Thomas Lecuit
@thomaslecuit.bsky.social
How are biological forms encoded? Group leader at IBDM Marseille, director of Turing Center for living systems (CENTURI). Professor at Collège de France, Paris: Dynamics of living systems
Pinned
Thomas Lecuit
@thomaslecuit.bsky.social
· Nov 24
And here is the link to access the whole pdf. Enjoy!
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
Reposted by Thomas Lecuit
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium reducing macromolecule diffusion | PNAS
Intracellular transport of macromolecules is crucial for the proper functioning of
most cellular processes. Although intracellular crowding is know...
www.pnas.org
January 26, 2026 at 9:42 AM
Happy to highlight our collaborative work from our @ijmonod.bsky.social team with @destriano.bsky.social, B. Goyeau and M. Chabanon.
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Cytoplasmic crowding acts as a porous medium that hinders macromolecular diffusivity.
Plus: a clever way to measure cell volume.
www.pnas.org/doi/10.1073/...
Reposted by Thomas Lecuit
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
In remembrance of Peer Bork | EMBL
EMBL and its community are deeply saddened by the death of Peer Bork, the organisation’s Interim Director General.
www.embl.org
January 16, 2026 at 6:33 PM
very sad news. Peer Bork was one of the leaders of our field, a wonderful scientist, and he's much too young to be gone. www.embl.org/news/embl-an...
Reposted by Thomas Lecuit
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
January 7, 2026 at 4:02 PM
Excited to share Alison's @alisonkickuth.bsky.social paper from the lab out in @nature.com this week! We uncovered how a mechanical ratchet mechanism drives cytokinesis in early #zebrafish embryos. Read more in this thread 🧵 and at www.nature.com/articles/s41... 🤩
@poldresden.bsky.social @mpi-cbg.de
@poldresden.bsky.social @mpi-cbg.de
Reposted by Thomas Lecuit
The hard truth about how hard it is to publish in Development
Editor-in-Chief @jamesbriscoe.bsky.social leads our team of Academic Editors in addressing the perception that Development is ‘too hard to publish in’ by discussing the journal's review process.
doi.org/10.1242/dev....
Editor-in-Chief @jamesbriscoe.bsky.social leads our team of Academic Editors in addressing the perception that Development is ‘too hard to publish in’ by discussing the journal's review process.
doi.org/10.1242/dev....
January 12, 2026 at 10:36 AM
The hard truth about how hard it is to publish in Development
Editor-in-Chief @jamesbriscoe.bsky.social leads our team of Academic Editors in addressing the perception that Development is ‘too hard to publish in’ by discussing the journal's review process.
doi.org/10.1242/dev....
Editor-in-Chief @jamesbriscoe.bsky.social leads our team of Academic Editors in addressing the perception that Development is ‘too hard to publish in’ by discussing the journal's review process.
doi.org/10.1242/dev....
Reposted by Thomas Lecuit
Is there a mathematics of discontinuous behavior? Christopher Zeeman was a leading proponent of Catastrophe Theory, a topological approach to sudden change that underpins much of today’s work on tipping points. This is his beautiful 1976 paper in @sciam.bsky.social www.jstor.org/stable/pdf/2...
January 12, 2026 at 11:27 PM
Is there a mathematics of discontinuous behavior? Christopher Zeeman was a leading proponent of Catastrophe Theory, a topological approach to sudden change that underpins much of today’s work on tipping points. This is his beautiful 1976 paper in @sciam.bsky.social www.jstor.org/stable/pdf/2...
Wonderful dinner in Paris with Claude Desplan, 1st mentor (who led me to become a scientist because his lab was such a cool place) & friend. Thank you for your energy, shear passion for science and sense of humour 🤩. And see you soon at the College de France in May June for your lecture series.
January 8, 2026 at 4:20 PM
Wonderful dinner in Paris with Claude Desplan, 1st mentor (who led me to become a scientist because his lab was such a cool place) & friend. Thank you for your energy, shear passion for science and sense of humour 🤩. And see you soon at the College de France in May June for your lecture series.
