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Reposted by Joe Chambers

Jonny Nixon-Abell @abelljonny.bsky.social · 2d

I may be a little biased here but I think this is SUCH a cool story….a new HCN1-focussed mechanism in Dravet syndrome (infant epilepsy). Helps to explain why current treatments haven’t worked and offers a novel genuinely druggable target.Awesome 🤩🤩🤩
www.biorxiv.org/content/10.1...

Increased HCN1 activity in human excitatory neurons drives excessive network bursting in Dravet syndrome

Dravet syndrome (DS) is a severe childhood epilepsy caused by mutations of the sodium channel NaV1.1. These mutations are thought to compromise the ability of inhibitory interneurons to regulate netwo...

www.biorxiv.org

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Joe Chambers @joechambers.bsky.social · Aug 13

Such elegant work, as ever!

MolinariLab-ER @molinarilab-er.bsky.social · Aug 4

Selective autophagy of organelles: the “disorder” is key. Intrinsically disordered regions of organellophagy receptors are interchangeable, required, and sufficient for organelle fragmentation and lysosomal delivery … and all about ORGATACs 😉
rdcu.be/ey8iL

The intrinsically disordered regions of organellophagy receptors are interchangeable and control organelle fragmentation, ER-phagy and mitophagy flux

Nature Cell Biology - Rudinskiy et al. examine organellophagy receptor features, finding modules of functionally conserved intrinsically disordered regions and defining shared features despite...

rdcu.be

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Reposted by Joe Chambers

Katie Downes @dr-downes.bsky.social · Jul 30

Very excited to announce that my first, first author paper, is now on BioRxiv! In this paper we unambiguously show #COPII coated vesicles in unperturbed human cells for the very first time!!

Make my day and check it out!
www.biorxiv.org/content/10.1...

#Cryo-ET #TeamTomo #Cryo-CLEM ❄️🔬❄️🔬❄️🔬❄️🔬

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Reposted by Joe Chambers

Jenny Dickens @jennydickens41.bsky.social · Jul 22

New preprint alert! Endogenous gene editing of alveolar organoids to investigate mechanisms of epithelial dysfunction in familial ILD. Kudos first author @eimearrutherford.bsky.social and thanks @thecimr.bsky.social @labrawlins.bsky.social @profmarciniak.bsky.social
www.biorxiv.org/content/10.1...

Endogenous gene editing of alveolar organoids reveals that expression of pathogenic variant SFTPC-I73T disrupts endosomal function, epithelial polarity and wound healing

Background: Idiopathic pulmonary fibrosis is a fatal lung disease of progressive lung parenchymal scarring caused by the aberrant response of an alveolar epithelium repeatedly exposed to injury. Under...

www.biorxiv.org

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Reposted by Joe Chambers

Alexandre Dumoulin @axonsalex.bsky.social · Jul 16

Thrilled to collaborate with @zhixingchen2.bsky.social Lab @pku1898.bsky.social !
We tested new PK Mem dyes—gentle, photostable tools to label the plasma membrane in live neurons, making it easier to track growth cone motility & axonal transport. #liveimaging #neuroscience
tiny.cc/3qhp001

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Joe Chambers @joechambers.bsky.social · Jun 24

Great opportunity!

Derivery Lab - MRC LMB @deriverylab.bsky.social · Jun 23

🚨 JOB ALERT 🚨
We're hiring a Research Assistant – no PhD needed!
Join us to explore the molecular mechanisms of receptor sorting in endosomes.
Experience in protein expression/purification, cloning & cell culture desired 🧫🔬
Apply now 👉 www.nature.com/naturecareer...

#STEMCareers #ResearchJobs

A picture of 3 rows of people on steps at the MRC LMB. From left to right - top row: Akaash, Vic, Lara - Middle row: Kerrie, Manu, Paddy - bottom row: Meg and Julie

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Joe Chambers @joechambers.bsky.social · Jun 11

Fantastic stuff by Sam and team!
3D tracking of individual proteins inside intracellular compartments. An amazing innovation towards understanding cellular environments.

Sam Daly @samofmidworld.bsky.social · Jun 10

Excited to share some recent work tracking the 3D movement of individual molecules inside the organelles of living cells (💡+ 🦠 + ⚽️💨) with the best team @joechambers.bsky.social
@jamesdmanton.bsky.social
@jsbeckwith.bsky.social @dgershlick.bsky.social @stevethechemist.bsky.social

bioRxiv Biophysics @biorxiv-biophys.bsky.social · Jun 10

Volumetric single-molecule tracking inside subcellular structures https://www.biorxiv.org/content/10.1101/2025.06.09.658280v1

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Reposted by Joe Chambers

Mann Lab @mannlab.bsky.social · Apr 16

Our paper is out in Nature today! We use Deep Visual Proteomics (DVP) to dissect α1-antitrypsin deficiency (AATD) in human liver at single-cell resolution.
Let us take a tour through proteotoxic stress in intact human tissue — one hepatocyte at a time.
www.nature.com/articles/s41...

Deep Visual Proteomics maps proteotoxicity in a genetic liver disease - Nature

High-resolution spatial proteomics were used to map molecular events during hepatocyte stress in pseudotime across all fibrosis stages, recapitulating known disease progression markers and revealing e...

www.nature.com

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Reposted by Joe Chambers

Falk Schneider @faldalf.bsky.social · Apr 22

#newPI and time is running.

