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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's
@asapresearch.parkinsonsroadmap.org
1.2K followers 130 following 480 posts
Global initiative rooted in Collaboration and Open Science to accelerate Parkinson's disease research. Programs include GP2 and CRN. https://parkinsonsroadmap.org/#
parkinsonsroadmap.org
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 20h
📣 New #publications from CRN Team Hurley!

➡️ Human transmembrane receptors initiate autophagosome biogenesis via ULK1 and WIPI–ATG13 complexes

🔗 bit.ly/47X259p

➡️ Neurons with pathogenic LRRK2 boost secretory autophagy and release exosomes for waste disposal and communication

🔗 bit.ly/45Mf1xx
NIX and BNIP3 initiate mitophagy through WIPI2 and WIPI3. Compensatory release of exosomes and SLAM-EVs.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 1d
GP2 is at the International Congress of Parkinson’s Disease and Movement Disorders® this week in Hawai’i!

Visit booth 8 in Exhibit Hall I to meet the team, check out our poster presentations tomorrow (10/8), and learn more about our global research progress.

🔗 Schedule: bit.ly/48Sqr4J
Four GP2 (Global Parkinson’s Genetics Program) team members pose behind an outreach booth at a conference. Two people are seated at a table covered in a light blue GP2 tablecloth, while two stand behind them smiling. The booth displays two tall banners, one on the left reading “Democratizing data” with text describing GP2’s effort to collect and genotype 150,000+ diverse Parkinson’s disease samples globally, and one on the right reading “Open science, global collaboration” with text about GP2’s commitment to understanding Parkinson’s genetics and sharing data securely. The table holds flyers, GP2-branded pens, and white stress balls designed like brains. A laptop and small sign with a QR code sit to the left.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 2d
📣 Don't miss out on the upcoming mito911 #webinar featuring Karin Reinisch, PhD, from the Yale School of Medicine.

👇 Reserve your spot using the link below.

📅 October 20
⏰ 11:00 AM ET
RSVP: bit.ly/4gPqCjo
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 5d
GP2 is proud to be strongly represented at this year’s International Congress of Parkinson’s Disease and Movement Disorders®. Our global community will showcase 24 abstracts on innovation in #Parkinsons research and approaches.

In Hawai’i this week? Stop by and say hello!

@movedisorder.bsky.social
Graphic with a teal-to-green gradient background promoting GP2 at the 40th MDS Congress. At the top, large bold text reads: “Explore the latest from GP2 at the 40th MDS Congress.” Below, a blue box highlights the date: “Wednesday, October 8.” Underneath, a light blue panel lists names of presenters and groups in three columns: Column 1: Caroline Gabbert, Fulya Akçimen, GP2’s Data Analysis Working Group, Henry Mauricio Chaparro-Solano Column 2: Kajsa Atterling Brolin, Kamalini Ghosh Galvelis, Lara Lange, Manuela Tan, Maria Teresa Periñan, Miguel Martín-Bórnez Column 3: Mohamed H. Yousef, Naomi Louie, Paula Reyes-Pérez, Sara Bandres-Ciga, Spencer Grant
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 6d
GP2 joined Patrick Short, PhD, on #TheGeneticsPodcast to discuss their publication in @ajhgnews.bsky.social, noting the scientific importance of diversifying genetic representation in #ParkinsonsResearch and how GP2 empowers scientists worldwide to lead research locally 🧪

🎧 bit.ly/4mHbCFp
Screenshot from The Genetics Podcast featuring three speakers in a split-screen format. On the left, the person wearing a headset is Sonya Dumanis, PhD, Deputy Director of ASAP. In the center, Patrick Short, PhD, host of the podcast, is smiling with their hand resting near their chin. On the right, Andrew Singleton, PhD, GP2 Co-Lead, is smiling. Logos for The Genetics Podcast and Sano Genetics appear in the top corners.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 7d
New outputs from CRN Team De Camilli!

⬅️ Vps13a KO & Vps13c KO mice are viable, embryonic development of Vps13a/Vps13c DKO mice is arrested at midgestation. #publication 🔗 bit.ly/4nN1fkf

➡️ Local neuromodulation shapes a neuron's metabolic resilience. #preprint 🔗 bit.ly/3Kh9XJf
Experimental design for the analysis of erythropoiesis via FACS. Local glycogen storage levels in dopamine neurons are modulated by D2 auto-receptors.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 8d
👏 We’re recognizing Anne-Caroline Martel, PhD, & Damien Pittard, MSc (Team Wichmann), as this month’s Open Science Champions!

They shared an extensive dataset with DANDI in the NWB format & set up an Inscopix platform in their lab to streamline data sharing, advancing transparency in #OpenScience.
A headshot of Anne-Caroline Martel and Damien Pittard, on a light blue background with dark blue text reading “Anne-Caroline Martel, PhD" and "Damien Pittard, MSc" below the headshots, with "Team Wichmann" above each headshot in white text. The "Open Science Champion" badge and ASAP logo are also present.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 9d
📣 New CRN Team Vangheluwe #publications!

