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Reposted by Michele Frison

Scott Soleimanpour @soleimanpourlab.bsky.social · 6h

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔

In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

www.science.org

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Michele Frison @frisophagy.bsky.social · 3d

In this week's mitophagy news 🪫🗑️

biomed.news/bims-tofagi/...

⚡The PP2A-B55α phosphatase is a master regulator of mitochondrial degradation and biogenesis⚡
-Mitochondrial ROS triggers mitophagy through activating the DNA damage response signaling pathway

Thanks to @biomednews.bsky.social

PP2A-B55α activates TFEB upon mitochondrial damage to support Parkin-dependent mitophagy.

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Reposted by Michele Frison

Mongabay @mongabay.com · 6d

Jane Goodall, who revealed the intimate lives of chimpanzees and gave the modern world a language of hope, has died at the age of 91.

“Every individual matters. Every individual has a role to play. Every individual makes a difference,” she told audiences. Those words remain her truest epitaph.

Jane Goodall (1934–2025): primatologist, conservationist, and messenger of hope

Jane Goodall, who revealed the intimate lives of chimpanzees and gave the modern world a language of hope, has died at the age of 91. Over the course of six decades, she moved from an unlikely young…

news.mongabay.com

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Michele Frison @frisophagy.bsky.social · 9d

That's fascinating! So much to learn from comparative studies

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Michele Frison @frisophagy.bsky.social · 9d

Lots of interesting papers in this week's mitophagy news! 🗑️🪫

biomed.news/bims-tofagi/...

-Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity
-Pink1 KO leads to APP-induced dopaminergic pathology
-An OMM-rupture sensor

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Reposted by Michele Frison

Anupam Patgiri @apatgiri.bsky.social · 24d

Replication competition drives the selective mtDNA inheritance in Drosophila ovary www.cell.com/cell-reports...

Replication competition drives the selective mtDNA inheritance in Drosophila ovary

Zhang et al. report a novel imaging method that can distinguish mtDNA variants with single-nucleotide polymorphisms at single-molecule resolution in situ. Using this method, they visualized dynamics o...

www.cell.com

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Michele Frison @frisophagy.bsky.social · 24d

In this week's issue of mitophagy news 🪫🗑️:

-Urolithin A increases healthspan via MERCS and Ca2+-mitophagy
-Parkin Induces Ubiquitination and Large Extracellular Vesicle Release of HMGB1 to Activate Antitumor Immunity
-a Parkin and hTau mouse cross

biomed.news/bims-tofagi/...

Urolithin A ameliorates the age-dependent decline of ER-mitochondria contacts and alters intracellular Ca2+ balance.

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Michele Frison @frisophagy.bsky.social · Sep 8

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations | Science www.science.org/doi/10.1126/...

Reversible compromise of physiological resilience by accumulation of heteroplasmic mtDNA mutations

Somatically acquired mitochondrial DNA mutations accumulate with age, but the mechanisms and consequences are poorly understood. Here we show that transient injuries induce a burst of persistent mtDNA...

www.science.org

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Reposted by Michele Frison

Nikita Kozhushko @nikitakozhushko.bsky.social · Sep 8

Celebrating Postdoc Research – National Postdoc Appreciation Week 2025!

#PostdocAppreciationWeek #PostdocResearch #CIMR #MBU #Cambridge #ResearchSeminar #ScienceCommunication #CambridgeUniversity

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Reposted by Michele Frison

The Hassan Brain Development Team @hassanbraindevlab.bsky.social · Sep 1

Latest from the lab, the beautiful work of Iryna Mohylyak and colleagues describing a temporal developmental transcriptional program for mitochondrial quality control and synaptic connectivity, with @jdejuan-sanz.bsky.social, Olga Corti and @steinaerts.bsky.social
labs
www.nature.com/articles/s41...

Temporal transcriptional regulation of mitochondrial morphology primes activity-dependent circuit connectivity - Nature Communications

This study investigates the developmental transcriptional regulation of mitochondrial quality control. Authors identify the Drosophila factor Mirana, homologous to mammalian TZAP, as a key temporal re...

www.nature.com

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Reposted by Michele Frison

Raywat Deonandan @deonandan.bsky.social · Sep 2

I love looking at this graph, showing it to my students, and sharing it on social media, even though it unerringly brings out the trolls.

This is the efficacy curve of Pfizer's mRNA COVID vaccine.

This, people, is what ended the emergency phase of the COVID pandemic. Despite what RFK Jr says.

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Michele Frison @frisophagy.bsky.social · Aug 30

Interesting data from macrophages

Anupam Patgiri @apatgiri.bsky.social · Aug 30

Evidence that mitochondria in macrophages are destroyed by microautophagy www.nature.com/articles/s41...

