Pablo J. Sáez
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pjsaez.bsky.social
Pablo J. Sáez
@pjsaez.bsky.social
Husband - Dad of 2 - Scientist 🇨🇱 Chilean expat.
I love to study how cells walk & talk.
PI of the @cellcommlab.bsky.social
#CellMigration #CellComm #calciumsignaling #organelles 🧪🔬
#FluorescenceFriday

Jost, Schweizer et al. @ Cuello lab found that a mutation linked to aortic aneurysmas led to distorted actin #cytoskeleton in VSMCs #mechanobiology

New collab @cellcommlab.bsky.social by @jboixcampos.bsky.social🔥

Full www.sciencedirect.com/science/arti...
#microscopy #cell 🧪🔬
January 16, 2026 at 9:43 PM
#FluorescenceFriday

Proud of our the last paper @cellcommlab.bsky.social & 1st one of @jboixcampos.bsky.social

We continue to study #CellMigration & how cells decide where to go: ↖️↗️⬇️?

(movie of the actin #cytoskeleton)

Full www.science.org/doi/10.1126/...
@focalplane.bsky.social @science.org 🧪🔬
January 9, 2026 at 4:23 PM
We combined cell biology, #AI based image analysis & a mathematical model to show how migratory behaviour changes with branching

For now macrophages & endothelial cells, but we have many more, stay tuned ;)

Kudos to all authors for the effort, especially to a great Padawan @jboixcampos.bsky.social
January 1, 2026 at 8:59 PM
#HappyNewYear !
Let's start 2026 with a @cellcommlab.bsky.social paper

How many branches is OK during #CellMigration?
It depends on the #cell: for ex. immune cells are just fine.

In collab. w. #NirGov @hfspo.bsky.social

Full www.science.org/doi/10.1126/...
@focalplane.bsky.social @science.org 🧪🔬
January 1, 2026 at 8:59 PM
Hot from the press !

Happy to see this out, and that @cellcommlab.bsky.social contributed with live-cell imaging

Autoimmunoglobulin-triggered extracellular vesicles (movie) contribute to kidney disease

Full www.cell.com/cell/fulltex...
@focalplane.bsky.social @cp-cell.bsky.social #microscopy 🧪🔬
December 4, 2025 at 3:41 PM
Even if "provisionally" accepted, those are the best words/news I've heard for quite a while...

Here some #blebs to "provisionally" cellebrate.
Let's see this #cell dance under the microscope.

@focalplane.bsky.social #fluorescencefriday #microscopy 🧪🔬
November 21, 2025 at 2:55 PM
I guess it never gets old...bc we love #CellMigration

ATP has many roles: energy currency, hydrotrope, and *danger signal*

Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost!

www.science.org/doi/full/10....
@focalplane.bsky.social #fluorescencefriday 🧪🔬
November 14, 2025 at 8:38 PM
I love to see the endoplasmic reticulum (ER, cyan) hitchhiking over microtubules (MTs, orange).

Also the membrane dynamics are lovely.

It's been a while, but here we are for a late #fluorescencefriday with some #microscopy
#scicomm #scisky @cellcommlab.bsky.social focalplane.bsky.social 🧪🔬
November 7, 2025 at 9:25 PM
Kudos to @eliasbarrigalab.bsky.social for the Innovation DGZ Prize for his work on #CellMigration

A great Chilean 🇨🇱 in #STEM 💪🏽🔥

@dgz.bsky.social #DGZ50
October 27, 2025 at 5:26 PM
Today 20 years after I started working in a scientific lab while still in 🇨🇱, my lab, the @cellcommlab.bsky.social has its 5th labversary.

What a ride ! I'm thankful for the support of my family, friends, & so many great collabs & colleagues.

Fig legend 👇🏽 + pending longer thread #PIlife #Science
September 1, 2025 at 10:00 PM
Post an image from your summer that confers peace
August 31, 2025 at 6:11 PM
Barely made ir for another #FluorescenceFriday

Ahhh the #Nucleus ... it never gets old.
This #cell has 2 bc why not !! It seems they are refusing to separate.

This 👇🏽 is an excellent chance to put your last work in the nucleus in this issue edited by @abbybuch.bsky.social @jcellsci.bsky.social
July 25, 2025 at 10:01 PM
#HotFromThePress !!

