andreuion.bsky.social
@andreuion.bsky.social
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andreuion.bsky.social
andreuion.bsky.social @andreuion.bsky.social · 15d
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⚡ This cycle is mechanosensitive & calcium-driven.
Chromatin compaction is triggered by Ca²⁺ and mechanics. Chromatin rewetting is associated to a Ca²⁺ spark, fueling nuclear + cytoskeletal changes, JNK activation, and actin ring formation.
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andreuion.bsky.social
andreuion.bsky.social @andreuion.bsky.social · 15d
1/ Link: www.biorxiv.org/content/10.1...
✂️ Wounding in the fly epidermis makes chromatin compact + detach from the lamina.
⏱️ Minutes later it re-expands & re-attaches.
A reversible, nuclear “dewetting” cycle right at the wound edge.
Mechanosensitive and Reversible Chromatin-Lamina Dewetting Triggers Cellular Contraction During Wound Healing
Tissue wounding causes rapid mechanical changes in the epithelium, but how these changes affect intracellular organization remains unclear. Using the Drosophila embryonic epidermis, we show that wound...
www.biorxiv.org
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andreuion.bsky.social
andreuion.bsky.social @andreuion.bsky.social · 15d
We know tissue mechanics matter in healing, but what happens at the chromatin level?
Our new preprint shows that chromatin briefly “de-wets” from the lamina, then re-wets to kick off repair.
Mechanics→chromatin→contraction→healing.
Led by amazing PhD students Guillermo Bengoetxea & Lenka Backová 🙌
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