Lightnews — Scholar-powered news

Holthuis Lab @holthuislab.bsky.social · 8d

I am pleased to 📣 today’s superb thesis defense by Christian Schroer on “Chemical strategies for studying lipid signaling and transport”. Part of his work was recently published in the JLR; the other part will follow soon. A very proud and somewhat tipsy “Doktorvater” 🥂

1 5

Holthuis Lab @holthuislab.bsky.social · Aug 31

Great to see this work on imaging cellular lipid logistics in Nature, where it belongs. Chapeau! Many gratulations to Andre, Alf and their co-workers!

André Nadler @nadlerlab.bsky.social · Aug 21

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism.
www.nature.com/articles/s41...

1 2 6

Holthuis Lab @holthuislab.bsky.social · Jul 5

That’s fantastic news, Fikadu! And very much deserved. Many congratulations, also to OHSU for this wise decision 🍾🍾🍾

Holthuis Lab @holthuislab.bsky.social · Jul 5

🔥🔥🔥 (= highly recommended) 👇🏼

James Saenz @jamessaenz.bsky.social · Jul 4

Hot off the press, our latest review of RNA-lipid interactions -> The secret life of RNA and lipids: "There is no life without RNA or lipids. But could there be life with only RNA and lipids?" @tcjea.bsky.social @bcube-tud.bsky.social be-tud.bsky.social

www.tandfonline.com/doi/full/10....

The secret life of RNA and lipids

There is no life without RNA or lipids. But could there be life with only RNA and lipids? The discovery that RNA can catalyse reactions in addition to encoding information opened new directions for...

www.tandfonline.com

5

Holthuis Lab @holthuislab.bsky.social · Jun 27

A university & its leadership standing for academic freedom, truth, integrity & shared values deserve support from across the globe. Those believing in these virtues greatly outnumber those who seek to undermine them. As admirer of the 1st class scientists working at UVA, I gladly signed the letter👇

Levental Lab @leventallab.bsky.social · Jun 27

When UVA is under threat, we speak up for truth, integrity, and the University we all love. #Wahoos4UVA www.wahoos4uva.com/letter

Sign the Letter: Stand with UVA and Support President Ryan’s Leadership

Join thousands of alumni, students, parents, and friends in supporting UVA’s progress and leadership. Sign the letter to defend the University against misinformation and celebrate its achievements und...

www.wahoos4uva.com

1 2 5

Holthuis Lab @holthuislab.bsky.social · Jun 7

Science is the engine of an open, pluralistic society. So scientists serve a central role in defending it. In 🇩🇪, the association „Wissenschaft für Demokratie – Wir für Dich“ was founded to strengthen the role of science in the public debate & in the fight against disinformation
wirfuerdemokratie.org

Wir für Demokratie | Unabhängig & Überparteilich

Demokratisches Engagement Für Dich. Für mich. Für uns alle. Wir sind ein gemeinnütziger Verein, der einen niedrigschwelligen Zugang zu demokratischer Beteiligung ermöglicht. Als Plattform für überpart...

wirfuerdemokratie.org

2

Holthuis Lab @holthuislab.bsky.social · May 16

Totally agree!

2

Holthuis Lab @holthuislab.bsky.social · May 16

Thank you so much @jamessaenz.bsky.social‬ for the inspiring #sfb1557 talk on lipid-sensitive riboswitches and the role of lipid diversity & membrane biophysics in the origin of life. A great scientist & wonderful colleague to hang out with 🍺, who is currently on the job market, but not for long… 🚴‍♂️

James Saenz @jamessaenz.bsky.social · May 15

Breakfast 🥐 on the train 🚂 Off to Osnabrük…looking forward to some great discussions with @joostholthuis.bsky.social and lab!

1 2 8

Reposted by Holthuis Lab

KNAW - Koninklijke Nederlandse Akademie van Wetenschappen @knaw-nl.bsky.social · May 15

Academische vrijheid staat onder druk en moet beter worden beschermd. Die conclusie lees je vandaag in dit KNAW-rapport: www.knaw.nl/nieuws/knaw-... Aanbevelingen o.m.: meer vrijheid van onderzoek, bescherming tegen intimidatie en minder inhoudelijke overheidsbemoeienis.

Rapport KNAW: Academische vrijheid in Nederland

1 21 41

Reposted by Holthuis Lab

Jacquelyn Gill @jacquelyngill.bsky.social · May 9

This is an absolute disaster. If we don't stop this, they will turn NSF into a pawn of the Trump administration. There will be no research on climate, biodiversity, or anything that isn't eugenics or AI or how to more efficiently destroy the planet for profit.

