Lightnews — Scholar-powered news

Susan Logue @loguesusan.bsky.social · Aug 14

I hope dinner was nice Stefan. Mulranny Park Hotel is one of my favourite places ❤️

Susan Logue @loguesusan.bsky.social · Aug 13

Interesting perspective on GRP78 by Amy Lee #ER_Literature
Stress-induced translocation of the endoplasmic reticulum chaperone GRP78/BiP and its impact on human disease and therapy | PNAS www.pnas.org/doi/10.1073/...

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

www.pnas.org

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Susan Logue @loguesusan.bsky.social · Jul 25

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry - Molecular & Cellular Proteomics www.mcponline.org/article/S153...

Dissecting Branch-Specific Unfolded Protein Response Activation in Drug-Tolerant BRAF-Mutant Melanoma using Data-Independent Acquisition Mass Spectrometry

Cells rely on the Unfolded Protein Response (UPR) to maintain ER protein homeostasis (proteostasis) when faced with elevated levels of misfolded and aggregated proteins. The UPR is comprised of three ...

www.mcponline.org

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Susan Logue @loguesusan.bsky.social · Jul 22

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR
www.biorxiv.org/content/10.1...

Optogenetic Clustering of Human IRE1 Reveals Differential Regulation of Transcription and mRNA Splice Isoform Abundance by the UPR

Inositol-requiring enzyme 1 (IRE1) is one of three known sensor proteins that respond to homeostatic perturbations in the metazoan endoplasmic reticulum. The three sensors collectively initiate an int...

www.biorxiv.org

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Susan Logue @loguesusan.bsky.social · Apr 27

Check out this weeks selection of Unfolded Protein Response papers!
biomed.news/bims-unfpre/...
Thanks @biomednews.bsky.social

bims-unfpre 2025-04-27 papers

biomed.news

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Reposted by Susan Logue

U of M Rady Faculty @um-radyfhs.bsky.social · Apr 15

After testing 8,500 drugs, the research team discovered that poziotinib – a drug that already exists and is approved for other cancers – reduced breast cancer brain metastasis tumours in mice after two weeks of treatment. #Medsky #cancerresearch #radyfaculty

UM-led study offers hope that existing drug can target metastatic brain tumours

A University of Manitoba-led study successfully eliminated breast-cancer derived brain tumours in mice, using a drug to penetrate the brain and eliminate metastatic brain tumours. After testing 8,500

news.umanitoba.ca

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Susan Logue @loguesusan.bsky.social · Apr 13

Lots of great Unfolded Protein Response papers this week....
biomed.news/bims-unfpre/... thanks @biomednews.bsky.social

bims-unfpre 2025-04-13 papers

biomed.news

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Susan Logue @loguesusan.bsky.social · Apr 4

🤩I'm sure this is the first of many beautiful images from the Hall Lab!!! 🎉

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Susan Logue @loguesusan.bsky.social · Mar 17

Happy St Patrick’s Day, Lá Fhéile Pádraig sona daoibh

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Susan Logue @loguesusan.bsky.social · Mar 14

Celebrating Irish change-makers across the globe
youtu.be/MeIcN6KJSlU?...

St Patrick’s Day 2025 – Celebrating Irish change-makers across the globe #stpatricksday

YouTube video by Department of Foreign Affairs and Trade, Ireland

youtu.be

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Reposted by Susan Logue

Joe Chambers @joechambers.bsky.social · Mar 10

Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.

A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.

@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics

The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

www.nature.com

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Reposted by Susan Logue

Catalina Vasilescu, PhD @cvasilescu.bsky.social · Mar 9

Here it is, the #mitochondrialdisease selection of papers from last week! 📚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoworld.bsky.social @mitowomen.bsky.social @mitoscientist.bsky.social

Many interesting findings, a few highlights in the comments below! 👇

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Susan Logue @loguesusan.bsky.social · Mar 9

Fantastic article from Linda Hendershot—an incredible scientist and one of the most supportive and inspiring researchers I've had the pleasure of meeting.
www.sciencedirect.com/science/arti...