Reposted by Thomas Lecuit
How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
January 5, 2026 at 8:00 AM
How can cells use information from neighboring cells to improve the spatial precision of morphogen patterns? 🤔
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
We show that cells can gain positional information by "talking" to their neighbors - how much depends critically on spatial correlations of the patterns.
buff.ly/w56OUJT
Reposted by Thomas Lecuit
Super nice to see this awesome set of lectures online! A really timely perspective on biology through the lens of information, which inspires much of our own research as well.
And here is the link to access the whole pdf. Enjoy!
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
I strongly believe that focusing on information & computation during Development provides an important framework, that encapsulates the genetic, chemistry & mechanics, but focusses on organisation, dynamics & logic.
PDF: tinyurl.com/4hn34t8w
January 5, 2026 at 8:34 AM
Super nice to see this awesome set of lectures online! A really timely perspective on biology through the lens of information, which inspires much of our own research as well.
Reposted by Thomas Lecuit
The CENTURI PhD Call 2026 is still ongoing. Applications are open until the end of the month, on January 28th!
Visit centuri-livingsystems.org/recruitment/ to apply.
#PHD #CENTURI
Visit centuri-livingsystems.org/recruitment/ to apply.
#PHD #CENTURI
January 5, 2026 at 8:34 AM
The CENTURI PhD Call 2026 is still ongoing. Applications are open until the end of the month, on January 28th!
Visit centuri-livingsystems.org/recruitment/ to apply.
#PHD #CENTURI
Visit centuri-livingsystems.org/recruitment/ to apply.
#PHD #CENTURI
Here is the link to download the PDF of my course#5 on Biological computation. I present & discuss Self-tuning, Adaptation and Learning in biological (non-neuronal) systems, in particular during embryonic development.
This course contains various personal ideas/proposals.
tinyurl.com/hcpwsbtm
This course contains various personal ideas/proposals.
tinyurl.com/hcpwsbtm
January 3, 2026 at 9:47 AM
Here is the link to download the PDF of my course#5 on Biological computation. I present & discuss Self-tuning, Adaptation and Learning in biological (non-neuronal) systems, in particular during embryonic development.
This course contains various personal ideas/proposals.
tinyurl.com/hcpwsbtm
This course contains various personal ideas/proposals.
tinyurl.com/hcpwsbtm
Please find below the link to watch the VIDEO of my course#5 @college-de-france.fr on Biological computation. I present and discuss Self-tuning, Adaptation and Learning in biological (non/neuronal) systems, in particular during embryonic development.
Enjoy!
tinyurl.com/4pv95an9
Enjoy!
tinyurl.com/4pv95an9
Qu’est-ce que l’information biologique (suite) ? (5) - Thomas Lecuit (2025-2026)
Enseignement 2025-2026 : Qu’est-ce que l’information biologique (suite) ? Cours du 18 décembre 2025 : Apprentissage non neuronal dans un système vivant Professeur : Thomas Lecuit Chaire Dynamiques du vivant Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/agenda/cours/qu-est-ce-que-information-biologique Tous les enseignements du Pr Thomas Lecuit : https://www.college-de-france.fr/chaire/thomas-lecuit-dynamiques-du-vivant-chaire-statutaire https://www.youtube.com/playlist?list=PLOj9pZ2YNGZ84uMY6DhPnqpL1rq5qNAVJ Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Soutenir le Collège de France : https://www.fondation-cdf.fr/faire-un-don Suivez-nous sur : Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-france.fr Facebook : https://www.facebook.com/College.de.France Instagram : https://www.instagram.com/collegedefrance LinkedIn : https://fr.linkedin.com/company/coll%C3%A8gedefrance
tinyurl.com
January 3, 2026 at 9:44 AM
Please find below the link to watch the VIDEO of my course#5 @college-de-france.fr on Biological computation. I present and discuss Self-tuning, Adaptation and Learning in biological (non/neuronal) systems, in particular during embryonic development.
