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Reposted by Catalina Vasilescu, PhD

Nature @nature.com · 2d

BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"

Stay tuned for more.
#NobelPrize

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Reposted by Catalina Vasilescu, PhD

Michele Frison @frisophagy.bsky.social · 3d

In this week's mitophagy news 🪫🗑️

biomed.news/bims-tofagi/...

⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

Thanks to @biomednews.bsky.social

PP2A-B55α activates TFEB upon mitochondrial damage to support Parkin-dependent mitophagy.

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 3d

Engineering Artificial Mitochondria with Self‐Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells - Fu - Angewandte Chemie International Edition - Wiley Online Library
onlinelibrary.wiley.com/doi/10.1002/...

Engineering Artificial Mitochondria with Self‐Amplifying Proton Generation for Autonomous Energy Supply and Metabolic Coupling in Artificial Cells

A mitochondria-mimicking ATP generator improves the enzyme instability of enzyme-based artificial mitochondria and eliminates the toxicity of H2O2 via quantitative enzyme co-compartmentalization. The....

onlinelibrary.wiley.com

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 3d

MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes | Nature Communications
www.nature.com/articles/s41...

MTCH2 modulates CPT1 activity to regulate lipid metabolism of adipocytes - Nature Communications

Increasing mitochondrial oxidative capacity and energy expenditure holds therapeutic potential for obesity and metabolic disorders. Here, the authors identify MTCH2 as a mitochondrial regulator of fatty acid oxidation via interaction with CPT1.

www.nature.com

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 3d

A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation | PNAS
www.pnas.org/doi/10.1073/...

A mouse model of MEPAN demonstrates a role for mitochondrial fatty acid synthesis in iron–sulfur cluster and supercomplex formation | PNAS

MEPAN (Mitochondrial Enoyl CoA Reductase Protein-Associated Neurodegeneration) is an early-onset movement disorder characterized by ataxia, dysarth...

www.pnas.org

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 3d

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 | Nature Communications
www.nature.com/articles/s41...

Cardiolipin dynamics promote membrane remodeling by mitochondrial OPA1 - Nature Communications

This study reveals how cardiolipin governs mitochondrial morphology by modulating the activity of human OPA1 and how its replacement by monolyso-cardiolipin, as observed in Barth syndrome, impacts mitochondrial membrane-shaping mechanisms.

www.nature.com

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Reposted by Catalina Vasilescu, PhD

RyanLab_TCD @ryanlab.bsky.social · 3d

📢Last weeks #immunometabolism discoveries @biomednews.bsky.social ⬇️⬇️⬇️

biomed.news/bims-imicid/...

Highlight:
Acetyl-CoA carboxylase-1 inhibition increases regulatory T-cell metabolism and graft-vs-host disease treatment efficacy via mitochondrial fusion

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 3d

#MitochondrialDisease papers from #week40! 📚 💚
biomed.news/bims-mitdis/...

@biomednews.bsky.social @gavinmcstay.bsky.social @mitoscientist.bsky.social

A few highlights below! 👇

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function
www.nature.com/articles/s42...

DDHD2 provides a flux of saturated fatty acids for neuronal energy and function - Nature Metabolism

Saber et al. show that the lipase DDHD2 provides endogenous saturated fatty acids to support fatty acid oxidation and energy production, proteostasis and membrane trafficking balance.

www.nature.com

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Reposted by Catalina Vasilescu, PhD

Korolchuk Lab @korolchuklab.bsky.social · 3d

#Autophagy and #mTOR papers from last week, enjoy thanks to @biomednews.bsky.social pre-selection engine. DM them if you want your own personalised feed.

biomed.news/bims-auttor/...

a woman in a red and white striped shirt is throwing papers into the air

ALT: a woman in a red and white striped shirt is throwing papers into the air

media.tenor.com

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Reposted by Catalina Vasilescu, PhD

Gabriele Zaffagnini @gzaffagnini.bsky.social · 3d

Happy Sunday egg-ficionados! Here come the latest papers on #oocyte cell biology:

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41027914/

Thanks @biomednews.bsky.social for preselecting! #cebooc

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Reposted by Catalina Vasilescu, PhD

