Holthuis Lab
@holthuislab.bsky.social
Lipid cell biologists who love to hang out with chemists & computer simulations experts to grasp the complex behavior of membranes
Reposted by Holthuis Lab
Key determinants of VDAC-hexokinase I complex assembly revealed by a minimal vesicle-based interaction assay https://www.biorxiv.org/content/10.1101/2025.11.03.686449v1
November 5, 2025 at 3:47 AM
Key determinants of VDAC-hexokinase I complex assembly revealed by a minimal vesicle-based interaction assay https://www.biorxiv.org/content/10.1101/2025.11.03.686449v1
Reposted by Holthuis Lab
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
November 7, 2025 at 10:44 AM
An Asgard archaeon with internal membrane compartments
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors!
www.biorxiv.org/content/10.1...
Such a worthy recipient. Maya is not only a great scientist but also a fantastic mentor and a rich source of inspiration.
🎉 Huge congrats to Maya Schuldiner from the Weizmann Institute (Israel) for the 🏅 Otto Warburg Medal 2026!
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
Her work on how proteins find their way to organelles and how these organelles talk to each other has reshaped how we think about cells 🧬✨
#OWM #WeizmannInstitute @elsevierconnect.bsky.social
October 27, 2025 at 10:43 AM
Such a worthy recipient. Maya is not only a great scientist but also a fantastic mentor and a rich source of inspiration.
📯 shoutout for this beautiful work by Kenji Maeda’s lab, who mapped 300 lipid species across 6 compartiments of humane cells. Besides uncovering general principles of lipid organization, the paper establishes a framework for exploring how lipid landscapes are regulated in physiology and disease 👇🏼
Lipid Landscape of human cells https://www.biorxiv.org/content/10.1101/2025.10.05.680593v1
October 26, 2025 at 11:03 AM
📯 shoutout for this beautiful work by Kenji Maeda’s lab, who mapped 300 lipid species across 6 compartiments of humane cells. Besides uncovering general principles of lipid organization, the paper establishes a framework for exploring how lipid landscapes are regulated in physiology and disease 👇🏼
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair
Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach,...
www.biorxiv.org
October 25, 2025 at 1:11 PM
Proud to share a preprint of our paper on how bridge-like lipid transport protein VPS13C senses lysosomal membrane tension in anticipation of membrane lesions to initiate net ER-to-lysosome lipid transfer for efficient lysosomal repair www.biorxiv.org/content/10.1...
Reposted by Holthuis Lab
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
October 17, 2025 at 3:18 PM
🚨🚨🚨 We are launching the 2nd application round for the Erasmus Mundus Joint Master’s Program MemBioMed, offering cutting-edge training on exploring the complex behavior of cellular membranes & unlocking their therapeutic potential. Students can apply here: life.univ-cotedazur.eu/internationa...
I am proud to 📣 today’s superb thesis defense by Milena Wessing on “Molecular dissection of ceramide-induced apoptosis: a bottom-up approach”. Two papers describing Milena’s heroic efforts are close to submission. It was a privilege serving as her “Doktorvater” 🥂
October 14, 2025 at 6:37 PM
I am proud to 📣 today’s superb thesis defense by Milena Wessing on “Molecular dissection of ceramide-induced apoptosis: a bottom-up approach”. Two papers describing Milena’s heroic efforts are close to submission. It was a privilege serving as her “Doktorvater” 🥂
I am pleased to 📣 today’s superb thesis defense by Christian Schroer on “Chemical strategies for studying lipid signaling and transport”. Part of his work was recently published in the JLR; the other part will follow soon. A very proud and somewhat tipsy “Doktorvater” 🥂
September 30, 2025 at 6:53 PM
I am pleased to 📣 today’s superb thesis defense by Christian Schroer on “Chemical strategies for studying lipid signaling and transport”. Part of his work was recently published in the JLR; the other part will follow soon. A very proud and somewhat tipsy “Doktorvater” 🥂
Great to see this work on imaging cellular lipid logistics in Nature, where it belongs. Chapeau! Many gratulations to Andre, Alf and their co-workers!
Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
August 31, 2025 at 12:45 PM
Great to see this work on imaging cellular lipid logistics in Nature, where it belongs. Chapeau! Many gratulations to Andre, Alf and their co-workers!
🔥🔥🔥 (= highly recommended) 👇🏼
Hot off the press, our latest review of RNA-lipid interactions -> The secret life of RNA and lipids: "There is no life without RNA or lipids. But could there be life with only RNA and lipids?" @tcjea.bsky.social @bcube-tud.bsky.social be-tud.bsky.social
www.tandfonline.com/doi/full/10....
www.tandfonline.com/doi/full/10....
The secret life of RNA and lipids
There is no life without RNA or lipids. But could there be life with only RNA and lipids? The discovery that RNA can catalyse reactions in addition to encoding information opened new directions for...
www.tandfonline.com
July 5, 2025 at 7:10 AM
🔥🔥🔥 (= highly recommended) 👇🏼
A university & its leadership standing for academic freedom, truth, integrity & shared values deserve support from across the globe. Those believing in these virtues greatly outnumber those who seek to undermine them. As admirer of the 1st class scientists working at UVA, I gladly signed the letter👇
When UVA is under threat, we speak up for truth, integrity, and the University we all love. #Wahoos4UVA www.wahoos4uva.com/letter
Sign the Letter: Stand with UVA and Support President Ryan’s Leadership
Join thousands of alumni, students, parents, and friends in supporting UVA’s progress and leadership. Sign the letter to defend the University against misinformation and celebrate its achievements und...
www.wahoos4uva.com
June 27, 2025 at 5:00 PM
A university & its leadership standing for academic freedom, truth, integrity & shared values deserve support from across the globe. Those believing in these virtues greatly outnumber those who seek to undermine them. As admirer of the 1st class scientists working at UVA, I gladly signed the letter👇
Science is the engine of an open, pluralistic society. So scientists serve a central role in defending it. In 🇩🇪, the association „Wissenschaft für Demokratie – Wir für Dich“ was founded to strengthen the role of science in the public debate & in the fight against disinformation
wirfuerdemokratie.org
wirfuerdemokratie.org
Wir für Demokratie | Unabhängig & Überparteilich
Demokratisches Engagement Für Dich. Für mich. Für uns alle. Wir sind ein gemeinnütziger Verein, der einen niedrigschwelligen Zugang zu demokratischer Beteiligung ermöglicht. Als Plattform für überpart...
wirfuerdemokratie.org
June 7, 2025 at 6:49 AM
Science is the engine of an open, pluralistic society. So scientists serve a central role in defending it. In 🇩🇪, the association „Wissenschaft für Demokratie – Wir für Dich“ was founded to strengthen the role of science in the public debate & in the fight against disinformation
wirfuerdemokratie.org
wirfuerdemokratie.org
Thank you so much @jamessaenz.bsky.social for the inspiring #sfb1557 talk on lipid-sensitive riboswitches and the role of lipid diversity & membrane biophysics in the origin of life. A great scientist & wonderful colleague to hang out with 🍺, who is currently on the job market, but not for long… 🚴♂️
Breakfast 🥐 on the train 🚂 Off to Osnabrük…looking forward to some great discussions with @joostholthuis.bsky.social and lab!
May 16, 2025 at 6:05 AM
Thank you so much @jamessaenz.bsky.social for the inspiring #sfb1557 talk on lipid-sensitive riboswitches and the role of lipid diversity & membrane biophysics in the origin of life. A great scientist & wonderful colleague to hang out with 🍺, who is currently on the job market, but not for long… 🚴♂️
Reposted by Holthuis Lab
Academische vrijheid staat onder druk en moet beter worden beschermd. Die conclusie lees je vandaag in dit KNAW-rapport: www.knaw.nl/nieuws/knaw-... Aanbevelingen o.m.: meer vrijheid van onderzoek, bescherming tegen intimidatie en minder inhoudelijke overheidsbemoeienis.
