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Reposted by Elias Adriaenssens

Scott Soleimanpour @soleimanpourlab.bsky.social · 8h

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔

In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n
www.science.org/doi/10.1126/...

TRAF6 integrates innate immune signals to regulate glucose homeostasis via Parkin-dependent and Parkin-independent mitophagy

TRAF6 bridges innate immune signaling to mitophagy to promote glucose control during metabolic stress.

www.science.org

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Reposted by Elias Adriaenssens

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12h

📣 New #publications from CRN Team Hurley!

➡️ Human transmembrane receptors initiate autophagosome biogenesis via ULK1 and WIPI–ATG13 complexes

🔗 bit.ly/47X259p

➡️ Neurons with pathogenic LRRK2 boost secretory autophagy and release exosomes for waste disposal and communication

🔗 bit.ly/45Mf1xx

NIX and BNIP3 initiate mitophagy through WIPI2 and WIPI3.

Compensatory release of exosomes and SLAM-EVs.

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Reposted by Elias Adriaenssens

Kenneth Ehses @denkenny.bsky.social · 13h

✨Excited that the main project of my PhD is now available as a pre-print on #bioRxiv

Here, we used #CryoET to visualise mitochondrial proteostatic stress and together with SPA #CryoEM shed light into the functional cycle of the Hsp60:10 chaperone system. #TeamTomo

🔗 www.biorxiv.org/content/10.1...

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Reposted by Elias Adriaenssens

Schuh Lab @schuhlab.bsky.social · 16h

How do oocytes prepare for life before life begins? 🧬
Our new review in Annual Review of Cell and Developmental Biology @annualreview explores how oocytes store proteins to support development and fertility. (1/5)
🔗 go.shr.lc/4o9hsk8

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Reposted by Elias Adriaenssens

Chris H. Hill @chillzaa.bsky.social · 1d

Enteroviruses cause over a billion infections each year, but the details of how their genomes capture host ribosomes have remained elusive. I'm pleased to share a new preprint from Miguel in our group, providing some new insights into this problem:
www.biorxiv.org/content/10.1...

Structural and mechanistic insights into translation initiation on the enterovirus Type 1 IRES

Enteroviruses are a widespread and diverse set of pathogens responsible for over ~1 billion human infections annually. Upon cell entry, translation of the virus genome is mediated by an internal ribos...

www.biorxiv.org

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Reposted by Elias Adriaenssens

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)

Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation

doi.org/10.1101/2025...

Fig. 1 – UBQLN2 is a conserved lysine-depleted protein. (A) Sequence comparison of
UBQLN2 orthologs in the indicated species. Intrinsically disordered regions in human
UBQLN2 based on MobiDB are shown as a blue bar. The domain organization based on the
SMART database is marked. Lysine residues are marked as black squares. (B) ESM-2
predictions of all possible single amino acid substitutions of human UBQLN2 presented as a
heat map. The wild-type residues are marked in blue. ESM-2 scores close to zero (light
yellow colors) indicate that the amino acid substitution is compatible with the ESM-2
language model, whereas negative scores (dark orange colors) indicate that the variant is
incompatible with the ESM-2 model. The domain organization (based on SMART) is aligned
above the map. Note that substitutions to lysine or cysteine in general appear detrimental, in
particular downstream of the UBL domain. (C) The AlphaFold2 predicted structured of
human UBQLN2 (AF-Q9UHD9-F1) (left panel). The UBL domain is colored blue, and the
UBA domain is colored orange and the STI1 regions green. Zoom in on the UBL domain
(right panel) with the lysine residues highlighted as stick representations and colored based
on the relative accessible surface area (rASA, dark red exposed; grey, buried).

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Reposted by Elias Adriaenssens

Maxim Tsenkov @mitsenkov.bsky.social · 1d

The latest #AlphaFold DB update is out!

We synchronised with UniProt release 2025_03, predicted protein isoforms across all species, and provide MSAs used to generate each prediction.

Proud of the team at the PDBe for the hard work that went into this. Grateful to play my part in it!

EMBL-EBI @ebi.embl.org · 1d

We’re renewing our collaboration with Google DeepMind!

We'll keep developing the AlphaFold Database to support protein science worldwide 🎉

To mark the moment we’ve synchronised the database with UniProtKB release 2025_03.

www.ebi.ac.uk/about/news/t...

🖥️🧬 #AlphaFold
@pdbeurope.bsky.social

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Reposted by Elias Adriaenssens

Kresten Lindorff-Larsen @lindorfflarsen.bsky.social · 1d

A good day to remember John Gurdon’s school report from his biology master at Eton

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Reposted by Elias Adriaenssens

Ryan Flynn @raflynn5.bsky.social · 1d

We’re excited to report work led by postdoc Jennifer Porat in the lab, finding that DNA accumulates on the surface of living cells and that the secreted extracellular protein DNASE1L3 can modulate its levels on B and T cells. With a new twist for ATAC-seq as well www.biorxiv.org/content/10.1...

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells

The extracellular space is a critical environment for discriminating self versus non-self nucleic acids and initiating the appropriate immune responses through signaling cascades to relay information ...

www.biorxiv.org

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Reposted by Elias Adriaenssens

Max Fels @mfels.bsky.social · 7d

Are viruses capable of regulating protein synthesis in the nuanced way of cellular organisms? Kinda! I’m excited to share some of my postdoc work that leveraged giant DNA viruses to address this question.

