Clausen Lab
@clausenlab.bsky.social
Molecular machines, Proteostasis, Ubiquitin Signaling, Cell Autonomous Defense, Protein Disorders and Team Nematode
@IMP Vienna
www.imp.ac.at/groups/tim-clausen/
@IMP Vienna
www.imp.ac.at/groups/tim-clausen/
Reposted by Clausen Lab
Join @uofglasgow.bsky.social for a funded 3.5 year PhD programme:
www.gla.ac.uk/colleges/mvl...
Also up for grabs is a project on antiviral PROTACs, supervised by us and the France lab (School of Chemistry) should ubiquitin and viruses appeal! Please get in touch with any questions.
www.gla.ac.uk/colleges/mvl...
Also up for grabs is a project on antiviral PROTACs, supervised by us and the France lab (School of Chemistry) should ubiquitin and viruses appeal! Please get in touch with any questions.
www.gla.ac.uk
November 24, 2025 at 3:47 PM
Join @uofglasgow.bsky.social for a funded 3.5 year PhD programme:
www.gla.ac.uk/colleges/mvl...
Also up for grabs is a project on antiviral PROTACs, supervised by us and the France lab (School of Chemistry) should ubiquitin and viruses appeal! Please get in touch with any questions.
www.gla.ac.uk/colleges/mvl...
Also up for grabs is a project on antiviral PROTACs, supervised by us and the France lab (School of Chemistry) should ubiquitin and viruses appeal! Please get in touch with any questions.
Reposted by Clausen Lab
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
November 24, 2025 at 1:03 PM
🪱 Selfish genes are everywhere and drive some of biology’s biggest innovations (CRISPR, antibody recombination, epigenetics). Yet almost no one asks the obvious question: how does a selfish gene begin? Our new manuscript uncovers how selfishness can emerge directly from the host genome.
Reposted by Clausen Lab
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
November 18, 2025 at 10:18 AM
Are you looking for female speakers in CryoEM for seminars and conferences? Are you a woman in CryoEM and not yet on the ‚woman in CryoEM‘ list? Find your speakers and add/update name and affiliation! docs.google.com/spreadsheets...
Reposted by Clausen Lab
Post 1
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
November 18, 2025 at 7:22 AM
Post 1
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
As noted yesterday: the in-vitro assay in the 2016 @cp-cell.bsky.social Cell paper from @brangwynnelab.bsky.social (dx.doi.org/10.1016/j.cell.2016.04.047) led to wrong conclusions about NPM1 LLPS in nucleolar assembly.
(see image)
Reposted by Clausen Lab
Inferring LLPS from macroscopic properties (roundness, “liquidity”) is unhelpful. Subcellular compartments likely arise from specific interactions among multivalent proteins—robust and insensitive to environment.
These interactions can generate structures with some LLPS-like properties
These interactions can generate structures with some LLPS-like properties
November 17, 2025 at 7:24 AM
Inferring LLPS from macroscopic properties (roundness, “liquidity”) is unhelpful. Subcellular compartments likely arise from specific interactions among multivalent proteins—robust and insensitive to environment.
These interactions can generate structures with some LLPS-like properties
These interactions can generate structures with some LLPS-like properties
great post on LLPS, flying elephants and phase behaviour beyond thermodynamics #PhaseFiction
The review by Banani, Lee, Hyman & Rosen (NRMCB 2017) www.nature.com/articles/nrm... on biomolecular condensates has >6000 citations. It…
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
1. Introduced a broad definition of “biomolecular condensates,” promoting acceptance that a unifying mechanism may underlie all membrane-less compartments.
Biomolecular condensates: organizers of cellular biochemistry - Nature Reviews Molecular Cell Biology
In addition to membrane-bound organelles, eukaryotic cells feature various membraneless compartments, including the centrosome, the nucleolus and various granules. Many of these compartments form thro...
www.nature.com
November 17, 2025 at 7:55 AM
great post on LLPS, flying elephants and phase behaviour beyond thermodynamics #PhaseFiction
Reposted by Clausen Lab
The devil is in the details
Atomically accurate de novo design of antibodies with RFdiffusion
www.nature.com/articles/s41...
success rates against each target range from 0% to 2% 😆
for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.