This cannot be allowed to happen.

Exclusive: NSF faces radical shake-up as officials abolish its 37 divisions

Changes seen as a response to presidential directives on what research to fund

www.science.org

12 480 900

Reposted by Holthuis Lab

American Society for Cell Biology @ascbiology.bsky.social · May 9

Science is under attack. Proposed 40% NIH cut threatens jobs, research, and medical progress. Call your reps, governor, and mayor now—urge them to stand up for science.

www.ascb.org/science-poli...

NIH Research Funding at Risk—Take Action Now! - ASCB

Along with supporting important scientific discoveries, federally funded scientific research has significant impact on state and local economies. It is estimated that, on average, every $1 of National...

www.ascb.org

1 40 62

Holthuis Lab @holthuislab.bsky.social · Apr 25

Thank you so much for the warm welcome, @gloriusgroup.bsky.social & @gloriusfrank.bsky.social! I thoroughly enjoyed the wonderful brainstorm on how to capture the complex dance of lipids during cell wounding and repair using the power of synthetic chemistry. So much left to explore and accomplish🧑‍🔬🧪🔬

Glorius Group @gloriusgroup.bsky.social · Apr 25

Big thanks to @holthuislab.bsky.social for an inspiring
@sfb1348.bsky.social
talk on interrogating lipid dynamics at sites of membrane permeabilization and repair! 🔬🧬
His work sheds light on the beautifully complex dance of lipids during cellular stress.
#LipidResearch #ScienceLecture

7

Reposted by Holthuis Lab

Sadaf Shadan @sshadan.bsky.social · Apr 23

At membrane contact sites, bridge-like transport proteins, e.g. LPD-3, mediate bulk lipid transfer between cellular organelles. @nature see cryo-EM structure of native LDP-3, and gain insights into its functioning and interaction with other proteins and lipids.
shorturl.at/lycuz & shorturl.at/ARpUK

Structural basis of lipid transfer by a bridge-like lipid-transfer protein - Nature

The LPD-3 complex structure reveals protein–lipid interactions that suggest a model for how the native LPD-3 complex mediates bulk lipid transport and provides a foundation for mechanistic studies of ...

shorturl.at

17 46

Reposted by Holthuis Lab

Tveriakhina Lab @tveriakhinalab.bsky.social · Apr 17

For everyone interested in organoid technology and skin regeneration there is a great postdoc opportunity in the Bartscherer Lab.
Check out the posting below.

www.uni-osnabrueck.de/universitaet...

www.biologie.uni-osnabrueck.de/en/research/...

51 FB 5 Research Associate (m/f/d) in the field of iPS-cell-based skin organoid technology: Uni Osnabrück

www.uni-osnabrueck.de

4 6

Reposted by Holthuis Lab

Jeremy Baskin @jeremybaskin.bsky.social · Apr 3

Groundbreaking study in Cell from @leventallab.bsky.social: phospholipid asymmetry is a defining feature of the plasma membrane and cholesterol fills the holes — major implications for how this membrane works. A #lipidtime must-read! www.cell.com/cell/abstrac...

Cell membranes sustain phospholipid imbalance via cholesterol asymmetry

This work challenges a major assumption in cell biology by showing that lipid bilayers can have drastically different phospholipid abundances between their two leaflets. This lipid abundance asymmetry...

www.cell.com

2 80 200

Holthuis Lab @holthuislab.bsky.social · Mar 25

📯📯📯 10 days left to apply for the International Master MemBioMed "From Membrane Biology to Neuroscience & Experimental Medicine". Scholarships available for selected students to acquire intensive training in analysing the complex behavior of biomembranes and exploiting their therapeutic potential 👇👇

Holthuis Lab @holthuislab.bsky.social · Feb 26

🚨🚨 We are proud to launch MemBioMed, a new international Master program offering interdisciplinary training in biomembrane research at 3 sites: Université de Côte d'Azur 🇫🇷 Università di Genova 🇮🇹 & Osnabrück University 🇩🇪. We offer 15 scholarships & encourage talented students to apply by April 6th ♻️🙏

7 7

Reposted by Holthuis Lab

André Nadler @nadlerlab.bsky.social · Mar 14

This is a beautiful paper. Very important implications - and further evidence for the link between lipid transbilayer movement / lipid asymmetry and directional lipid transport.

