Hellerschmied Lab
@hellerschmiedlab.bsky.social
Biochemistry and cell biology lab @unidue-zmb.bsky.social
Excited about secretory pathway and #Golgi #proteostasis mechanisms
funded by AvHStiftung, part of @crc1430.bsky.social
(tweets by PI)
Excited about secretory pathway and #Golgi #proteostasis mechanisms
funded by AvHStiftung, part of @crc1430.bsky.social
(tweets by PI)
Pinned
New online: Conformational plasticity of a BiP–GRP94 chaperone complex
Conformational plasticity of a BiP–GRP94 chaperone complex
Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
go.nature.com
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
Reposted by Hellerschmied Lab
Happy that we could contribute to this exciting paper from the @spanglab.bsky.social!
Exciting preprint from @franbottanelli.bsky.social and @annespang.bsky.social! ARF-1 regulates FERARI-mediated endosomal kiss-and-run recycling by controlling selective cargo loading into vesicles.
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs
www.biorxiv.org/content/10.6...
January 13, 2026 at 8:30 PM
Happy that we could contribute to this exciting paper from the @spanglab.bsky.social!
Reposted by Hellerschmied Lab
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
January 10, 2026 at 12:47 AM
Join us for the #Ubiquitin & Friends Symposium 2026, April 29-30, in Vienna!
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Fantastic guest speakers👇 & many slots for talks from abstracts, flash-talks & posters. Lots of opportunities to network. Register now to save your spot!
➡️ www.protein-degradation.org/symposium/
#ubfriends2026
Reposted by Hellerschmied Lab
Fun preprint from @marius-lemberg.bsky.social! TMED9 drives Golgi-bypass secretion of proTGFα via a RHBDL4-independent pathway requiring GRASP65, autophagy machinery and ALIX.
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
January 13, 2026 at 8:08 PM
Fun preprint from @marius-lemberg.bsky.social! TMED9 drives Golgi-bypass secretion of proTGFα via a RHBDL4-independent pathway requiring GRASP65, autophagy machinery and ALIX.
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
A Golgi-bypass secretion mechanism for proTGFα involving TMED9 and GRASP65
www.biorxiv.org/content/10.6...
Reposted by Hellerschmied Lab
Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪
January 5, 2026 at 2:48 PM
Happy new year! I've so enjoyed the end-of-year lists of people's favorite papers from 2025, so I made a list of 16 #lipidtime studies from 2025 that I found interesting. Here they are in no particular order (please add more if you would like!), and here's to much more exciting science in 2026! 🧪
Reposted by Hellerschmied Lab
New research group leader @matthiasmuhar.bsky.social joins @mpi-cbg.de! 🥳 With his group "Functional genomics of proteome remodeling,” Matthias wants to pursue high-throughput genetic studies to understand how protein turnover is regulated. Welcome, Matthias! www.mpi-cbg.de/news-outreac...
New research group leader for functional genomics
Molecular biologist Matthias Muhar becomes part of the MPI-CBG faculty
www.mpi-cbg.de
December 11, 2025 at 2:15 PM
New research group leader @matthiasmuhar.bsky.social joins @mpi-cbg.de! 🥳 With his group "Functional genomics of proteome remodeling,” Matthias wants to pursue high-throughput genetic studies to understand how protein turnover is regulated. Welcome, Matthias! www.mpi-cbg.de/news-outreac...
Reposted by Hellerschmied Lab
Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇
📢 Please help spread the word: We’re hiring a Head of Student & Postdoc Affairs to coordinate our international PhD program, provide guidance & career counseling, lead training programs, collaborate on EDI initiatives, and manage alumni relations. Apply at www.fmi.ch/education-ca...
December 8, 2025 at 11:47 AM
Please repost - position of Head of Student & Postdoc Affairs available at our Institute in the heart of Europe (Basel, Switzerland) 👇
Reposted by Hellerschmied Lab
Research Specialist in Microscopy and Spatial Transcriptomics (80-100%)
www.biozentrum.unibas.ch/open-positio...
@biozentrum.unibas.ch @unibas.ch #biozentrum #biozentrumbasel #universityofbasel #researchjobs #sciencejobs #basel #job #hiring #recruiting #carreers #research #specialist #microscopy
www.biozentrum.unibas.ch/open-positio...
@biozentrum.unibas.ch @unibas.ch #biozentrum #biozentrumbasel #universityofbasel #researchjobs #sciencejobs #basel #job #hiring #recruiting #carreers #research #specialist #microscopy
December 10, 2025 at 9:31 AM
Research Specialist in Microscopy and Spatial Transcriptomics (80-100%)
www.biozentrum.unibas.ch/open-positio...
@biozentrum.unibas.ch @unibas.ch #biozentrum #biozentrumbasel #universityofbasel #researchjobs #sciencejobs #basel #job #hiring #recruiting #carreers #research #specialist #microscopy
www.biozentrum.unibas.ch/open-positio...
@biozentrum.unibas.ch @unibas.ch #biozentrum #biozentrumbasel #universityofbasel #researchjobs #sciencejobs #basel #job #hiring #recruiting #carreers #research #specialist #microscopy
Reposted by Hellerschmied Lab
SAVE THE DATE!
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
December 8, 2025 at 1:16 PM
SAVE THE DATE!
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
The EMBO workshop "Ubiquitin and Ubiquitin-like proteins in Health and Disease" will be on September 2026.
Exciting line up of talks and an amazing location!
