Lightnews — Scholar-powered news

epithelial mechanics fan club @epimechfc.bsky.social · 20h

Oikonomou, P., Calvary, L., Cirne, H. C., Welch, A. E., ... & Nerurkar, N. L. (2025). Application and measurement of tissue-scale tension in avian epithelia in vivo to study multiscale mechanics and inter-germ layer coupling. Development, #EpithelialMechanics doi.org/10.1242/dev....

5

epithelial mechanics fan club @epimechfc.bsky.social · 1d

Harris, A. R., Peter, L., Bellis, J., Baum, B., Kabla, A. J., & Charras, G. T. (2012). Characterizing the mechanics of cultured cell monolayers. Proceedings of the National Academy of Sciences of the United States of America, #EpithelialMechanics doi.org/10.1073/pnas...

1 6

epithelial mechanics fan club @epimechfc.bsky.social · 2d

Khalilgharibi, N., Fouchard, J., Asadipour, N., ... & Charras, G. (2019). Stress relaxation in epithelial monolayers is controlled by the actomyosin cortex. Nature physics, 15(8), 839–847. doi.org/10.1038/s415... #EpithelialMechanics

1 5

epithelial mechanics fan club @epimechfc.bsky.social · 3d

About symmetry-breaking in embryonic development
bsky.app/profile/epim...

epithelial mechanics fan club @epimechfc.bsky.social · 4d

How do dynamic forces influence symmetry-breaking in embryonic development?

Hi, I’m @dr-rajendra-s-negi.bsky.social & in this thread, I’d like to introduce some aspects of the interdisciplinary research on tissue dynamics.

1

epithelial mechanics fan club @epimechfc.bsky.social · 4d

Thank you for your attention! #EpithelialMechanics I'm @dr-rajendra-s-negi.bsky.social , Postdoctoral researcher @manningresearch.bsky.social

For more threads like this follow @epimechfc.bsky.social bsky.app/profile/epim...

epithelial mechanics fan club (@epimechfc.bsky.social)

📚 Welcome to the Epithelial Mechanics Fan Club! 🌟 We're all about sharing research papers and threads. If you'd like to contribute, please send DM us! 💬 Our goal is to build a community that…

bsky.app

1

epithelial mechanics fan club @epimechfc.bsky.social · 4d

This review explains "cell jamming," where cells stop moving due to crowding, tension, and reduced fluctuations, and suggests identifying the main cause in experiments doi.org/10.1016/j.ce...

1 4

epithelial mechanics fan club @epimechfc.bsky.social · 4d

This research shows that organ movement through tissue generates viscoelastic drag forces, causing specific cell shape changes. These forces, observed in experimental studies, play a crucial role in shaping cells during development. doi.org/10.1016/j.cd...

1 1

epithelial mechanics fan club @epimechfc.bsky.social · 4d

This study reveals that asymmetric cell volume & shape changes in Kupffer's vesicle are regulated by ion flux, occurring independently of lumen expansion

Ion flux distinguishes intrinsic cellular mechanisms from lumen-generated forces in morphogenesis doi.org/10.7554/eLif...

1 1

epithelial mechanics fan club @epimechfc.bsky.social · 4d

Research suggests that fluid-like drag forces from an organ's movement through surrounding tissue can influence its structure and function.

This study examines zebrafish Kupffer's vesicle & the shape changes of its monociliate cells during development. doi.org/10.1016/j.bp...

1

epithelial mechanics fan club @epimechfc.bsky.social · 4d

Vertex & Voronoi models are used to study the mechanical properties & behaviors of cells and tissues.

Here the differences in boundary behavior in the 3D vertex and Voronoi models are presented: journals.plos.org/ploscompbiol...

1

epithelial mechanics fan club @epimechfc.bsky.social · 4d

How do dynamic forces influence symmetry-breaking in embryonic development?

Hi, I’m @dr-rajendra-s-negi.bsky.social & in this thread, I’d like to introduce some aspects of the interdisciplinary research on tissue dynamics.

1 3 15

Reposted by epithelial mechanics fan club

Julia Eckert @juliaeckert.bsky.social · 6d

@epimechfc.bsky.social discussion with @dedenonmathieu.bsky.social at #CellMech2025 :)

CellMech2025 @cellmech2025.bsky.social · 6d

Coffee break in full swing at #cellmech2025 —fueling up for the next session!