Journal of Cell Biology @jcb.org · Mar 13

Any1 is a phospholipid scramblase involved in #endosome biogenesis, say Jieqiong Gao, Christian Ungermann and colleagues (Osnabrück University): rupress.org/jcb/article/...

#Membrane #lipid #Organelles #Biochemistry

2 16

Reposted by Holthuis Lab

Waggoner Lab @labwaggoner.bsky.social · Mar 7

Review @cp-cellchembiol.bsky.social @volkerhaucke-lab.bsky.social
Mechanisms and functions of lysosomal lipid homeostasis
www.cell.com/cell-chemica...

Mechanisms and functions of lysosomal lipid homeostasis

In this review Ebner et al. summarize and discuss the rapidly increasing knowledge regarding the mechanisms of lysosomal lipid turnover and export as well as the pathways for the homeostatic control a...

www.cell.com

10 19

Reposted by Holthuis Lab

Sean Ryder @seanryderphd.bsky.social · Mar 2

Taking a cue from @cantlonlab.bsky.social, I have written an op-ed for my local newspaper about the impact of the NIH funding chaos. I'd appreciate it if you read and share. #NIH #Research #Science #Worcester

www.telegram.com/story/opinio...

Opinion/Guest column: Gutting NIH a disaster in the marking for research, local economy

Less research equates to less business between the university and these Worcester companies, spreading the pain far beyond campus borders.

www.telegram.com

5 51 91

Reposted by Holthuis Lab

GBM (Gesellschaft für Biochemie und Molekularbiologie) @gbmev.bsky.social · Mar 2

Who would have ever thought of such a thing happening?

PharmBlog @pharmblog.bsky.social · Mar 2

Aus gegebenem Anlass:

Europe PMC: europepmc.org

Uniprot BLAST: www.uniprot.org/blast

PubMed/PMC und NCBI BLAST scheinen (momentan) nicht zu funktionieren. Beides sind enorm wichtige Tools für die Biowissenschaften, und zwar von den amerikanischen NIH, die mehr und mehr unter Beschuss geraten.

Europe PMCHome - Europe PMC

Europe PMC is an archive of life sciences journal literature.

europepmc.org

4 3

Reposted by Holthuis Lab

Oded Rechavi @odedrechavi.bsky.social · Mar 1

Friends! The science that we love is under threat. World-wide, there're forces seeking to make it corporate-like, focused on deliverables, or even the enemy of society. Take a stand & celebrate science & music! #theconferencetoendallconferences - Registration starts NOW!
woodstock.img.cas.cz

9 58 150

Holthuis Lab @holthuislab.bsky.social · Mar 2

Pubmed has been down since yesterday. If this is a result of Trump’s NIH funding freeze, it’s extremely bad news for the scientific community not just in the USA but across the world.

Oded Rechavi @odedrechavi.bsky.social · Mar 2

Pubmed

1

Reposted by Holthuis Lab

Fran Bottanelli @franbottanelli.bsky.social · Feb 28

2 weeks left to sing up! Membrane dynamics from single cells to whole organisms! Come and hang out with us in sunny San Feliu! Please re-post

Fran Bottanelli @franbottanelli.bsky.social · Nov 12

Registration is open for the 2025 iteration of the wonderful @EMBOevents workshop on cell polarity and membrane dynamics #EMBOcellPolarity25 I am organizing with Ed Munro! Wonderful lineup wonderful please please sign up and share! meetings.embo.org/event/25-cel...

Cell polarity and membrane dynamics

The ability of cells to polarize is essential for organismal development and physiology, and its impairment underlies numerous diseases. The establishment and maintenance of cell polarity requires a …

meetings.embo.org

10 12

Reposted by Holthuis Lab

Robert Arkowitz @robertarkowitz.bsky.social · Feb 26

www.nature.com/articles/d41...

Postdocs and PhD students hit hard by Trump’s crackdown on science

As US federal grants remain frozen and budget cuts loom, anxiety and fear grip early-career researchers.

www.nature.com

3 1

Holthuis Lab @holthuislab.bsky.social · Feb 26

🚨🚨 We are proud to launch MemBioMed, a new international Master program offering interdisciplinary training in biomembrane research at 3 sites: Université de Côte d'Azur 🇫🇷 Università di Genova 🇮🇹 & Osnabrück University 🇩🇪. We offer 15 scholarships & encourage talented students to apply by April 6th ♻️🙏

1 2