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Alison Forrester @aforrester.bsky.social · 8d

I'm very happy to have been involved in this roadmap. Thank you all for the fantastic discussions, I hope that it initiates many more!

Ishier Raote @ishier.bsky.social · 8d

ER exit sites are dynamic ER subdomains that integrate signals, reshape membranes and steer secretion. Twelve groups in the field came together to map their diversity, regulation, unanswered questions and future directions.
www.nature.com/articles/s41...

Towards a unified framework for the function of endoplasmic reticulum exit sites - Nature Reviews Molecular Cell Biology

Endoplasmic reticulum exit sites (ERES) are specialized ER subdomains that regulate the export of secreted cargo. This Roadmap explores how ERES integrate biochemical and mechanical signals to coordinate trafficking and proposes a multidisciplinary strategy to investigate their function, including in disease.

www.nature.com

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Alison Forrester @aforrester.bsky.social · Jun 18

Dear all, I have coined a phrase:
To A.Iron
Definition: To polish text using AI

@academic-chatter.bsky.social

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Alison Forrester @aforrester.bsky.social · May 15

Im not going to be sharing my photos of our glorious day on Ile de Batz….. maybe of the dinner later?? 😉😉

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Reposted by Alison Forrester

Parkinson's Foundation Research @pfresearchteam.bsky.social · Apr 22

📄Shoutout to our 2019 Research Center awardees at Yale (@pdc-lab.bsky.social, @shawnferguson.bsky.social) for their new publication on the bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage:
www.nature.com/articles/s41...

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage - Nature Cell Biology

Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal damage.

www.nature.com

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Reposted by Alison Forrester

Itai Yanai @itaiyanai.bsky.social · Apr 22

For clear thinking, cultivate passionate indifference. Buddhists call it non-attachment. We all have hopes, desires and ambitions. Non-attachment means acknowledging them, accepting them, and then not inserting them into a process that has nothing to do with you. podcasts.apple.com/us/podcast/n...

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Reposted by Alison Forrester

PSL-Qlife @pslqlife.bsky.social · Apr 22

Congrats to the Johannes lab! 👏 E MacDonald, @aforrester.bsky.social @cessvala.bsky.social E Dransart, A Akhil Shp, L Leconte, V Chambon, D Ghosh, A Pinet, D Bhatia, B Lombard, D Loew, MShafaq-Zadah, @christianwunder.bsky.social
@institutcurie.bsky.social
pubmed.ncbi.nlm.nih.gov/39984654/

Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis - PubMed

Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynam...

pubmed.ncbi.nlm.nih.gov

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Reposted by Alison Forrester

Hannah Long @hannahlong.bsky.social · Mar 20

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

Postdoctoral Researcher

Our research is focused on understanding how genetic changes in the non-coding genome can impact gene regulatory mechanisms, alter developmental processes and ultimately affect human craniofacial shap...

elxw.fa.em3.oraclecloud.com

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Alison Forrester @aforrester.bsky.social · Mar 20

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

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Alison Forrester @aforrester.bsky.social · Mar 20

Thank you for the commentary Ishier! It's been great having everyone here!

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Reposted by Alison Forrester

Ishier Raote @ishier.bsky.social · Mar 4

A terrific perspective from Vivek Malhotra @naturecomms.bsky.social on the fundamental importance of pathways and mechanisms by which cells secrete proteins, ensuring their delivery in the correct quantities and at the appropriate times.
Interesting section on unanswered questions.

rdcu.be/ecb2B

The pathways of secretory cargo export at the endoplasmic reticulum

Nature Communications - The author presents an overview of the complex challenge of protein export from the Endoplasmic Reticulum, and discusses how cells may deploy novel pathways utilizing...

rdcu.be

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Reposted by Alison Forrester

Eric Chevet @ericchevet.bsky.social · Feb 26

journals.biologists.com/jcs/article/...

