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Reposted by Pierre Millard

Ricard Solé @ricardsole.bsky.social · Apr 28

How can biological systems anticipate future events? In our new paper with @jordiplam.bsky.social, we show how a simple genetic circuit can predict future trends through a simple (and perhaps widespread) mechanism @drmichaellevin.bsky.social @koseskalab.bsky.social www.biorxiv.org/content/10.1...

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Reposted by Pierre Millard

labnikel.bsky.social @labnikel.bsky.social · 2d

🚀 Thrilled to share our new Nature Communications article:
“A blueprint for designing the next-generation of synthetic C1 microbes”
We propose a framework to unlock sustainable, carbon-efficient biomanufacturing using non-canonical hosts.
🔗 www.nature.com/articles/s41... A short 🧵1/4

A blueprint for designing the next-generation of synthetic C1 microbes - Nature Communications

Synthetic one-carbon assimilation could contribute to a more sustainable and circular carbon economy, but much work in this field has focused on model microorganisms. Here the authors provide their perspective on the potential value of non-model microbes, and how that potential could be realised.

www.nature.com

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Reposted by Pierre Millard

Proceedings of the National Academy of Sciences @pnas.org · 4d

For 25 years, the Chair of the @laskerfdn.bsky.social Jury has reflected on the intersection of science and art in an annual essay. This year, Joseph L. Goldstein explores “From simplicity to complexity: A path to innovation in science and art.” Read now: www.pnas.org/doi/10.1073/...

2025 Lasker Awards – “From simplicity to complexity: A path to innovation in science and art.” Read the essay in a PNAS Perspective. Portrait of Joseph L. Goldstein.

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Reposted by Pierre Millard

Astropierre @astropierre.com · 16d

Suite à la migration de scientifiques et d'universitaires de X, Bluesky est devenue une l'une des alternatives.

Afin d'évaluer sa viabilité/pertinence pour la communication scientifique, cette étude présente une analyse à grande échelle de la diffusion d'articles scientifiques sur Bluesky.

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Reposted by Pierre Millard

Guim Aguadé-Gorgorió @guimaguade.bsky.social · May 20

Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests www.biorxiv.org/content/10.1...

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Reposted by Pierre Millard

AnniZLab: [🦠, 🧬 , ✨] @annizlab.bsky.social · 23d

Cool! Some gut microbes make 2-MiCit from propionate. In vitro, it inhibits 3D colon tumor growth (and normal cells at high dose). Just a 'lucky' one among millions of microbial by-products? I haven't thought of any selective advantage 🤔 Thoughts? 🦠🧪 #microsky #microbiomesky doi.org/10.1016/j.ce...

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Reposted by Pierre Millard

Saez-Rodriguez Group @saezlab.bsky.social · 23d

🥁 Check out our new preprint on OmniPath, the prior knowledge resource for #SystemsBiology, and its brand-new OmniPath Explorer web app! 🥳

📖 Preprint: www.biorxiv.org/content/10.1...
🔍 Explorer: explore.omnipathdb.org

OmniPath integrates 160+ resources for multi-omics analysis & modeling.

🧶⬇️

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Reposted by Pierre Millard

Glen Dsouza @nonresidentdesi.bsky.social · Jun 13

Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours.

www.science.org/doi/10.1126/...

#MicroSKy #Microbiology

Antagonism as a foraging strategy in microbial communities

In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...

www.science.org

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Reposted by Pierre Millard

Julien Luneau @juliensluneau.bsky.social · Aug 20

Congrats Snorre!!! 👏 It's great to see this coming out 🎉
and thank you for giving the chance to be a (small) part of this very cool work!

"Microbes release lower-value metabolites at higher rates" 🦠

Snorre Sulheim @sulheim.bsky.social · Aug 20

Excited to share the first results from my postdoc at @dmf-unil.bsky.social with @saramitri.bsky.social
www.biorxiv.org/content/10.1...

Microbes release lower-value metabolites at higher rates

Microbes release a wide range of metabolites into their environment, yet the reasons for this release and the factors that influence release rates are not well understood. Here, using a combination of...

www.biorxiv.org

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Reposted by Pierre Millard

Grace Lindsay @neurograce.bsky.social · 26d

I've only read the abstract and I already know this paper is so very correct 👀

JJ @jjodx.bsky.social · 27d

The myth of optimality in human movement science

www.sciencedirect.com/science/arti...

