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Ben Goult @bengoult.bsky.social · 4d

Great time in Paris at the Valorant Champions with Oliver.

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Ben Goult @bengoult.bsky.social · 12d

Trip was amazing! tired (and clumsy apparently) on my first day back.

Ben Goult @bengoult.bsky.social · 12d

ha!

Ben Goult @bengoult.bsky.social · 13d

First day back at @liverpooluni.bsky.social after my 4 week trip, and got off to a bad start as broke my best espresso cup. 😭

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Ben Goult @bengoult.bsky.social · 14d

This was an excellent meeting.

Benoit Ladoux @bladoux.bsky.social · 15d

Exciting science in Leipzig at the Physics of Cancer Meeting.
conference.uni-leipzig.de/poc/2025/

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Reposted by Ben Goult

Jeremy Hollis @jeremyahollis.bsky.social · 28d

So excited to see the first part of my thesis work with @harmitmalik.bsky.social and @melodygcampbell.bsky.social in print! www.science.org/doi/10.1126/... We have a bit of evolution and a whole lotta structure to figure out how new protein domains work

Molecular exaptation by the integrin αI domain

An ancient protein domain insertion seamlessly preserved conformational signaling while providing a novel surface for adaptation.

www.science.org

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Reposted by Ben Goult

Martin Humphries @martinhumphries.bsky.social · Sep 4

Venkatesh B, et al. (@tanentzapflab.bsky.social lab) Inside-out integrin activation is essential for early mammalian development. Mol Biol Cell. 2025 Sep 3;:mbcE25030106. [Epub ahead of print]. PMID: 40901728

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Reposted by Ben Goult

Byron Lab @thebyronlab.bsky.social · Sep 8

Excellent science, inspiring discussions … and scientists in the sea!

Special thanks to Andreja, @bengoult.bsky.social, Vasso, Nina, Marina and Marija for organising such a great meeting! 🐬 🐬

A school of scientists swimming in the Adriatic Sea on a sunny day, with the greenery of the Dalmatian coast in the background.

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Reposted by Ben Goult

Thomas Iskratsch @tiskratsch.bsky.social · Sep 5

🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!

Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling

Cardiomyocytes’ sensing of extracellular matrix stiffness is imprinted in the talin interactome and regulates their phenotype.

www.science.org

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Ben Goult @bengoult.bsky.social · Sep 5

Really happy to have contributed to this great story as part of our BHF special project grant.

Thomas Iskratsch @tiskratsch.bsky.social · Sep 5

🎉It's finally out! Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling | Science Advances www.science.org/doi/10.1126/... - Amazing work Emilie, Ioannis and all co-authors and collaborators!

Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling

Cardiomyocytes’ sensing of extracellular matrix stiffness is imprinted in the talin interactome and regulates their phenotype.

www.science.org

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Reposted by Ben Goult

Ben Goult @bengoult.bsky.social · Aug 28

Excited to share our new preprint in @biorxiv-neursci.bsky.social

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵 the paper is summarised in this video.

www.biorxiv.org/content/10.1...

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Ben Goult @bengoult.bsky.social · Aug 30

Sea was quite moody tonight

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Ben Goult @bengoult.bsky.social · Aug 30

Our new CDKL5 constructs with N-terminal GFP and functional PDZ binding motif will be available on @addgene.bsky.social very soon. www.addgene.org/Ben_Goult/

Addgene: Ben Goult Lab Materials

www.addgene.org

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Ben Goult @bengoult.bsky.social · Aug 30

Almost all previous studies on CDKL5 have used a C-terminal tagging strategy (presumably to position the tag away from the kinase domain), but here we show that such modification of the C-term is disasterous as it abolishes CDKL5 synaptic localisation and function. www.biorxiv.org/content/10.1...

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Ben Goult @bengoult.bsky.social · Aug 29

The amazing video abstract was made by Sam Barnett, and is the 7th video in our MeshCODE to Scale series. www.youtube.com/playlist?lis...

MeshCODE to scale animations - YouTube

A series of short animations that show how memory molecules work and how they can be used in the brain to store information in a binary format. Animations ta...

www.youtube.com

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Ben Goult @bengoult.bsky.social · Aug 28

ADHERE 2 conference is next week!

Great line up of speakers and fun acitivities planned, this is going to be amazing!

Hope to see you all in Zadar, Croatia. ☀️

event.fourwaves.com/adhere2/pages

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Ben Goult @bengoult.bsky.social · Aug 28

Thanks Tom!

Ben Goult @bengoult.bsky.social · Aug 28

Brilliant work led by Yasumi Otani in the lab, Neil Ball, and great collaborations with Emily Goodall and @zech-lab.bsky.social and Vignesh Srinivasan and @saarikangaslab.bsky.social

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Ben Goult @bengoult.bsky.social · Aug 28

CDKL5 is an essential kinase in the brain, and mutations in the CDKL5 gene cause a devastating childhood epilepsy condition, called CDKL5 Deficiency Disorder (CDD).

Here we report two new interactions of CDKL5; 1) with talin and 2) with PSD-95 and SHANKs which lead to a new view of CDKL5 function.

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Ben Goult @bengoult.bsky.social · Aug 28

Excited to share our new preprint in @biorxiv-neursci.bsky.social

"Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains"

Instead of a 🧵 the paper is summarised in this video.

www.biorxiv.org/content/10.1...

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Ben Goult @bengoult.bsky.social · Jul 28

In the week I was out of office, this cheeky opportunist dropped a root into a nearby plants pot. 🌱

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Reposted by Ben Goult

Patrick Oakes @pwoakes.bsky.social · Jul 21

Congratulations to @stefanosala89.bsky.social , with help from @shreya-c.bsky.social al‬ on the optogenetic experiments, for the awesome story! Read the full preprint here: www.biorxiv.org/content/10.1... and thanks for listening!

LIM Domain Proteins link molecular and global tension by recognizing strained actin in adhesions

Mechanotransduction is fundamental to cell signaling and depends on force-sensitive adhesion proteins. How these proteins differentiate and integrate their responses to tension remains an open questio...

www.biorxiv.org

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Ben Goult @bengoult.bsky.social · Jul 21

This is amazing, art work based on The MeshCODE Theory.

www.davinci-project.com/collection/a...

Thanks Nash Cruz and Mireya Vazquez-Prada

A Mechanical Basis for Memory — da Vinci

www.davinci-project.com

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Reposted by Ben Goult

Artem K. Efremov @artemefremov.bsky.social · Jul 18

Our study on the mechanosensitive behavior of cell adhesion, showing the existence of a force-transmission mechanism that behaves very differently from the well-known 'load-and-fail' mechanism, was published in Nature Physics:

www.nature.com/articles/s41...

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Reposted by Ben Goult

Molecular & Clinical Cancer Medicine (MCCM) @livunicancer.bsky.social · Jul 16

ISMIB seminar Thursday 17th July 1pm Physiology Seminar Room

Speaker: Prof Haguy Wolfenson

Title: Understanding and modulating cell fate decisions mediated by cell-ECM interactions

Host @bengoult.bsky.social

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