It has already been a month since I officially joined the University of Warwick as Assistant Professor. I am excited to announce and build the Fluorescence and Membrane Dynamics (FMD) Lab:

warwick.ac.uk/fac/sci/med/...

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Reposted by Joe Chambers

Stefan Marciniak @profmarciniak.bsky.social · Mar 28

Well done Jessy @jessyzhu-jiayi.bsky.social who gave her #biologists100 flash talk today about her new GCN2 activators

@biologists.bsky.social
@thecimr.bsky.social

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Joe Chambers @joechambers.bsky.social · Mar 27

Fantastic Skytorial!

Natalia Brzozowska @nataliabrzozowska.bsky.social · Mar 12

Excited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12]

www.nature.com/articles/s41...

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics

The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

www.nature.com

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Joe Chambers @joechambers.bsky.social · Mar 27

Congratulations @lily-wu.bsky.social for winning a poster prize at the @biologists.bsky.social #biologists100 conference! What a superstar!
@thecimr.bsky.social @profmarciniak.bsky.social @matthoare20.bsky.social

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Joe Chambers @joechambers.bsky.social · Mar 25

Great to see this published! Congrats on a really beautiful paper!

Jonny Nixon-Abell @abelljonny.bsky.social · Mar 24

😊 Very happy to see this out! A real group effort from the Hyslop lab (@thecimr.bsky.social) including brilliant collaborations with
@knowleslab.bsky.social,
Vendruscolo lab, @michael-e-ward.bsky.social lab,
@deriverylab.bsky.social lab,
@profmarciniak.bsky.social lab
🎉🎉🎉

ANXA11 biomolecular condensates facilitate protein-lipid phase coupling on lysosomal membranes - Nature Communications

Nixon-Abell et al. show that ANXA11 condensation on lysosomal membranes causes a coupled phase transition of the underlying lipids and mechanical stiffening of the overall ensemble involved in RNP gra...

www.nature.com

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Reposted by Joe Chambers

Alison Forrester @aforrester.bsky.social · Feb 23

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

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Reposted by Joe Chambers

Alison Forrester @aforrester.bsky.social · Mar 20

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

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Joe Chambers @joechambers.bsky.social · Mar 21

Fantastic conference! Thanks so much to you and @fenech-lab.bsky.social for bringing us all together! What a great community.

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Joe Chambers @joechambers.bsky.social · Mar 10

Special congratulations to the first and second authors, Natalia Brzozowska and Lily Wu!

Thanks to The MRC @ukri.org, CRUK, @wellcometrust.bsky.social, and @alpha1foundation.bsky.social for funding

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Joe Chambers @joechambers.bsky.social · Mar 10

Delighted to share our latest paper on alpha-1-antitrypsin deficiency, in @naturegenet.bsky.social.

A fun collaboration between groups of @matthoare20.bsky.social, @profmarciniak.bsky.social, and Peter Campbell.

@thecimr.bsky.social ky.social, @sangerinstitute.bsky.social, Early Cancer Institute

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics

The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

www.nature.com

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Reposted by Joe Chambers

Miguel Mestre @miguelcmestre.bsky.social · Feb 13

We present:

Direct-view oblique plane microscopy

www.biorxiv.org/content/10.1...

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Joe Chambers @joechambers.bsky.social · Jan 30

Amazing Conference Alert!!
Registration is now open for EUROSERPIN2025. Come and join us in beautiful Brescia, Italy, this May to get excited about the wonderful world of serpin proteins!
Visit euroserpin.eu to sign up. Early-bird rates offered until February 28th.

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Reposted by Joe Chambers

Jenny Dickens @jennydickens41.bsky.social · Jan 15

Great to see this collaborative effort out! Check out our new alveolar organoid model, ripe for studying disease mechanisms including those involving surfactant proteins:

www.embopress.org/doi/full/10....

Front cover image to follow soon!

@eimearrutherford.bsky.social @profmarciniak.bsky.social

A novel human fetal lung-derived alveolar organoid model reveals mechanisms of surfactant protein C maturation relevant to interstitial lung disease | The EMBO Journal

imageimageDisorders of surfactant protein biology cause dysfunction of alveolar type 2 cells and can lead to interstitial lung disease. This study describes the development of genetically manipulable, mature human fetal-derived alveolar type 2 ...

www.embopress.org

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Joe Chambers @joechambers.bsky.social · Jan 15

Thanks!

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Joe Chambers @joechambers.bsky.social · Jan 14

Great list. I would love to join, if there's still space please!

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Reposted by Joe Chambers

Sophie Trefely @trefelylab.bsky.social · Jan 8

We have a postdoc opportunity at the interface of metabolism and epigenetics! 🔥🧬

The project will investigate novel metabolic factors driving diabetic cardiomyopathy🫀, and test targeted dietary interventions 🍽️

For more detail and to apply:
babrahaminstitute.livevacancies.co.uk#/job/details...

hireful.

babrahaminstitute.livevacancies.co.uk

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Reposted by Joe Chambers

Janet Kumita @jrkumita.bsky.social · Jan 7

‼️Deadline 16th January 2025‼️Applications are open for the 2025 Experience Postgrad Life Sciences programme. Paid 8-week summer internships aimed to enhance diversity among life scientists of the future!! @cambridgebiosci.bsky.social @corpuscambridge.bsky.social www.exppg.lifesci.cam.ac.uk

Experience Postgrad Life Sciences | Enhancing diversity among life scientists of the future

www.exppg.lifesci.cam.ac.uk

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