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wpokrzywa.bsky.social
Wojciech Pokrzywa
@wpokrzywa.bsky.social
370 followers 330 following 4 posts
Group Leader at the IIMCB_Poland, pokrzywalab.com. Founder of LumiRare (lumirare.com). Passionate about proteostasis, the ubiquitin-proteasome system, exophers, and C. elegans research. Exploring rare diseases and molecular mechanisms of aging.
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wpokrzywa.bsky.social
Wojciech Pokrzywa @wpokrzywa.bsky.social · 2d
Preprint alert! 🚨
We reveal molecular switches that enable the nucleolus to reorganise into a proteostasis hub - coordinating protein quality control with ribosome biogenesis and cross-talk with other stress-responsive organelles.
A big tour de force by the team 💪
www.biorxiv.org/content/10.1...
CHIP, VCP, and Nucleolar Gatekeepers Remodel the Nucleolus into a Stress-Responsive Proteostasis Hub
The nucleolus, classically dedicated to ribosome biogenesis, also acts as a stress-responsive proteostasis hub. During heat shock, misfolded proteins accumulate in its granular component (GC), but whe...
www.biorxiv.org
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wpokrzywa.bsky.social
Wojciech Pokrzywa @wpokrzywa.bsky.social · Feb 17
We have an open postdoc position! Join us to study how ubiquitin ligases and non-canonical modifications regulate protein stability.
🗓️Apply by: 10.03.2025
🔬Start: 01.08.2025 | Warsaw
💰Salary: ~8300 PLN gross
More & apply: tinyurl.com/pokrzywalab-...
Please share! 🚀
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Reposted by Wojciech Pokrzywa
emaleckaphd.bsky.social
Ewelina Malecka @emaleckaphd.bsky.social · Jan 24
We're hiring! 🚨 Looking for a talented MSc graduate to join our team to work on bacteriophages, and bacterial translation using cutting-edge techniques like transcriptomics, proteomics, and single-molecule microscopy. Apply today: bit.ly/3PQjR46
IIMCB
bit.ly
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wpokrzywa.bsky.social
Wojciech Pokrzywa @wpokrzywa.bsky.social · Jan 24
We have identified a novel MAPK1 variant linked to a unique psychiatric disorder with early-onset dementia and demonstrated its role in age-dependent neurodegeneration. Thanks to all collaborators involved!
www.researchsquare.com/article/rs-5...
A novel MAPK1 variant in a family with complex psychiatric and neurodegenerative clinical phenotype
Neurodegenerative disorders leading to dementia often have multifactorial etiologies, but monogenic causes are occasionally identified. We report a three-generation family with two individuals (mother...
www.researchsquare.com
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wpokrzywa.bsky.social
Wojciech Pokrzywa @wpokrzywa.bsky.social · Jan 9
Our first educational project, DEGRADATOR, is now in the Journal of Chemical Education @acspublications.bsky.social
Tested with 97 high school students, it enhances understanding of protein degradation. A step towards making molecular biology more accessible.
Read more: pubs.acs.org/doi/10.1021/...
DEGRADATOR: A Gaming Expedition Into Targeted Protein Degradation Therapies
In an era of rapid scientific advancement, the need for engaging educational tools is critical. DEGRADATOR, a 2D computer game, bridges this gap by immersing players in the ubiquitin-proteasome system...
pubs.acs.org
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