Pablo J. Sáez
@pjsaez.bsky.social
Husband - Dad of 2 - Scientist 🇨🇱 Chilean expat.
I love to study how cells walk & talk.
PI of the @cellcommlab.bsky.social
#CellMigration #CellComm #calciumsignaling #organelles 🧪🔬
I love to study how cells walk & talk.
PI of the @cellcommlab.bsky.social
#CellMigration #CellComm #calciumsignaling #organelles 🧪🔬
Pinned
Pablo J. Sáez
@pjsaez.bsky.social
· Jan 18
How cells decide where to go? #CellMigration
Last year we published our 1st paper @cellcommlab.bsky.social, showing how actin-based membrane oscillations define a new direction ( #cancer & non-cancer #cells )
Full www.nature.com/articles/s41...
@naturephysics.bsky.social @focalplane.bsky.social 🧪🔬
Last year we published our 1st paper @cellcommlab.bsky.social, showing how actin-based membrane oscillations define a new direction ( #cancer & non-cancer #cells )
Full www.nature.com/articles/s41...
@naturephysics.bsky.social @focalplane.bsky.social 🧪🔬
Hot from the #preprint
Leukocyte + #CellMigration + physics = cool
Microtubules enable torque-based steering during dendritic cell migration.
Actomyosin contractility is required for noise-modulation strategy used by neutrophils.
Full @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Leukocyte + #CellMigration + physics = cool
Microtubules enable torque-based steering during dendritic cell migration.
Actomyosin contractility is required for noise-modulation strategy used by neutrophils.
Full @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Torque-based immune cell chemotaxis in complex environments
Directed migration in chemical gradients is crucial to the immune response, yet how immune cells navigate complex tissues remains incompletely understood. Using in vitro migration assays and theoretic...
www.biorxiv.org
November 23, 2025 at 2:39 PM
Hot from the #preprint
Leukocyte + #CellMigration + physics = cool
Microtubules enable torque-based steering during dendritic cell migration.
Actomyosin contractility is required for noise-modulation strategy used by neutrophils.
Full @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Leukocyte + #CellMigration + physics = cool
Microtubules enable torque-based steering during dendritic cell migration.
Actomyosin contractility is required for noise-modulation strategy used by neutrophils.
Full @biorxivpreprint.bsky.social www.biorxiv.org/content/10.1...
Even if "provisionally" accepted, those are the best words/news I've heard for quite a while...
Here some #blebs to "provisionally" cellebrate.
Let's see this #cell dance under the microscope.
@focalplane.bsky.social #fluorescencefriday #microscopy 🧪🔬
Here some #blebs to "provisionally" cellebrate.
Let's see this #cell dance under the microscope.
@focalplane.bsky.social #fluorescencefriday #microscopy 🧪🔬
November 21, 2025 at 2:55 PM
Even if "provisionally" accepted, those are the best words/news I've heard for quite a while...
Here some #blebs to "provisionally" cellebrate.
Let's see this #cell dance under the microscope.
@focalplane.bsky.social #fluorescencefriday #microscopy 🧪🔬
Here some #blebs to "provisionally" cellebrate.
Let's see this #cell dance under the microscope.
@focalplane.bsky.social #fluorescencefriday #microscopy 🧪🔬
Do you want to do some frontier of knowledge research? There's still time to register for the next webinar of @hfspo.bsky.social
By far one of the best agencies I've worked with for my beloved HFSP project, even if it's a bumpy road...no risk no glory...
www.hfsp.org/hfsp-events/...
By far one of the best agencies I've worked with for my beloved HFSP project, even if it's a bumpy road...no risk no glory...
www.hfsp.org/hfsp-events/...
HFSP Webinar 2025: Research Grants | Human Frontier Science Program
www.hfsp.org
November 19, 2025 at 8:36 AM
Do you want to do some frontier of knowledge research? There's still time to register for the next webinar of @hfspo.bsky.social
By far one of the best agencies I've worked with for my beloved HFSP project, even if it's a bumpy road...no risk no glory...
www.hfsp.org/hfsp-events/...
By far one of the best agencies I've worked with for my beloved HFSP project, even if it's a bumpy road...no risk no glory...
www.hfsp.org/hfsp-events/...