The importance of delivering Recherche d'Avenir – research for the future

In recent years, several European countries, including France, have reduced their investment in scientific research, with biomedical research taking a significant hit. The primary casualty is basic re...

journals.biologists.com

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Reposted by Alison Forrester

Jim Hurley @jimhurley.bsky.social · Feb 24

Lab manager position open. Does the idea of helping a busy structural cell biology and biochemistry-based drug discovery lab stave off chaos appeal to you? Apply now at tinyurl.com/4dsvpwbw

An error has occurred.

tinyurl.com

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Reposted by Alison Forrester

Rebecca Mosher @rm0sher.bsky.social · Feb 21

Just a week left to apply for this postdoc position in my lab in Oxford.

Rebecca Mosher @rm0sher.bsky.social · Jan 22

I'm happy to announce a postdoctoral position is available in my lab. We have lots of great data to analyze with respect to transposons & epigenetics and cool biological questions to answer.
Please reskeet and share.

Joining | The Mosher Lab

www.mosherlab.com

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Reposted by Alison Forrester

Christian Wunder @ Curie Institute @christianwunder.bsky.social · Feb 22

... and soon the structural glycoswitch: www.biorxiv.org/content/10.1...

Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate

Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N...

www.biorxiv.org

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Alison Forrester @aforrester.bsky.social · Feb 23

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

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Reposted by Alison Forrester

ewanmacdonald.bsky.social @ewanmacdonald.bsky.social · Jan 29

I'm happy to share our review latest review on flotillins! We discuss the recent insights into the structure of these interesting proteins from cyro-EM studies.
doi.org/10.1111/boc....

Flotillins in membrane trafficking and physiopathology

Flotillin 1 and 2 scaffold sphingolipid-rich membrane microdomains involved in endocytosis and endolysosome maturation through the generation of sphingosine 1-phosphate (S1P) by sphingosine kinase 2...

doi.org

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Alison Forrester @aforrester.bsky.social · Feb 19

Going Green at the Department of Biology and Faculty of Medicine at the University of Namur! We've worked on it for a year, now it's time to go big 😁💚🔬 The initiative seems to be making some waves and it's great to see som much enthusiasm! @fsilvestrelab.bsky.social #sustainability #GreenLab

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Reposted by Alison Forrester

Luciano A. Masullo @lumasullo.bsky.social · Feb 10

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬

The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy

www.biorxiv.org/content/10.1...

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Reposted by Alison Forrester

Club Exo Endo @clubexo-endo.bsky.social · Feb 6

Inscriptions for the 27th annual meeting of the Club Exo-Endo are opened. Please register on exoendo.org !!

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Reposted by Alison Forrester

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Feb 6

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime

www.nature.com/articles/s41...

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods

Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

www.nature.com

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Reposted by Alison Forrester

André Nadler @nadlerlab.bsky.social · Jan 31

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...

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Reposted by Alison Forrester

Fran Bottanelli @franbottanelli.bsky.social · Feb 3

Our plasmids for editing are now on @addgene.bsky.social! www.addgene.org/Francesca_Bo... I promise you a detailed protocol on how to use them is coming very very soon! Currently proofreading :)

Addgene: Francesca Bottanelli Lab Materials

www.addgene.org

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Reposted by Alison Forrester

Jim Hurley @jimhurley.bsky.social · Feb 6

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

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Reposted by Alison Forrester

Club Exo Endo @clubexo-endo.bsky.social · Feb 6

We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !

Club Exo Endo - Exocytose Endocytose

Le Club Exocytose-Endocytose est une association à but non lucratif, sans financement ni cotisation. Il rassemble près de 340 chercheurs, enseignants ou étudiants travaillant dans des domaines variés ...

exoendo.org

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Reposted by Alison Forrester

Felix Campelo @felixmendu.bsky.social · Jan 27

The #MembraneTrafficking seminar series is back this Thursday, and we are very happy to start the 2025 season with two talks by early career scientists: Adam Krahn from the Glick Lab at University of Chicago and @jkefauver.bsky.social at CINN-CSIC, Spain.

MEMBRANE TRAFFICKING | Membrane Trafficking

felixcampelo.wixsite.com

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