@dimitristypas.bsky.social
Senior editor @naturesmb.bsky.social. Views and opinions are personal.
Pinned
High-throughput peptide-centric local stability assay extends protein–ligand identification to membrane proteins, tissues and bacteria - Nature Structural & Molecular Biology
Li et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and...
www.nature.com
Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
Reposted
Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️
November 5, 2025 at 10:15 AM
Happy to see our HT-PELSA paper now published in @natsmb.nature.com 🎊 Big thanks for the constructive review process! 📖Read the manuscript here (www.nature.com/articles/s41...) & check the thread for additional information ⬇️
I'd be remiss not to highlight this study www.nature.com/articles/s41... from the lab of @kevincorbett.bsky.social now out @natsmb.nature.com Always striking to see how inventive bacteria are and what an unorthodox ubiquitylation-like mechanism this may be (probably oxyester dependent).
Mechanistic basis for protein conjugation in a diverged bacterial ubiquitination pathway - Nature Structural & Molecular Biology
Ye et al. define the structure and mechanisms of a bacterial pathway that performs ubiquitination-like protein conjugation, revealing new insights into the evolution and biological roles of ubiquitina...
www.nature.com
November 6, 2025 at 8:46 AM
I'd be remiss not to highlight this study www.nature.com/articles/s41... from the lab of @kevincorbett.bsky.social now out @natsmb.nature.com Always striking to see how inventive bacteria are and what an unorthodox ubiquitylation-like mechanism this may be (probably oxyester dependent).
Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
High-throughput peptide-centric local stability assay extends protein–ligand identification to membrane proteins, tissues and bacteria - Nature Structural & Molecular Biology
Li et al. further develop a high-throughput peptide-centric local stability assay that speeds up sample preparation 100-fold and extends protein–ligand identification to membrane proteins, tissues and...
www.nature.com
November 6, 2025 at 8:40 AM
Very glad to see this work www.nature.com/articles/s41... by the @savitski-lab.bsky.social out @natsmb.nature.com High hopes that HT-PELSA will be a very useful tool to study protein-ligand interactions.
Very happy that this insightful story by @andersshansen.bsky.social is out @natsmb.nature.com, www.nature.com/articles/s41.... A nice press release explaining the progress also from the home institute @mitdeptofbe.bsky.social here: news.mit.edu/2025/surpris...
Dynamics of microcompartment formation at the mitosis-to-G1 transition - Nature Structural & Molecular Biology
Goel et al. produce high-resolution three-dimensional genome structure mapping from mitosis to G1 phase to show unseen interactions between enhancers and promoters in prometaphase. Polymer modeling in...
www.nature.com
October 20, 2025 at 9:30 AM
Very happy that this insightful story by @andersshansen.bsky.social is out @natsmb.nature.com, www.nature.com/articles/s41.... A nice press release explaining the progress also from the home institute @mitdeptofbe.bsky.social here: news.mit.edu/2025/surpris...
The @natsmb.nature.com Returning Home series is now complete, www.nature.com/nsmb/article... with the final piece by Hugo Sepulveda on his return to Chile published. It has been a joy to work on this series and, if our readers appreciate these pieces, I hope that it may continue or evolve!
World View
| Nature Structural & Molecular Biology
Browse the archive of articles on Nature Structural & Molecular Biology
www.nature.com
October 15, 2025 at 9:39 PM
The @natsmb.nature.com Returning Home series is now complete, www.nature.com/nsmb/article... with the final piece by Hugo Sepulveda on his return to Chile published. It has been a joy to work on this series and, if our readers appreciate these pieces, I hope that it may continue or evolve!
We @natsmb.nature.com aim to provide a stage for our readers. That includes voicing their experiences and perspectives. We hope this makes us a more attuned and representative outlet for our communities. We launched new content to do so and explain why in our editorial www.nature.com/articles/s41...