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
November 14, 2025 at 8:38 PM
I guess it never gets old...bc we love #CellMigration
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
ATP has many roles: energy currency, hydrotrope, and *danger signal*
Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!
www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
Reposted by Pablo J. Sáez
ICYMI - In September, we co-hosted a mini-symposium with the Membrane Trafficking webinar series. You can view the recordings of the talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and the keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
FocalPlane features... membrane trafficking recordings - FocalPlane
FocalPlane features... membrane trafficking recordings - News
focalplane.biologists.com
November 14, 2025 at 2:33 PM
ICYMI - In September, we co-hosted a mini-symposium with the Membrane Trafficking webinar series. You can view the recordings of the talks from @nickader.bsky.social, @maiblab.bsky.social and Mónica Quiñones-Frías, and the keynote lecture from Gillian Griffiths @griffithslab.bsky.social.
Reposted by Pablo J. Sáez
To help you plan your conference travel for 2026, we’ve been busy updating our #CellBiology events calendar on FocalPlane.
If we are missing your event, feel free to add it to the calendar or reach out to our Community Manager @helenzsci.bsky.social.
focalplane.biologists.com/cell-biology...
If we are missing your event, feel free to add it to the calendar or reach out to our Community Manager @helenzsci.bsky.social.
focalplane.biologists.com/cell-biology...
November 12, 2025 at 2:05 PM
To help you plan your conference travel for 2026, we’ve been busy updating our #CellBiology events calendar on FocalPlane.
If we are missing your event, feel free to add it to the calendar or reach out to our Community Manager @helenzsci.bsky.social.
focalplane.biologists.com/cell-biology...
If we are missing your event, feel free to add it to the calendar or reach out to our Community Manager @helenzsci.bsky.social.
focalplane.biologists.com/cell-biology...
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
November 7, 2025 at 9:25 PM
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Also the membrane dynamics are lovely.
It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
Reposted by Pablo J. Sáez
Registration is OPEN for our Spring meeting: Dynamic Cell VI
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
October 31, 2025 at 10:06 AM
Registration is OPEN for our Spring meeting: Dynamic Cell VI
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
🗓️ 21st-26th April 2026
📍Reading, UK
Co-organised with @biochemsoc.bsky.social @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology
Register here:
www.eventsforce.net/biochemsoc/f...
Reposted by Pablo J. Sáez
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
journals.biologists.com
November 3, 2025 at 5:32 PM
Our special issue on ‘Cilia and Flagella’ is now out! Huge thanks to all (authors + reviewers) who contributed, and to our wonderful Guest Editors (@cilialab.bsky.social + @lottepedersen.bsky.social) for pulling it together.
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Happy reading!
#cilia #flagella
journals.biologists.com/jcs/issue/13...
Reposted by Pablo J. Sáez
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
October 14, 2025 at 1:50 PM
We hire!
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
The CytoMorpho Lab is looking for an engineer with a background in cell and molecular biology to join our team in Paris. This is a 18-month contract position, but we're open to exploring long-term opportunities.
More details here:
cytomorpholab.com/index.php/jo...
Reposted by Pablo J. Sáez
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
October 21, 2025 at 3:57 PM
We hiring! Please share this post with your talented ECRs
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
We're looking for a postdoc interested in the formation and function of tertiary lymphoid structures - project funded by Wellcome
Based at @lmcb-ucl.bsky.social at University College London
Apply here:
www.jobs.ac.uk/job/DPD418/r...
Reposted by Pablo J. Sáez
We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience
recruiting.paylocity.com/recruiting/j...
recruiting.paylocity.com/recruiting/j...
Lieber Institute For Brain Development - Staff Scientist I, Translational Neuroscience
A little about us:The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with develop...
recruiting.paylocity.com
October 29, 2025 at 4:03 PM
We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience
recruiting.paylocity.com/recruiting/j...
recruiting.paylocity.com/recruiting/j...
Reposted by Pablo J. Sáez
Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...
October 27, 2025 at 7:00 AM
Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...
Kudos to @eliasbarrigalab.bsky.social for the Innovation DGZ Prize for his work on #CellMigration
A great Chilean 🇨🇱 in #STEM 💪🏽🔥
@dgz.bsky.social #DGZ50
A great Chilean 🇨🇱 in #STEM 💪🏽🔥
@dgz.bsky.social #DGZ50
October 27, 2025 at 5:26 PM
Kudos to @eliasbarrigalab.bsky.social for the Innovation DGZ Prize for his work on #CellMigration
A great Chilean 🇨🇱 in #STEM 💪🏽🔥
@dgz.bsky.social #DGZ50
A great Chilean 🇨🇱 in #STEM 💪🏽🔥
@dgz.bsky.social #DGZ50
When your email box is so bad that every time day you are in the "my dog eat the homework" situation...
