Lightnews — Scholar-powered news

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Cahir O'Kane @cahirokane.bsky.social · 1d

#ER_Literature

Cell Biology J-Club @cellclub.bsky.social · 1d

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates www.biorxiv.org/content/10.1...

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates

The endoplasmic reticulum (ER)'s continuous morphology is tightly controlled by ER-shaping proteins, whose genetic or expression defects drive a spectrum of neurodegenerative disorders from Hereditary...

www.biorxiv.org

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Eric Chevet @ericchevet.bsky.social · 1d

@inserm.fr @insermgrandouest.bsky.social

Eric Chevet @ericchevet.bsky.social · 1d

MARK YOUR CALENDAR - Brain Tumor meeting by the sea -- March 23-25, 2026 #Saint_Malo #palais_du_grand_large

Reposted by Eric Chevet

Eric Chevet @ericchevet.bsky.social · 1d

MARK YOUR CALENDAR - Brain Tumor meeting by the sea -- March 23-25, 2026 #Saint_Malo #palais_du_grand_large

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Eric Chevet @ericchevet.bsky.social · 1d

MARK YOUR CALENDAR - Brain Tumor meeting by the sea -- March 23-25, 2026 #Saint_Malo #palais_du_grand_large

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Cell Reports @cp-cellreports.bsky.social · 1d

ER stress tolerance is regulated by copper-dependent PERK kinase activity

Newton et al. establish PERK as a copper-regulated kinase. The copper dependency of PERK kinase activity is characterized in vitro utilizing glutathione pull-down assays, kinase assays, and CETSA. The physiological implications of this regulatory paradigm for the modulation of ER stress tolerance are demonstrated in cellular and animal models.

dlvr.it

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Prachee Avasthi @pracheeac.bsky.social · 4d

New Blog Post:
Scholarly Communication Is a Research Problem. This Means You.

pracheeac.substack.com/p/scholarly-...

Scholarly Communication Is a Research Problem. This Means You.

Scholarly Communication Is a Research Problem.

pracheeac.substack.com

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Mathieu M.J.E. Rebeaud @chercheurjuteux.com · 3d

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

elifesciences.org/articles/107...

Nuclear and cytosolic J-domain proteins provide synergistic control of Hsf1 at distinct phases of the heat shock response

The nuclear J-domain protein Apj1 controls the shut-off phase of the yeast heat shock response by displacing DNA-bound heat shock transcription factor Hsf1.

elifesciences.org

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Reposted by Eric Chevet

Korolchuk Lab @korolchuklab.bsky.social · 3d

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...

a woman in a red and white striped shirt is throwing papers into the air

ALT: a woman in a red and white striped shirt is throwing papers into the air

media.tenor.com

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Eric Chevet @ericchevet.bsky.social · 3d

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

bims-proteo 2025-10-05 papers

biomed.news

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The Guardian @theguardian.com · 5d

Riot women! Inside Sally Wainwright’s joyous, raucous TV show about menopausal punks

The Happy Valley creator has turned her darkest hour into a rebellious tale of midlife women uniting in musical anarchy. The team behind the highly awaited drama talk vodka, rock’n’roll and hot flushes

www.theguardian.com

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Shonna McBride @shonmcbride.bsky.social · 5d

europepmc.org ftw

Europe PMCHome - Europe PMC

Europe PMC is an archive of life sciences journal literature.

europepmc.org

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Glenn Masson @glennmasson.bsky.social · 5d

Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Wiseman Lab @wisemanlab.bsky.social · 6d

Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756

Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio

apply.interfolio.com

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Matthew Freeman @mjafreeman.bsky.social · 8d

Did you know that the cytoplasmic domain of the pseudoprotease iRhom2 mediates distinct signaling mechanisms to control activation of the cell surface protease ADAM17?

You do now

Brought to you mainly by the outstanding Dr Fangfang Lu

Open access, of course

www.jbc.org/article/S002...

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Soragni:Lab @alice.soragnilab.com · 8d

What incredible news today. I feel so grateful to have worked closely with Tony over the years and to have witnessed firsthand his vision, energy, and commitment to advancing functional precision medicine. I cannot think of a steadier (and more needed) force at the NCI at this time /n

The Society for Functional Precision Medicine @thesfpm.bsky.social · 9d

We want to congratulate our President, Dr. Tony Letai, on his appointment as Director of the NCI. This announcement marks an historic moment for cancer research. Dr. Letai has been a tireless advocate and visionary leader for functional precision medicine 🧵

www.nih.gov/news-events/...

