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Reposted by Hannah Long

Raquel Fueyo @fueyoraquel.bsky.social · 2d

⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab

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Reposted by Hannah Long

Mikhail Spivakov @mspivakov.bsky.social · 5d

Many enhancers that drive tissue-specific gene expression are already connected to gene promoters in human pluripotent cells.

In a new preprint, we share some clues about when, how, and why this happens!

www.biorxiv.org/content/10.1...

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency

In primed human pluripotent stem cells (hPSCs) resembling post-implantation epiblast, numerous lineage-specific enhancers assume the poised chromatin state, co-marked by H3K4me1 and Polycomb-associate...

www.biorxiv.org

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Hannah Long @hannahlong.bsky.social · 7d

Many congratulations Raquel, and to everyone involved! Really exciting work 🤩

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Hannah Long @hannahlong.bsky.social · 13d

Amazing resource! Congratulations to all involved 🐥 🔬

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Reposted by Hannah Long

Danve Castroverde @danvec.bsky.social · 20d

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

www.science.org

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Hannah Long @hannahlong.bsky.social · 20d

Looking forward to listening!

Epigenetics Podcast @epigeneticspod.bsky.social · 20d

In this episode of the Epigenetics Podcast, we talked with @em6wong.bsky.social from the University of New South Wales in Sydney about her work on how evolution shapes mammalian genes. #podcast #epigenetics #chromatin

Listen here: www.activemotif.com/podcasts-emi...

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Reposted by Hannah Long

Alex Stark @alex-stark.bsky.social · 21d

deadline tomorrow, Sept 19! www.csh-asia.org?content/2767

WELCOME-Meetings-Cold Spring Harbor Asia

www.csh-asia.org

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Reposted by Hannah Long

Genes & Development @genesdev.bsky.social · 23d

RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
By Williamson et al.
➡️ https://tinyurl.com/gd352648

#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion

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Reposted by Hannah Long

Nature Reviews Genetics @natrevgenet.nature.com · 22d

New online! Is enhancer-driven gene regulation all wrapped up?

Is enhancer-driven gene regulation all wrapped up?

Nature Reviews Genetics, Published online: 16 September 2025; doi:10.1038/s41576-025-00880-9In this Comment, Wendy Bickmore discusses mechanistic models of how 3D genome organization facilitates communication between distant enhancers and their target promoters to regulate gene expression.

www.nature.com

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Hannah Long @hannahlong.bsky.social · Sep 2

Amazing evolutionary gene regulatory story about dorsoventral limb and fin patterning! Congratulations to all the team 🙌

M. Brent Hawkins @homeobox.bsky.social · Jul 7

We take for granted that our hands have two sides and can articulate in an endless number of ways. But what about a fish’s fin? Can a fish know something “like the back of its fin,” or have its future told with a fin palm reading? Check out this bluetorial to find out 👇🧪🧬🐟 doi.org/10.1101/2025...

Schematics depicting the dorsal and ventral sides of fins and limbs

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Reposted by Hannah Long

FragileNucleosome @fnucleosome.bsky.social · Sep 1

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

Fragile Nucleosome Fall Seminars:
September 10 Grace Bower, Kvon Lab @ UC Irvine, USA
Jennifer Phillips-Cremins, UPenn, USA

September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA
Juanma Schvartzman, Columbia University, USA

October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA
Alex Federation, Talus Bio, USA

October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland
Seungsoo Kim, UC Irvine, USA

November 5 Hannah Long, University of Edinburgh, UK
Jeff Vierstra, Altius Institute, USA

November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada
Sarah Teichmann, University of Cambridge, UK

December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain
Jonathan Henninger, Carnegie Mellon, USA

December 17 Rebecca Berrens, Oxford University, UK
Jean-Benoit Lalanne, University of Montreal, Canada

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Reposted by Hannah Long

Alexis Verger 🧬🧫🧪 @alexis-verger.cpesr.fr · Aug 28

If you like transcription regulation and its mechanisms, this WIP list is for you.

I'm sure I've forgotten lots of people, so don't hesitate to let me know so I can add you to the list.

go.bsky.app/8vTgeXB

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Hannah Long @hannahlong.bsky.social · Aug 28

Thank you!

Hannah Long @hannahlong.bsky.social · Aug 28

Great list! Can I request to be added too?

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Reposted by Hannah Long

Dirk Benzinger @dbenzinger.bsky.social · Aug 27

Super excited that our latest work is out!

We use optogenetics to dynamically control and study the formation of morphogen gradients.

If you are interested in optogenetic tools and/or how cells shape and process extracellular signals, check out @jamesbriscoe.bsky.social's thread and the paper.