What if instead of analyzing 4-6 pathology markers you could check >100 in the *same* sample?

@maltekuehl.com & co @puellesv.bsky.social lab introduce #PathoPlex, method that could even predict disease

Full www.nature.com/articles/s41...
@focalplane.bsky.social @nature.com 🧪🔬
July 18, 2025 at 1:14 PM
This is why we love #cellmigration

#Leukocytes: #Neutrophils (cyan) #Macrophages (orange) chemotaxis.

I couldn't share it before the retirement of @zebrafishrock.bsky.social, but cool #microscopy in #zebrafish continue to rock !

#scicomm #scisky @cellcommlab.bsky.social @focalplane.bsky.social 🧪🔬
July 8, 2025 at 10:18 AM
Post yourself from another era.

(20 years ago)
June 29, 2025 at 6:38 PM
Do you know what happens if you squeeze a #cell?

If the #confinement is high, the nucleus (green) will be super tense & the compressed cells will react like this👇🏽changing their #cytoskeleton (magenta)

Full: www.science.org/doi/10.1126/...
#scicomm #microscopy #sciencesky @focalplane.bsky.social 🧪🔬
June 28, 2025 at 12:32 PM
#FluorescenceFriday

#Mitochondria, powerhouse of the #cell were labeled (cyan) and it's possible to visualize how they reach *every* corner to provide energy.

All recorded under the microscope @cellcommlab.bsky.social

#scicomm #sciencesky #microscopy #organelles @focalplane.bsky.social 🧪🔬
June 20, 2025 at 7:24 PM
This is why we love #cell dynamics !

Look at this #macrophage branching exploring the surroundings videoed under the microscope

This what immune cells do in our body in search of bacteria, viruses and death cells

#microscopy #cellbio #sciencesky @focalplane.bsky.social @cellcommlab.bsky.social 🧪🔬
June 7, 2025 at 10:14 PM
It was a great @dgz.bsky.social session with a lot of #CellMigration and trafficking of #ImmuneCells

Thanks to all the speakers: @liz-kurtz.bsky.social, #ZahraaA, @labliston.bsky.social and #StefanU
April 29, 2025 at 12:26 PM
100 years ago it was founded the most successful and popular football team in Chile 🇨🇱: #ColoColo ⚽🏆

This year I had the chance to be in, Valladolid, where David Arellano (the the founder of the club) died (Hotel Inglaterra).
He died while playing for Colo-Colo.

#centenarioalbo #ColoColo100
April 19, 2025 at 3:44 PM
Hot from the press: #CellMigration #vesicles #organelles

Jeppesen et al @mag2art.bsky.social lab introduce blebbisomes: organelle-rich motile vesicles, have immune checkpoint inhibitors, released by #cancer cells & used for #cellcomm

@naturecellbiology.bsky.social www.nature.com/articles/s41... 🧪🔬
February 22, 2025 at 6:53 AM
An oldie (10 y!) but goodie: cellular interaction at the top! #cellcomm

Video of a T cell (orange) interacting with a target cell (blue)

From Chen et al. @ Betzig lab (@hhmijanelia.bsky.social) game changing paper !!

Full science.org/doi/10.1126/... @focalplane.bsky.social #scicomm #microscopy 🧪🔬
February 18, 2025 at 8:38 PM
Hot from the press for #CellMigration + #Nucleus aficionados

Karling @helenweavers.bsky.social lab show *in vivo* how immune cell adapt quickly to confined microenvironments during motility.

Live-cell imaging, image analysis, #Drosophila !

Full @emboreports.org
www.embopress.org/doi/full/10....
February 10, 2025 at 5:50 AM
#CellMigration happens all the time in our bodies. This may (or not) rely on adhesion molecules

#Cancer cells switch strategies during metastasis to invade other tissues

Naomi Wee (naomiwee.com) did this neat movie to explain it:
www.youtube.com/watch?v=D9aD...
#SciSky 🧪🔬 @cellcommlab.bsky.social
February 6, 2025 at 10:44 AM
The #nucleus contains the info of a #cell, but it does much more than that !!

Since the nucleus is *big*, acts as the main intracellular obstacle, and during #CellMigration can get 'trapped'/stuck until the cell pushes it FWD.

#scicomm @focalplane.bsky.social @cellcommlab.bsky.social
#Skyscience
February 1, 2025 at 3:45 PM