Voices of NSMB - Nature Structural & Molecular Biology
We are delighted to introduce additional content types at Nature Structural & Molecular Biology, which allow us to offer more discussion of societal and scientific issues, better represent the uni...
www.nature.com
October 15, 2025 at 9:36 PM
We @natsmb.nature.com aim to provide a stage for our readers. That includes voicing their experiences and perspectives. We hope this makes us a more attuned and representative outlet for our communities. We launched new content to do so and explain why in our editorial www.nature.com/articles/s41...
Reposted
here is the correct link: ista.ac.at/en/job/tenur...
Tenure-based Research Staff Scientist Position in Computational Structural Biology
ISTA (www.ista.ac.at) is seeking a highly skilled Staff Scientist in Computational Structural Biology to support and advance the Institute’s structural biology research through the development and imp...
ista.ac.at
October 15, 2025 at 12:44 PM
here is the correct link: ista.ac.at/en/job/tenur...
Reposted
Come work with us! 🧪
🚨Job Alert!🚨
We seek an #Editor to join Nat Metabolism and work in collaboration with Nat Communications.
If being a #Metabolism editor is for you, check out our #job posting below and apply before Oct 26th! Locations: US, China. Details below🧪
springernature.wd3.myworkdayjobs.com/de-DE/Spring...
We seek an #Editor to join Nat Metabolism and work in collaboration with Nat Communications.
If being a #Metabolism editor is for you, check out our #job posting below and apply before Oct 26th! Locations: US, China. Details below🧪
springernature.wd3.myworkdayjobs.com/de-DE/Spring...
Associate or Senior Editor (Nature Metabolism and Nature Communications)
Job Title: Associate or Senior Editor (Nature Metabolism and Nature Communications) Location(s): New York, Jersey City, Philadelphia, Beijing or Shanghai Application Deadline: October 26th, 2025 About...
springernature.wd3.myworkdayjobs.com
October 8, 2025 at 3:08 PM
Come work with us! 🧪
Reposted
New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Nature Structural & Molecular Biology, Published online: 06 October 2025; doi:10.1038/s41594-025-01686-3Here Schwämmle et al. develop CRISPR reporter screens to map transcription-factor-regulatory element interactions at the Xist locus, revealing a two-step mechanism integrating developmental and X-dosage signals to initiate X-chromosome inactivation.
go.nature.com
October 6, 2025 at 12:34 PM
New online: Reporter CRISPR screens decipher cis-regulatory and trans-regulatory principles at the Xist locus
Our series on scientists Returning Home after working abroad continues here @natsmb.nature.com
Dr. Furlan-Magaril has authored an inspiring and thoughtful piece on her scientific trip leading her back to Mexico. www.nature.com/articles/s41...
Dr. Furlan-Magaril has authored an inspiring and thoughtful piece on her scientific trip leading her back to Mexico. www.nature.com/articles/s41...
Returning home: a story of chromatin and community - Nature Structural & Molecular Biology
Exile, discovery, and resilience have shaped my journey as a group leader in Mexico. From exploring chromatin architecture to building a lab and community, this is how science became my vocation and my home.
www.nature.com
October 7, 2025 at 1:33 PM
Our series on scientists Returning Home after working abroad continues here @natsmb.nature.com
Dr. Furlan-Magaril has authored an inspiring and thoughtful piece on her scientific trip leading her back to Mexico. www.nature.com/articles/s41...
Dr. Furlan-Magaril has authored an inspiring and thoughtful piece on her scientific trip leading her back to Mexico. www.nature.com/articles/s41...
Reposted
New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
Nature Structural & Molecular Biology, Published online: 25 September 2025; doi:10.1038/s41594-025-01681-8This study reveals how human small ubiquitin-like modifier (SUMO) E1 recruits its E2 partner UBC9 and transfers SUMO1 through large structural changes, uncovering key mechanisms that ensure specificity and fidelity in SUMOylation, an essential protein modification pathway.
go.nature.com
September 25, 2025 at 11:59 AM
New online: Cryo-EM structures reveal the molecular mechanism of SUMO E1–E2 thioester transfer
The September @natsmb.nature.com issue is out! www.nature.com/articles/s41...
