PSL-Qlife
@pslqlife.bsky.social
100 followers
110 following
30 posts
🔬Institut Convergences PSL-Qlife is dedicated to research and innovation in quantitative biology, gathering 160+ teams from 8 research institutes in Paris!
© Image credit @memilieterret.bsky.social & @mhverlhac.bsky.social lab
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PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Mechanical strengthening of cell-cell adhesion during mouse embryo compaction
Compaction is the first morphogenetic movement of the eutherian mammals and involves
a developmentally regulated adhesion process. Previous studies investigated cellular
and mechanical aspects of comp...
www.cell.com
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Electroluminescence and energy transfer mediated by hyperbolic polaritons - PubMed
Under high electrical current, some materials can emit electromagnetic radiation beyond incandescence. This phenomenon, referred to as electroluminescence, leads to the efficient emission of visible p...
pubmed.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Pervasive formation of double-stranded RNAs by overlapping sense/antisense transcripts in budding yeast mitosis and meiosis - PubMed
Previous RNA profiling studies revealed coexpression of overlapping sense/antisense (s/a) transcripts in pro- and eukaryotic organisms. Functional analyses in yeast have shown that certain s/a mRNA/mR...
pubmed.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
A tunable and versatile chemogenetic near-infrared fluorescent reporter
Near-infrared (NIR) fluorescent reporters open interesting perspectives for multiplexed imaging with higher contrast and depth using less toxic light. Here, we propose nirFAST, a small (14 kDa) chemog...
pmc.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Decoupling shear stress and pressure effects in the biomechanics of autosomal dominant polycystic kidney disease using a perfused kidney-on-chip
Kidney tubular cells are submitted to two distinct mechanical forces generated by the urine flow: shear stress and hydrostatic pressure. In addition, …
www.sciencedirect.com
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Breast tumors from ATM pathogenic variant carriers display a specific genome-wide DNA methylation profile - Breast Cancer Research
Background The ataxia-telangiectasia mutated (ATM) kinase phosphorylates and activates several downstream targets that are essential for DNA damage repair, cell cycle inhibition and apoptosis. Germlin...
breast-cancer-research.biomedcentral.com
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Pennate diatoms make non-photochemical quenching as simple as possible but not simpler
Studies of marine microalgal photosynthesis are heavily moulded on legacy research from organisms like Arabidopsis and Chlamydomonas, despite the differences between primary and secondary endosymbiont...
pmc.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
MMnc: multi-modal interpretable representation for non-coding RNA classification and class annotation
As the biological roles and disease implications of non-coding RNAs continue to emerge, the need to thoroughly characterize previously unexplored non-coding RNAs becomes increasingly urgent. These mol...
pmc.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Combining Two Mechanistically Distinct Reactions from a Single Iron Complex: A Tandem Approach to Thermally Stable and Recyclable Polymers
An iron-based catalytic system can act as an efficient and selective tandem catalyst for the production of poly(silylether)s, followed by the ring-opening polymerization of lactide, providing direct ...
onlinelibrary.wiley.com
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Parasitic plasmids are anchored to inactive regions of eukaryotic chromosomes through a nucleosome signal | The EMBO Journal
imageimageThe naturally occurring S. cerevisiae 2µ plasmid is one of few documented cases of eukaryotic plasmids, undergoing equal
distribution between mother and daughter cells during mitosis. Using ...
www.embopress.org
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Uracil processing by SMUG1 in the absence of UNG triggers homologous recombination and selectively kills BRCA1/2-deficient tumors
Musiani et al. demonstrated that in the absence of UNG, uracil excision by SMUG1 induces
replication stress, evidenced by its impact on replication fork progression, accumulation
of single-strand brea...
www.cell.com
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Kinetic Redox Shotgun Proteomics Reveals Specific Lipopolysaccharide Effects on Intestinal Epithelial Cells, Mitigated by a Mn Superoxide Dismutase Mimic
Proteomics and redoxomics are efficient to quantify the effects of bacterial lipopolysaccharide in intestinal epithelial cells (HT29) at the proteome and at the Cys-redoxome levels. Oxidative stress ....
onlinelibrary.wiley.com
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Adaptable Range-Separated Hybrids for the Description of Excited States: Tuning the Range Separation Parameter on Effective Charge Transfer Distance - PubMed
In this contribution, we describe a novel approach, rooted in the time-dependent density functional theory, enabling to adapt range-separated hybrids (RSHs) to correctly describe excited states (ESs) ...
pubmed.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis - PubMed
Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynam...
pubmed.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Negative global-scale association between genetic diversity and speciation rates in mammals
Genetic diversity is critical for species evolution and their adaptability to global changes, while speciation rate is critical for explaining large-scale patterns of species richness. Exploring corre...
pmc.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
A single microfluidic device for multi-omics analysis sample preparation - PubMed
Combining different "omics" approaches, such as genomics and proteomics, is necessary to generate a detailed and complete insight into microbiome comprehension. Proper sample collection and processing and accurate analytical methods are crucial in generating reliable data. We previously developed th …
pubmed.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Unravelling single-cell DNA replication timing dynamics using machine learning reveals heterogeneity in cancer progression
Genomic heterogeneity has largely been overlooked in single-cell replication timing (scRT) studies. Here, we develop MnM, an efficient machine learning-based tool that allows disentangling scRT profil...
pmc.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22
Sequence-dependent activity and compartmentalization of foreign DNA in a eukaryotic nucleus - PubMed
In eukaryotes, DNA-associated protein complexes coevolve with genomic sequences to orchestrate chromatin folding. We investigate the relationship between DNA sequence and the spontaneous loading and a...
pubmed.ncbi.nlm.nih.gov
PSL-Qlife
@pslqlife.bsky.social
· Apr 22