Lightnews — Scholar-powered news

Reposted by Falk Schneider

André Nadler @nadlerlab.bsky.social · 1h

Lipid imaging on the cover of @nature.com! Great times for lipid cell biology indeed. And a fantastic recognition of all the hard work by the team, especially Juan M. Iglesias-Artola and Kristin Böhlig (who made the cover). Link to article: www.nature.com/articles/s41...

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Reposted by Falk Schneider

Shifaan Thowfeequ @shifaant.bsky.social · 19h

The 'sparks' of life! Our latest work on the role of #calcium dynamics in the early #embryo. 🎇🔬🐁

@idrm.ox.ac.uk @oxforddpag.bsky.social @srinivas-lab.bsky.social #lightsheetmicroscopy #GCAMP

PLOS Biology @plosbiology.org · 1d

During #development, distal visceral #endoderm (DVE) cells migrate to shape A-P axis specification. @m-stower.bsky.social @srinivas-lab.bsky.social &co reveal the role of Ca2+ dynamics in this, showing that inhibition of #calcium transients causes DVE arrest @plosbiology.org 🧪 plos.io/4nHWxF4

Epiblast Ca2+ waves propagate from the apical to basal domain. The images show selected time points from movies of E5.5 GCaMP6f embryos imaged using a ZEISS lattice light-sheet 7 microscope. Top row: An example of an epiblast wave involving a large proportion of the tissue captured by imaging a volume of the embryo at 20-s intervals. A total of 9/16 embryos showed at least one epiblast Ca2+ wave. Bottom row: Faster imaging at 5-s interval revealed that the Ca2+ wave in the epiblast can be preceded by a transient in a neighboring VE cell—this was observed in 5/19 events from 9 embryos (white arrowheads).

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Reposted by Falk Schneider

Miki Ebisuya @ebisuyamiki.bsky.social · 21h

New preprint from the lab! We discovered a transient fluidization in the basal region of human forebrains by tracking microdroplets in cerebral organoids.This “basal fluidization”, absent in gorilla and mouse, may contribute to greater surface expansion in human forebrains
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doi.org/10.1101/2025...

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Falk Schneider @faldalf.bsky.social · 19h

Wow - very fun "imaging" approach.

You had me at "We bombard living cells with millions of nanoparticles traveling at 1000 m/s."🎯💣

-> Reading list. 📖👓

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 20h

Ballistic Microscopy (BaM) https://www.biorxiv.org/content/10.1101/2025.10.07.681030v1

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Reposted by Falk Schneider

Joachim Goedhart @joachimgoedhart.bsky.social · 12d

Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM by Juan Manuel Garcia-Arcos and team: www.biorxiv.org/content/10.1...

Frequency dependence of fast-lifetime FLIM and fits for C2C12 cells.

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Reposted by Falk Schneider

Nature Methods @natmethods.nature.com · 15d

Squeezed light field microscopy (SLIM) combines concepts from tomography and compressed sensing with light field microscopy for volumetric imaging at kilohertz rates.

www.nature.com/articles/s41...

Kilohertz volumetric imaging of in vivo dynamics using squeezed light field microscopy - Nature Methods

Squeezed light field microscopy (SLIM) combines ideas from tomography and compressed sensing with light field microscopy to enable volumetric imaging at kilohertz rates, as demonstrated in blood flow imaging in zebrafish and voltage imaging in leeches and mice.

www.nature.com

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Reposted by Falk Schneider

Lew Lab @ WashU @lewlab.com · 20d

Happy to share our recent review in @natphoton.nature.com on #singlemolecule #orientation #localization #microscopy, co-authored with Sophie Brasselet @cnrs.fr @institutfresnel.bsky.social. See molecule motions and rotations in action! doi.org/10.1038/s415... @washuengineers.bsky.social @washu.edu

Single-molecule orientation and localization microscopy - Nature Photonics

The Review discusses recent advances in single-molecule orientation and localization microscopy (SMOLM) along with remaining challenges and promises for future developments of the field.

doi.org

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Reposted by Falk Schneider

Stacey Ogden 🦔 @labogden.bsky.social · 20d

Trainees: Struggling to find the best figure arrangement for a manuscript draft? Do the 🧪 equivalent of an arts and crafts project:

1. Print draft figures and cut each panel into its own square.
2. Find a big table.
3. Move the panels around until you see the story.

This is your paper. 🤓

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Reposted by Falk Schneider

Falk Schneider @faldalf.bsky.social · 23d

Attending a workshop can shape your thinking and science.

My first blog post @focalplane.bsky.social about my journey from being a student on an @mblscience.bsky.social course to returning as faculty teaching in @pair-up.bsky.social microscopy course

focalplane.biologists.com/2025/09/14/t...

There and Back Again – An MBL Story - FocalPlane

There and Back Again – An MBL Story - News

focalplane.biologists.com

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Reposted by Falk Schneider

Itay Budin @ibudin.bsky.social · 23d

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology

An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...

www.nature.com

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Reposted by Falk Schneider

FocalPlane @focalplane.bsky.social · 22d

There and back again – An @mblscience.bsky.social story
We hear about @faldalf.bsky.social‘s experience at MBL starting with the Physical Biology of the Cell course as a student in 2018, before returning as a teacher for the recent PAIR-UP microscopy course.
focalplane.biologists.com/2025/09/14/t...