We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.
We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.
Focus on ubiquitylation and protein degradation - Nature Structural & Molecular Biology
We highlight primary research and commissioned content that delve into the biology of ubiquitylation and degradation mechanisms.
www.nature.com
September 17, 2025 at 6:38 AM
The September @natsmb.nature.com issue is out! www.nature.com/articles/s41...
We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.
We feature very interesting papers on ubiquitylation and degradation. Really excited to continue to serve the proteostasis and PTMs communities and publish conceptually insightful work.
Reposted
New Online! Learning about break-induced replication from bacteriophages
Learning about break-induced replication from bacteriophages
Nature Reviews Molecular Cell Biology, Published online: 09 September 2025; doi:10.1038/s41580-025-00898-1Break-induced replication (BIR), a DNA double-strand break repair mechanism, was first studied in the 1960s in bacteriophages, showing that DNA could recombine by a 'break–copy' mechanism.
bit.ly
September 9, 2025 at 1:18 PM
New Online! Learning about break-induced replication from bacteriophages
A captivating read on a very interesting topic, the closer-than-anticipated relationship between ubiquitin and ADP-ribose just out @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
The rise of ADP-ribose–ubiquitin - Nature Structural & Molecular Biology
Post-translational modifications show mechanistic crosstalk, exemplified by the ADP-ribose–ubiquitin hybrid signal, in which one post-translational modification modifies another. This Comment highlights its discovery, mechanistic basis and functional consequences, and outlines critical questions for understanding this emerging signaling paradigm.
www.nature.com
September 8, 2025 at 12:58 PM
A captivating read on a very interesting topic, the closer-than-anticipated relationship between ubiquitin and ADP-ribose just out @natsmb.nature.com
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
August 28, 2025 at 5:35 PM
We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉
Reposted
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: [email protected]
For more information, please contact: [email protected]
August 28, 2025 at 8:23 AM
Three-Year Funded Postdoctoral Position to study organelle architecture in mammalian oocytes – Terret-Verlhac Lab, CIRB, Collège de France (Starting 2026).
For more information, please contact: [email protected]
For more information, please contact: [email protected]
This insightful manuscript implicating STAG3 in mitotic, rather than the known meiotic, control of chromatin architecture came out a couple of days ago. Glad to see it in our pages @natsmb.nature.com and I am looking forward to see what the community will think www.nature.com/articles/s41...
The mitotic STAG3–cohesin complex shapes male germline nucleome - Nature Structural & Molecular Biology
Nagano et al. identify the third mitotic cohesin complex, STAG3–cohesin, which, with its unique biophysical properties, weakens insulation and rewires regulatory interactions of spermatogonial stem ce...
www.nature.com
August 27, 2025 at 10:50 AM
This insightful manuscript implicating STAG3 in mitotic, rather than the known meiotic, control of chromatin architecture came out a couple of days ago. Glad to see it in our pages @natsmb.nature.com and I am looking forward to see what the community will think www.nature.com/articles/s41...
Reposted
Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin.
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
August 26, 2025 at 4:18 PM
Congratulations to Masahiro Nagano on his new paper on STAG3-cohesin.
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
STAG3-cohesin has a much shorter residence time which leads to altered 3D genome organization and STAG3-cohesin is important for male germ cell differentiation.
www.nature.com/articles/s41...
@natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Returning home: there and back again in Czechia - Nature Structural & Molecular Biology
Returning to Central Europe was appealing and challenging. Here, I reflect on my part in rebuilding a research career in Czechia and fostering a collaborative scientific community across the region.
www.nature.com
August 12, 2025 at 11:54 AM
@natsmb.nature.com has published three pieces on scientists returning to their country of origin after working abroad. www.nature.com/nsmb/article... Two more will come out. The most recent one by @hanasedlackova.bsky.social hits home for me, a very interesting read.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted
📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...
https://nature.com/articles/s4159…
August 7, 2025 at 5:28 PM
📢 Excited to share my World View article, just published in @NatureSMB, where I reflect on returning to Czechia and building research group grounded in collaboration🤝, resilience and curiosity💡. www.nature.com/articles/s41...
