@qiangguo.bsky.social
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qiangguo.bsky.social
What's the role of stress granules in translation? Here we provide a clue: we characterized the distribution of ribosomal complexes within SGs and reproduced this landscape with a phase-field model, pointing to a new regulatory mechanism. #TEAMTOMO www.science.org/doi/10.1126/...
Translation landscape of stress granules
Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.
www.science.org
qiangguo.bsky.social
Wow, nice story~ This interaction is suprising for me~ Back 2018, after the HTT-HAP40 story, we screened a lot of interactiors of HTT, and none of them really stable enough for structural study. We should try these filamental structuctures as well😀
istaresearch.bsky.social
Cryo-ET visualization of HTT bound to F-actin, highlighted in the yellow square on the left.
On the right, a detailed zoom-in view of the molecular model of the HTT/F-actin complex is shown.
📷 © Florian Schur