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

www.biorxiv.org

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Reposted by Elias Adriaenssens

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 2d

Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress https://www.biorxiv.org/content/10.1101/2025.10.06.680693v1

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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 2d

DNASE1L3 surveils mitochondrial DNA on the surface of distinct mammalian cells https://www.biorxiv.org/content/10.1101/2025.10.05.680464v1

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Reposted by Elias Adriaenssens

Briggs Group @briggsgroup.bsky.social · 2d

The mechanistic basis of cargo selection during Golgi maturation. From Rebecca Taylor, @katciazynska.bsky.social, @jggkaufman.bsky.social & @grigorytagiltsev.bsky.social at @mpibiochem.bsky.social with David Owen and Sean Munro's group @cellbiol-mrclmb.bsky.social | www.science.org/doi/10.1126/...

The mechanistic basis of cargo selection during Golgi maturation

Resident proteins of the Golgi recycle in vesicles and the protein GOLPH3 enables the COPI vesicle coat to accomplish this.

www.science.org

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Reposted by Elias Adriaenssens

The Daum Lab @daumlab.bsky.social · 2d

Out in Science Advances: Our #cryoEM structure of HFTV1, a virus infecting the halophile #archaea. *First full atomic structure (containing all structural proteins) of any tailed virus!* Congrats and thanks to all co-authors and our fantastic collaborators! www.science.org/doi/10.1126/...

Cryo-EM resolves the structure of the archaeal dsDNA virus HFTV1 from head to tail

This structure of an archaeal tailed virus (arTV) provides detailed insights into arTV assembly and infection mechanisms.

www.science.org

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Reposted by Elias Adriaenssens

Jonny Nixon-Abell @abelljonny.bsky.social · 2d

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...

Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome

Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...

www.biorxiv.org

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Reposted by Elias Adriaenssens

Karolinska Institutet @ki.se · 2d

The 2025 #NobelPrize in Physiology or Medicine has been awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their groundbreaking discoveries concerning peripheral immune tolerance that prevents the immune system from harming the body 🧪 www.nobelprize.org/prizes/medic...

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Reposted by Elias Adriaenssens

Rahul K @theresearch.bsky.social · 2d

Principles of cotranslational mitochondrial protein import

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Reposted by Elias Adriaenssens

dave dougan @douganlab.bsky.social · 3d

And now for something completely different in co-translational targeting: Molecular Cell www.cell.com/molecular-ce...

And now for something completely different in co-translational targeting

In two recent papers in Cell, Zhu et al. and Luo et al. use selective ribosome profiling to identify the substrates and timing of co-translational protein targeting to mitochondria. The results sugges...

www.cell.com

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Reposted by Elias Adriaenssens

qiangguo.bsky.social @qiangguo.bsky.social · 3d

What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...

Translation landscape of stress granules

Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

www.science.org

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Reposted by Elias Adriaenssens

Susan Shao @sshaolab.bsky.social · 5d

Beautiful reconstitution of amino acid stress-dependent ISR activation by my @harvardcellbio.bsky.social colleagues presenting a unifying mechanism for GCN2 activation, which requires ribosome collisions and is enhanced by cognate uncharged tRNA in the A site! www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Reposted by Elias Adriaenssens

Harvard Med Cell Biology @harvardcellbio.bsky.social · 6d

Historically, viruses were thought to primarily use host cell's translational machinery. New work from @harvardcellbio.bsky.social faculty Amy Lee reveals that a giant DNA virus encodes its own IF4F initiation complex, suggesting an unexpected evolutionary innovation. www.biorxiv.org/content/10.1...

Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life

In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...

www.biorxiv.org

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Reposted by Elias Adriaenssens

Glenn Masson @glennmasson.bsky.social · 6d

Ooohhh....GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling | Science www.science.org/doi/10.1126/...

GCN1 couples GCN2 to ribosomal state to initiate amino acid response pathway signaling

During nutrient deprivation, activation of the protein kinase GCN2 regulates cell survival and metabolic homeostasis. In addition to amino acid stress, GCN2 is activated by a variety of cellular stres...

www.science.org

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Reposted by Elias Adriaenssens

bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 6d

De novo design of RNA and nucleoprotein complexes https://www.biorxiv.org/content/10.1101/2025.10.01.679929v1

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Reposted by Elias Adriaenssens

Arne Elofsson @bioinfo.se · 6d

Elaborate machinery for inserting proteins into the outer membrane of bacteria www.nature.com/articles/d41...

Elaborate machinery for inserting proteins into the outer membrane of bacteria

Bacteria in the gut use an unusual molecular apparatus to insert complex proteins into their outer membrane.

www.nature.com

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Reposted by Elias Adriaenssens

Erin Doherty @erinedoherty.bsky.social · 7d

Now online at @nature.com we show how the Panoptes defense system protects against viruses that attempt immune evasion - and expands our understanding of the role of oligonucleotides in immunity.

Check out this work co-led with @benadler.bsky.social here:

www.nature.com/articles/s41...

A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature

Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.

www.nature.com

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