Reposted
Another installment of the 'Returning home" series at NSMB.
This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw
This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw
ICYMI: New online: Returning home to navigate challenges and meet potential in Poland
Returning home to navigate challenges and meet potential in Poland
Nature Structural & Molecular Biology, Published online: 29 July 2025; doi:10.1038/s41594-025-01641-2After training internationally, I chose to return to Poland to start my own research group, a decision neither taken lightly nor regretted.
go.nature.com
July 30, 2025 at 1:17 PM
Another installment of the 'Returning home" series at NSMB.
This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw
This time, we're returning to Poland! Read below the piece from Lidia Wróbel from IIMCB, Warsaw
Out @natsmb.nature.com a great Q&A with @fmattiroli.bsky.social. I really enjoyed reading it and I am very happy that Francesca had the time to work with us. www.nature.com/articles/s41...
Q&A with Francesca Mattiroli - Nature Structural & Molecular Biology
Francesca Mattiroli leads a research group at the Hubrecht Institute in Utrecht in the Netherlands, delving into the dynamics of chromatin during DNA synthesis. Here we ask her about her research etho...
www.nature.com
July 27, 2025 at 7:52 PM
Out @natsmb.nature.com a great Q&A with @fmattiroli.bsky.social. I really enjoyed reading it and I am very happy that Francesca had the time to work with us. www.nature.com/articles/s41...
Did not have time to post about this before vacation. Such a joy to have this chat with @davidlabmsk.bsky.social and Nobel Laureate Charles Rice on Yael's amazing work, capitalising on chromatin biology to understand hepatitis. www.nature.com/articles/s41...
Q&A with Yael David and Charles Rice on using chromatin biology to understand hepatitis - Nature Structural & Molecular Biology
Yael David leads her lab focused on studying the fundamental mechanisms of epigenetic regulation of transcription at Memorial Sloan Kettering Cancer Center, and Charles Rice is the Maurice R. and Cori...
www.nature.com
July 27, 2025 at 7:47 PM
Did not have time to post about this before vacation. Such a joy to have this chat with @davidlabmsk.bsky.social and Nobel Laureate Charles Rice on Yael's amazing work, capitalising on chromatin biology to understand hepatitis. www.nature.com/articles/s41...
Reposted
Working with collaborators at the Crick Institute and the University of Utah, CSHL's President and CEO Bruce Stillman explores how pre-replicative complexes (pre-RCs)—even earlier than ORCs—assemble to initiate DNA replication in all plants, animals, and fungi.
Researchers at the Crick, @cshlnews.bsky.social and the @utah.edu have laid out in detail how the ‘pre-replicative complex’ is assembled at the start of DNA replication.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Mechanisms for licensing origins of DNA replication in eukaryotic cells - Nature Structural & Molecular Biology
Here, the authors comprehensively discuss the different mechanisms for origin licensing in yeast and human cells. Importantly, they present intuitive videos illustrating such mechanisms with unprecede...
www.nature.com
July 1, 2025 at 4:56 PM
Working with collaborators at the Crick Institute and the University of Utah, CSHL's President and CEO Bruce Stillman explores how pre-replicative complexes (pre-RCs)—even earlier than ORCs—assemble to initiate DNA replication in all plants, animals, and fungi.
Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @natsmb.nature.com will publish 5 pieces on those that returned. The first one discusses Dr. Gomes Dias' return to Brazil. Touching and inspiring. www.nature.com/articles/s41...
LinkedIn
This link will take you to a page that’s not on LinkedIn
lnkd.in
July 3, 2025 at 4:55 PM
Scientists travel to work. Some continue to travel during their career, some set roots to an adopted country, some return. @natsmb.nature.com will publish 5 pieces on those that returned. The first one discusses Dr. Gomes Dias' return to Brazil. Touching and inspiring. www.nature.com/articles/s41...