Hellerschmied Lab
@hellerschmiedlab.bsky.social
Biochemistry and cell biology lab @unidue-zmb.bsky.social
Excited about secretory pathway and #Golgi #proteostasis mechanisms
funded by AvHStiftung, part of @crc1430.bsky.social
(tweets by PI)
Excited about secretory pathway and #Golgi #proteostasis mechanisms
funded by AvHStiftung, part of @crc1430.bsky.social
(tweets by PI)
Pinned
New online: Conformational plasticity of a BiP–GRP94 chaperone complex
Conformational plasticity of a BiP–GRP94 chaperone complex
Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
go.nature.com
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
Reposted by Hellerschmied Lab
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Seeding biosensor cell line that reproduces the Alzheimer tau fold
The assembly of tau protein into amyloid filaments through templated seeding is believed
to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer’s
disease (AD) and ot...
www.jbc.org
November 21, 2025 at 5:08 PM
I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...
www.jbc.org/article/S002...
Reposted by Hellerschmied Lab
Join us in Lunteren, the Netherlands on March 5 & 6, 2026 for the 32nd Dutch Cancer Biology meeting. We have two fantastic keynote speakers: @andrea-musacchio.bsky.social and @colindascheele.bsky.social and the rest of the program will be by early-career scientists. Info: www.dutchcancerbiology.nl
November 22, 2025 at 5:46 AM
Join us in Lunteren, the Netherlands on March 5 & 6, 2026 for the 32nd Dutch Cancer Biology meeting. We have two fantastic keynote speakers: @andrea-musacchio.bsky.social and @colindascheele.bsky.social and the rest of the program will be by early-career scientists. Info: www.dutchcancerbiology.nl
Reposted by Hellerschmied Lab
📢 We’re on Social Media!
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Department of Medical Biochemistry and Biophysics | LinkedIn
Department of Medical Biochemistry and Biophysics | 184 followers on LinkedIn. Driving Discovery in Biochemistry and Biophysics under the Northern Lights | Research at the Department of Medical Bioche...
www.linkedin.com
November 21, 2025 at 1:09 PM
📢 We’re on Social Media!
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Want to keep up with research news, lab highlights, and opportunities from the Department of Medical Biochemistry and Biophysics at Umeå University?
✅ Follow us on LinkedIn:
👉 www.linkedin.com/company/mbb-...
…and here on Bluesky: @mbb-umu.bsky.social
#UmeaUniversity
Reposted by Hellerschmied Lab
A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!
Please share!
November 19, 2025 at 5:20 PM
A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!
Please share!
Reposted by Hellerschmied Lab
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
November 17, 2025 at 11:55 AM
Ten days left to apply to be a @crick.ac.uk Early Career Group Leader
Closing date 27th November
www.crick.ac.uk/careers-stud...
Closing date 27th November
www.crick.ac.uk/careers-stud...
Reposted by Hellerschmied Lab
It was wonderful to organize the @gbmev.bsky.social Cellular Organelles meeting in Düsseldorf along with Andreas Reichert at University of Düsseldorf. Leading Organelles biologists from Germany attended the 2025 meeting. Thanks to the constant support from Konstanze Winklhofer and Johannes Hermann
November 14, 2025 at 3:53 PM
It was wonderful to organize the @gbmev.bsky.social Cellular Organelles meeting in Düsseldorf along with Andreas Reichert at University of Düsseldorf. Leading Organelles biologists from Germany attended the 2025 meeting. Thanks to the constant support from Konstanze Winklhofer and Johannes Hermann
Reposted by Hellerschmied Lab
Deadline coming up soon!
November 17, 2025 at 2:07 PM
Deadline coming up soon!
Reposted by Hellerschmied Lab
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Filament formation and NAD processing by noncanonical human FAM118 sirtuins
Nature Structural & Molecular Biology - Baretić and Missoury et al. identify vertebrate proteins FAM118B and FAM118A as sirtuins similar to bacterial antiphage enzymes and show that...
rdcu.be
November 17, 2025 at 11:37 AM
Very happy to share our collaborative project on FAM118 proteins - noncanonical sirtuins that form filaments and process NAD in human and other vertebrate cells.
Reposted by Hellerschmied Lab
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Please RT
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
November 17, 2025 at 3:55 PM
The Vienna BioCenter Summer School 2026 call is now open for talented undergrads, it's a great opportunity for students who are interested in graduate study in the life sciences. Please RT
https://training.vbc.ac.at/summer-school/
https://training.vbc.ac.at/summer-school/
Reposted by Hellerschmied Lab
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Proteome-wide in silico screening for human protein-protein interactions
Protein-protein interactions (PPIs) drive virtually all biological processes, yet most PPIs have not been identified and even more remain structurally unresolved. We developed a two-step computational...
biorxiv.org
November 12, 2025 at 9:26 PM
Thrilled to share that the final piece of my PhD work is now on bioRxiv! biorxiv.org/content/10.1... With support from @nvidia and the @NSF, we used AlphaFold to screen 1.6M+ protein pairs, revealing thousands of potential novel PPIs. All data can be viewed at predictomes.org/hp
Reposted by Hellerschmied Lab
🚨We have just launched a search to fill a new Jr group leader position!🚨
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Job Offers - Rudolf Virchow Center for Integrative and Translational Bioimaging
www.uni-wuerzburg.de
November 12, 2025 at 3:13 PM
🚨We have just launched a search to fill a new Jr group leader position!🚨
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Great conditions to kickstart your own independent carreer - happy to answer any questions you might have.
please spread the word and repost!
www.uni-wuerzburg.de/en/rvz/jobs-...
