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kerenlasker.bsky.social
Keren Lasker
@kerenlasker.bsky.social
410 followers 290 following 36 posts
Membraneless Organelles in Bacteria: Structure, Dynamics, Function, and Engineering. Assistant Professor @scripps.edu. https://laskerlab.org/
laskerlab.org
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kerenlasker.bsky.social
Keren Lasker @kerenlasker.bsky.social · Dec 30
1/ 🚨We’re thrilled to share our latest study:

"Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure" 🌟

www.biorxiv.org/content/10.1...

How do biomolecular condensates achieve their cellular roles? It comes down to their internal structure. 🧵⬇️
Cellular Function of a Biomolecular Condensate Is Determined by Its Ultrastructure
Biomolecular condensates play key roles in the spatiotemporal regulation of cellular processes. Yet, the relationship between atomic features and condensate function remains poorly understood. We stud...
www.biorxiv.org
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kerenlasker.bsky.social
Keren Lasker @kerenlasker.bsky.social · 4d
Warmest congratulations, Alex. You truly are the scaffold of our community! 💫
So incredibly well-deserved, and I'm beyond excited to see what's next for you! 🚀✨
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Reposted by Keren Lasker
laskerfdn.bsky.social
Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 27d
Congratulations to Lucy Shapiro, 2025 #LaskerAward winner! – “for a 55-year career in biomedical science – honored for discovering how bacteria generate distinct daughter cells; and for exemplary leadership at the national level”
#Lasker2025 #LaskerLaureate #devbio 🧪
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kerenlasker.bsky.social
Keren Lasker @kerenlasker.bsky.social · 27d
Over the moon to see my postdoc advisor, Prof. Lucy Shapiro, receive a Lasker Award—a brilliant salute to her decades of trail-blazing science, visionary leadership, and transformative mentorship. Congratulations!
laskerfdn.bsky.social
Albert and Mary Lasker Foundation @laskerfdn.bsky.social · 27d
Congratulations to this year’s #LaskerAward winners!
Basic: Dirk Görlich & Steven L. McKnight
Clinical: Michael J. Welsh, Jesús (Tito) González, & Paul A. Negulescu
Special Achievement: Lucy Shapiro
Laskerfoundation.org
#Lasker2025 #LaskerLaureate
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scripps.edu
Scripps Research @scripps.edu · Jun 10
Join us this Thursday, June 12, at 1PM for the first of our three summer virtual masterclasses — where seasoned PIs share how they transformed foundational science into VC-backed startups. 🔬🌟

🎟️ For more info, contact [email protected].
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Reposted by Keren Lasker
erc.europa.eu
European Research Council (ERC) @erc.europa.eu · May 28
🎉 Congratulations to Wolfgang Baumeister @maxplanck.de, awarded the 2025 #ShawPrize in Life Science & Medicine for pioneering work in cryo-ET!

Learn more 👉 europa.eu/!JBXDBG
#FrontierResearch #ERCSyG #CryoET #StructuralBiology #shawprize2025
ERC grantee wins the Shaw Prize in Life Science and Medicine
2025 Shaw Prize honours ERC-funded research in molecular imaging
europa.eu
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alexholehouse.bsky.social
Alex Holehouse @alexholehouse.bsky.social · May 23
Now published! Big congrats to first author @gginell.bsky.social

We are actively working improving/updating various aspects of FINCHES; don't hesitate to reach out if you run into issues, have questions.
www.science.org/doi/10.1126/...
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Reposted by Keren Lasker
rhp-lab.bsky.social
Rasmus Hartmann-Petersen @rhp-lab.bsky.social · May 15
In collaboration with the @lindorfflarsen.bsky.social group we release our map of degrons in >5,000 human cytosolic proteins with >99% coverage. A machine learning model trained on the data identifies missense variants forming degrons in exposed & disordered regions. Work led by @vvouts.bsky.social.
A complete map of human cytosolic degrons and their relevance for disease
Degrons are short protein segments that target proteins for degradation via the ubiquitin-proteasome system and thus ensure timely removal of signaling proteins and clearance of misfolded proteins fro...
www.biorxiv.org
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Reposted by Keren Lasker
lindorfflarsen.bsky.social
Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · Apr 17
AlphaFold is amazing but gives you static structures 🧊

