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hellerschmiedlab.bsky.social
Hellerschmied Lab
@hellerschmiedlab.bsky.social
280 followers 390 following 12 posts
Biochemistry and cell biology lab @unidue-zmb.bsky.social Excited about secretory pathway and #Golgi #proteostasis mechanisms funded by AvHStiftung, part of @crc1430.bsky.social (tweets by PI)
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hellerschmiedlab.bsky.social
Hellerschmied Lab @hellerschmiedlab.bsky.social · Jul 15
Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
natsmb.nature.com
Nature Structural & Molecular Biology @natsmb.nature.com · Jul 14
New online: Conformational plasticity of a BiP–GRP94 chaperone complex
Conformational plasticity of a BiP–GRP94 chaperone complex
Nature Structural & Molecular Biology, Published online: 14 July 2025; doi:10.1038/s41594-025-01619-0BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mechanism of chaperone cooperation underlying this quality control process.
go.nature.com
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Reposted by Hellerschmied Lab
ishier.bsky.social
Ishier Raote @ishier.bsky.social · 8d
ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...
Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology
Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.
www.nature.com
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unicologne.bsky.social
Universität zu Köln @unicologne.bsky.social · 6d
🧬Ubiquitin Precursor: A Key to Healthy Aging?
Scientists @cecad.bsky.social and @hhu.de have identified a new form of the protein Ubiquitin, responsible for proteostasis and healthy aging opening up potentially new perspectives for the treatment of cancer and age-related diseases. uni.koeln/BLXJA
A quiet ally: a ubiquitin precursor promotes stress resistance and longevity
In response to cellular stress, the protein CxUb is activated to identify damaged proteins, thereby maintaining cellular health. The discovery could lead to ways to improve the treatment of cancer and...
uni.koeln
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wpokrzywa.bsky.social
Wojciech Pokrzywa @wpokrzywa.bsky.social · 2d
Preprint alert! 🚨
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...
CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub
The nucleolus, classically dedicated to ribosome biogenesis, also acts as a stress-responsive proteostasis hub. During heat shock, misfolded proteins accumulate in its granular component (GC), but whe...
www.biorxiv.org
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imprs-lm.bsky.social
IMPRS for Living Matter @imprs-lm.bsky.social · 16d
The Sacca' lab investigates the behavior of molecular motors within engineered DNA origami nano-compartments to understanding of how nanoscale confinements influence biochemical processes and energy conversion. Interested? Then apply to @imprs-lm.bsky.social

#IMPRS #PhDposition #Syntheticbiology
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imprs-lm.bsky.social
IMPRS for Living Matter @imprs-lm.bsky.social · Sep 3
Are you eager to join an international community of scientists to tackle novel and exciting research projects in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.
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imprs-lm.bsky.social
IMPRS for Living Matter @imprs-lm.bsky.social · 12d
If you would like to contribute to uncover the mechanisms by which proteolytic enzymes in the ubiquitin system operate and exploit these insights for novel therapeutic approaches, then apply to the Gersch lab @maltegersch.bsky.social #IMPRS-LM.

#IMPRS #PhDposition #PhDprogram #ChemicalBiology
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chembiotalks.bsky.social
Virtual ChemBioTalks @chembiotalks.bsky.social · 15d
The 5th Virtual @chembiotalks.bsky.social on September 30th are one week away. We have an exciting program including our keynotes Sarah O'Connor (@oconnorlab.bsky.social) and @craigmcrews.bsky.social.

Make sure to register for free: web.cvent.com/event/...
#ChemSky #ChemBio
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vcmentowski.bsky.social
Verena Cmentowski @vcmentowski.bsky.social · 23d
Excited to share our new paper! 🎉
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
www.science.org/doi/10.1126/...
Very thankful to @andrea-musacchio.bsky.social for his mentorship and support over the years.
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
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Reposted by Hellerschmied Lab
andrea-musacchio.bsky.social
Andrea Musacchio @andrea-musacchio.bsky.social · 23d
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona | Science Advances www.science.org/doi/10.1126/...

Congratulations @vcmentowski.bsky.social for solving a remarkably challenging molecular puzzle
The BUB1 and BUBR1 paralogs scaffold the kinetochore fibrous corona
The kinetochore fibrous corona docks on CENP-E and a second elusive receptor identified as the checkpoint protein BUB1.
www.science.org
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Reposted by Hellerschmied Lab
rbdamgaard.bsky.social
Rune Busk Damgaard @rbdamgaard.bsky.social · 22d
A few months ago, our review “The Molecular Toolbox for Linkage Type-Specific Analysis of Ubiquitin Signaling” 🧬🧰🛠️ came out in ChemBioChem. Time to give it a spotlight!

chemistry-europe.onlinelibrary.wiley.com/doi/full/10....
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maxplanck.de
Max-Planck-Gesellschaft @maxplanck.de · 23d
Early-career researchers: want to run your own lab? 🌟Max Planck Research Groups offer 6+ years, up to €2.7M in funding, open-topic freedom, team support & tenure-track opportunities. Intrigued? 😃Apply by Oct 14, 2025! www.mpg.de/max-planck-r...
Graphic with a blue background and light green dots. The text 'call for applications' appears in green, and 'Ausschreibung' in white. A white arrow on the right points diagonally upward.
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franznarberhaus.bsky.social
Franz Narberhaus @franznarberhaus.bsky.social · Sep 3
jobs.ruhr-uni-bochum.de/jobposting/b...
W1TTW2 Professorship in Biology of Microorganisms (m/f/d)
jobs.ruhr-uni-bochum.de
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maxplanck.de
Max-Planck-Gesellschaft @maxplanck.de · 29d
Springboard for an international scientific career! 🧬🧪🔭⚛️🧠🌱 Call for #MaxPlanckResearchGroups launched; applications are possible until October 14, 2025 www.mpg.de/max-planck-r... #ScienceCareer
Call for Applications / Ausschreibung
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jasmeenoberoi.bsky.social
Jasmeen Oberoi @jasmeenoberoi.bsky.social · 29d
🧬🧪 A research technician position - Protein Biochemistry (6 months) is available in my lab @gdsc-sussex.bsky.social investigating structure and function of fusion kinase complexes in Leukaemia.

