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Wiseman Lab @wisemanlab.bsky.social · 6d

Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756

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Eric Chevet @ericchevet.bsky.social · 3d

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

bims-proteo 2025-10-05 papers

biomed.news

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 3d

#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

www.nature.com

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Korolchuk Lab @korolchuklab.bsky.social · 3d

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 10d

#MitochondrialDisease papers from #week39! 📚 👇
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social @mitoscientists.bsky.social

A few highlights below!

Ribonucleotide incorporation into mitochondrial DNA drives inflammation - Nature

Imbalanced nucleotide metabolism leads to age- and mtDNA-dependent inflammatory responses and senescence-associated secretory phenotype in senescence.

nature.com

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Michele Frison @frisophagy.bsky.social · 24d

In this week's issue of mitophagy news 🪫🗑️:

-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross

biomed.news/bims-tofagi/...

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

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Korolchuk Lab @korolchuklab.bsky.social · 10d

#Autophagy and #mTOR papers from last 4 weeks, buildup due to laziness but lots of cool stuff here, have a look!

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

biomed.news/bims-auttor/...

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Korolchuk Lab @korolchuklab.bsky.social · Sep 4

And another amazing #mTOR paper👇🏼Where do people get strength from to put so much work into this?

www.life-science-alliance.org/content/8/11...

Amino acid–dependent TSC2 dephosphorylation by lysosome–PP2A regulates mTORC1 signaling transduction

The mammalian target of rapamycin complex 1 (mTORC1) signaling pathway, composed of amino acid (AA)–sensing (Ragulator/LAMTOR-Rag) and growth factor (GF)–sensing (AKT-TSC1/2-Rheb) axes, pivotally regu...

www.life-science-alliance.org

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Korolchuk Lab @korolchuklab.bsky.social · Sep 2

#mTOR research field never ceases to amaze, what a tour de force! 👇🏼

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal www.embopress.org/doi/full/10....

mTORC1 senses glutamine and other amino acids through GCN2 | The EMBO Journal

imageimageDuring starvation, individual amino acid levels are thought to be relayed via distinct metabolic sensors, but how mTORC1 senses glutamine remains unclear. This study finds that GCN2 kinase acts as a unifying module in suppression of ...

www.embopress.org

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Korolchuk Lab @korolchuklab.bsky.social · Aug 24

www.nature.com/articles/s41...

Structural basis for the dynamic regulation of mTORC1 by amino acids - Nature

Using cryo-electron microscopy, the interactions of Sestrin2 and CASTOR1 with GATOR2 were resolved, revealing how mTORC1 activation is regulated and how nutrient availability triggers signalling for c...

www.nature.com

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Korolchuk Lab @korolchuklab.bsky.social · Aug 19

Proteomic aging signatures across mouse organs and life stages | The EMBO Journal www.embopress.org/doi/full/10....

Proteomic aging signatures across mouse organs and life stages | The EMBO Journal

imageimageGenomic and transcriptomic studies have advanced our system-level understanding of aging, but large-scale proteomic analyses of the underlying processes remain limited. This resource provide...

www.embopress.org

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Korolchuk Lab @korolchuklab.bsky.social · Aug 17

#mTOR and #autophagy papers from last week. Lots of interesting new stuff, enjoy thanks to @biomednews.bsky.social pre-selection!

biomed.news/bims-auttor/...

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Christian Frezza @frezzalab.bsky.social · Aug 17

Good Sunday all! There is another beutifully exciting selection of papers in #cancermetabolism and #mitochondrialbiology waiting for you here: biomed.news/bims-camemi/... Biomed News #keepreading

"Things take the time they take. Don't worry."