⬅️ They expressed GEM-SCOPe in differentiated astrocytes & neurons from a stem cell PRKN-knockout model of PD.
🔗 bit.ly/4lbSNtg

➡️ They compared iPSC-derived DANs from two sibling pairs where siblings both had GD, but only one developed PD.
🔗 bit.ly/4mgKIVc
Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockout. Genetically encoded and modular subcellular organelle probes reveal dysfunction in lysosomes and mitochondria driven by PRKN knockout.
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12d
Using cryo-ET, CRN Team Reck-Peterson showed that full-length LRRK2 can oligomerize on microtubules in its autoinhibited state. Both WT-LRRK2 and PD-linked LRRK2 mutants formed filaments on microtubules.

🔗 Read the full #preprint to learn more about their recent research: bit.ly/3VrVNaB
Cryo-ET structure of the microtubule-associated autoinhibited LRRK2^I2020T.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 12d
Thank you, Louis-Eric, for the suggestion!
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 13d
LARGE-PD is building the first large genetic and environmental dataset for Hispanic communities with #ParkinsonsDisease, spanning 14 countries and 37 sites. We are now recruiting in the U.S. through the Cleveland Clinic 🌎

🧪 Learn more: bit.ly/3HSpLRR

#HispanicHeritageMonth
A group photo of people smiling and posing outside a modern building. There is also a green to purple gradient frame, including the ASAP logo.
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 14d
In GP2’s latest blog, Dr. Cholpon Shambetova shows how supporting local scientists through training and fostering trust through collaboration and relationship-building has advanced #ParkinsonsDisease research in Kyrgyzstan.

🔗 Learn more: bit.ly/4mpezub
A large group photo of people smiling and posing in front of a screen featuring the GP2 logo. They are around a long wooden table, covered in laptops, and surrounded by office chairs. A photo of someone presenting to a group of people at individual desks with laptops. A group photo of people smiling around two side-by-side tables. The GP2 logo is being presented on a screen behind them. A small group of people sitting around someone sitting and two people standing next to them. They are all wearing lanyards.
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 15d
The NIH is exploring how to improve access to research and manage publishing costs. We shared a response grounded in #OpenScience.

We recommend:
🔹 Requiring preprints
🔹 Funding preprint infrastructure
🔹 Supporting services that add real value to research

🧪 Read ASAP's full response: bit.ly/467PdME
A white background with a colorful frame. In the center of the graphic, black text reads, “Strengthening Open Science" with a laptop black-and-white icon to the left of the text. The ASAP logo is in the bottom right corner.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 16d
CRN Team Vangheluwe studied ATP10B, a lipid flippase in late endosomes and lysosomes, and its role in #ParkinsonsDisease. They found that depleting ATP10B negatively affects the viability of dopaminergic neurons both in vivo and in vitro.

🔗 Read the full #publication: bit.ly/46wH9nI
ATP10B KO results in a decreased number of dopaminergic neurons in human iPSC-derived midbrain culture.
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 19d
As #OpenScienceWeek wraps up, we thank our partners and community for advancing a culture of collaboration and transparency.

Open Science helps ensure that shared resources and data accelerate progress toward understanding and treating #Parkinsons.

Resources ➡️ bit.ly/41NxZSa
A white background with a colorful frame. In the center of the graphic, black and blue text reads, “Thank you for celebrating Open Science Week with ASAP." The ASAP logo and two "Open Science stars" are also present.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 20d
🧑‍🔬🧪 For early-career scientists, Open Science means opportunity.

As #OpenScienceWeek continues, Naman Vatsa, PhD (@namanvatsa.bsky.social) of CRN Team Biederer, shares how open datasets and training programs empower the next generation of #Parkinsons researchers ⬇️

#ScienceForAll
A blue to green gradient graphic exploring how Open Science is shaping the future of Parkinson’s disease research. It features a quote from Naman Vatsa, PhD (CRN Team Biederer), highlighting how Open Science accelerates speed and connectivity through open datasets, shared repositories, and preprints. He shares that open data and cross-team discussions have personally sparked new research directions. A headshot of Vatsa, the ASAP logo, and an Open Science Star are also present. A blue to green gradient graphic highlighting Open Science’s role in advancing equity and accessibility in Parkinson’s disease research. It features a quote from Naman Vatsa, PhD (CRN Team Biederer), describing how Open Science lowers barriers for early-career scientists. Vatsa emphasizes the value of programs like the CRN fellowship, which support postdocs in leading projects, expanding skills, and building networks beyond a single lab or institution. A headshot of Vatsa, the ASAP logo, and an Open Science Star are also present.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 21d
Global challenges require global solutions 🧪