Enjoy!
tinyurl.com/4pv95an9
Enjoy!
tinyurl.com/4pv95an9
Reposted by Thomas Lecuit
#Science #Biologie
🧬 « Qu’est-ce que l’information biologique (suite) ? »
🖥️ Le cours du Pr @thomaslecuit.bsky.social, titulaire de la chaire Dynamiques du vivant, est terminé... mais toutes les vidéos sont à retrouver sur notre site web !
👉 https://tinyurl.com/bddcxahd
🧬 « Qu’est-ce que l’information biologique (suite) ? »
🖥️ Le cours du Pr @thomaslecuit.bsky.social, titulaire de la chaire Dynamiques du vivant, est terminé... mais toutes les vidéos sont à retrouver sur notre site web !
👉 https://tinyurl.com/bddcxahd
December 22, 2025 at 1:21 PM
#Science #Biologie
🧬 « Qu’est-ce que l’information biologique (suite) ? »
🖥️ Le cours du Pr @thomaslecuit.bsky.social, titulaire de la chaire Dynamiques du vivant, est terminé... mais toutes les vidéos sont à retrouver sur notre site web !
👉 https://tinyurl.com/bddcxahd
🧬 « Qu’est-ce que l’information biologique (suite) ? »
🖥️ Le cours du Pr @thomaslecuit.bsky.social, titulaire de la chaire Dynamiques du vivant, est terminé... mais toutes les vidéos sont à retrouver sur notre site web !
👉 https://tinyurl.com/bddcxahd
And here is the PDF of the 4th course @college-de-france.fr. You will find the justification and presentation of geometric representation of cell decisions, a parsimonious mathematical model for signalling and cell state transitions
tinyurl.com/yc7u296j
tinyurl.com/yc7u296j
December 16, 2025 at 9:57 AM
And here is the PDF of the 4th course @college-de-france.fr. You will find the justification and presentation of geometric representation of cell decisions, a parsimonious mathematical model for signalling and cell state transitions
tinyurl.com/yc7u296j
tinyurl.com/yc7u296j
Please find below the link to watch the VIDEO of my course#4 @college-de-france.fr on Biological computation. I present and discuss Geometric analysis of cell decisions during development, a mathematical formulation of Waddington landscapes.
Enjoy!
tinyurl.com/3zay96xx
Enjoy!
tinyurl.com/3zay96xx
Qu’est-ce que l’information biologique (suite) ? (4) - Thomas Lecuit (2025-2026)
Enseignement 2025-2026 : Qu’est-ce que l’information biologique (suite) ? Cours du 11 décembre 2025 : Vision dynamique du traitement d'information Professeur : Thomas Lecuit Chaire Dynamiques du vivant Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/agenda/cours/qu-est-ce-que-information-biologique Tous les enseignements du Pr Thomas Lecuit : https://www.college-de-france.fr/chaire/thomas-lecuit-dynamiques-du-vivant-chaire-statutaire https://www.youtube.com/playlist?list=PLOj9pZ2YNGZ84uMY6DhPnqpL1rq5qNAVJ Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Soutenir le Collège de France : https://www.fondation-cdf.fr/faire-un-don Suivez-nous sur : Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-france.fr Facebook : https://www.facebook.com/College.de.France Instagram : https://www.instagram.com/collegedefrance LinkedIn : https://fr.linkedin.com/company/coll%C3%A8gedefrance
tinyurl.com
December 16, 2025 at 9:48 AM
Please find below the link to watch the VIDEO of my course#4 @college-de-france.fr on Biological computation. I present and discuss Geometric analysis of cell decisions during development, a mathematical formulation of Waddington landscapes.
Enjoy!
tinyurl.com/3zay96xx
Enjoy!
tinyurl.com/3zay96xx
Reposted by Thomas Lecuit
Have you ever wondered what you would find if you could keep your eyes on a bee for more than a few meters? Us, too!
preprint (with videos!) + thread 🧵
Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking
www.biorxiv.org/content/10.6...