Mary Oliver

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Nature Cell Biology @natcellbio.nature.com · Aug 14

🍹@martenslab.bsky.social @elias-adriaenssens.bsky.social & co show that, unlike soluble, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected flexibility in the selective #autophagy machinery.
bit.ly/4lpGh9P

Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery - Nature Cell Biology

Adriaenssens et al. show that unlike soluble cargo receptors, transmembrane cargo receptors initiate autophagosome biogenesis by recruiting the FIP200/ULK1 or WIPI–ATG13 complex, revealing unexpected ...

bit.ly

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asofiahcosta.bsky.social @asofiahcosta.bsky.social · Aug 10

Just finished selecting the top novel computational and analytical methods for small molecule analysis.

biomed.news/bims-metlip/...

A collaboration with @Bims_BiomedNews

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Eric Chevet @ericchevet.bsky.social · Aug 10

This week's selection of articles and many #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

bims-proteo 2025-08-10 papers

biomed.news

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Christian Frezza @frezzalab.bsky.social · Aug 10

Good Sunday all. A wonderful selection of papers in #cancermetabolism and #mitochondrialbiology is waiting for you. Check it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"Our plans never turn out as tasty as reality."-Ram Dass

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Korolchuk Lab @korolchuklab.bsky.social · Aug 10

#Autophagy and #mTOR papers from last week, not the usual abundance but worth keeping an eye on. Thanks to @biomednews.bsky.social for the reliable service!

biomed.news/bims-auttor/...

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Eric Chevet @ericchevet.bsky.social · Aug 3

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Diffusing protein binders to intrinsically disordered proteins www.nature.com/articles/s41...

bims-proteo 2025-08-03 papers

biomed.news

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Christian Frezza @frezzalab.bsky.social · Aug 3

Good Sunday, all. This week was a blast for @cancermetabolism and @mitochondrialbiology. Don't miss the curated issue of papers, check it here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

"There was another life that I might have had, but I am having this one."-Kazuo Ishiguro

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Korolchuk Lab @korolchuklab.bsky.social · Aug 3

#Autophagy and #mTOR papers from last week, lots of cool stuff, enjoy!

biomed.news/bims-auttor/...

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Korolchuk Lab @korolchuklab.bsky.social · Aug 2

www.embopress.org/doi/full/10....

Phosphoribosyl ubiquitination of SNARE proteins regulates autophagy during Legionella infection | The EMBO Journal

imageimageAmong the hundreds of proteins that are secreted by Legionella pneumophila (the causative agent of Legionnaires’ disease) during infection, the SidE class of effectors modify host proteins b...

www.embopress.org

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · Jul 27

Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex - PMC
pmc.ncbi.nlm.nih.gov/articles/PMC...

Structure of human mitochondrial pyruvate carrier MPC1 and MPC2 complex

The Mitochondrial Pyruvate Carrier (MPC) bridges cytosolic and mitochondrial metabolism by transporting pyruvate into mitochondria for ATP production and biosynthesis of various essential molecules. M...

pmc.ncbi.nlm.nih.gov

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · Jul 27

#MitochondrialDisease collection of papers from #week30! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease | New England Journal of Medicine
www.nejm.org/doi/10.1056/...

Mitochondrial Donation in a Reproductive Care Pathway for mtDNA Disease | NEJM

Pathogenic variants in mitochondrial DNA (mtDNA) are a common cause of severe, often fatal, inherited metabolic disease. A reproductive care pathway was implemented to provide women carrying pathog...

www.nejm.org

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Eric Chevet @ericchevet.bsky.social · Jul 24

#ER_literature

MOREL Lab / MEMBRAMICS research @membramics-lab.bsky.social · Jul 24

Endosome–ER contact sites in phagophore formation: Trends in Cell Biology www.cell.com/trends/cell-...

Check out the recent spotlight published in @cp-trendscellbio.bsky.social about our study on ER-endosome contacts in autophagy by @julianedagraca.bsky.social

Endosome–ER contact sites in phagophore formation

Autophagy is a crucial ‘self-eating’ mechanism used by eukaryotic cells to degrade and recycle cytosolic materials. A recent study by Da Graça et al. reports that the dynamic mobilization of endosome–...

www.cell.com

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