2 10

epithelial mechanics fan club @epimechfc.bsky.social · 5d

Dasgupta, A., Merkel, M., Clark, M. J., Jacob, A. E., Dawson, J. E., Manning, M. L., & Amack, J. D. (2018). Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer’s vesicle. Elife #EpithelialMechanics elifesciences.org/articles/30963

5

epithelial mechanics fan club @epimechfc.bsky.social · 6d

Lawson-Keister, Elizabeth, and M. Lisa Manning. "Jamming and arrest of cell motion in biological tissues." Current Opinion in Cell Biology 72 (2021): 146-155. #EpithelialMechanicsReview doi.org/10.1016/j.ce...

3 9

Reposted by epithelial mechanics fan club

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · 9d

Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...

Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications

Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

www.nature.com

7 8 14

epithelial mechanics fan club @epimechfc.bsky.social · 7d

Sanematsu, P. C., Erdemci-Tandogan, G., Patel, H., Retzlaff, E. M., Amack, J. D., & Manning, M. L. (2021). 3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo. Cells & development #EpithelialMechanics

3D viscoelastic drag forces contribute to cell shape changes during organogenesis in the zebrafish embryo

The left-right organizer in zebrafish embryos, Kupffer's Vesicle (KV), is a simple organ that undergoes programmed asymmetric cell shape changes that …

doi.org

7

epithelial mechanics fan club @epimechfc.bsky.social · 8d

Erdemci-Tandogan, G., Clark, M. J., Amack, J. D., & Manning, M. L. (2018). Tissue flow induces cell shape changes during organogenesis. Biophysical journal, 115(11), 2259-2270. #EpithelialMechanics doi.org/10.1016/j.bp...

1 3

epithelial mechanics fan club @epimechfc.bsky.social · 9d

Lawson-Keister E, Zhang T, Nazari F, Fagotto F, Manning ML (2024) Differences in boundary behavior in the 3D vertex and Voronoi models. PLOS Computational Biology #EpithelialMechanics journals.plos.org/ploscompbiol...

6

epithelial mechanics fan club @epimechfc.bsky.social · 11d

About controlling stretch/compression in epithelial system
bsky.app/profile/epim...

epithelial mechanics fan club @epimechfc.bsky.social · 17d

Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.

1 1 2

epithelial mechanics fan club @epimechfc.bsky.social · 12d

Tavano, S., Brückner, D. B., ... & Heisenberg, C. P. (2025). BMP-dependent patterning of ectoderm tissue material properties modulates lateral mesendoderm cell migration during early zebrafish gastrulation. Cell Reports, #EpithelialMechanics doi.org/10.1016/j.ce...

1 3

epithelial mechanics fan club @epimechfc.bsky.social · 13d

Grata, A., & Levayer, R. (2025). Epithelial cell extrusion at a glance. Journal of Cell Science, 138(8), #EpithelialMechanicsReview doi.org/10.1242/jcs....

1 8

epithelial mechanics fan club @epimechfc.bsky.social · 14d

Ciccone, Giuseppe, et al. "Epithelial Cell Mechanoresponse to Matrix Viscoelasticity and Confinement Within Micropatterned Viscoelastic Hydrogels." Advanced Science 2025 #EpithelialMechanics doi.org/10.1002/advs...

7

Reposted by epithelial mechanics fan club

andreuion.bsky.social @andreuion.bsky.social · 15d

We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌

1 4 15

epithelial mechanics fan club @epimechfc.bsky.social · 15d

Shroff, N. P., Xu, P., Kim, S., Shelton, E. R., Gross, B. J., Liu, Y., ... & Klein, O. D. (2024). Proliferation-driven mechanical compression induces signalling centre formation during mammalian organ development. Nature cell biology, #EpithelialMechanics www.nature.com/articles/s41...

3 14

Reposted by epithelial mechanics fan club

epithelial mechanics fan club @epimechfc.bsky.social · 17d

Ever wondered how to control stretch/compression in your epithelial system? Do you know why it’s important, which mechanotransduction mechanisms could be involved? I am @valeriaventurini.bsky.social and today I will guide you through this journey.

1 11 34