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Julien Colombani & Ditte Andersen lab

@colombani-lab.bsky.social

840 followers 240 following 19 posts

Drosophila geneticists at the Department of Biology, Copenhagen University. We study intestinal stem cell, inter-organ communication and cancer biology. #Drosophila https://www1.bio.ku.dk/english/research/cell-neurobiology/andersen-colombani-lab/

www1.bio.ku.dk

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Reposted by Julien Colombani & Ditte Andersen lab

corderolab.bsky.social @corderolab.bsky.social · 7d

Excited to share our collaborative PhD project with Adam Dobson ([email protected]) on interorgan signalling in the ageing gut. Please contact Adam If you are a highly motivated student wanted to work on a super exciting Fly project.

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · 8d

@epimechfc.bsky.social

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · 9d

Please read the very nice complementary story from our colleagues @corderolab.bsky.social
doi.org/10.1016/j.de...

Redirecting

doi.org

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · 9d

Nice team work from our PhD student Duncan Mackay with the precious help of @alphyjohn.bsky.social and colleagues, and a great collaboration with Matteo Rauzi lab

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · 9d

Excited to share our last paper describing how intestinal stem cell migration promotes gut regeneration!
www.nature.com/articles/s41...

Pvf1-Pvr-mediated crosstalk between trachea and gut guides intestinal stem cell migration to promote gut regeneration - Nature Communications

Adult stem cells often reside in specialized niches that they exit upon injury. Here they show that in Drosophila, after damage the gut-associated trachea produces the PDGF-VEGF-related ligand Pvf1, which acts as a guidance cue directing ISC migration toward injury sites.

www.nature.com

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · 16d

- Rouba, Nhi and Lizzie have posters in session 1 & 2

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · 16d

We are looking forward to seeing you at the @edrc2025.bsky.social
You can find us
- On Thursday 25th at the workshop: INTERORGAN COMMUNICATION IN THE ERA OF OMICS,
- On Saturday morning 27th @alphyjohn.bsky.social will give a talk in the session stem cells and regeneration
- On poster sessions

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Reposted by Julien Colombani & Ditte Andersen lab

corderolab.bsky.social @corderolab.bsky.social · Aug 11

2 post-doc positions open in the lab to do research on inter-organ signalling in regeneration and cancer in flies and mice.

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Reposted by Julien Colombani & Ditte Andersen lab

corderolab.bsky.social @corderolab.bsky.social · Jul 21

Very happy and proud to share the latest work from our lab.
Neuroendocrine control of intestinal regeneration through the vascular niche.
www.sciencedirect.com/science/arti...

Neuroendocrine control of intestinal regeneration through the vascular niche in Drosophila

Robust and controlled intestinal regeneration involves reciprocal interactions between the intestinal epithelium and its microenvironment. Here, we id…

www.sciencedirect.com

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · May 18

Not yet!

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · May 16

Great meeting!

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Apr 30

Great works of @rustenlab.bsky.social and @Basler lab independently showing how premalignant cells can exploit Toll-NF-κB signaling, in concert with oncogenic Ras, to enable unchecked growth #Drosophila Papers: plos.io/4jqpmUh and plos.io/3RGWESS Primer: plos.io/3GyUeU0

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Reposted by Julien Colombani & Ditte Andersen lab

PLOS Biology @plosbiology.org · Apr 30

#InnateImmunity is a crucial surveillance framework. However, @colombani-lab.bsky.social explores 2 @plosbiology.org studies which show that pre-malignant cells can exploit these regulatory circuits to enable unchecked #cancer growth 🧪 Papers: plos.io/4jqpmUh plos.io/3RGWESS Primer: plos.io/3GyUeU0

$Schematics Top: While Toll-NF-κB pathway activation alone inhibits differentiation, trapping cells in a progenitor-like state, it also increases cell death rates leading to an overall reduction in tissue size. Bottom: In the presence of oncogenic RasV12, these progenitor-like cells become refractory to cell death, which drives tumor growth. Additionally, NF-κB/Dorsal activates JNK signaling and enhances the invasiveness of polarity-deficient RasV12/scrib−/− tumors.$

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Reposted by Julien Colombani & Ditte Andersen lab

corderolab.bsky.social @corderolab.bsky.social · Apr 17

Happy to share the preprint of our latest work on gut/vascular interactions in flies and mice! www.biorxiv.org/cgi/content/...

Intestinal Tissue Mechanics Regulate Angiogenesis and Stem Cell Proliferation via Vascular Piezo

The vasculature is a prominent component of developmental and adult tissue microenvironments. How, tissue specific characteristics and environmental states influence vascular biology and function, rem...

www.biorxiv.org

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Dec 17

Great lab! Great Xmas lunch!

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Dec 13

Reposted by Julien Colombani & Ditte Andersen lab

EDRC2025 @edrc2025.bsky.social · Nov 20

Welcome to the #EDRC2025 account of the 28th European Drosophila Conference which will take place in Alicante from the 25th to the 28th of September 2025! Stay tuned for the upcoming news!

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Nov 18

👋

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Nov 18

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Nov 14

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Sep 4

Excited to share our last preprint describing how intestinal stem cell migration promotes gut regeneration!
www.biorxiv.org/content/10.1...

Pvf1-PvR-mediated crosstalk between the trachea and the gut guides intestinal stem cell migration to promote gut regeneration.

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

www.biorxiv.org

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Mar 4

The small intestine adapt its size according to nutrient intake 👇👇
www1.bio.ku.dk/english/news...

The small intestine adapt its size according to nutrient intake

Resizing of the intestine is a highly conserved strategy employed by a wide range of organisms to cope with fluctuation in nutrient availability. Nevertheless, very little is known about the mechanism...

www1.bio.ku.dk

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Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Jan 4

Exciting beginning of the year with the accepted version of our activins paper "Drosophila activins adapt gut size to food intake and promote regenerative growth"
rdcu.be/du9K2

Julien Colombani & Ditte Andersen lab @colombani-lab.bsky.social · Dec 26

Wishing everyone happy holidays! Thank you to the lab for creating a lovely environment!

Here is the latest photo of us celebrating at our recent Christmas lunch!