James Briscoe @jamesbriscoe.bsky.social · Aug 26

Our latest: We developed a chemo-optogenetic system for precise spatiotemporal control of morphogen production. Using dual light + small molecule control of Sonic Hedgehog production, we recapitulated neural tube patterning in vitro & measured spread of Shh

🧵

www.sciencedirect.com/science/arti...

Investigating morphogen and patterning dynamics with optogenetic control of morphogen production

Morphogen gradients provide the patterning cues that instruct cell fate decisions during development. Here, we establish an optogenetic system for the…

www.sciencedirect.com

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Reposted by Hannah Long

David Gokhman @david-gokhman.bsky.social · Aug 27

Denisovans or their close relatives identified in the fossil record using a gene regulatory phenotyping method. Now out:
www.pnas.org/doi/10.1073/...

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Reposted by Hannah Long

Craig Kaplan @triggerloop.bsky.social · Aug 26

Eva Nogales @nogaleslab.bsky.social introducing the 2025 CSH Mechanisms of Eukaryotic Transcription Meeting. Co-organizing with Wendy Bickmore @wbickmor.bsky.social and Joanna Wysocka. Will intermittently try to update as allowed

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Reposted by Hannah Long

Alex Radzisheuskaya @a-radzisheuskaya.bsky.social · Aug 13

Registration is still open for Transcription and Chromatin UK 2025. Join our growing research community in Manchester this September!

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Reposted by Hannah Long

Eileen Furlong @eileen-furlong.bsky.social · Jul 30

To all post-docs: The Genome Biology dept ‪@embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...

Group Leader - Genome Biology Unit

Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...

embl.wd103.myworkdayjobs.com

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Reposted by Hannah Long

Eva D'haene @eedhaene.bsky.social · Jul 31

👇 Highly recommend applying if you want to join a great team and work on a high-profile, inter-university project! #postdocjobs

Sarah Vergult @svergult.bsky.social · Jul 31

📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...

Postdoctoral fellow

www.ugent.be

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Reposted by Hannah Long

Nicky Whiffin @nickywhiffin.bsky.social · Jul 31

📣 We are recruiting! Please share!!

Are you a bioinformatician / computational scientist who wants to apply your skills to understanding regulatory biology and improving rare disease diagnosis and treatment? 🧠 💻 🧬 🩺

We have two roles available 👇

🧵 1/4

Image of an old building in Oxford with the heading 'postdoc opportunities' and the text 'computational approaches to improve rare disease diagnosis and treatment' and 'Big Data Institute, University of Oxford'

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Reposted by Hannah Long

Alejandro Brenes @ajbrenes.com · Jul 27

Happy to share our latest preprint doing low cell number (mini-bulk) and single cell #proteomics on tumour associated neutrophils from human glioblastoma where we find multiple functional states that would be invisible to scRNAseq, some showing pro-tumoural states with potential therapeutic value

Single cell proteomic analysis defines discrete neutrophil functional states in human glioblastoma

Neutrophils are vital innate immune cells shown to infiltrate glioblastomas, however we currently lack the molecular understanding of their functional states within the tumour niche. Neutrophils are k...

www.biorxiv.org

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Reposted by Hannah Long

Vicki Metzis @vmetzis.bsky.social · Jul 14

Interested in developmental epigenetics? So are we! Apply now to join us for your postdoc!

Multiple positions across multiple groups @mrc-lms.bsky.social

Projects spanning germline demethylation, gene regulation, genome architecture in development & disease 👇👇

lms.mrc.ac.uk/work/vacanci...

MRC Postdoctoral Research Scientists x 5 - MRC Laboratory of Medical Sciences

Applications are now open for up to five postdoctoral positions in the area of developmental epigenetics.

lms.mrc.ac.uk

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Reposted by Hannah Long

Rob Illingworth @illingworth-lab.bsky.social · Jul 12

Excited to share our hot-off-the-press @biorxivpreprint.bsky.social
that explores how PRC1-mediated H2AK119ub deposition safeguards lineage fidelity during forebrain development. Fantastic work by @lucyadoyle.bsky.social and our colleagues & collaborators. 🥳🧬🧠🔬
www.biorxiv.org/content/10.1...

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain

The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimen...

www.biorxiv.org

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Reposted by Hannah Long

Sara Luzzi @saraluzzi.bsky.social · Jun 28

Transcription and Chromatin UK is back! This time in Manchester, 17th-19th September. Send your abstract by 17th July for the opportunity to discuss your work with the UK RNA and epigenetics community, and with leading experts from abroad. Click the link below and spread the word!

Biochemical Society @biochemsoc.bsky.social · Jun 26

Taking place on 17-19 September 2025, Transcription and Chromatin UK will showcase cutting-edge research and is a ‘mustattend’ for anyone within the transcription and epigenetics community🧪. Register now: www.eventsforce.net/biochemsoc/2...

Transcription and Chromatin UK
Manchester, UK
17-19 September 2025
Earlybird deadline: 17 July 2025

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