The myth of optimality in human movement science

The concept of optimality dominates contemporary human movement science, with researchers across biomechanics, motor control, and neuroscience routine…

www.sciencedirect.com

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Pierre Millard @pierremillard.bsky.social · 26d

In our new review, we revisit overflow #metabolism across living organisms and propose universal principles of its functioning, integrating insights from studies on yeast, bacterial, and mammalian cells 🦠✨

First first-author paper of Thomas Gosselin-Monplaisir 🥳

👉 Read it here: urlr.me/82Zspc

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Reposted by Pierre Millard

Cell Reports @cp-cellreports.bsky.social · Sep 7

Polysomes and mRNA control the biophysical properties of the eukaryotic cytoplasm

Gade et al. report that polysomes and mRNA levels impact the biophysical properties of the cytoplasm. Using passive rheology probes and single-particle tracking, they demonstrate that intracellular diffusion is enhanced when polysomes are disassembled or when mRNA levels are reduced in eukaryotic cells.

dlvr.it

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Reposted by Pierre Millard

AnniZLab: [🦠, 🧬 , ✨] @annizlab.bsky.social · Sep 9

A plasmid golden ratio? 🧬
Plasmid copy number ≈ 2.5% of chromosome size—consistent across bacterial species!
pmc.ncbi.nlm.nih.gov/articles/PMC... @jerorb.bsky.social
🧪 #microbesky

a Scatter plots showing the correlation between plasmid size (x-axis) and PCN (y-axis) for the analysed genera. Each point represents the median PCN and plasmid size for each PTU, and error bars indicate the standard deviation from the median. Grey lines represent ordinary least squares regression, with the surrounding shaded area indicating 95% confidence intervals. The scaling factor or slope, k, is indicated on each panel. b Distribution of total DNA load per plasmid (x-axis) relative to chromosome size per genus (y-axis). The DNA load of each plasmid is calculated by multiplying the plasmid size by the copy number and then expressed as a proportion relative to the chromosome size. The point inside the box marks the median. The upper and lower hinges correspond to the 25th and 75th percentiles, and whiskers extend to 1.5 times the interquartile range. Only Escherichia and Salmonella significantly differ from All; Kruskal–Wallis test followed by Dunn’s test for pairwise multiple comparisons p < 10−4; effect size = 0.006. c Relative plasmid DNA load observed (%) (x-axis) and expected (y-axis) per cell. The y-axis indicates the expected plasmid DNA load (%) inside a cell when it contains one plasmid (1n), two plasmids (2n), and so on. This expected data has been calculated by generating a sequence from 1 to 9 multiplied by the median of the DNA load per plasmid (2.49%). Each green point represents a single genome, and the black points are the median for each category. Shading indicates interquartile ranges. Pearson’s p value and coefficient are shown for the correlation between expected and observed plasmid DNA.

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Pierre Millard @pierremillard.bsky.social · 26d

Overflow metabolism: Why cells waste nutrients—and why it’s not really waste

go.nature.com/4n39Ijw

Overflow metabolism: Why cells waste nutrients—and why it’s not really waste

Cells often appear to waste nutrients by releasing them as useless, and sometimes toxic, by-products—a phenomenon known as overflow metabolism. Far from being mere waste, these molecules also play vit...

go.nature.com

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Reposted by Pierre Millard

Ricard Solé @ricardsole.bsky.social · Sep 10

Can a single cell learn? Even without a brain, some microbes show simple forms of cognition. Can this basal cognition be engineered? Check our new paper with @jordiplam.bsky.social on the minimal synthetic circuits & their cognitive limits. @drmichaellevin.bsky.social www.biorxiv.org/content/10.1...

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Reposted by Pierre Millard

Alex Fedorec @ajfedorec.bsky.social · Aug 13

I'm going to be advertising for a few positions in my group in the next couple of months for a big project on synthetic microbial communities.

I would love to hear from you if you are interested and I'd also appreciate if everyone could share this far and wide!

