True 😂😂 but is that how we feel? We could be so much more POLARIZING 🤩

Congrats and thanks to all poster coauthors @leonerossetti.bsky.social @icfortunato.bsky.social @ricardalert.bsky.social @xaviertrepat.bsky.social -- nothing can stop us!

Stoked to announce that I received a poster award! 🔥😍

Many thanks to the #25EngLife organizers for the amazing meeting!

Keep an eye on the upcoming tissue force (tension) sensors 🔥🔥
from @baldaufsci.bsky.social

My recent postdoctoral work is out today in @nature.com! We found that physical confinement makes melanoma cells more invasive and drug tolerant. Thanks to all who made this work possible @whitefishlab.bsky.social @mskcancercenter.bsky.social #NIH #NCI www.nature.com/articles/s41...

📢Conference alert📢

Only one week left to register for the Engineering Life 2025 Symposium at Dresden September 1-3. This year's edition focuses on the function of mechanical forces in biology.

engineering-life-dresden.de

Great success for Dresden and Saxony!
Physics of Life is one of the excellence clusters
‪@poldresden.bsky.social‬

Positional memory has implications for bioengineering. Transplanting salamander cells in a way that alters their spatial organisation changes signalling topology and results in predictable (but amazing) phenotypes such as too many fingers - or even extra limbs!
🧵3/14

1/14 “Epithelial” & “Mesenchymal” aren’t binary categories—they form a spectrum, or better yet, a multidimensional space. This becomes especially clear in collective cell migration, which often depends on a finely tuned degree of “mesenchymal-ness”.

#cellbio #devbio #cellmigration

In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro.
journals.biologists.com/jcs/article/...

all of human knowledge at my fingertips

We're so back

Will visit it when I am in Dresden on April 16!

einstein sent this to curie in 1911 when she was being harassed by tabloids. it contains everything you’d want in such a letter:

(1) your haters are trash
(2) you’re a baller, a true queen
(3) i have determined the statistical law of motion of the diatomic molecule in planck’s radiation field 🧪⚛️

this is a good time to note that the proposed candidate for NIH director has never run a lab, cared for patients, led a major research and healthcare institution, or been a principal investigator on an NIH grant

The spheroid fusion analysis I did in this new study is much better than in my old paper!

I don't "fit" any dumb-bell 2D shape anymore to the data (unstable).
Instead, I use moment analysis/aspect ratios, which can be converted to tissue fluidity (very robust).

This circuit can be used to propagate a change in cell fate in 2D in a wave-like pattern… And also in 3D!

In this animation, a spheroid of “sender” cells (red+green=yellow) is fused with a spheroid of “transceiver” cells. Activated transceivers become green.

And look at this stunning synthetic biology!

Stunning optogenetic guidance!

🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1

Good morning, and wtf is this

Large-scale collective motion of epithelial cells not as a fluid, but as a polar elastic solid.
Our new study posted on Biorxiv:
www.biorxiv.org/content/10.1...

Couldn't find one so made a quick physics of life list, enjoy! go.bsky.app/EA2VsDN