RESEARCH PAPER: Condensation of human OAS proteins initiates diverse antiviral activities in response to West Nile virus
By Briggs et al. and James Burke

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1162.abstract

RESEARCH COMMUNICATION: Structural basis of nucleosome recognition by the conserved Dsup and HMGN nucleosome-binding motif
By Alegrio-Louro et al. and Andres Leschziner

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1155.full

REVIEW: Modeling and targeting general and chromosome-specific aneuploidy in cancer.
By Aleah Goldberg, Maria Trifas and Teresa Davoli

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1132.abstract

📽️ G&D Tapes 📽️

G&D Author, Aishwarya Pawar, tells us about their new study showing that PHF6 and PHIP function together to suppress stemness programs and leukemia progression.
@aishwarya2510.bsky.social
@paralkarlab.bsky.social

Learn more here:
➡️ genesdev.cshlp.org/content/39/1...

OUTLOOK: A new link in the leukemia genetic puzzle
By Xiaodi Wu and Ross Levine

Learn more here:
➡️ https://genesdev.cshlp.org/content/39/19-20/1129.full

G&D's Editor-in-Chief, Andrew Dillin, will be at #FusionAging25
If you’d like to chat about publishing your work with #genesdev, feel free to reach out to dillin[at]berkeley[dot]edu

RESEARCH PAPER: Leukemia mutated proteins PHF6 and PHIP form a chromatin complex that represses acute myeloid leukemia stemness
By Pawar et al. and Vikram Paralkar
Aishwarya Pawar
Vikram Paralkar

Learn more here:
 ➡️ https://genesdev.cshlp.org/content/39/19-20/1219.abstract

🚨 NEW ISSUE ALERT!!! 🚨

New Outlook, Review and Research Papers online now at Genes & Development.

Click on the link to learn more:
➡️ https://genesdev.cshlp.org/content/39/19-20.toc

How does the brain connect with each muscle to control the body? Check out new videos from @columbiamed.bsky.social & @zuckermanbrain.bsky.social that reveal two key molecules behind this vital process in fruit flies. @genesdev.bsky.social

zuckermaninstitute.columbia.edu/microscopic-...

🧠💪🪰

Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.

G&D will be at Biology of Cancer 2025 #cshlcancer this week. Come find us in Grace Lobby or schedule an appointment below if you'd like to chat about your work or learn more about publishing with us.

<a href="https://bsky.app/profile/did:plc:4gb34vaxz2lzseq4bqsngavr" class="hover:underline text-blue-600 dark:text-sky-400" target="_blank" rel="noopener">@cshlmeetings.bsky.social <a href="https://bsky.app/profile/did:plc:vmgobpps53ca6r3b5ylzmt3p" class="hover:underline text-blue-600 dark:text-sky-400" target="_blank" rel="noopener">@genesdev.bsky.social

➡️ https://tinyurl.com/GenesDev-MeetTheEditors

RESEARCH PAPER: Bystander activation across a TAD boundary supports a cohesin-dependent transcription cluster model for enhancer function
By Williamson et al.
➡️ https://tinyurl.com/gd352648

#chromatin #enhancer #transcription #sonichedgehog #TAD #cohesin #genomics #3Dgenome #loopextrusion

OUTLOOK: Lineage rewiring in lung adenocarcinoma via HNF4α and NKX2-1 dynamics
By Alice Feng, Alena Yermalovich, and Matthew Meyerson
➡️ https://tinyurl.com/gd353142

Read the paper:
➡️ https://tinyurl.com/gd352742

#KRAS #hybrididentity #lineage #plasticity #lungcancer #cancertherapy

G&D's Editor-in-Chief, Andrew Dillin will be at the 2025 Frontiers in Metabolism – Mechanisms of Metabolic Disease meeting at the Morgridge Institute for Research @<a href="https://uwmadison.bsky.social." class="hover:underline text-blue-600 dark:text-sky-400" target="_blank" rel="noopener">uwmadison.bsky.social. If you’d like to chat about publishing your work with us, feel free to reach out to dillin<a href="https://bsky.app/profile/did:plc:berkeley.edu" class="hover:underline text-blue-600 dark:text-sky-400" target="_blank" rel="noopener">@berkeley.edu

RESEARCH PAPER: Opposing lineage specifiers induce a pro-tumor hybrid identity state in lung adenocarcinoma
By Fort et al.
➡️ https://tinyurl.com/gd352742

#cancer #gastrointestinal #lung #transcriptionfactor #tumorigenesis #RAS/MEK #signaling #lineage #plasticity #cancertherapy

OUTLOOK: Speed of life: tuning the ticktock of the segmentation clock
By Sally Lowell
➡️ https://tinyurl.com/gd353096

Read the paper:
➡️ https://tinyurl.com/gd352909

#Notch #E3ligase #segmentationclock #somitogenesis #somitoid

RESEARCH PAPER: ELAV mediates circular RNA biogenesis in neurons
By Alfonso-Gonzalez et al.
➡️ https://tinyurl.com/gd352670

#circRNA #neuroscience #RNAbindingprotein #Drosophila #embryos #neurons #mRNA #introns #splicing

REVIEW: Timing is everything: transcription bursting in development
By Jee Min Kim and Daniel Larson
➡️ https://tinyurl.com/gd352465

#transcription #molecularbiology #transcriptionbursting #embryonicdevelopment #stemcell #differentiation #mRNA #development #molecularmechanism

📽️ G&D Tapes 📽️

G&D Author, Edel McCrea tells us about their new study in #genesdev reporting a role for tyrosine phosphatase PTNP14 in the sexually dimorphic regulation of Hippo pathway function.

Learn more here:
➡️ https://tinyurl.com/gd352620

RESEARCH PAPER: Analysis of knockout mice reveals critical female-specific roles for the Hippo pathway component PTPN14
By McCrea et al.
➡️ https://tinyurl.com/gd352620

#Hippo #Development #SexDifferences #YAPTAZ #signaling #WoundHealing #PTPN14 #CornealDisease #uterus #WomensHealth

Excited to share that our manuscript “MEF2C controls segment-specific gene regulatory networks that direct heart tube morphogenesis” is now online @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
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📽️ G&D Tapes 📽️

G&D Author, Hedda Meijer tells us about their recent study in #genesdev that demonstrates the functional significance of the interaction between NOTCH1/NICD and the F-box protein FBXW7 during somitogenesis.

Learn more here:
➡️ https://tinyurl.com/gd352909

RESEARCH PAPER: NOTCH1 S2513 is critical for the regulation of NICD levels impacting the segmentation clock in hiPSC-derived PSM cells and somitoids
By Meijer et. al
➡️ https://tinyurl.com/gd352909

#segmentationclock #NOTCH #NICD #somite #somitoid #embryo #patterning

🚨 NEW ISSUE ALERT!!! 🚨

New Outlooks, Review and Research Papers online now at Genes & Development.

Click on the link for more:
➡️ genesdev.cshlp.org/content/39/1...

REVIEW: Studying ovarian aging and its health impacts: modern tools and approaches
By Bérénice A. Benayoun, Alison Kochersberger, and Jennifer L. Garrison
➡️ genesdev.cshlp.org/content/39/1...

@bbparis1984.bsky.social @jennifergarrison.bsky.social
#reproductiveaging #ovary #aging #womenshealth