A BiP-centric view of endoplasmic reticulum functions and of my career

After completing my post-doctoral training at the University of Alabama, Birmingham and a brief period on the faculty there, I joined the Department o…

www.sciencedirect.com

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Reposted by Susan Logue

Donna Martin @drdonnamartin.bsky.social · Mar 8

Hugh Kearns @umanitoba.bsky.social April 7 Bannatyne Campus, April 10 at FG
7 secrets to research success QR code for details

Photo of Hugh Kearns, announcing Sam Weiner Distinguished Visitor Awardee QR code to register

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Susan Logue @loguesusan.bsky.social · Mar 5

This weeks selection of Unfolded Protein Response papers
biomed.news/bims-unfpre/... @biomednews.bsky.social

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Susan Logue @loguesusan.bsky.social · Feb 28

Now to sprinkle the last ingredient of a little magic dust over this grant…….third time lucky?🤞🤞

a man wearing sunglasses and a white tank top says " a little bit of magic dust "

ALT: a man wearing sunglasses and a white tank top says " a little bit of magic dust "

media.tenor.com

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Susan Logue @loguesusan.bsky.social · Feb 23

Past few weeks of Unfolded Protein Response papers! #ERStress @biomednews.bsky.social
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...

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Susan Logue @loguesusan.bsky.social · Feb 21

@ericchevet.bsky.social thats what weekends are for 🤣

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Susan Logue @loguesusan.bsky.social · Feb 21

After a long delay time to catch up on Unfoled Protein Response related papers! @biomednews.bsky.social
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...
biomed.news/bims-unfpre/...

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Reposted by Susan Logue

Meaghan Jones @meaghanjones.bsky.social · Feb 11

Come be my colleague! We are hiring very broadly in cancer biology. Great colleagues and department, lots of support, sure the winter is cold but our hearts are warm!

Biochemistry & Medical Genetics @umbmg.bsky.social · Feb 11

🚨We're hiring! 🚨

BMG is seeking an Assistant/Associate Professor with expertise in Cancer Biology—focusing on genetics and/or biochemistry.

📅 Application review begins March 31, 2025.

🔗More info: viprecprod.ad.umanitoba.ca/DEFAULT.ASPX...

viprecprod.ad.umanitoba.ca

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Reposted by Susan Logue

Biochemistry & Medical Genetics @umbmg.bsky.social · Feb 11

🚨We're hiring! 🚨

BMG is seeking an Assistant/Associate Professor with expertise in Cancer Biology—focusing on genetics and/or biochemistry.

📅 Application review begins March 31, 2025.

🔗More info: viprecprod.ad.umanitoba.ca/DEFAULT.ASPX...

viprecprod.ad.umanitoba.ca

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Reposted by Susan Logue

McManusLab @kirkmcmanuslab.bsky.social · Feb 11

Great opportunity for an Assistant/Associate Professor position in #CancerBiology in the Department of Biochemistry & Medical Genetics at the University of Manitoba. Supportive environment and Winnipeg is a great and affordable city!
bit.ly/4gKnmnS

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Susan Logue @loguesusan.bsky.social · Jan 16

ER stress peeps I have a question - is there a paper that demonstrates p-PERK ab are not always a reliable method to detect PERK activation? I have a vague recollection of a paper but can’t seem to find it….

Reposted by Susan Logue

Eric Chevet @ericchevet.bsky.social · Jan 6

The University of Rennes is recruiting an assistant professor (Maître de Conférence) in bioinformatics with a research activity in our unit (oss-clcc.univ-rennes.fr) - if you seek for some information regarding the research them please DM me

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Reposted by Susan Logue

Cahir O'Kane @cahirokane.bsky.social · Jan 5

Experience Postgrad Life Sciences in @cambridgebiosci.bsky.social
Paid 8-week research internships, for undergraduates in their penultimate year at a UK/Irish university. Aimed at talented students who might not otherwise feel they can easily access summer research opportunities.

Experience Postgrad Life Sciences | Enhancing diversity among life scientists of the future

www.exppg.lifesci.cam.ac.uk

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