Scripps is conducting a tenure track assistant professor search. This is a broad search across multiple departments for outstanding individuals that could integrate into the multi-disciplinary environment at Scripps Research. All interested should apply! Please share. apply.interfolio.com/174756

I had a great visit with a lot of old (long time not age!) and new friends!

🚨 #teamtomo!🚨
Did you know there's a dedicated cryoEM/ET Mini-Symposium at the upcoming ASCB/EMBO meeting in Philly (Dec 6–10)??

Thrilled to share a new preprint! 📝 🎉 Lewis lab PhD student Casadora wondered: Do mtDNA synthesis and lipid droplet biogenesis co-occur at the same membrane contact sites? Or can we discern distinct ER-mito contact classes? Evidence suggests the latter, relevant in overnutrition!

New work from the lab (w/ @preronabora.bsky.social @mashiatzaman.bsky.social @mitomorph.bsky.social @nanigrotjahn.bsky.social) identifying a compound that activates OMA1-DELE1-HRI signaling to induce mitochondrial remodeling in MFN2-deficient cells. Check it out 👇
www.biorxiv.org/content/10.1...

TMED9 mediates export of misfolded #prion proteins from the ER. @pskcellbio.bsky.social &co show that TMED9 also helps capture #misfolded GPI-anchored proteins that are released by calnexin in the ER and moved into the Golgi for degradation via the RESET pathway @plosbiology.org 🧪 plos.io/44kURu5

I know print journals aren't exactly on everyone's radar these days, but we’re still geeking out that our latest study—led by the brilliant @attychang.bsky.social—landed the cover of the April issue of JCB! 🤩

@zidlab.bsky.social @tomo.science @hamid13r.bsky.social

Published an op-ed for @cnn.com: “Nobel laureate: I owe America my success. Today, its scientific future is in danger.”
A personal reflection on what’s at stake as science funding gets slashed. I’d be grateful if you could amplify both in and beyond the science world.
www.cnn.com/2025/04/09/h...

🚨 The April 13 deadline to submit abstracts for short talk consideration is coming up fast!

Trainees and early-career researchers—don’t miss your chance to present your work and be eligible for talk and poster prizes at @faseborg.bsky.social
#FASEB2025 #ERSRC

New work from Zaman et al., in the Shutt Lab @mitomorph.bsky.social, describes a novel variant in MFN2 linked to mtDNA-mediated inflammation and muscle myopathy
www.life-science-alliance.org/content/8/6/...

…your poor student…🤣

Fantastic article from Linda Hendershot—an incredible scientist and one of the most supportive and inspiring researchers I've had the pleasure of meeting.
www.sciencedirect.com/science/arti...

OpEd by @scripps.edu Pres. Pete Shultz: "the consequences would extend beyond Scripps Research, threatening the broader San Diego life sciences ecosystem, which contributes over $27 billion to the regional economy and supports tens of thousands of jobs."
www.sandiegouniontribune.com/2025/02/25/o...

Past few weeks of Unfolded Protein Response papers! #ERStress @biomednews.bsky.social
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...

Very happy to share the latest preprint from my lab led by Kaylee Vosbigian @kaylee-vosbigian.bsky.social ! We found that Anaplasma activates the ATF6 branch of the unfolded protein response in Ixodes ticks to facilitate cholesterol uptake for growth and survival. #MicroSky #Anaplasma #ticks

Excited to be involved in this cool project led by @yananchenlab.bsky.social and her team showing protection afforded by the ATF6 activator AA147 in a mouse model of multiple sclerosis. Check it out! 👇

1/ 🚨We’re thrilled to share our latest study:

"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟

www.biorxiv.org/content/10.1...

How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️

A huge week for Prakhyat, our joint @scripps.edu student with the @wisemanlab.bsky.social! He was awarded an AHA earlier in the week and today he passed his PhD candidacy exam! Because Prakh is so chill, we celebrated with chocolate-coffee liquid nitrogen ice cream. 😎

Congrats to our amazing @scripps.edu grad student Prakhyat Mathur (joint with @wisemanlab.bsky.social) for being awarded a predoctoral fellowship from the AHA @americanheart.bsky.social. Prakh will be investigating how mitochondrial stress activates the integrated stress response. Well-earned Prakh!

🌟 Registration is now OPEN for the #FASEB Endoplasmic Reticulum Conference 2025 #ERSRC! 🎉 Join us June 8-12, 2025, in Melbourne 🏖️, FL, for cutting-edge science and networking.

Check out the program and register here 👇

events.faseb.org/event/endoplasmic-reticulum-function-disease