1/9
preprint (with videos!) + thread 🧵
Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking
www.biorxiv.org/content/10.6...
1/9
December 6, 2025 at 2:01 PM
Have you ever wondered what you would find if you could keep your eyes on a bee for more than a few meters? Us, too!
preprint (with videos!) + thread 🧵
Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking
www.biorxiv.org/content/10.6...
1/9
preprint (with videos!) + thread 🧵
Precise, individualized foraging flights in honey #bees 🐝 revealed by multicopter drone-based tracking
www.biorxiv.org/content/10.6...
1/9
Here is the link to download the PDF of my 3rd course @cdf1530 on biological computation. I present and discuss network motifs that reveal the hidden logic of complex networks.
tinyurl.com/5ynpspad
tinyurl.com/5ynpspad
December 9, 2025 at 1:23 PM
Here is the link to download the PDF of my 3rd course @cdf1530 on biological computation. I present and discuss network motifs that reveal the hidden logic of complex networks.
tinyurl.com/5ynpspad
tinyurl.com/5ynpspad
Please find below the link to watch the VIDEO of my 3rd course @college-de-france.fr on Biological computation. I present and discuss Network motifs that reveal the hidden logic of complex genetic and biochemical networks.
Enjoy!
tinyurl.com/yyky4w2m
Enjoy!
tinyurl.com/yyky4w2m
Qu’est-ce que l’information biologique (suite) ? (3) - Thomas Lecuit (2025-2026)
Enseignement 2025-2026 : Qu’est-ce que l’information biologique (suite) ? Cours du 4 décembre 2025 : Vision logique des flux d’information Professeur : Thomas Lecuit Chaire Dynamiques du vivant Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/agenda/cours/qu-est-ce-que-information-biologique Tous les enseignements du Pr Thomas Lecuit : https://www.college-de-france.fr/chaire/thomas-lecuit-dynamiques-du-vivant-chaire-statutaire https://www.youtube.com/playlist?list=PLOj9pZ2YNGZ84uMY6DhPnqpL1rq5qNAVJ Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Soutenir le Collège de France : https://www.fondation-cdf.fr/faire-un-don Suivez-nous sur : Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-france.fr Facebook : https://www.facebook.com/College.de.France Instagram : https://www.instagram.com/collegedefrance LinkedIn : https://fr.linkedin.com/company/coll%C3%A8gedefrance
tinyurl.com
December 9, 2025 at 1:05 PM
Please find below the link to watch the VIDEO of my 3rd course @college-de-france.fr on Biological computation. I present and discuss Network motifs that reveal the hidden logic of complex genetic and biochemical networks.
Enjoy!
tinyurl.com/yyky4w2m
Enjoy!
tinyurl.com/yyky4w2m
Reposted by Thomas Lecuit
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
December 5, 2025 at 4:11 PM
#LivingArchitectures
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
We put cells and cytoskeleton filaments on the architecture of the musée d'Orsay.
www.musee-orsay.fr/fr/agenda/ev...
Scientists of the #CytoMorphoLab adapted their protocols to illustrate the questions that keep them awake at night.
-> Two shows on the 24th and 25th of January.
Awesome. What an adventure! Can’t wait for discoveries to come.
And ‘Searching for the Asgards’ the movie: www.youtube.com/watch?v=mgmE...
Collaboration for Understanding | Searching for the Asgards
YouTube video by Schmidt Ocean
www.youtube.com
December 4, 2025 at 8:20 PM
Awesome. What an adventure! Can’t wait for discoveries to come.
Reposted by Thomas Lecuit
wow... crawling motility in Asgard #archaea!! www.biorxiv.org/content/10.1...
look at these crazy moves!! Let's face it, what these cells want for Christmas is #cilia... the best type of motility appendage...
look at these crazy moves!! Let's face it, what these cells want for Christmas is #cilia... the best type of motility appendage...