Secretary Kennedy Swears in Dr. Anthony Letai as Director of the National Cancer Institute

Dr. Letai will serve as NCI’s 18th director.

www.nih.gov

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Journal of Cell Biology @jcb.org · 9d

Dolichol-linked oligosaccharide (DLO) is the precursor for asparagine-linked protein #glycosylation. Sheng-Tao Li, Tadashi Suzuki et al. identify a DLO-pyrophosphatase (Llp1), which is involved in DLO homeostasis/quality control. rupress.org/jcb/article/...

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Jim Woodgett @jwoodgett.bsky.social · 10d

A government deciding who to fund not based on the quality or potential of ideas and proposals but based on their institution’s compliance with their political agenda. George Orwell was 40 years off.

Jeremy Berg @jeremymberg.bsky.social · 10d

New from the Washington Post

[Gift link]

wapo.st/3KqjcXB

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White House considers funding advantage for colleges that align with Trump policies

The proposal has the potential to transform the government’s vast research funding operation, which has long awarded university grants based on scientific merit.

wapo.st

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Damien BARRAUD MD @damienbarraudmd.bsky.social · 10d

Chers confrères, surtout ne dites pas que Pozzob est un complotiste et donc un idiot. Vous risqueriez comme moi d'etre sanctionné pour avoir deshonoré la profession

Esprit de Qontradiction @grandsachoir.bsky.social · 11d

Je ne dis pas que Pozzo Di Borgo est un sombre crétin, je constate juste qu’il pense que les lettres UK sur une plaque d’immatriculation avec un drapeau britannique signifient Ukraine 😂😂😂 #PozzoLeClown

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Reposted by Eric Chevet

Dr Aurélie Chatenet-Calyste @achatenetc.bsky.social · 10d

L' #ESR subit actuellement un gigantesque plan social dont personne ne parle hors des intéressés. Les seniors partent, les postes de titulaires sont gelés, blanchis et ne seront pourvus qu'au compte-goutte sur de longues années . Beaucoup seront supprimés.

Joan Stavo-Debauge @jostavodebauge.bsky.social · 10d

Le fait est qu'il y aura de moins en moins de postes de titulaires et de financements : on assiste à un démantèlement à bas bruit de l'ESR, les jeunes chercheuses et chercheurs précaires deviendront vieilles et vieux, la titularisation ne viendra pas.

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asofiahcosta.bsky.social @asofiahcosta.bsky.social · 10d

Just went through some exciting new papers on cutting-edge metabolome and lipidome analysis methods.
Find them here 👉 lnkd.in/eHbcAc7K
A collaboration with @biomednews.bsky.social

a woman leaning against a tree reading a book with gilmore club on the bottom

ALT: a woman leaning against a tree reading a book with gilmore club on the bottom

media.tenor.com

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Damien BARRAUD MD @damienbarraudmd.bsky.social · 10d

CNEWS va protester à propos du laxisme consistant a proposer des activités et sorties ludiques aux malfaiteurs

Le Parisien @leparisien.fr · 11d

L’ancien président de la République assiste au match PSG-Auxerre, quelques jours après sa condamnation à cinq ans de prison pour association de malfaiteurs.

PSG - Auxerre : tout juste condamné, Nicolas Sarkozy est présent au Parc des Princes

l.leparisien.fr

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Reposted by Eric Chevet

Christian Frezza @frezzalab.bsky.social · 10d

Good Sunday, all. Last week has seen some amazing papers in #cancermetabolism and #mitochondrialbiology. Don't miss the curated summary: biomed.news/bims-camemi/...
@biomednews.bsky.social #keepreading

"Forever is composed of nows." -Emily Dickinson

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Eric Chevet @ericchevet.bsky.social · 10d

This week's very rich selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Predicting protein-protein interactions in the human proteome www.science.org/doi/10.1126/...

bims-proteo 2025-09-28 papers

biomed.news

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Reposted by Eric Chevet

Dr. Donita C. Brady of Brady Lab UPenn @bradylabupenn.bsky.social · 11d

🚨 Our 4th example of metalloallosteric regulation of kinase activity. Out today in @CellReports with @KJSsci. The ER stress sensor kinase PERK needs copper to work. Without copper, PERK can’t protect cells under stress. cell.com/cell-reports/p…

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Stefan Marciniak @profmarciniak.bsky.social · 11d

Our new reviewed preprint now available in @elife.bsky.social

“A GCN1-independent activator of the kinase GCN2”

First authors, PhD student @jessyzhu-jiayi.bsky.social & PDRA @giulia-ema.bsky.social

Pleased to be exploring the new eLife publishing model

#ISRliterature

doi.org/10.7554/eLif...

A GCN1-independent activator of the kinase GCN2

doi.org

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