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Reposted by Sarah Vergult

Eva D'haene @eedhaene.bsky.social · Jul 31

👇 Highly recommend applying if you want to join a great team and work on a high-profile, inter-university project! #postdocjobs

Sarah Vergult @svergult.bsky.social · Jul 31

📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...

Postdoctoral fellow

www.ugent.be

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Sarah Vergult @svergult.bsky.social · Jul 31

📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline August 31: www.ugent.be/en/work/scie...

Postdoctoral fellow

www.ugent.be

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Sarah Vergult @svergult.bsky.social · Jun 3

📣 In our recent study, we present a minimally invasive RNA-seq protocol using short-term cultured peripheral blood mononuclear cells (PBMCs), with and without cycloheximide treatment. A big shout-out to Laurenz and Erika who were instrumental in carrying out the study!
www.nature.com/articles/s41...

Cracking rare disorders: a new minimally invasive RNA-seq protocol - npj Genomic Medicine

npj Genomic Medicine - Cracking rare disorders: a new minimally invasive RNA-seq protocol

www.nature.com

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Sarah Vergult @svergult.bsky.social · May 27

🔥🔥

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Sarah Vergult @svergult.bsky.social · May 27

Excellent poster talks from all Ghent PhD students at #eshg25! Well done 👏🏻👏🏻

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Sarah Vergult @svergult.bsky.social · May 25

Excellent talk by my colleague @elfridedebaere.bsky.social on cis regulatory elements in eye diseases at #eshg25. If you did not attend her session, I highly recommend to watch it on the virtual platform. Enhanceropathies research at Ghent University is on 🔥

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Sarah Vergult @svergult.bsky.social · May 25

Excellent flash talk by #FunGen PhD student @lisahamerlinck.bsky.social ! If you missed it, you still have the chance to check out her poster P10.003 tomorrow between 16:00-17:00. #eshg25

Michael B Vaughan @michael-b-vaughan.bsky.social · May 25

@lisahamerlinck.bsky.social kicking ass at #eshg2025

Sharing work on non-coding regulatory disruptions of FOXG1.

#FunGen @svergult.bsky.social @eedhaene.bsky.social

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Sarah Vergult @svergult.bsky.social · May 25

If you are interested in a postdoc position on neural organoids in the lovely city of Ghent, Belgium, and happen to be at #eshg25, feel free to come and have a chat with me. Or, if you know other interested people, feel free to share with them.

Sarah Vergult @svergult.bsky.social · May 22

📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline: June 23
Link: www.ugent.be/en/work/scie...

Postdoctoral fellow

www.ugent.be

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Reposted by Sarah Vergult

James Fasham @jamesfasham.bsky.social · May 24

🗣️ Quote of #ESHG2025 (so far)

"Who licks bone !?!" 🦴
- Johannes Krause

Anyone have that on your bingo card?

Well apparently archeologists do, to distinguish bone from stones and it causes problems in DNA sequencing. 🤔

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Reposted by Sarah Vergult

James Fasham @jamesfasham.bsky.social · May 24

@ahoischen.bsky.social insisting junior researchers get the mic at #ESHG2025 🎤👩‍🔬👨‍🔬

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Sarah Vergult @svergult.bsky.social · May 24

Also go and check out all the great work by our other colleagues at the Center for Medical Genetics and Ghent University! @elfridedebaere.bsky.social and many others

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Sarah Vergult @svergult.bsky.social · May 24

On my way to #eshg25!
If you are interested in the work we do at the FunGen lab, check out the flash talk on Sunday and poster on Monday by @lisahamerlinck.bsky.social or come and have a coffee with team members @michael-b-vaughan.bsky.social, @eedhaene.bsky.social or me. Hope to see you there!

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Sarah Vergult @svergult.bsky.social · May 22

📣Job Alert: We are looking for a postdoctoral researcher with hands-on experience in neural tissue culture, preferably neural organoids, for a collaborative project on Alzheimer's disease and MS between KULeuven, UHasselt and UGent in Belgium. Deadline: June 23
Link: www.ugent.be/en/work/scie...

Postdoctoral fellow

www.ugent.be

Reposted by Sarah Vergult

Michael B Vaughan @michael-b-vaughan.bsky.social · May 19

Really enjoying Neurogenomics25 @humantechnopole.bsky.social Excellent space, excellent talks, excellent coffee!

I'll be sharing some of our research ( @svergult.bsky.social ) on the ability of Clinically Accessible Tissues to accurately reflect neuronal gene regulation ( poster #66) #neurogen25

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Sarah Vergult @svergult.bsky.social · May 19

If you are at the Neurogenomics conference in Milan, go and check out the posters of @eedhaene.bsky.social and @michael-b-vaughan.bsky.social. #neurogen25

Eva D'haene @eedhaene.bsky.social · May 19

Looking forward to exciting science and to connect with colleagues in Milan at the Neurogenomics conference @humantechnopole.bsky.social Presenting our research ( @svergult.bsky.social @lisahamerlinck.bsky.social ) on noncoding variants in the FOXG1 locus during the poster session (#88) #neurogen25

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Sarah Vergult @svergult.bsky.social · May 13

Free access link to the paper (50 days): www.sciencedirect.com/science/arti...

Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder

8q21.11 microdeletions involving ZFHX4 have previously been associated with a syndromic form of intellectual disability, hypotonia, unstable gait, and…

www.sciencedirect.com

Sarah Vergult @svergult.bsky.social · May 13

Paper Alert!! Last year we reported on ZFHX3 loss of function (LoF), today we report that also ZFHX4 LoF is associated with an NDD. Great collaboration the ZFHX4 consortium, excellently led by María del Rocío Perez Baca and María Palomares. As always great collab with co-supervisor Bert Callewaert.

The American Journal of Human Genetics @ajhgnews.bsky.social · May 13

📣New from @svergult.bsky.social & co
📄Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder

Loss of function of the zinc finger homeobox 4 gene, ZFHX4, underlies a neurodevelopmental disorder

We associate ZFHX4 loss of function with syndromic intellectual disability. While ZFHX4 deletions showed a mild methylation profile, protein-truncating variants did not. Multi-omics data implicate ZFH...

www.cell.com

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Reposted by Sarah Vergult

Claudia Gonzaga-Jauregui @cgonzagaj.bsky.social · Apr 11

Final talk of this year's #GRD25 conference, also selected from submitted abstracts, is Eva D'haene from Ghent University talking about "Non-coding structural variants disrupt a critical regulatory region steering FOXG1 transcription during early neurodevelopment"

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Sarah Vergult @svergult.bsky.social · Mar 13

📣 New preprint from the FunGen lab, see below 👇👇👇! This research was led by two incredible ladies in my lab, postdoctoral researcher @eedhaene.bsky.social and PhD student Lisa Hamerlinck. Nice to see how a team effort of years finally came together. If you want to know more, read Eva's 🧵 below.

Eva D'haene @eedhaene.bsky.social · Mar 13

📢 New preprint from the FunGen lab @svergult.bsky.social on how non-coding structural variants disrupt FOXG1 regulation during early neurodevelopment. Great teamwork from Lisa Hamerlinck and everyone in the lab! Thread below👇
www.medrxiv.org/content/10.1...

#GeneRegulation #RareDisease #Epigenomics

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Sarah Vergult @svergult.bsky.social · Feb 28

Today is #rarediseaseday2025

Rare diseases are rare, but there are many people living with a rare disease.

By brighten up our workplace with shades of pink, blue, green, and purple 🩷💙💚💜 we, the FunGen team, want to help raising visibility for rare diseases.

#ShareYourColours

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Sarah Vergult @svergult.bsky.social · Feb 11

To all great women in science: Happy #WomenInScienceDay! Glad to have met many great female scientists and hope to meet many more 🥰!

Science Magazine @science.org · Feb 11

Marie Sklodowska Curie was the first woman to receive a #NobelPrize and the first person to receive the honor twice.

In 2017, #ScienceBooks explored the dynamics that established Curie as “the most iconic of all female scientists.” #WomenInScienceDay

The making and remaking of Marie Curie

The famous physicist's legacy looms large 150 years after her birth

scim.ag

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Reposted by Sarah Vergult

Hannah Long @hannahlong.bsky.social · Feb 9

Prof Joe Marsh and I have a PhD project as part of the 2025 Edinburgh Doctoral College Scholarship: "Integrating AI, Biophysical Modelling and Experimental Validation for Enhancer Variant Interpretation". Closing date for applications is 25 April 2025. Please get in touch if you are interested! 🧬🧠

Edinburgh Doctoral College Scholarship

Applications now open for 2025 intake

institute-genetics-cancer.ed.ac.uk

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Reposted by Sarah Vergult

Sudarshan Pinglay @sudpinglay.bsky.social · Jan 31

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.

www.science.org/doi/10.1126/...

Multiplex generation and single-cell analysis of structural variants in mammalian genomes

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

www.science.org

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Sarah Vergult @svergult.bsky.social · Jan 31

As always, great meeting!! 👇🏻👇🏻

Rada-Iglesias Lab @radaiglesiaslab.bsky.social · Jan 31

Together with @smandrup.bsky.social and Minna Kaikkonen we are happy to announce the 3rd Edition of the EMBO Workshop on #Enhancers and #Enhanceropathies. This time we will meet during the beautiful Danish summer (June 16-21).

Book the dates and register soon!!!

meetings.embo.org/event/25-enh...

Enhancer Mechanics and Enhanceropathies

Join us for the highly anticipated third EMBO workshop on Enhancer Mechanics and Enhanceropathies! Building on the success of our previous meetings in Santander (2021) and Marseilles (2023), this eve…

meetings.embo.org

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Reposted by Sarah Vergult

Ewan Birney @ewanbirney.bsky.social · Dec 19

I want to provide an overview and perspective of rare disease genomic testing, which is a real success story of science impacting health - a science which goes back over 100 years and yet is still striding forward and much more to come.

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