There and Back Again – An MBL Story - FocalPlane

There and Back Again – An MBL Story - News

focalplane.biologists.com

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Reposted by Falk Schneider

Akaash Kumar @akaashkumar.bsky.social · 23d

🚨Publication alert🚨
My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...

Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics

A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...

www.nature.com

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Reposted by Falk Schneider

Gabriel Abrahams @gabriel-abrahams.bsky.social · 23d

www.sciencenews.org/article/biol...

Scientists made a biological quantum bit out of a fluorescent protein

Researchers could use quantum effects to develop new types of medical imaging inside cells themselves.

www.sciencenews.org

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Falk Schneider @faldalf.bsky.social · 23d

Attending a workshop can shape your thinking and science.

My first blog post @focalplane.bsky.social about my journey from being a student on an @mblscience.bsky.social course to returning as faculty teaching in @pair-up.bsky.social microscopy course

focalplane.biologists.com/2025/09/14/t...

There and Back Again – An MBL Story - FocalPlane

There and Back Again – An MBL Story - News

focalplane.biologists.com

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Reposted by Falk Schneider

Cell Reports @cp-cellreports.bsky.social · Sep 7

Polysomes and mRNA control the biophysical properties of the eukaryotic cytoplasm

Gade et al. report that polysomes and mRNA levels impact the biophysical properties of the cytoplasm. Using passive rheology probes and single-particle tracking, they demonstrate that intracellular diffusion is enhanced when polysomes are disassembled or when mRNA levels are reduced in eukaryotic cells.

dlvr.it

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Reposted by Falk Schneider

Erdinc Sezgin @sciezgin.bsky.social · Sep 8

Previous preprint is now published in RSC Chemical Biology.
If you are interested in plasma membrane labeling, see the paper! 👇
pubs.rsc.org/en/content/a...

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Reposted by Falk Schneider

European Research Council (ERC) @erc.europa.eu · Sep 4

📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope

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Reposted by Falk Schneider

Dr. Allyson Sgro @allysonsgro.bsky.social · Aug 30

Anyone know where I can buy this hex key set?

A hand holding a rainbow-colored hex key set.

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Reposted by Falk Schneider

Ricard Solé @ricardsole.bsky.social · Aug 30

Can cellular life be created in the lab? We are not yet there, but clearly getting closer! Check this paper where a new scenario for protocell replication is presented by Job Boekhoven and co-workers @manlius.bsky.social www.cell.com/chem/pdf/S24...

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Reposted by Falk Schneider

Aurelia @vesiclesmasher.bsky.social · Aug 30

For details of measured forces, comparisons with model systems, actin monitoring, and speculation about glycocalyx dimensions please have a look at our preprint!

www.biorxiv.org/content/10.1...

Flow transports extracellular lipid-anchored proteins across the surface of living COS-7 cells

The rapid diffusion of membrane lipids and membrane proteins in living cell plasma membranes demonstrates that the membrane is fluid. However, motion of membrane molecules is inhibited on one side by ...

www.biorxiv.org

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Reposted by Falk Schneider

Aurelia @vesiclesmasher.bsky.social · Aug 30

I am so excited for everyone to see this! Dr. Sreeja Sasidharan, legendary postdoc, recently showed that flow moves proteins sideways through a glass-supported lipid bilayer. We wanted to see if this could happen on the surface of living cells! AND IT CAN

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Reposted by Falk Schneider

Sam Lewis, Ph.D. @samlewis.bsky.social · Aug 29

I'm happy to share new work in collaboration with Elena Koslover's lab! First author Keaton developed a mathematical framework for diffusion of soluble material through mitochondrial networks. Then, Lewis lab PhD candidate Camryn used live cell imaging to parameterize... 1/3

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Reposted by Falk Schneider

Torsten Wittmann @microtubule.bsky.social · Aug 28

Some first raw (not deskewed) data of live human induced pluripotent stem cells from #Snouty now ready for some serious live imaging. Light sheet moving at a 38-degree angle through the cell layer; coverslip is on the bottom.

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Reposted by Falk Schneider

Ben Goult @bengoult.bsky.social · Aug 28

Excited to share our new preprint in @biorxiv-neursci.bsky.social

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵 the paper is summarised in this video.

www.biorxiv.org/content/10.1...

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Reposted by Falk Schneider

Pierre Millard @pierremillard.bsky.social · Nov 15

Enzymes are typically analyzed in vitro. Ever wondered how enzymes function within cells? Want to measure enzymatic parameters of your favorite enzyme in cellulo ? Here an approach combining systems and synthetic for in vivo enzymology.

www.embopress.org/doi/full/10....

@inrae-france.bsky.social

Combining systems and synthetic biology for in vivo enzymology | The EMBO Journal

imageimageThe physiological significance of enzymatic parameters determined in classical in vitro settings vastly different from cellular conditions remains limited. Here, a generic approach combining...

www.embopress.org

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