In a fantastic teamwork, @mcagiada.bsky.social and @emilthomasen.bsky.social developed AF2χ to generate conformational ensembles representing side-chain dynamics using AF2 💃

Code: github.com/KULL-Centre/...
Colab: github.com/matteo-cagia...
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thibautbrunet.bsky.social
Thibaut Brunet @thibautbrunet.bsky.social · Apr 3
Striking new study from @archaeon-alex.bsky.social's lab just out in @science.org on multicellular development induced by compression in Archaea: www.science.org/doi/10.1126/...
Tissue-like multicellular development triggered by mechanical compression in archaea
The advent of clonal multicellularity is a critical evolutionary milestone, seen often in eukaryotes, rarely in bacteria, and only once in archaea. We show that uniaxial compression induces clonal mul...
www.science.org
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Reposted by Keren Lasker
pelhamjackie.bsky.social
jackie pelham @pelhamjackie.bsky.social · Mar 17
Announcing the joint @idpseminars.bsky.social / BPS IDP Subgroup Trainee Symposium Speakers!

Join us on Mar 27, 12–2pm CST for 6 exciting talks focused on Intrinsically Disordered Proteins as part of #BophysicsWeek2025 with the @biophysicalsoc.bsky.social Sign up now using the QR code below!
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Reposted by Keren Lasker
jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Mar 12
This summer in beautiful Santa Barbara we will run a 3-day conference on “Biological Physics of Biomolecular Condensates: Bridging Theory and Experiment” June 16 to 18th. Register now: www.kitp.ucsb.edu/activities/b...
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Reposted by Keren Lasker
chadbourn.bsky.social
Mark Chadbourn @chadbourn.bsky.social · Mar 5
Big health breakthrough: a protein from tardigrades can now protect human cells from radiation.

That’s going to lead to better cancer therapies.
Radioprotection of healthy tissue via nanoparticle-delivered mRNA encoding for a damage-suppressor protein found in tardigrades - Nature Biomedical Engineering
Radiation-therapy-induced DNA damage in oral and rectal epithelial cells can be reduced via the nanoparticle-mediated local delivery of messenger RNA encoding for a damage-suppressor protein found in ...
www.nature.com
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Reposted by Keren Lasker
jerelleaj.bsky.social
Jerelle Joseph @jerelleaj.bsky.social · Mar 6
New Preprint ‼️ Work led by the incredible @ananyac2000.bsky.social 💃🏽💃🏽 Mpipi-T is finally here!!! 🥳🥳 👇🏽👇🏽

www.biorxiv.org/content/10.1...
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ascbiology.bsky.social
American Society for Cell Biology @ascbiology.bsky.social · Mar 4
MBoC #CallForPapers: Special Issue on Biomolecular Condensates

Submit to be considered by lead editors:
Amy Gladfelter, University of North Carolina
Jeffrey B. Woodruff, UT Southwestern Medical Center
Huaiying Zhang, Carnegie Mellon University

www.molbiolcell.org/biomolecular... #CellBiology
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ascbiology.bsky.social
American Society for Cell Biology @ascbiology.bsky.social · Mar 3
From MBoC
AI: A transformative opportunity in cell biology, by Sandra Schmid, Chan Zuckerberg Biohub Network, et al.

doi.org/10.1091/mbc.... #CellBiology
AI: A transformative opportunity in cell biology | Molecular Biology of the Cell
The success of artificial intelligence (AI) algorithms in predicting protein structure and more recently, protein interactions, demonstrates the power and potential of machine learning and AI for adva...
doi.org
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Reposted by Keren Lasker
rohitpappu68.bsky.social
Rohit V. Pappu @rohitpappu68.bsky.social · Feb 28
www.biorxiv.org/content/10.1...
Molecular grammars of intrinsically disordered regions that span the human proteome
Intrinsically disordered regions (IDRs) of proteins are defined by functionally relevant molecular grammars. This refers to IDR-specific non-random amino acid compositions and non-random patterning of...
www.biorxiv.org
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Reposted by Keren Lasker
raflynn5.bsky.social
Ryan Flynn @raflynn5.bsky.social · Feb 27
Excited to share the work of Jonathan Perr where he uncovered a surprisingly common feature of cell surfaces - the presentation and clustering of RNA binding proteins with #glycoRNA.

