Scripps Research
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Scripps Research is one of the world's largest, private, non-profit biomedical research organizations. We are Science Changing Life.
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A major concern this flu season is reassortment, when seasonal flu and bird flu infect the same host and swap genetic material, potentially creating a new, more dangerous strain. With H5N1 in cows and human cases emerging, our virology labs are closely tracking its evolution. More: ow.ly/thLP50WafhH
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A new @pnas.org study from Marco Mravic’s lab describes a computer-guided strategy to design synthetic membrane proteins, revealing how a conserved amino acid motif forms stabilizing hydrogen bonds that help proteins stay folded in lipid, even under boiling conditions.
Scripps Research scientists unlock new patterns of protein behavior in cell membranes
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Former Scripps Research assistant professor Shimon Sakaguchi has been awarded the 2025 #NobelPrize for discovering regulatory T cells—work that reshaped immunology and inspired therapies now in clinical trials for cancer, autoimmune disease and transplant complications.
Former Scripps Research assistant professor awarded 2025 Nobel Prize in Physiology or Medicine
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The Fall 2025 edition of Scripps Research Magazine is here—featuring how the Skaggs Graduate School is enhancing graduate education in chemical and biological science and features alumni whose contributions are advancing discoveries across academia, industry and beyond.
Fall 2025 - Scripps Research Magazine
Learning today, leading tomorrowFrom innovative outreach programs to a nationally ranked graduate school, Scripps Research leads the way in educating the scientists of tomorrow.
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Join in person on the Scripps Research campus or attend virtually via Zoom on Wednesday, October 8, 2025 at 4:00 p.m. PT | 7:00 p.m. ET.

🎟️ Registration is free! Reserve your seat now using the links below.

💻 Virtual: ow.ly/p4Ov50X6khV

📍 In-person: ow.ly/3hbv50X6kgW
The Front Row at Scripps Research: lecture with Howard Hang, PhD
Take a seat in the front row and listen as some of the world’s foremost scientists introduce you to innovative medicines and treatments.
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#DidYouKnow: Your gut is home to trillions of microbes that help shape your immune system 🧫

In our next Front Row lecture, Scripps Research professor Howard Hang will explore how microbial metabolites influence immunity and what this means for treating infection, cancer and chronic inflammation.
Reposted by Scripps Research
xinjin.bsky.social
Actively hiring! Video made by Sora-2 but the job post is 100% real.

Apply here: hhmi.wd1.myworkdayjobs.com/en-US/Extern...
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Scripps Research Associate Prof. Xin Jin (@xinjin.bsky.social) has been named one of only 30 @hhmi.org Freeman Hrabowski Scholars, recognized for advancing genomic tools—including in vivo Perturb-seq—to map how genes shape brain circuits and uncover clues to neurological disease and brain health.
Scripps Research associate professor named an HHMI Freeman Hrabowski Scholar
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In back-to-back @science.org and @nature.com studies, Phil Baran’s lab reveals a radical cross-coupling method using sulfonyl hydrazides—enabling seven new reactions, pharma adoption, and the ability to retain about 90% of a molecule’s 3D shape.

More at: ow.ly/CAh450X1Qmt
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Congrats to Scripps Research Prof. @donnablack.bsky.social on being elected to @raeng.org.uk for her work in developing Reaction Progress Kinetic Analysis (RPKA) and research in molecular chirality—shaping both drug development and our understanding of life’s chemical origins. ow.ly/uefs50X1exY
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The paraventricular nucleus of the thalamus (PVT), a brain region linked to stress, may explain why people relapse even when alcohol no longer feels rewarding.

A recent study from Scripps Research shows it activates when alcohol relieves withdrawal, driving negative reinforcement in the brain.
Researchers find brain region that fuels compulsive drinking
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Wearables like Apple Watch & Fitbit may help monitor pregnancy. ⌚️

A study in @ebiomedicine.bsky.social led by Giorgio Quer & Tolúwalàṣẹ Àjàyí (@laseajayi.com) found heart rate tracked by wearables aligned with hormone changes, offering potential for early detection and improved remote care access.
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The wait is almost over—#IBDCuttingEdge2025 starts tomorrow!

Join @scrippshealth.bsky.social, @ucsdmedschool.bsky.social & @crohnscolitisfdn.bsky.social for a three-day CME event on translational science, clinical trials, surgery & drug discovery in IBD care.

🎟️ Secure your spot: ow.ly/4FPU50VFUGW
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Today at 4 p.m. PT, join us for a new Front Row with Benjamin Cravatt, PhD. He’ll share how chemical biology is expanding access to targets once thought undruggable. Free and open to the public, online or in person. Registration is free! 🎟️

💻 Virtual: ow.ly/8Xbn50WYqNQ
📍 In-person: ow.ly/AOjk50WYqNq
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In our last Front Row, Travis Young, PhD, shared how Scripps Research is developing switchable CAR-T cells that activate only with a companion molecule. The design could help prevent neurological side effects and enable retreatment without reengineering.

Watch the full lecture: ow.ly/TQAq50WYqrQ
scripps.edu
A new study reveals how regulatory T cells in the skin modulate pain—not just immune responses—by releasing enkephalins that act on sensory neurons.

The work, led by Scripps Research Assistant Professor Alejandra Mendoza (@thepenkpanther.bsky.social) uncovers a neuromodulatory role for Tregs.
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
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Scripps Research scientists combine cryoEM with the graphical neural network-based structure building tool, ModelAngelo, to identify monoclonal antibodies from polyclonal responses—reducing discovery time from weeks to under a day while improving accuracy and scalability for therapeutic development.
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📣 We’re just days away from #IBDCuttingEdge2025 —a three-day CME event exploring the future of IBD care: translational science, clinical trials, surgery, and multidisciplinary models led by top experts.

Join us:
📅 Sept 19–21, 2025
📍Coronado, CA
🎟️ ow.ly/v6qx50VFLVm
scripps.edu
Our next Front Row lecture: Prof. Benjamin Cravatt will explain how his large-scale protein profiling research and innovative chemical technologies are helping identify novel drugs for therapeutic targets previously deemed ‘undruggable.’

💻 Virtual: ow.ly/43J250WWar8
📍 In-person: ow.ly/7aBj50WWaqS
scripps.edu
Meet Katie Russell, president of the Donald E. and Delia B. Baxter Foundation 👋

In our Q&A, “On doing good: Katie Russell,” she shares the foundation’s legacy, its focus on supporting young investigators, and why its partnership with Scripps Research is so meaningful.
On doing good: Katie Russell - Scripps Research Magazine
The Donald E. and Delia B. Baxter Foundation was established in 1959 by Delia Baxter in memory of her husband, an accomplished physician and engineer who developed the first commercially prepared intr...
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Reposted by Scripps Research
thepenkpanther.bsky.social
After many years of work I’m so happy to share our work on #scienceimmunology on how Treg cells modulate nociception to dampen skin inflammation! My handle will make a lot more sense now!🕵🏻‍♀️
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception
Regulatory T cells curb noxious sensory signaling to dampen cutaneous inflammation, a neuromodulatory mechanism for immunosuppression.
www.science.org
scripps.edu
Next week, Scripps Research scientists Amy Lightner, Michael Bollong & Arnab Chatterjee will speak at #IBDCuttingEdge2025, sharing insights on regenerative medicine, clinical trials, and drug discovery in IBD.

Join us next week, Sept 19–21 | 📍 Coronado, CA
🎟️ Register now: ow.ly/xPsK50VFU8L