and outside the classroom, as my recent paper explains. Fingers crossed we get to explore this question soon for emerging synthetic biotechnology within SynthImmune
www.tandfonline.com/doi/epdf/10....

Moral education and the psychology of moral discourse: Journal of Moral Education: Vol 0, No 0 - Get Access

www.tandfonline.com

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Reposted by Kerstin Göpfrich

SFB1638 @sfb1638.bsky.social · May 19

Our PIs Kerstin (@kgoepfrich.bsky.social) and Michael (@meineckelab.bsky.social) joined Wolfgang Heim to talk about scientific CVs, engaging in public outreach and the wonders of cellular membrane remodelling. Don’t miss the SFB1638 edition of Überlebensstrategien — now streaming!

SFB 1638 Umbau von zellulären Membranen – wie veränderte Form Funktion schafft

YouTube video by UniHeidelberg

www.youtube.com

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Kerstin Göpfrich @kgoepfrich.bsky.social · May 14

On the show, we also talk about the potential of bottom up synthetic biology approaches for immunology - the aim of our excellence cluster SynthImmune (in German). We hope to get funded!

SFB1638 @sfb1638.bsky.social · Apr 29

Our SFB1638 PI Kerstin Göpfrich (@kgoepfrich.bsky.social) joined Gert #Scobel and Tobias Erb to explore the future of synthetic biology—its promise, challenges, and big ideas. Catch the super interesting discussion on @3sat (@3sat.bluesky.com.de)

www.3sat.de/wissen/scobe...

Biologie aus dem Baukasten

Ingenieure, Informatiker, Chemiker und Biologen kreieren künstliche biologische Systeme. Die synthetische Biologie verändert die Zukunft und definiert die Grenzen der Wissenschaft neu.

www.3sat.de

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Kerstin Göpfrich @kgoepfrich.bsky.social · May 14

Awesome, congrats! Looking forward to take this further together, hopefully within our excellence cluster SynthImmune - fingers crossed for 22nd May!

Wolfgang Huber @wkhuber.bsky.social · Jan 3

How to do differential expression with scRNAseq data? State of the art is "pseudo-bulk" analysis with RNA-seq methods like edgeR or DESeq2, where "cell type" is encoded as discrete categories. Biologically, discrete categories are not always the most appropriate concept.(1/3)
doi.org/10.1038/s415...

Analysis of multi-condition single-cell data with latent embedding multivariate regression - Nature Genetics

Latent embedding multivariate regression models multi-condition single-cell RNA-seq using a continuous latent space, enabling data integration, per-cell gene expression prediction and clustering-free ...

doi.org

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Reposted by Kerstin Göpfrich

Wolfgang Huber @wkhuber.bsky.social · May 14

The SynthImmune project by Heidelberg University& partner institutes advances a "bottom-up" synthetic biology approach to immunotherapies.
Hoping they do well in the German government's Excellence Strategy—anticipating the announcement on 22 May.

Perspective article: www.nature.com/articles/s41...

Bottom-up synthetic immunology - Nature Nanotechnology

This Perspective highlights bottom-up molecular engineering and modular nanobiotechnological approaches for developing effective immunotherapeutics and their potential in personalized medicine.

www.nature.com

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Reposted by Kerstin Göpfrich

SFB1638 @sfb1638.bsky.social · Apr 28

An exciting new approach in single-cell metabolomics from two SFB1638 groups! Carsten Hopf’s group from CeMOS with support from the Göpfrich lab (@kgoepfrich.bsky.social) unveil tech that tracks brain cell changes linked to neurodegeneration.

advanced.onlinelibrary.wiley.com/doi/10.1002/...

Mass‐Guided Single‐Cell MALDI Imaging of Low‐Mass Metabolites Reveals Cellular Activation Markers

The PRISM-MS workflow transforms single-cell mass spectrometry imaging by allowing detailed analysis of low-mass metabolites in large cell populations without metabolite degradation. By introducing n...

advanced.onlinelibrary.wiley.com

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Reposted by Kerstin Göpfrich

Erik Poppleton @floppleton.bsky.social · Apr 26

Boosting to the 🧬Molecular Programming🧬 feed! Check out our new design tool at PyFuRNAce.de! I particularly like the “make simple origami” button, which makes it so easy to get a base structure which you can functionalize!

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Reposted by Kerstin Göpfrich

ZMBH @zmbh.uni-heidelberg.de · Apr 24

There is a German language video of a TV discussion on "Biology From the Building Block" in which ZMBH's Kerstin Goepfrich @kgoepfrich.bsky.social was one of the two invided experts: www.3sat.de/wissen/scobe...

Biologie aus dem Baukasten

Ingenieure, Informatiker, Chemiker und Biologen kreieren künstliche biologische Systeme. Die synthetische Biologie verändert die Zukunft und definiert die Grenzen der Wissenschaft neu.

www.3sat.de

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