Critically support by #NIH @cp-cell.bsky.social www.cell.com/cell/abstrac...
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
Mammalian cells present RNA-binding proteins on the cell surface that form clustered domains containing glycoRNAs.
www.cell.com
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Reposted by Keren Lasker
liam-rooney.bsky.social
Liam Rooney @liam-rooney.bsky.social · Feb 25
First senior-author paper is out today in the Journal of Microscopy! 🧪🔬

We present the first 3D printed microscope where both the optics & frame are entirely 3D printed - a low-cost, accessible, and reproducible tool for histological imaging!

onlinelibrary.wiley.com/doi/full/10.1111/jmi.13398
An exploded view of the 3D-printed microscope. A front-facing (A), oblique (B), and side-facing view (C) of the microscope are presented, with the chassis coloured in grey and the positions of additional components highlighted with different colours (orange = LED light source, magenta = 3D-printed condenser lens, blue = 3D-printed objective lens, green = CMOS camera). A scale bar is presented in (a) to provide a visualisation of the size of the microscope setup.
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Reposted by Keren Lasker
scripps.edu
Scripps Research @scripps.edu · Feb 26
In a new op-ed for the @sandiegouniontribune.com, Scripps Research President and CEO Pete Schultz discusses how proposed changes to federal science funding could have unintended consequences for biomedical research, innovation, and the broader life sciences ecosystem in San Diego.
Opinion: Science funding cuts are based on flawed logic. Here’s the truth.
Earlier this month, the National Institutes of Health issued supplemental guidance indicating it would immediately impose a 15% cap on indirect costs for research grants, an unprecedented and abrup…
www.sandiegouniontribune.com
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Reposted by Keren Lasker
hbschmidt.bsky.social
Broder Schmidt @hbschmidt.bsky.social · Feb 25
Ever wondered how mammalian cells sense osmotic stress? There's gotta be a signaling pathway, right?

We propose a *one-component system*: NFAT5, the transcription factor that executes the osmoprotective response, is also the stress sensor!

www.science.org/doi/full/10....
Direct ionic stress sensing and mitigation by the transcription factor NFAT5
Intracellular ionic strength is sensed and regulated by a prion-like domain in a transcription factor.
www.science.org
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kerenlasker.bsky.social
Keren Lasker @kerenlasker.bsky.social · Feb 15
🎉🎉 Kudos to @bornanovak.bsky.social , Jeff, Ryan, and @alexholehouse.bsky.social —this breakthrough work paves the way for exciting new frontiers in disordered protein research! 🌟✨
bornanovak.bsky.social
Borna Novak @bornanovak.bsky.social · Feb 15
Excited to announce the newest member of the flock - STARLING (conSTruction of intrinsicAlly disoRdered proteins ensembles efficientLy vIa multi-dimeNsional Generative models).
www.biorxiv.org/content/10.1...
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kerenlasker.bsky.social
Keren Lasker @kerenlasker.bsky.social · Feb 15
Part 2 is starting soon! 🤩
kerenlasker.bsky.social
Keren Lasker @kerenlasker.bsky.social · Feb 15
Part I of BIV subgroup starts in an hour (8:30 am PT)
Join us!
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kerenlasker.bsky.social
Keren Lasker @kerenlasker.bsky.social · Feb 15
🚀 Join us at #BPS2025 tomorrow at 8:30 AM for a spectacular lineup of cutting-edge methods & biology in Biopolymers In Vivo! 🧪🔬

🧠 AI & IDP phase behavior | 🌱 Protein thermosensing | ❄️ Cryo-EM
🧬 GTPase activity | 🛠️ Engineered condensates | 🤖 Deep learning | 💧 Phase separation
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brianliau.bsky.social
Brian Liau @brianliau.bsky.social · Feb 12
Today in @nature.com we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
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