For today’s #OpenScienceWeek feature, Bishal Basak, PhD of CRN Team Hurley, discusses how initiatives and programs like GP2, PPMI, and AMP PD are advancing #Parkinsons research through shared data and collaboration ⬇️

#ScienceForAll
A blue graphic focused on Open Science’s impact in accelerating Parkinson’s disease research. It features a quote from Bishal Basak, PhD (CRN Team Hurley), highlighting how global collaboration and shared resources, like biospecimens, genetic and clinical data from MJFF’s PPMI and AMP PD, advance biomarker and therapy discovery. A headshot of Basak, the ASAP logo, and an Open Science Star are also present. A blue graphic showcasing a quote about Open Science’s role in equity and accessibility in Parkinson’s disease research. The graphic includes a quote from Bishal Basak, PhD (CRN Team Hurley), emphasizing how Open Science expands access for researchers and institutions regardless of resources, reduces duplication, and fosters global collaboration. The quote also highlights GP2's open genetic data sharing. A headshot of Basak, the ASAP logo, and an Open Science Star are also present.
asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 22d
How does rapid, transparent sharing accelerate #Parkinsons research? 🧪

Kicking off our #OpenScienceWeek highlights, Cole Sitron, PhD (@pelletfraction.bsky.social) of CRN Team Harper, explains how Open Science lays the foundation for faster, more equitable discovery ⬇️

#ScienceForAll
A purple to blue gradient graphic highlighting Open Science’s role in promoting equity and accessibility in Parkinson’s disease research. It features a quote from Cole Sitron, PhD (CRN Team Harper), emphasizing that Open Science encourages a collaborative approach leading to faster discoveries. A headshot of Sitron, the ASAP logo, and an Open Science Star are also present. A purple to blue gradient graphic about Open Science’s role in Parkinson’s disease research that includes a quote from researcher Cole Sitron, PhD (CRN Team Harper), emphasizing the importance of open access to data to further discoveries. A headshot of Sitron, the ASAP logo, and an Open Science Star are also present.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 23d
ASAP is celebrating #OpenScienceWeek!

Open Science drives stronger collaboration, better accessibility, and faster discovery in #Parkinsons research.

All week, we’ll highlight voices from the ASAP network on how they put open science into practice.

👉 Follow along for updates!
A white background with a colorful frame. In the center of the graphic, black text reads, “ASAP celebrates Open Science Week." The ASAP logo and two "Open Science stars" are also present.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 26d
This month’s Discover ASAP episode features @danacobblewis.bsky.social talking with Miguel Gonzalez-Lozano, PhD, about EndoMap, a new open-access tool mapping the endosomal system in #Parkinsons 🗺️ 🧪

🔗 Learn how this resource accelerates discovery and supports drug development: bit.ly/4njfGfM
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 27d
🧠📈 We are excited to welcome Alain Dagher, MD, PhD, from McGill University, as the September LRRK2 #webinar speaker.

👇 Reserve your spot using the link below.

📅 September 25
⏰ 1:00 PM ET
RSVP: bit.ly/3K1efUO
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 28d
Last week, the ASAP team shared our commitment to #OpenScience at the 10th International Congress on Peer Review and Scientific Publication. The session highlighted how funders can expand the sharing of data, code, protocols, and materials. #PRC10

@peerreviewcongress.bsky.social

🔗 bit.ly/4ngFl8S
Robert Thibault, PhD, speaks at a podium on a conference stage with dark blue curtains during the “Open Science and Data Sharing” session at the 10th International Congress on Peer Review and Scientific Publication. A colleague sits at a table as a large slide with the ASAP logo shows his talk title, “A Funder-Led Intervention to Increase the Sharing of Data, Code, Protocols, and Key Laboratory Materials.”
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · 29d
🧪 Calling PD cohort leads: Help map immune-focused PD cohorts.

Your responses will shape funding, enable collaboration, and inform the immune biomarker strategy.

Eligible cohorts include PD/at-risk participants who have immune data/samples.

🗓️ Survey closes September 17
👉 Take: bit.ly/3JR1fkN
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Sep 8
CRN Team Edwards investigated changes in cholinergic modulation of striatal direct pathway medium spiny neurons (dMSNs) in mice with partial or complete dopamine (DA) depletion, modeling early and advanced stages of #ParkinsonsDisease (PD).

🔗 Check out the full #publication: bit.ly/4ngU5Vu
Reductions in M4-signaling are more sensitive to the extent of DA loss in the DLS than in the DMS.
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asapresearch.parkinsonsroadmap.org
Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Sep 5
CRN Team Liddle used STC-1 enteroendocrine cells to evaluate how deltamethrin, a common pyrethroid, affects EEC function and found that deltamethrin alters serotonergic pathway expression and inhibits adrenergic-induced EEC hormone release.

🔗 Check out the full #publication: bit.ly/45Me7zP
A white background with a colorful frame. In the center of the graphic, black text reads, “New publication from Team Liddle." The ASAP logo is in the bottom right corner.