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Pablo J. Sáez

@pjsaez.bsky.social

1.5K followers 440 following 200 posts

Husband - Dad of 2 - Scientist 🇨🇱 Chilean expat. I love to study how cells walk & talk. PI of the @cellcommlab.bsky.social #CellMigration #CellComm #calciumsignaling #organelles 🧪🔬

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Pablo J. Sáez @pjsaez.bsky.social · Jan 18

How cells decide where to go? #CellMigration

Last year we published our 1st paper @cellcommlab.bsky.social, showing how actin-based membrane oscillations define a new direction ( #cancer & non-cancer #cells )

Full www.nature.com/articles/s41...
@naturephysics.bsky.social @focalplane.bsky.social 🧪🔬

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Reposted by Pablo J. Sáez

Nat Clarke @natclarke.bsky.social · 11h

🚨 My lab is hiring at all levels!

Interested in animal origins & evolutionary cell biology?

I'm recruiting a postdoc, PhD students & a research assistant to study the molecular evolution of cell adhesion using marine invertebrates + comparative genomics.

🔗: clarkelab.com/join/

Please repost!

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Pablo J. Sáez @pjsaez.bsky.social · 1d

Ils ont même un chanson en français 😉
Pour les petits et petites @guijacquemet.bsky.social @christlet.bsky.social @agathechaigne.bsky.social

youtu.be/nvP5YKlw9-Y?...

Pablo J. Sáez @pjsaez.bsky.social · 1d

Do you like the @npr.org tiny desk? Try this one👇🏽

"31 minutos" was one the most viewed shows "for kids" in Latin America.
It's the Chilean 🇨🇱 version of Sesame Street with acid humour, political critic & great music played by members of actual bands!
#31minutos en #ElTiny

youtu.be/UEqTIwRrWvA?...

31 Minutos: Tiny Desk Concert

YouTube video by NPR Music

youtu.be

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Reposted by Pablo J. Sáez

PLOS Biology @plosbiology.org · 1d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

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Reposted by Pablo J. Sáez

Jean-Yves Tinevez @jytinevez.bsky.social · 1d

Job alert!

We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks?

See also on the forum:
forum.image.sc/t/research-e...

Research engineer in Bioimage Analysis for the researchers of the inIdEx FORMULA

Hi all We are looking for a bioimage analysis to work in an image analysis core facility in beautiful Paris. Can I ask you to share this opportunity with your networks? The position is in the Instit...

forum.image.sc

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Reposted by Pablo J. Sáez

Manuel Thery @manuelthery.bsky.social · 1d

What would happen if cells would express more molecular motors ?
They would break all microtubules 😱
As shown by recent great work from @kjverhey1.bsky.social

rupress.org/jcb/article-...

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Reposted by Pablo J. Sáez

Katrina Velle @katrinavelle.bsky.social · 3d

PhD or Master's position available for Fall 2026!

Interested in how actin drives cell crawling, eating, dividing, or osmoregulation? What about pathogenesis of a brain-eating amoeba? Or eukaryotic evolution? If so, apply through my website: katrinavelle.wixsite.com/science/cont...
Please share!

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Pablo J. Sáez @pjsaez.bsky.social · 5d

Gorgeous imaging. What did you use for RhoA?

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Pablo J. Sáez @pjsaez.bsky.social · 5d

Good one !

For me it would be a milestone to one day talk about live-cell imaging, migration and empanadas...

Reposted by Pablo J. Sáez

napari @napari.org · 6d

napari 0.6.5 is out! 🚀

Rapid-fire highlights are: colorbar overlay, custom startup script, and better and prettier documentation! Check out the full release notes here: napari.org/dev/release/...

Image depicting the napari viewer in grid mode with scale bars and color bars enabled

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Reposted by Pablo J. Sáez

Felix Campelo @felixmendu.bsky.social · Jul 4

Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio

meetings.embo.org/event/26-org...

Intracellular mechanics and organelle mechanobiology

Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…

meetings.embo.org

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Pablo J. Sáez @pjsaez.bsky.social · 10d

Happily checking grant application instructions until I found that a collaborator, who is a co-applicant is part of the evaluation committee...
why...why...

a close up of yoda with suffering written on the bottom

ALT: a close up of yoda with suffering written on the bottom

media.tenor.com

Reposted by Pablo J. Sáez

France-BioImaging @france-bioimaging.bsky.social · 22d

We are thrilled to announce that our Image Contest is back! 🔬🏆

Submit your best images & try to win your registration fees for one 2026 #microscopy related event.
📆Before November 14th, 2025

Info & entries👉 france-bioimaging.org/fbi-special-...

