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Hilgers Lab @hilgerslab.bsky.social · 12d

Our lab, in full force at the European Drosophila Research Conference in Alicante @edrc2025.bsky.social. Here, after an amazing day of exciting science!
#Drosophila

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Hilgers Lab @hilgerslab.bsky.social · 20d

Our study on the biogenesis of neuronal circular RNAs is out in Genes&Development @genesdev.bsky.social !
genesdev.cshlp.org/content/earl...
Our celebration picture features first authors @carlosalfonsog.bsky.social and @shimengjin.bsky.social holding the fabulous circular cake, and most co-authors.

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Hilgers Lab @hilgerslab.bsky.social · Jun 20

New paper from our lab! Fabulous and brilliant @carlosalfonsog.bsky.social and @shimengjin.bsky.social, together with fantastic co-authors, show that the neuronal protein ELAV promotes biogenesis of circular RNAs in the brain. This happens through inhibition of forward ("classical") splicing.

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jun 10

👀 New study: The stability of circular RNAs makes them ideal for long-lasting regulatory tasks in neurons. Researchers from the @hilgerslab.bsky.social have now identified the protein ELAV protein as a master regulator of circular RNA production in the nervous system, crucial for brain function.

Running circles in my head

Researchers in Freiburg have identified the protein ELAV as a key regulator of circular RNA production in the nervous system, which is crucial for brain function.

www.ie-freiburg.mpg.de

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Hilgers Lab @hilgerslab.bsky.social · May 27

Celebrating an accepted paper is fun for many reasons! A while ago we had a little get-together for Anton's @antonhess.bsky.social and Dominika's (first authors) paper published in @emboreports.org. Featuring, the larval-brain-shaped (3rd instar) cake baked by lab star chef and co-author Hasan.

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Hilgers Lab @hilgerslab.bsky.social · Mar 14

So excited to host my friend and former labmate @laghalab.bsky.social as a ... (drumroll) Special Guest at our institute! Mark your calendars and expect a great talk with beautiful live imaging.

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Mar 13

We are excited. Mounia Lagha will be our 1st Special Guest in 2025.🤗

📆 March 20, 1pm

The Lagha lab (@igmm-montpel.bsky.social) uses live imaging to study mechanisms of transcription & translation in living embryos. Join us for an enlightening talk next Thursday.
(Host: @hilgerslab.bsky.social)

Seminar announcement for a Max Planck Special Guest Seminar featuring Mounia Lagha from IGMM, France. The talk, titled 'Lighting Up the Central Dogma to Dissect How Sharp Developmental Patterns Are Established,' is scheduled for March 20, 2024, at 1:00 PM at MPI-IE, Lecture Hall in Freiburg.

The Lagha lab investigates the mechanisms governing gene expression during development, focusing on the interplay between transcription and translation. They pioneered methods to study the translation of single mRNA molecules in Drosophila embryos, revealing critical heterogeneity in translation. This work has led to the discovery of translation factories and intragenic translation heterogeneity, uncovering a novel layer of variation in gene expression.
To achieve a comprehensive understanding of gene expression precision, the Lagha Lab integrates transcriptional and translational regulation. They employ advanced quantitative imaging techniques to simultaneously monitor mRNA and protein dynamics in living Drosophila embryos with high spatio-temporal resolution. These observations are combined with theoretical models to formulate predictions, which are then tested through genetic and optogenetic manipulations. The lab's research aims to bridge the gap between transcription and translation, providing an integrated, multiscale view of gene expression control.

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Reposted by Hilgers Lab

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Mar 13

We are excited. Mounia Lagha will be our 1st Special Guest in 2025.🤗

📆 March 20, 1pm

The Lagha lab (@igmm-montpel.bsky.social) uses live imaging to study mechanisms of transcription & translation in living embryos. Join us for an enlightening talk next Thursday.
(Host: @hilgerslab.bsky.social)

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Hilgers Lab @hilgerslab.bsky.social · Mar 3

Don't miss this exciting conference dedicated to the study of gene expression regulation, one molecule at a time! Technologies ranging from (epi)genomics, (epi)transcriptomics, to functional (epi)genetics and imaging!
@stirlingchurchman.bsky.social @laghalab.bsky.social @arnaudkr.bsky.social

Gene regulation: one molecule at a time

www.embl.org

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Reposted by Hilgers Lab

IGMM-Montpellier @igmm-montpel.bsky.social · Feb 26

Biolum Seminar Series
by Valérie Hilgers 5th of march at 11h00 @biolum-montpellier.bsky.social @hilgerslab.bsky.social @mpi-ie.bsky.social @laghalab.bsky.social

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Hilgers Lab @hilgerslab.bsky.social · Feb 26

Fantastic @embo.org lecture course in Pune, India! Lots of cool science, great interactions and condensation (pun intended) with RNA enthusiasts from all over the world. With Rick @rickmarsman.bsky.social and Sakshi @sakshigorey.bsky.social presenting posters. #EMBOrnaProtein #RNA

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Hilgers Lab @hilgerslab.bsky.social · Feb 23

Paper is out! Great team effort led by Dominika Grzejda and Anton Heß @antonhess.bsky.social

EMBO Reports @emboreports.org · Feb 22

Valérie Hilgers and co-workers @hilgerslab.bsky.social @mpi-ie.bsky.social and @zmbh.uni-heidelberg.de show that the conserved #neuronal #protein Pumilio differentially binds to mRNA 3′ UTR isoforms to regulate localization of synaptic proteins. #neuroscience

www.embopress.org/doi/full/10....

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Hilgers Lab @hilgerslab.bsky.social · Feb 7

WOW ! Congratulations, George! And also congratulations to your mentors, who Iook very proud 😁

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Hilgers Lab @hilgerslab.bsky.social · Feb 5

Yoooohoooo! We're here now :-)

Max Planck Institute of Immunobiology and Epigenetics @mpi-ie.bsky.social · Jan 7

Every time we see the little rising bluesky sun, a smile spreads across our faces. 🎉 A warm welcome the lab of Valérie Hilgers on bsky: Follow them to stay connected: ➡️ @hilgerslab.bsky.social

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Hilgers Lab @hilgerslab.bsky.social · Jan 20

Welcome, Juliane !

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