May 15, 2025 at 4:57 AM
Academische vrijheid staat onder druk en moet beter worden beschermd. Die conclusie lees je vandaag in dit KNAW-rapport: www.knaw.nl/nieuws/knaw-... Aanbevelingen o.m.: meer vrijheid van onderzoek, bescherming tegen intimidatie en minder inhoudelijke overheidsbemoeienis.
Reposted by Holthuis Lab
This is an absolute disaster. If we don't stop this, they will turn NSF into a pawn of the Trump administration. There will be no research on climate, biodiversity, or anything that isn't eugenics or AI or how to more efficiently destroy the planet for profit.
This cannot be allowed to happen.
This cannot be allowed to happen.
Exclusive: NSF faces radical shake-up as officials abolish its 37 divisions
Changes seen as a response to presidential directives on what research to fund
www.science.org
May 9, 2025 at 3:42 AM
This is an absolute disaster. If we don't stop this, they will turn NSF into a pawn of the Trump administration. There will be no research on climate, biodiversity, or anything that isn't eugenics or AI or how to more efficiently destroy the planet for profit.
This cannot be allowed to happen.
This cannot be allowed to happen.
Reposted by Holthuis Lab
Science is under attack. Proposed 40% NIH cut threatens jobs, research, and medical progress. Call your reps, governor, and mayor now—urge them to stand up for science.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
NIH Research Funding at Risk—Take Action Now! - ASCB
Along with supporting important scientific discoveries, federally funded scientific research has significant impact on state and local economies. It is estimated that, on average, every $1 of National...
www.ascb.org
May 9, 2025 at 4:35 PM
Science is under attack. Proposed 40% NIH cut threatens jobs, research, and medical progress. Call your reps, governor, and mayor now—urge them to stand up for science.
www.ascb.org/science-poli...
www.ascb.org/science-poli...
Thank you so much for the warm welcome, @gloriusgroup.bsky.social & @gloriusfrank.bsky.social! I thoroughly enjoyed the wonderful brainstorm on how to capture the complex dance of lipids during cell wounding and repair using the power of synthetic chemistry. So much left to explore and accomplish🧑🔬🧪🔬
Big thanks to @holthuislab.bsky.social for an inspiring
@sfb1348.bsky.social
talk on interrogating lipid dynamics at sites of membrane permeabilization and repair! 🔬🧬
His work sheds light on the beautifully complex dance of lipids during cellular stress.
#LipidResearch #ScienceLecture
@sfb1348.bsky.social
talk on interrogating lipid dynamics at sites of membrane permeabilization and repair! 🔬🧬
His work sheds light on the beautifully complex dance of lipids during cellular stress.
#LipidResearch #ScienceLecture
April 25, 2025 at 11:10 AM
Thank you so much for the warm welcome, @gloriusgroup.bsky.social & @gloriusfrank.bsky.social! I thoroughly enjoyed the wonderful brainstorm on how to capture the complex dance of lipids during cell wounding and repair using the power of synthetic chemistry. So much left to explore and accomplish🧑🔬🧪🔬
Reposted by Holthuis Lab
At membrane contact sites, bridge-like transport proteins, e.g. LPD-3, mediate bulk lipid transfer between cellular organelles. @nature see cryo-EM structure of native LDP-3, and gain insights into its functioning and interaction with other proteins and lipids.
shorturl.at/lycuz & shorturl.at/ARpUK
shorturl.at/lycuz & shorturl.at/ARpUK
Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature
The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...
shorturl.at
April 23, 2025 at 3:14 PM
At membrane contact sites, bridge-like transport proteins, e.g. LPD-3, mediate bulk lipid transfer between cellular organelles. @nature see cryo-EM structure of native LDP-3, and gain insights into its functioning and interaction with other proteins and lipids.
shorturl.at/lycuz & shorturl.at/ARpUK
shorturl.at/lycuz & shorturl.at/ARpUK
Reposted by Holthuis Lab
For everyone interested in organoid technology and skin regeneration there is a great postdoc opportunity in the Bartscherer Lab.