We are all eager to see your work!

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Reposted by Pablo J. Sáez

Ivan Radin @radinbio.bsky.social · 23d

Do you know what happens when you touch a carnivorous sundew plant?
If the touch is strong and large enough, a cytosolic calcium wave will spread from the site of touch throughout the whole plant, but if you only touch one tentacle (see post below), the calcium wave will be local and less intense.

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Reposted by Pablo J. Sáez

Thomas Worzfeld @worzfeld.bsky.social · 29d

Great to be invited to the 5th Inflammation & Imaging Symposium in Münster with exciting scientific talks and discussions! www.uni-muenster.de/Cells-in-Mot... @uni-muenster.de

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Reposted by Pablo J. Sáez

Anna Obenauf @obenaufa.bsky.social · Sep 4

Exciting FULL PROFESSORSHIP at the Vienna BioCenter - Molecular Mechanisms of Disease Mechanisms: www.maxperutzlabs.ac.at/news/open-po... Come be our colleague!

Full Professorship in Molecular Mechanisms of Disease

The Max Perutz Labs - one of Europe’s leading institutes for basic research in the life sciences - invite applications for a Full Professorship in Molecular Mechanisms of Disease. We are seeking outst...

www.maxperutzlabs.ac.at

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Pablo J. Sáez @pjsaez.bsky.social · Sep 1

Top, expectations vs reality of what a PI does 😜

Bottom panel, for ECRs an example of the learning curve doing #microscopy

Left, one of the very 1st figure panels I ever did, using a camera to take the pic *from* the eyepiece, 2005.

Right, fragment of the last figure panel I prepared, 2025.

Pablo J. Sáez @pjsaez.bsky.social · Sep 1

Today 20 years after I started working in a scientific lab while still in 🇨🇱, my lab, the @cellcommlab.bsky.social has its 5th labversary.

What a ride ! I'm thankful for the support of my family, friends, & so many great collabs & colleagues.

Fig legend 👇🏽 + pending longer thread #PIlife #Science

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Reposted by Pablo J. Sáez

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Aug 27

Applications are now open for the Stanford Science Fellows postdoctoral program, opportunity to join an exciting community of scholars!

stanfordsciencefellows.stanford.edu

Science Fellows

stanfordsciencefellows.stanford.edu

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Pablo J. Sáez @pjsaez.bsky.social · Aug 31

Post an image from your summer that confers peace

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Reposted by Pablo J. Sáez

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Aug 27

Spread the word - we at @stanford-chemh.bsky.social are searching to fill a new junior faculty at the interface of molecular and computational science. See link below!

Sarafan ChEM-H @stanford-chemh.bsky.social · Aug 26

Open faculty position!
We're seeking applicants for a tenure-track faculty position at the junior level (Assistant or untenured Associate Professor) with research programs that exist at the interface between molecular science and computation. Apply here: stanford.io/45MF3Qa

Open Faculty Position: Assistant or Associate (Untenured) Professor

Application deadline: 11:55 PM on Wednesday, October 15, 2025

Sarafan ChEM-H is seeking candidates with research programs that exist at the interface between molecular science and computation.

Click the link above to learn more & apply!

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Reposted by Pablo J. Sáez

The Company of Biologists @biologists.bsky.social · Aug 27

Our first extraordinary biologist featured this week is Jennifer Lippincott-Schwartz, a @jcellsci.bsky.social Editor, @focalplane.bsky.social Scientific Advisory Board member and plenary speaker at the Biologists @ 100 conference. #biologists100 #100biologists

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Reposted by Pablo J. Sáez

Carmofon Lab @carmofonlab.bsky.social · Apr 10

Out on today's issue! :)

www.nature.com/articles/s41...

Strength in numbers: tumor cells cooperate to survive under metabolic stress

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Pablo J. Sáez @pjsaez.bsky.social · Aug 9

Very cool, Melike ! Until when are you around?
I'll be there later this year, also maybe a good time to catch up with @gautamdey.bsky.social ;)

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Pablo J. Sáez @pjsaez.bsky.social · Aug 9

Maybe a young grandpa?
(Any consolation?)