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Leo Otsuki

@leootsuki.bsky.social

800 followers 400 following 69 posts

Group leader at the Hubrecht Institute, fascinated by tissue regeneration. Studies the axolotl, a vertebrate capable of regenerating entire limbs after injury, and uses the principles learnt to build 3D tissues in vitro. 🇳🇱🇦🇹🇬🇧🇯🇵

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Reposted by Leo Otsuki

the Node @the-node.bsky.social · 6d

Limb regeneration guide for axolotls 📋

Laura Turchi (@turchil.bsky.social) highlights a recent paper by @leootsuki.bsky.social and team on The Node ⬇️👀

thenode.biologists.com/limb-regener...

Limb regeneration guide for axolotls - the Node

A recent paper from Otsuki and colleagues investigates the molecular mechanisms driving limb regeneration in axolotl

thenode.biologists.com

Reposted by Leo Otsuki

Hubrecht Institute @hubrechtinstitute.bsky.social · 12d

Ready to establish your own research group at the Hubrecht Institute for Molecular and Developmental Biology? We’re seeking a tenure-track group leader to develop an innovative research line within our vibrant scientific community. Learn more & apply! https://f.mtr.cool/jncxfqkuds

Leo Otsuki @leootsuki.bsky.social · Jul 28

Thank you very much, Osvaldo!

Leo Otsuki @leootsuki.bsky.social · Jul 28

Thank you! I cannot wait to get started.

Leo Otsuki @leootsuki.bsky.social · Jul 26

Thank you, Yan!

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thanks, Çağrı!

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thank you, Yasin! You are always so kind. I wish you all the best in your new home too.

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thanks, Sanjay! I wish you also exciting next steps!

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thank you, Amro!

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thank you very much, Diana!

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thank you, Josh. Looking forward to crossing paths again!

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thanks very much, Neha!

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thank you, Filipa - you are always so kind! I'm looking forward.

Leo Otsuki @leootsuki.bsky.social · Jul 25

Thank you, Osvaldo. You've always been an amazing source of support and encouragements. I can't wait to pop over and see you - I'm sure Aida and I can arrange something :)

Leo Otsuki @leootsuki.bsky.social · Jul 25

Grateful and excited to launch the Otsuki Regeneration Group at the Hubrecht Institute!
🔗 www.hubrecht.eu/research-gro...

We study how tissues regenerate - and use those principles to build 3D tissues in vitro.

Full announcement: www.linkedin.com/in/leo-otsuk...

@hubrechtinstitute.bsky.social

Reposted by Leo Otsuki

Hubrecht Institute @hubrechtinstitute.bsky.social · Jul 10

🧬 Looking for a PhD position in molecular or developmental biology? 🔬

✉️ The Hubrecht Institute now has its very own PhD program! Applications are open and will be accepted until September 15th. Read more here 👉 www.hubrecht.eu/hipp/

Leo Otsuki @leootsuki.bsky.social · Jul 3

Thank you very much 😊🎉

Leo Otsuki @leootsuki.bsky.social · Jul 3

Thank you, Aniek :)

Leo Otsuki @leootsuki.bsky.social · Jul 2

I highly recommend signing up for this! I found it so informative and constructive. I owe a lot to Sumru and Mekayla, from answering my super-naive questions to advising on my proposal and setup last year. Thanks so much, you are treasures of the regeneration community!

International Society for Regenerative Biology @isrbio.bsky.social · Jul 1

Last two weeks to sign up for the Career Catalyst Mentorship Programme. Opportunities for 1:1 Mentoring. docs.google.com/forms/d/e/1F...

Leo Otsuki @leootsuki.bsky.social · Jun 16

A (little bit) more info here: www.linkedin.com/feed/update/...

Salamanders normally regenerate only the missing part of the arm after an injury - e.g. | Leo Otsuki

Salamanders normally regenerate only the missing part of the arm after an injury - e.g. a wrist-level injury only regenerates a hand. But if they receive retinoic acid (RA), this control is overridden...

www.linkedin.com

Leo Otsuki @leootsuki.bsky.social · Jun 16

Precise degradation of Retinoic acid (RA) determines which part of the limb a salamander regenerates. Congratulations to the team, expertly led by Tim Duerr in James Monaghan's group:

Retinoic acid breakdown is required for proximodistal positional identity during axolotl limb regeneration - Nature Communications

How axolotl salamanders know what portion of the limb to regenerate remains a mystery. In this article, the authors show that precise retinoic acid degradation is critical for instructing…

Leo Otsuki @leootsuki.bsky.social · Jun 9

This raises exciting questions about the molecular and physical requirements for re-building each part of the limb.

Congratulations to all the authors @jamesmonaghan.bsky.social lab on a beautiful study!

Leo Otsuki @leootsuki.bsky.social · Jun 9

Similar to whole-limb regeneration, nerves are essential for the digits to regenerate. Amazingly, the authors found that the second finger regenerates more accurately than the others (why?) - but apparently not due to the degree of nerve innervation or differences in classical limb patterning genes.

Leo Otsuki @leootsuki.bsky.social · Jun 9

Axolotls accurately regenerate their limbs but frequently make mistakes during finger regeneration, which surprises me given their apparently simple structure. This study, led by Jackson Griffiths from James Monaghan's lab, dives deep into this fascinating paradox. www.biorxiv.org/content/10.1....

A Characterization of Axolotl Digit Regeneration: Conserved Mechanisms, Divergent Patterning, and a Critical Role for Hedgehog Signaling

Axolotl digits offer an experimentally versatile model for studying complex tissue regeneration. Here, we provide a comprehensive morphological and molecular characterization of digit regeneration,…

www.biorxiv.org

Reposted by Leo Otsuki

Tatiana Sandoval Guzmán @tatianasg.bsky.social · May 27

We are really grateful and honored for this comment on our latest preprint! AND we share the spotlight with the Monaghan lab!
Thanks @woutermasselink.bsky.social and @dev-journal.bsky.social

Development @dev-journal.bsky.social · May 27

In preprints: retinoic acid degradation and tissue stiffness coordinate axolotl limb regeneration

Wouter Masselink @woutermasselink.bsky.social‬ discusses two #preprints from the groups of James Monaghan and @tatianasg.bsky.social‬:
journals.biologists.com/dev/article/...

In preprints: a new preprint curation initiative from Development