Check out the posting below.
www.uni-osnabrueck.de/universitaet...
www.biologie.uni-osnabrueck.de/en/research/...
Check out the posting below.
www.uni-osnabrueck.de/universitaet...
www.biologie.uni-osnabrueck.de/en/research/...
51 FB 5 Research Associate (m/f/d) in the field of iPS-cell-based skin organoid technology: Uni Osnabrück
www.uni-osnabrueck.de
April 17, 2025 at 3:19 PM
For everyone interested in organoid technology and skin regeneration there is a great postdoc opportunity in the Bartscherer Lab.
Check out the posting below.
www.uni-osnabrueck.de/universitaet...
www.biologie.uni-osnabrueck.de/en/research/...
Check out the posting below.
www.uni-osnabrueck.de/universitaet...
www.biologie.uni-osnabrueck.de/en/research/...
Reposted by Holthuis Lab
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
Cell membranes sustain phospholipid imbalance via cholesterol asymmetry
This work challenges a major assumption in cell biology by showing that lipid bilayers
can have drastically different phospholipid abundances between their two leaflets.
This lipid abundance asymmetry...
www.cell.com
April 3, 2025 at 3:07 PM
Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...
📯📯📯 10 days left to apply for the International Master MemBioMed "From Membrane Biology to Neuroscience & Experimental Medicine". Scholarships available for selected students to acquire intensive training in analysing the complex behavior of biomembranes and exploiting their therapeutic potential 👇👇
🚨🚨 We are proud to launch MemBioMed, a new international Master program offering interdisciplinary training in biomembrane research at 3 sites: Université de Côte d'Azur 🇫🇷 Università di Genova 🇮🇹 & Osnabrück University 🇩🇪. We offer 15 scholarships & encourage talented students to apply by April 6th ♻️🙏
March 25, 2025 at 11:18 PM
📯📯📯 10 days left to apply for the International Master MemBioMed "From Membrane Biology to Neuroscience & Experimental Medicine". Scholarships available for selected students to acquire intensive training in analysing the complex behavior of biomembranes and exploiting their therapeutic potential 👇👇
Reposted by Holthuis Lab
This is a beautiful paper. Very important implications - and further evidence for the link between lipid transbilayer movement / lipid asymmetry and directional lipid transport.
Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/...
#Membrane #lipid #Organelles #Biochemistry
#Membrane #lipid #Organelles #Biochemistry
March 14, 2025 at 9:06 AM
This is a beautiful paper. Very important implications - and further evidence for the link between lipid transbilayer movement / lipid asymmetry and directional lipid transport.
Reposted by Holthuis Lab
Review @cp-cellchembiol.bsky.social @volkerhaucke-lab.bsky.social
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Mechanisms and functions of lysosomal lipid homeostasis
In this review Ebner et al. summarize and discuss the rapidly increasing knowledge
regarding the mechanisms of lysosomal lipid turnover and export as well as the pathways
for the homeostatic control a...
www.cell.com
March 7, 2025 at 6:20 PM
Review @cp-cellchembiol.bsky.social @volkerhaucke-lab.bsky.social
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...
Reposted by Holthuis Lab
Taking a cue from @cantlonlab.bsky.social, I have written an op-ed for my local newspaper about the impact of the NIH funding chaos. I'd appreciate it if you read and share. #NIH #Research #Science #Worcester
www.telegram.com/story/opinio...
www.telegram.com/story/opinio...
Opinion/Guest column: Gutting NIH a disaster in the marking for research, local economy
Less research equates to less business between the university and these Worcester companies, spreading the pain far beyond campus borders.
www.telegram.com
March 2, 2025 at 1:20 PM
Taking a cue from @cantlonlab.bsky.social, I have written an op-ed for my local newspaper about the impact of the NIH funding chaos. I'd appreciate it if you read and share. #NIH #Research #Science #Worcester
www.telegram.com/story/opinio...
www.telegram.com/story/opinio...