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Reposted by Pierre Millard

Tanmay Bharat @tbharat-lab.bsky.social · Aug 31

Sub-cellular chemical mapping in bacteria using correlated cryogenic electron and mass spectrometry imaging

Congrats Hannah Ochner and authors on this important paper! Strong collaboration with @kiranrpatil.bsky.social

www.biorxiv.org/cgi/content/...
@mrclmb.bsky.social @wellcometrust.bsky.social

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Reposted by Pierre Millard

Enrico Orsi @eorsi.bsky.social · 28d

Please repost!

Postdoc in adaptive laboratory evolution and C1 synthetic metabolism!

Location: DTU Biosustain

🦠🧬🔬

Starting in 01/2026!

Fell free to reach out if you have questions!
efzu.fa.em2.oraclecloud.com/hcmUI/Candid...

efzu.fa.em2.oraclecloud.com

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Reposted by Pierre Millard

deshadock.bsky.social @deshadock.bsky.social · 26d

Je pense à ce fil depuis hier, et je me posais la question de ce que ça implique pour les efforts d'apprendre la programmation et ou l'algorithmique aux non spécialistes.

Julien Gossa @juliengossa.cpesr.fr · 27d

My two cents after two months of AI-assisted programming.

Agile methods are going to lose ground, and we’ll go back to requirement documents and specifications/designs carefully tied up in advance.

And this poses an educational challenge.

a black and white photo of a boy with the caption dude copilot is so goo- shut up get out of my head

ALT: a black and white photo of a boy with the caption dude copilot is so goo- shut up get out of my head

media.tenor.com

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Reposted by Pierre Millard

Philip Ball @philipcball.bsky.social · Sep 5

Regulation by RNAs might be even more extensive than we thought. Many enzymes and other proteins not previously considered as RNA-binding proteins do seem to fall into this class & might have their activity regulated by RNA.
www.cell.com/cell/fulltex...

Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

The advent of system-wide proteomic approaches has largely expanded the number of RNA-binding proteins (RBPs). This review discusses how recent discoveries are transforming our understanding of biolog...

www.cell.com

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Reposted by Pierre Millard

Olivier Borkowski @oborkowski.bsky.social · Aug 29

Strategies and applications of synthetic cell communication
doi.org/10.1038/s415...

Strategies and applications of synthetic cell communication - Nature Chemical Biology

Recent advances in engineering bottom-up synthetic cells have created powerful compartmentalized biochemical reactors with cell-like abilities. To push the boundaries of the collective capabilities of...

doi.org

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Reposted by Pierre Millard

Clausen Lab @clausenlab.bsky.social · Aug 21

big one! a decade in the making. nadler & team develop tools to track lipid transport in living cells at single-species resolution. turns out non-vesicular, asymmetry-driven transport is the main architect of organelle identity. feels like the dawn of a golden era for lipid biology. rdcu.be/eBGJv

Quantitative imaging of lipid transport in mammalian cells

Nature - Directional, non-vesicular lipid transport is responsible for fast, species-selective lipid sorting into organelle membranes.

rdcu.be

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Reposted by Pierre Millard

Nature @nature.com · Aug 28

For life to emerge on Earth, peptides must first have formed without the aid of enzymes — but how? Reactions of sulfur-containing molecules might have been key

go.nature.com/4oX04jC

Origins of life: the molecules that could have unlocked peptide synthesis

For life to emerge on Earth, peptides must first have formed without the aid of enzymes — but how? Reactions of sulfur-containing molecules might have been key.

go.nature.com

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Reposted by Pierre Millard

Zeynep Baharoglu @zeynepbaharoglu.bsky.social · Aug 23

Aggresomes protect mRNA under stress in Escherichia coli
www.nature.com/articles/s41... "prolonged stress leading to ATP depletion in Escherichia coli results in increased aggresome formation, compaction and selective mRNA enrichment within these aggresomes" 🦠 #microsky #rnasky

Aggresomes protect mRNA under stress in Escherichia coli - Nature Microbiology

Ribonucleoprotein aggresomes exclude ribonucleases and protect mRNA to promote rapid translation reactivation and cellular recovery after stress alleviation in Escherichia coli.

www.nature.com

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Reposted by Pierre Millard

Olivier Borkowski @oborkowski.bsky.social · Aug 27

Autocatalytic selection of gene functions in vitro
doi.org/10.1101/2025...

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