Evidence that mitochondria in macrophages are destroyed by microautophagy - Nature Communications

Mitophagy, the selective degradation of mitochondria, has been thought to occur via macroautophagy. Here, the authors present data indicating that microautophagy also mediates mitophagy in macrophages...

www.nature.com

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Reposted by Michele Frison

Current Biology @currentbiology.bsky.social · Aug 28

Feeling mitochondrially challenged lately?

Here are two classic reviews on #mitochondria that should help.

www.cell.com/current-biol...

www.cell.com/current-biol...

The Origin and Diversification of Mitochondria

Moving beyond the simplistic view of mitochondria as the power house of the cell, Roger et al. present the immense diversity of mitochondria and mitochondrial functions across eukaryotes, and bring th...

www.cell.com

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Michele Frison @frisophagy.bsky.social · Aug 17

In biomed.news/bims-tofagi/...

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

bims-tofagi 2025-08-10 papers

biomed.news

Michele Frison @frisophagy.bsky.social · Aug 17

In this week's issue of #mitophagy news:

-Mitochondrial damage (AntA) in neurons trigger degradation of negative autophagy regulators
-transcriptional dynamics of mitophagy during muscle development
-And much more 🪫🗑️

Link 👇
biomed.news/bims-tofagi/...

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Reposted by Michele Frison

Cambridge Clinical Mitochondrial Research Group @mitocamb.bsky.social · Aug 7

This is amazing news!! @camneurodept.bsky.social @mrc-mbu.bsky.social @jellevda.bsky.social @ritahorvath.bsky.social @mito-news.bsky.social

The Lily Foundation @lilyfoundation.bsky.social · Aug 7

📢 BREAKING NEWS!

The first ever treatment for a mitochondrial disease has been approved for use by NHS England! Idebenone is now available for LHON patients

A huge milestone for the mito community! 💥

www.thelilyfoundation.org.uk/news/first-e...

@mitocamb.bsky.social

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Reposted by Michele Frison

Jim Hurley @jimhurley.bsky.social · Jul 31

Congratulations @kev-in-situ-et.bsky.social and the whole team on in situ cryo-ET images of OA-induced mitochondria damage and Parkin-dependent mitophagy out now tinyurl.com/25b82cp4. We couldn't have done it without in situ guru @wilflinglab.bsky.social and mito guru @samlewis.bsky.social .‬

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Michele Frison @frisophagy.bsky.social · Aug 5

Last week's mitophagy news is packed with papers!! 📚🧑‍💻

Full list 👇
biomed.news/bims-tofagi/...

Highlights:
-in vitro reconstitution of receptor-mediated mitophagy reveals key principles
-cytosolic phosphoUbiquitin inhibits proteasomal activity and is neurotoxic

Thanks to @biomednews.bsky.social

Ubiquitin phosphorylation inhibits both ubiquitin chain elongation and ubiquitin proteasome interactions.

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Michele Frison @frisophagy.bsky.social · Jul 27

Cell type–specific purifying selection of synonymous mitochondrial DNA variation

www.pnas.org/doi/10.1073/...

Cell type–specific purifying selection of synonymous mitochondrial DNA variation | PNAS

While somatic variants are well-characterized drivers of tumor evolution, their influence on cellular fitness in nonmalignant contexts remains unde...

www.pnas.org

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Michele Frison @frisophagy.bsky.social · Jul 27

Below is the link to another week of #mitophagy papers! 🔋🗑️

biomed.news/bims-tofagi/...

Thanks to @biomednews.bsky.social for pre-sorting.

This week's highlight:
PNPLA7 is required for the Parkin-dependent mitophagy shut-down that leads to mitochondrial accumulation in adipose tissue browning

PNPLA7 is a MAM protein and interacts with Parkin to facilitate mitochondrial translocation of Parkin.

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Reposted by Michele Frison

Elias Adriaenssens @elias-adriaenssens.bsky.social · Jul 25

And it's out!

I'm thrilled to share our new paper (Adriaenssens et al., Nat Cell Biol 2025).

This paper describes a new mechanism for the initiation of autophagosome biogenesis.

We found that this WIPI-ATG13-driven pathway is preferentially used by a group of transmembrane autophagy receptors.

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Reposted by Michele Frison

Scott Soleimanpour @soleimanpourlab.bsky.social · Jul 21

Type 2 diabetes is often considered a protein misfolding disease. But where are these toxic proteins found? 🤔

🚨In new work out today in @natmetabolism.nature.com, we show that mitochondrial protein misfolding (yes mitos🤯) leads to beta cell damage in T2D. 🚨 nature.com/articles/s42... 1/n