Atomically accurate de novo design of antibodies with RFdiffusion
www.nature.com/articles/s41...
success rates against each target range from 0% to 2% 😆
for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.
November 13, 2025 at 8:11 AM
The devil is in the details
Atomically accurate de novo design of antibodies with RFdiffusion
www.nature.com/articles/s41...
success rates against each target range from 0% to 2% 😆
for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.
Atomically accurate de novo design of antibodies with RFdiffusion
www.nature.com/articles/s41...
success rates against each target range from 0% to 2% 😆
for SARS-CoV2 RBD target, 9000 designs screened, 5 SPR confirmed binders.
Reposted by Clausen Lab
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
November 12, 2025 at 10:32 AM
✨ Passionate about cell biology or biochemistry? Join the Martens Lab as a postdoc to uncover why autophagy stalls at disease-linked protein aggregates - and how to restart it 🧠 Apply here ➡️ tinyurl.com/24dcrcke
Reposted by Clausen Lab
Join us for Journal Club tomorrow, November 12th, as Dr. Elias Adriaenssens presents his recently published article in Nature Cell Biology, titled “Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.”
We look forward to seeing you there!
We look forward to seeing you there!
November 12, 2025 at 2:38 AM
Join us for Journal Club tomorrow, November 12th, as Dr. Elias Adriaenssens presents his recently published article in Nature Cell Biology, titled “Reconstitution of BNIP3/NIX-mitophagy initiation reveals hierarchical flexibility of the autophagy machinery.”
We look forward to seeing you there!
We look forward to seeing you there!
Reposted by Clausen Lab
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Chemical biology 2026
www.embl.org
November 11, 2025 at 5:46 PM
Registration for THE chemical biology conference of 2026 is now open! EMBO ChemBio 2026 in Heidelberg
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
DeGrado, Arikin, Picotti (Keynotes). @lmkdassama.bsky.social @brianliau.bsky.social @rhodamine110.bsky.social @benlehner.bsky.social @alitavassoli.bsky.social
www.embl.org/about/info/c...
Reposted by Clausen Lab
🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
November 6, 2025 at 5:20 PM
🤯This is wow! Molecular mechanism of mRNA export. by @juliusbrennecke.bsky.social @plaschkalab.bsky.social
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Clausen Lab
Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
High-throughput peptide-centric local stability assay extends protein–ligand identification to membrane proteins, tissues and bacteria - Nature Structural & Molecular Biology
Li et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and...
www.nature.com
November 6, 2025 at 8:40 AM
Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
Reposted by Clausen Lab
Postdoc position available in my lab in Jena (Germany.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
Postdoc (m/f/x)
Our Research Group led by Janine Kirstein, Professorin at Friedrich-Schiller-University Jena, is looking for a highly motivated and talented Postdoctoral Researcher (m/f/x) to join a research project ...
jobs.leibniz-fli.de
November 4, 2025 at 7:39 AM
Postdoc position available in my lab in Jena (Germany.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
jobs.leibniz-fli.de/jobposting/6...
If you're interested in protein biochemistry of amyloid proteins and chaperones, this job may be for you. B2 Level German is required as the candidate will be involved in teaching in German.
Reposted by Clausen Lab
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
October 31, 2025 at 9:24 AM
📢 Open Call! The Max Perutz Labs invite applications for a Full Professorship in Integrative Structure Biology with a focus on in situ structural biology using cryo-electron tomography (cryo-ET) and related methods. More details ➡️ tinyurl.com/brswbymu
Reposted by Clausen Lab
'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'
Tissue-specific consequences of tag fusions on protein expression in transgenic mice
Author summary To better understand the function of specific proteins, researchers need ways to quantify their abundance, to visualise their movements, to understand what other molecules they interact...
journals.plos.org
October 26, 2025 at 6:18 PM
'In this manuscript, we show that tag fusions often change protein expression to a degree that is highly dependent on cell and tissue context. We characterise two underlying mechanisms, providing information that should help others to design more effective transgenic strategies'
Reposted by Clausen Lab
October 24, 2025 at 4:06 AM
Reposted by Clausen Lab
On that note: hello world! My new lab on genetics of proteome remodeling is starting at the incredible MPI-CBG. We have big plans and open positions for PhD students and an RA. Apply now (!) at imprs.mpi-cbg.de and tinyurl.com/2vywj6f6 respectively.