But this email is actually a dog, that actually eats the homeworks...wtf
But this email is actually a dog, that actually eats the homeworks...wtf
a crowd of people with their hands on their heads
ALT: a crowd of people with their hands on their heads
media.tenor.com
October 20, 2025 at 11:08 AM
When your email box is so bad that every time day you are in the "my dog eat the homework" situation...
But this email is actually a dog, that actually eats the homeworks...wtf
But this email is actually a dog, that actually eats the homeworks...wtf
Reposted by Pablo J. Sáez
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
October 13, 2025 at 12:44 AM
The future of High-Content Imaging has arrived.
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
-> Ultra-fast 3D imaging of multi-well plates at high resolution using an air objective!
See previous posts and the new miOPM preprint for details: doi.org/10.1101/2025...
Reposted by Pablo J. Sáez
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
October 9, 2025 at 1:08 PM
New preprint from our lab! ER geometry sets the tempo of neuronal bursting via Ca²⁺ store-refill—revealing selective neuronal vulnerability to ER-structure problems. Thread to follow.🧠⚡️
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
www.biorxiv.org/content/10.1...
#Neurodegeneration #NeuroCellBiology #Calcium #bioRxiv
Reposted by Pablo J. Sáez
🚨 My lab is hiring at all levels!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
October 8, 2025 at 5:49 PM
🚨 My lab is hiring at all levels!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
Interested in animal origins & evolutionary cell biology?
I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.
🔗: clarkelab.com/join/
Please repost!
Do you like the @npr.org tiny desk? Try this one👇🏽
"31 minutos" was one the most viewed shows "for kids" in Latin America.
It's the Chilean 🇨🇱 version of Sesame Street with acid humour, political critic & great music played by members of actual bands!
#31minutos en #ElTiny
youtu.be/UEqTIwRrWvA?...
"31 minutos" was one the most viewed shows "for kids" in Latin America.
It's the Chilean 🇨🇱 version of Sesame Street with acid humour, political critic & great music played by members of actual bands!
#31minutos en #ElTiny
youtu.be/UEqTIwRrWvA?...
31 Minutos: Tiny Desk Concert
YouTube video by NPR Music
youtu.be
October 7, 2025 at 6:44 PM
Do you like the @npr.org tiny desk? Try this one👇🏽
"31 minutos" was one the most viewed shows "for kids" in Latin America.
It's the Chilean 🇨🇱 version of Sesame Street with acid humour, political critic & great music played by members of actual bands!
#31minutos en #ElTiny
youtu.be/UEqTIwRrWvA?...
"31 minutos" was one the most viewed shows "for kids" in Latin America.
It's the Chilean 🇨🇱 version of Sesame Street with acid humour, political critic & great music played by members of actual bands!
#31minutos en #ElTiny
youtu.be/UEqTIwRrWvA?...
Reposted by Pablo J. Sáez
During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4
October 7, 2025 at 8:18 AM
During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4
Reposted by Pablo J. Sáez
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA
Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...
forum.image.sc
October 7, 2025 at 12:39 PM
Job alert!
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?
See also on the forum:
forum.image.sc/t/research-e...
Reposted by Pablo J. Sáez
What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
October 7, 2025 at 3:08 PM
What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social
rupress.org/jcb/article-...
Reposted by Pablo J. Sáez
PhD or Master's position available for Fall 2026!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
October 5, 2025 at 5:29 PM
PhD or Master's position available for Fall 2026!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!
Reposted by Pablo J. Sáez
napari 0.6.5 is out! 🚀
Rapid-fire highlights are: colorbar overlay, custom startup script, and better and prettier documentation! Check out the full release notes here: napari.org/dev/release/...
Rapid-fire highlights are: colorbar overlay, custom startup script, and better and prettier documentation! Check out the full release notes here: napari.org/dev/release/...
October 2, 2025 at 11:44 AM
napari 0.6.5 is out! 🚀
Rapid-fire highlights are: colorbar overlay, custom startup script, and better and prettier documentation! Check out the full release notes here: napari.org/dev/release/...
Rapid-fire highlights are: colorbar overlay, custom startup script, and better and prettier documentation! Check out the full release notes here: napari.org/dev/release/...
Reposted by Pablo J. Sáez
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...
Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
meetings.embo.org
July 4, 2025 at 3:50 PM
Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio
meetings.embo.org/event/26-org...
meetings.embo.org/event/26-org...