Organised by @kulathu.bsky.social, @merbllab.bsky.social, @simonapolo.bsky.social, Claudio Joazeiro.
Registration open soon.
Reposted by Hellerschmied Lab
Please share and spread the word!
Save the Date for the 34th GP2A 2026 & SIGMA-1 Europe Conference on Medicinal Chemistry in Gothenburg, Sweden at 26th- 28th of August 2026. Registration open in January 2026. Speakers will be announced soon. #MedChem #ChemBio #youngresearcher @naturvetenskap.bsky.social
December 4, 2025 at 6:23 PM
Please share and spread the word!
Reposted by Hellerschmied Lab
Thrilled to be selected as one of the 28 EMBO Young Investigators for 2026! It is an incredible honor, and I am especially proud to be the second scientist from Czechia chosen since the programme began in 2001. Happy to join Tomas Pluskal in representing our country in the EMBO YIP.
Congratulations to the new cohort of 28 EMBO Young Investigators! They are joining an international network of more than 800 life scientists – Welcome!
Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
Read the press release here:
https://www.embo.org/press-releases/twenty-eight-group-leaders-become-embo-young-investigators/
December 2, 2025 at 3:52 PM
Thrilled to be selected as one of the 28 EMBO Young Investigators for 2026! It is an incredible honor, and I am especially proud to be the second scientist from Czechia chosen since the programme began in 2001. Happy to join Tomas Pluskal in representing our country in the EMBO YIP.
Reposted by Hellerschmied Lab
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Seeding biosensor cell line that reproduces the Alzheimer tau fold
The assembly of tau protein into amyloid filaments through templated seeding is believed
to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer’s
disease (AD) and ot...
www.jbc.org
November 21, 2025 at 5:08 PM
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Reposted by Hellerschmied Lab
Join us in Lunteren, the Netherlands on March 5 & 6, 2026 for the 32nd Dutch Cancer Biology meeting. We have two fantastic keynote speakers: @andrea-musacchio.bsky.social and @colindascheele.bsky.social and the rest of the program will be by early-career scientists. Info: www.dutchcancerbiology.nl
November 22, 2025 at 5:46 AM
Join us in Lunteren, the Netherlands on March 5 & 6, 2026 for the 32nd Dutch Cancer Biology meeting. We have two fantastic keynote speakers: @andrea-musacchio.bsky.social and @colindascheele.bsky.social and the rest of the program will be by early-career scientists. Info: www.dutchcancerbiology.nl
Reposted by Hellerschmied Lab
📢 We’re on Social Media!
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Department of Medical Biochemistry and Biophysics | LinkedIn
Department of Medical Biochemistry and Biophysics | 184 followers on LinkedIn. Driving Discovery in Biochemistry and Biophysics under the Northern Lights | Research at the Department of Medical Bioche...
www.linkedin.com
November 21, 2025 at 1:09 PM
📢 We’re on Social Media!
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Reposted by Hellerschmied Lab
A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!
Please share!
November 19, 2025 at 5:20 PM
A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!
Please share!
Reposted by Hellerschmied Lab
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted by Hellerschmied Lab
It was wonderful to organize the @gbmev.bsky.social Cellular Organelles meeting in Düsseldorf along with Andreas Reichert at University of Düsseldorf. Leading Organelles biologists from Germany attended the 2025 meeting. Thanks to the constant support from Konstanze Winklhofer and Johannes Hermann
November 14, 2025 at 3:53 PM
It was wonderful to organize the @gbmev.bsky.social Cellular Organelles meeting in Düsseldorf along with Andreas Reichert at University of Düsseldorf. Leading Organelles biologists from Germany attended the 2025 meeting. Thanks to the constant support from Konstanze Winklhofer and Johannes Hermann
Reposted by Hellerschmied Lab
Deadline coming up soon!
November 17, 2025 at 2:07 PM
Deadline coming up soon!
Reposted by Hellerschmied Lab
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 11:37 AM
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Reposted by Hellerschmied Lab
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Please RT
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
November 17, 2025 at 3:55 PM
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Please RT
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
Reposted by Hellerschmied Lab
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Hellerschmied Lab
🚨We have just launched a search to fill a new Jr group leader position!🚨
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Job Offers - Rudolf Virchow Center for Integrative and Translational Bioimaging
www.uni-wuerzburg.de
November 12, 2025 at 3:13 PM
🚨We have just launched a search to fill a new Jr group leader position!🚨
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Reposted by Hellerschmied Lab
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
November 12, 2025 at 10:32 AM
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
Reposted by Hellerschmied Lab
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Junior Group Leader Positions | Research Institute of Molecular Pathology
www.imp.ac.at
November 10, 2025 at 10:49 AM
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Reposted by Hellerschmied Lab
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Reposted by Hellerschmied Lab
Today we celebrate the birthday of not one, but two amazing women in science! 🤗🎉Marie Skłodowska-Curie (1867), who discovered #radium & #polonium & pioneered #radioactivity, & Lise Meitner (1878), whose brilliance uncovered the physics behind #nuclearfission. Happy birthday, trailblazers! ✨
November 7, 2025 at 1:10 PM
Today we celebrate the birthday of not one, but two amazing women in science! 🤗🎉Marie Skłodowska-Curie (1867), who discovered #radium & #polonium & pioneered #radioactivity, & Lise Meitner (1878), whose brilliance uncovered the physics behind #nuclearfission. Happy birthday, trailblazers! ✨