📅 Deadline: 29th September 2025.

🙏 Please share with anyone who might be interested.
Research Technician – Protein Biochemistry at University of Sussex
Explore an exciting academic career as a Research Technician – Protein Biochemistry. Don't miss out on other academic jobs. Click to apply and explore more opportunities.
www.jobs.ac.uk
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fmiscience.bsky.social
FMI science @fmiscience.bsky.social · Sep 8
🚨 We're hiring, please share! The FMI seeks a tenure-track Group Leader (Assistant Prof) in Structural Biology 🔬
Innovative scientists in genome regulation, RNA metabolism, or protein homeostasis—especially using cutting-edge approaches—apply now at www.fmi.ch/education-ca...
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katherinedonovan.bsky.social
Katherine A Donovan @katherinedonovan.bsky.social · Sep 8
Just a few days until our annual hybrid TPD event! In-person registration is full, but you can still join us live on Zoom via our regular biweekly link.

Register for the Zoom stream here: dfci.zoom.us/webinar/regi...
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ericchevet.bsky.social
Eric Chevet @ericchevet.bsky.social · Sep 7
This week selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...
Highlight: ATF6 activation alters colonic lipid metabolism causing tumour-associated microbial adaptation www.nature.com/articles/s42...
bims-proteo 2025-09-07 papers
biomed.news
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womeninautophagy.bsky.social
Women in Autophagy @womeninautophagy.bsky.social · Sep 3
📅 Less than 2 weeks left to submit your abstract for our 6th Annual Symposium Webinar!

🎉Don’t miss this chance to share your work, hear the latest advances in autophagy research, and connect with a vibrant community! 🎉

The link for abstraction submission is below 👇

forms.office.com/r/wZbTvPePwR
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cellclub.bsky.social
Cell Biology J-Club @cellclub.bsky.social · Sep 3
www.biorxiv.org/content/10.1...
Mechanical forces stimulate Golgi export
Human cells face a wide range of external mechanical stimuli that vary with cell type, state, and pathological conditions. The rapidly growing field of mechanobiology investigates how cells sense and ...
www.biorxiv.org
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Reposted by Hellerschmied Lab
jcb.org
Journal of Cell Biology @jcb.org · Sep 3
Our new collection offers cell biologists practical, expert-driven guidance and best practices in the design, execution, and analysis of experiments, and the subsequent communication of their results to their peers. 👉 rupress.org/jcb/collecti...

#Reproducibility
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delladavid-lab.bsky.social
delladavid-lab.bsky.social @delladavid-lab.bsky.social · Sep 2
Exciting news📣: #ProteostasisUK is hiring a network manager to help drive an ambitious, #BBSRC funded initiative connecting and expanding #Proteostasis research across the UK. Position initially for 3 years. Deadline September 28th. More info: tinyurl.com/f83rp673 & proteostasisuk.co.uk Please RT
hireful.
tinyurl.com
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dangrabarczyk.bsky.social
Dan Grabarczyk @dangrabarczyk.bsky.social · Aug 27
Happy to share our work on the structure and function of the unusual E3 ligase ZNFX1 @cp-cell.bsky.social. It uses a nucleic acid-activated transthiolation mechanism, ubiquitinating and clustering RNA to protect cells in an immune response. @clausenlab.bsky.social
www.cell.com/cell/fulltex...
A split-site E3 ligase mechanism enables ZNFX1 to ubiquitinate and cluster single-stranded RNA into ubiquitin-coated nucleoprotein particles
Grabarczyk et al. show the structure and mechanism of a non-canonical ubiquitin ligase, which is activated through nucleic-acid-induced oligomerization and is critical for cell survival during immune ...
www.cell.com
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training.ebi.embl.org
EMBL-EBI Training @training.ebi.embl.org · Aug 27
We're hiring! Join our team and help us further global bioinformatics knowledge.

Part-time Events Officer: embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Full-time Senior Scientific Project Officer: embl.wd103.myworkdayjobs.com/en-US/EMBL/d...

Closing date 14 September 2025.
#SciJob #EventProfs
🧬🥼🧪
Decorative image that shows employees at EMBL-EBI stand in the training suites smiling and networking at a bioinformatics training course.
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cellclub.bsky.social
Cell Biology J-Club @cellclub.bsky.social · Aug 27
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy
www.nature.com/articles/s41...
A chaperone-proteasome-based fragmentation machinery is essential for aggrephagy - Nature Cell Biology
Mauthe et al. find that protein aggregate clearance requires fragmentation of the aggregate by a chaperone module and a proteasomal regulatory particle for recruitment and clustering of selective auto...
www.nature.com
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douganlab.bsky.social
dave dougan @douganlab.bsky.social · Aug 24
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits. www.nature.com/articles/s41...
Co-translational ribosome pairing enables native assembly of misfolding-prone subunits - Nature Communications
Protein complexes are essential for cell function. Here, authors show that paired ribosomes can help each other’s nascent chains fold correctly, enabling proper dimer assembly and preventing misfoldin...
www.nature.com
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