October 21, 2025 at 9:53 PM
On that note: hello world! My new lab on genetics of proteome remodeling is starting at the incredible MPI-CBG. We have big plans and open positions for PhD students and an RA. Apply now (!) at imprs.mpi-cbg.de and tinyurl.com/2vywj6f6 respectively.
Reposted by Clausen Lab
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
October 9, 2025 at 7:37 PM
Just out in @science.org: Together with the lab of @wilhelmpalm.bsky.social, we used sequential in-vitro/in-vivo CRISPR screens to decipher metabolic adaptations in tumors. We find that acidosis is a dominant factor that shapes energy metabolism and stress resilience. www.science.org/doi/10.1126/...
Reposted by Clausen Lab
The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)
Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation
doi.org/10.1101/2025...
Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation
doi.org/10.1101/2025...
October 7, 2025 at 9:20 PM
The proteasome-substrate-shuttle protein UBQLN2 contains—like other quality control system proteins—a long region devoid of lysine (a lysine desert)
Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation
doi.org/10.1101/2025...
Martin Grønbæk-Thygesen (from @rhp-lab.bsky.social) et al show that introducing K here causes ubiquitylation and degradation
doi.org/10.1101/2025...
Reposted by Clausen Lab
Science has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Nobel Laureate Professor Sir John Gurdon dies aged 92
It is with great sadness that the University shares the news of the death of Professor Sir John Gurdon, founder of the Gurdon Institute.
www.cam.ac.uk
October 7, 2025 at 7:07 PM
Science has lost a GIANT and the world has lost one of the kindest most inspiring people I had the pleasure of knowing. Just an extraordinary man whose curiosity was infectious and whose dry wit will always be memorable- RIP John
www.cam.ac.uk/research/new...
www.cam.ac.uk/research/new...
Reposted by Clausen Lab
Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
Axel Mogk, Marta Carroni et al
www.embopress.org/doi/full/10....
Axel Mogk, Marta Carroni et al
www.embopress.org/doi/full/10....
September 29, 2025 at 11:56 AM
Allosteric control of the bacterial ClpC/ClpP protease and its hijacking by antibacterial peptides
Axel Mogk, Marta Carroni et al
www.embopress.org/doi/full/10....
Axel Mogk, Marta Carroni et al
www.embopress.org/doi/full/10....
Reposted by Clausen Lab
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
A Leishmania virulence factor harnesses an allosteric kinase switch to regulate its ubiquitin ligase activity
Stringent control of ubiquitylation is a central requirement of signaling specificity in eukaryotes. Here, we discover a domain module integrating pro…
www.sciencedirect.com
September 24, 2025 at 3:30 PM
Allosteric activation of a ubiquitin ligase by an internal kinase domain! Congratulations to our team member Thornton Fokkens for this fascinating discovery in a neglected disease area with strong therapeutic need. Many thanks to all our great collaborators!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Clausen Lab
Spectacular work. Absolutely spectacular. Go check out the paper. It truly is #lipidtime now
Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...
Leaflet-specific phospholipid imaging using genetically encoded proximity sensors - Nature Chemical Biology
An approach combining bioorthogonal chemistry with genetically encoded fluorogen-activating proteins enables subcellular imaging of phospholipids and glycans, as well as the visualization of lipid tra...
www.nature.com
September 15, 2025 at 6:07 PM
Spectacular work. Absolutely spectacular. Go check out the paper. It truly is #lipidtime now
so well deserved
Congratulations to Dirk Görlich and Steven L. McKnight, 2025 #LaskerAward winners! - “for discoveries that exposed the structures and functions of low-complexity domains within protein sequences” 🧪
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
@mpi-nat.bsky.social
#Lasker2025 #LaskerLaureate #structuralbiology #phaseseparation
September 12, 2025 at 8:29 AM
so well deserved
Reposted by Clausen Lab
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
September 8, 2025 at 3:16 PM
Dear scientific community,
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...
I am looking for two postdoctoral structural biologists to join my group at the Department of Biochemistry, University of Oxford.
my.corehr.com/pls/uoxrecru...
my.corehr.com/pls/uoxrecru...