Reposted by Hellerschmied Lab
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
November 12, 2025 at 10:32 AM
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
Reposted by Hellerschmied Lab
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Junior Group Leader Positions | Research Institute of Molecular Pathology
www.imp.ac.at
November 10, 2025 at 10:49 AM
Great career opportunity at @viennabiocenter.bsky.social: The @impvienna.bsky.social is looking for a new Junior Group Leader in cell and molecular biology, synthetic biology, genomics, gene regulation, development, cancer, immunology or infection biology.
More: www.imp.ac.at/career/open-...
More: www.imp.ac.at/career/open-...
Reposted by Hellerschmied Lab
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
November 9, 2025 at 6:04 PM
Check out our @ascbiology.bsky.social #CellBio2025 Minisymposium on ER Homeostasis. With THIS speaker lineup, this event will be as dynamic, transformative and productive as the ER itself!
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
So don’t 𝗦𝗧𝗥𝗘𝗦𝗦, 𝙩𝙧𝙖𝙣𝙨𝙡𝙤𝙘𝙖𝙩𝙚 yourselves over and join us to 𝗡𝗘𝗧𝗪𝗢𝗥𝗞 in world of the ER. (All PUNS intended.)
Reposted by Hellerschmied Lab
Today we celebrate the birthday of not one, but two amazing women in science! 🤗🎉Marie Skłodowska-Curie (1867), who discovered #radium & #polonium & pioneered #radioactivity, & Lise Meitner (1878), whose brilliance uncovered the physics behind #nuclearfission. Happy birthday, trailblazers! ✨
November 7, 2025 at 1:10 PM
Today we celebrate the birthday of not one, but two amazing women in science! 🤗🎉Marie Skłodowska-Curie (1867), who discovered #radium & #polonium & pioneered #radioactivity, & Lise Meitner (1878), whose brilliance uncovered the physics behind #nuclearfission. Happy birthday, trailblazers! ✨
Reposted by Hellerschmied Lab
Nov 7th is the birthday of both Lise Meitner & Marie Curie. Of the 13 chemical elements named directly after real people (not mythological figures) only two are named after women: meitnerium and curium (the latter of which is named in honour of both Marie & her husband) #chemsky 🧪
November 7, 2025 at 9:49 PM
Nov 7th is the birthday of both Lise Meitner & Marie Curie. Of the 13 chemical elements named directly after real people (not mythological figures) only two are named after women: meitnerium and curium (the latter of which is named in honour of both Marie & her husband) #chemsky 🧪
Reposted by Hellerschmied Lab
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
November 5, 2025 at 10:59 AM
📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Genome Biology. We are particularly interested in researchers investigating the molecular and biophysical mechanisms underlying genome function and regulation. More details ➡️ tinyurl.com/3t7vvdct
Reposted by Hellerschmied Lab
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
November 6, 2025 at 4:20 PM
Mechanism of #autophagy initiation by transmembrane selective autophagy receptors
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
@elias-adriaenssens.bsky.social & @martenslab.bsky.social review emerging mechanistic differences between soluble and transmembrane autophagy receptors
www.embopress.org/doi/full/10....
Reposted by Hellerschmied Lab
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation www.biorxiv.org/content/10.1...
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation
Misfolded or unassembled membrane proteins in the endoplasmic reticulum (ER) are polyubiquitinated, translocated into the cytosol, and degraded by the proteasome, a poorly understood process that is c...
www.biorxiv.org
November 3, 2025 at 3:35 PM
Lipid bilayer thinning near a ubiquitin ligase selects ER membrane proteins for degradation www.biorxiv.org/content/10.1...
Reposted by Hellerschmied Lab
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
November 3, 2025 at 7:33 PM
#MembraneTraffickers! Our next online seminar is this Thursday, Nov 6 at 5 PM CEST!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
We’ll hear from @agatawitkowska.bsky.social on mechanical control of neurotransmission and @abdourachidthiam.bsky.social on lipid storage mechanisms in health and disease.
Spread the word and join the discussion!
Reposted by Hellerschmied Lab
ICYMI: New Online! Decoding ubiquitin signals inside cells
Decoding ubiquitin signals inside cells
Nature Reviews Molecular Cell Biology, Published online: 31 October 2025; doi:10.1038/s41580-025-00919-zIn this Tools of the Trade article, Kiss (Schulman lab) discusses the development of UbiREAD, a method that delivers in vitro-ubiquitinated protein reporters into cells to systematically assess how different ubiquitin chain configurations affect protein stability and degradation.
bit.ly
November 3, 2025 at 5:06 PM
ICYMI: New Online! Decoding ubiquitin signals inside cells
Reposted by Hellerschmied Lab
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Hellerschmied Lab
Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...
October 27, 2025 at 7:00 AM
Mark your calendars! The next SFB 1348 International Meeting will take place in #Münster from May 27-29, 2026, with a focus on #Mechanochemical signals at cellular interfaces. Stay tuned for more details and updates at www.uni-muenster.de/SFB1348/en/m...
Reposted by Hellerschmied Lab
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
Reposted by Hellerschmied Lab
📣 #OpenCall: SNSF Starting Grants 2026
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw
October 6, 2025 at 8:01 AM
📣 #OpenCall: SNSF Starting Grants 2026
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw
For researchers wanting to lead their own independent project and research team in Switzerland.
🗓️ Submission deadline: 5 May 2026
➡️ https://sohub.io/rptw