December 2, 2025 at 10:30 PM
wow... crawling motility in Asgard #archaea!! www.biorxiv.org/content/10.1...
look at these crazy moves!! Let's face it, what these cells want for Christmas is #cilia... the best type of motility appendage...
look at these crazy moves!! Let's face it, what these cells want for Christmas is #cilia... the best type of motility appendage...
Reposted by Thomas Lecuit
New preprint! Do you like ocean waves? We found similar waves on bacterial colonies! We found that this collective behavior, known as rippling, is nothing but surface waves on an active nematic. @princeton.edu @mpipks.bsky.social @ub.edu @icreacommunity.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
December 2, 2025 at 8:02 PM
New preprint! Do you like ocean waves? We found similar waves on bacterial colonies! We found that this collective behavior, known as rippling, is nothing but surface waves on an active nematic. @princeton.edu @mpipks.bsky.social @ub.edu @icreacommunity.bsky.social
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Here is the link to download the pdf of my 2nd course on complexity and information during development:
tinyurl.com/b7szw7v3
tinyurl.com/b7szw7v3
December 1, 2025 at 1:32 PM
Here is the link to download the pdf of my 2nd course on complexity and information during development:
tinyurl.com/b7szw7v3
tinyurl.com/b7szw7v3
Here is the link to my 2nd course at the College de France @college-de-france.fr
In it I address the problem of how complexity increases during development with constant information (arising from Shannon information theory).
Algorithmic information is key.
Enjoy.
Video link:
tinyurl.com/ze664hnv
In it I address the problem of how complexity increases during development with constant information (arising from Shannon information theory).
Algorithmic information is key.
Enjoy.
Video link:
tinyurl.com/ze664hnv
Qu’est-ce que l’information biologique (suite) ? (2) - Thomas Lecuit (2025-2026)
Enseignement 2025-2026 : Qu’est-ce que l’information biologique (suite) ? Cours du 27 novembre 2025 : Complexité et information au cours du développement Professeur : Thomas Lecuit Chaire Dynamiques du vivant Retrouvez les enregistrements audios et vidéos du cycle : https://www.college-de-france.fr/fr/agenda/cours/qu-est-ce-que-information-biologique Tous les enseignements du Pr Thomas Lecuit : https://www.college-de-france.fr/chaire/thomas-lecuit-dynamiques-du-vivant-chaire-statutaire https://www.youtube.com/playlist?list=PLOj9pZ2YNGZ84uMY6DhPnqpL1rq5qNAVJ Le Collège de France est une institution de recherche fondamentale dans tous les domaines de la connaissance et un lieu de diffusion du « savoir en train de se faire » ouvert à tous. Les cours, séminaires, colloques sont enregistrés puis mis à disposition du public sur le site internet du Collège de France. Découvrez toutes les ressources du Collège de France : https://www.college-de-france.fr Soutenir le Collège de France : https://www.fondation-cdf.fr/faire-un-don Suivez-nous sur : Threads : https://www.threads.net/@collegedefrance Bluesky : https://bsky.app/profile/college-de-france.fr Facebook : https://www.facebook.com/College.de.France Instagram : https://www.instagram.com/collegedefrance LinkedIn : https://fr.linkedin.com/company/coll%C3%A8gedefrance
tinyurl.com
December 1, 2025 at 1:30 PM
Here is the link to my 2nd course at the College de France @college-de-france.fr
In it I address the problem of how complexity increases during development with constant information (arising from Shannon information theory).
Algorithmic information is key.
Enjoy.
Video link:
tinyurl.com/ze664hnv
In it I address the problem of how complexity increases during development with constant information (arising from Shannon information theory).
Algorithmic information is key.
Enjoy.
Video link:
tinyurl.com/ze664hnv
Reposted by Thomas Lecuit
One of our founding directors Anthony Hyman @hymanlab.bsky.social will become @embl.org Director General: www.mpi-cbg.de/news-outreac...
November 27, 2025 at 1:20 PM
One of our founding directors Anthony Hyman @hymanlab.bsky.social will become @embl.org Director General: www.mpi-cbg.de/news-outreac...