Danielle Beckman @daniellebeckman.bsky.social · 5d

👻 "Dark Forest Within" 🧠
What if the brain is a creepy forest? Our neurons are the 🌲, old (as old as we are!), and without mobility. Suddenly, comes the microglia, our brain's immune cells. Everything lights up when they move around.
🟢microglia🟣neurons
#FluorescenceFriday 🎃

Confocal microscopy photo showing neurons and microglia

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Reposted by Catalina Vasilescu, PhD

Eric Chevet @ericchevet.bsky.social · 3d

This week's selection of articles and #preprints on #proteostasis thanks to @biomednews.bsky.social -- biomed.news/bims-proteo/...

Highlight: Translation landscape of stress granules www.science.org/doi/10.1126/...

bims-proteo 2025-10-05 papers

biomed.news

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Reposted by Catalina Vasilescu, PhD

Christian Frezza @frezzalab.bsky.social · 3d

Good Sunday, all. Here is a wonderful selection of papers in #cancermetabolism and #mitochondrialbiology ready for you! biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading

Without courage, wisdom bears no fruit. -Baltasar Gracián

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 4d

👉 Which of these lessons resonates most with you in your own work?

Catalina Vasilescu, PhD @cvasilescu.bsky.social · 4d

4️⃣ Technology evolves faster than funding cycles
Nucleic acid therapies, multi-omics, AI: the tools move fast. Funding and regulation struggle to keep pace.

5️⃣ Hope matters as much as science
Science provides possibilities. Hope keeps patients and researchers moving forward together.

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 4d

2️⃣ Patients drive urgency
Behind every dataset is a family waiting for answers. They remind us why timelines matter.

3️⃣ Small datasets, big challenges
Rare diseases often mean small cohorts - but that makes rigorous science and creative methods even more critical.

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 4d

5 Lessons from Studying Rare Genetic Disorders 🧬💡

Working in the field of rare diseases has taught me lessons that go far beyond the lab:

1️⃣ Collaboration is everything
Progress doesn’t happen in isolation. Scientists, clinicians, patients, and biotech teams must work together.

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 5d

Congratulations 🎊

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Reposted by Catalina Vasilescu, PhD

Carsten Schulte @carstenschulte4.bsky.social · 5d

Jane Goodall, one of my inspirations to study biology. What a big loss for humanity! RIP

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Reposted by Catalina Vasilescu, PhD

Fusion Conferences @fusionconf.bsky.social · 8d

@mitogene.bsky.social we are looking forward to your presentation at #MitoCellFate in Malta!
Please share this with your followers to let them know the Earlybird & Talk submission deadline is fast approaching - Monday 10 November.
Register & Submit here: bit.ly/46TS4Ii

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 6d

Good candidate for antisense oligo-based correction!

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Reposted by Catalina Vasilescu, PhD

Anna Clemens, PhD @annaclemens.com · 10d

Keeping a clear head space during the writing process can be a huge struggle.
Learn a repeatable structure that will help you stay focused (and give you confidence!) when writing papers.

Take a seat at this free training: https://annaclemens.com/training

#AcademicSky #PhDchat #Postdoc

Free writing training for researchers

Learn how to get published in high-ranking journals without lacking structure in the writing process

annaclemens.com

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 10d

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues | bioRxiv
www.biorxiv.org/content/10.1...

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues

High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...

www.biorxiv.org

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 10d

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function - Chen - Advanced Science - Wiley Online Library
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Mitochondria‐Localized Nestin Protects Mesenchymal Stem Cells from Senescence by Maintaining Cristae Structure and Function

Nestin localizes to the mitochondrial IMS through its MTS and the TOM20 import machinery. Within the mitochondria, Nestin interacts with Mic60 via its C-terminal Tail3 domain. Loss of mitochondrial N....

advanced.onlinelibrary.wiley.com

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Catalina Vasilescu, PhD @cvasilescu.bsky.social · 10d

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging | Nature Aging

www.nature.com/articles/s43...

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging - Nature Aging

Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential in C. elegans and mouse models.

www.nature.com

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